LOCUS       NM_172552               3523 bp    mRNA    linear   ROD 08-FEB-2024
DEFINITION  Mus musculus thymine DNA glycosylase (Tdg), transcript variant 2,
            mRNA.
ACCESSION   NM_172552 XM_989239
VERSION     NM_172552.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3523)
  AUTHORS   Aranda,S., Alcaine-Colet,A., Ballare,C., Blanco,E., Mocavini,I.,
            Sparavier,A., Vizan,P., Borras,E., Sabido,E. and Di Croce,L.
  TITLE     Thymine DNA glycosylase regulates cell-cycle-driven p53
            transcriptional control in pluripotent cells
  JOURNAL   Mol Cell 83 (15), 2673-2691 (2023)
   PUBMED   37506700
  REMARK    GeneRIF: Thymine DNA glycosylase regulates cell-cycle-driven p53
            transcriptional control in pluripotent cells.
REFERENCE   2  (bases 1 to 3523)
  AUTHORS   Tricarico,R., Madzo,J., Scher,G., Cohen,M., Jelinek,J., Maegawa,S.,
            Nagarathinam,R., Scher,C., Chang,W.C., Nicolas,E., Slifker,M.,
            Zhou,Y., Devarajan,K., Cai,K.Q., Kwok,T., Nakajima,P., Xu,J.,
            Mancuso,P., Doneddu,V., Bagella,L., Williams,R., Balachandran,S.,
            Maskalenko,N., Campbell,K., Ma,X., Canadas,I., Viana-Errasti,J.,
            Moreno,V., Valle,L., Grivennikov,S., Peshkova,I., Kurilenko,N.,
            Mazitova,A., Koltsova,E., Lee,H., Walsh,M., Duttweiler,R.,
            Whetstine,J.R., Yen,T.J., Issa,J.P. and Bellacosa,A.
  TITLE     TET1 and TDG Suppress Inflammatory Response in Intestinal
            Tumorigenesis: Implications for Colorectal Tumors With the CpG
            Island Methylator Phenotype
  JOURNAL   Gastroenterology 164 (6), 921-936 (2023)
   PUBMED   36764492
  REMARK    GeneRIF: TET1 and TDG Suppress Inflammatory Response in Intestinal
            Tumorigenesis: Implications for Colorectal Tumors With the CpG
            Island Methylator Phenotype.
REFERENCE   3  (bases 1 to 3523)
  AUTHORS   Onodera,A., Gonzalez-Avalos,E., Lio,C.J., Georges,R.O.,
            Bellacosa,A., Nakayama,T. and Rao,A.
  TITLE     Roles of TET and TDG in DNA demethylation in proliferating and
            non-proliferating immune cells
  JOURNAL   Genome Biol 22 (1), 186 (2021)
   PUBMED   34158086
  REMARK    GeneRIF: Roles of TET and TDG in DNA demethylation in proliferating
            and non-proliferating immune cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3523)
  AUTHORS   Schwarz,S.D., Grundbacher,E., Hrovat,A.M., Xu,J., Kusnierczyk,A.,
            Vagbo,C.B., Schar,P. and Schuermann,D.
  TITLE     Inducible TDG knockout models to study epigenetic regulation
  JOURNAL   F1000Res 9, 1112 (2020)
   PUBMED   33082936
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3523)
  AUTHORS   Hassan,H.M., Isovic,M., Kolendowski,B., Bauer-Maison,N.,
            Onabote,O., Cecchini,M., Haig,A., Maleki Vareki,S., Underhill,T.M.
            and Torchia,J.
  TITLE     Loss of Thymine DNA Glycosylase Causes Dysregulation of Bile Acid
            Homeostasis and Hepatocellular Carcinoma
  JOURNAL   Cell Rep 31 (1), 107475 (2020)
   PUBMED   32268085
REFERENCE   6  (bases 1 to 3523)
  AUTHORS   Niederreither,K., Harbers,M., Chambon,P. and Dolle,P.
  TITLE     Expression of T:G mismatch-specific thymidine-DNA glycosylase and
            DNA methyl transferase genes during development and tumorigenesis
  JOURNAL   Oncogene 17 (12), 1577-1585 (1998)
   PUBMED   9794235
REFERENCE   7  (bases 1 to 3523)
  AUTHORS   Um,S., Harbers,M., Benecke,A., Pierrat,B., Losson,R. and Chambon,P.
  TITLE     Retinoic acid receptors interact physically and functionally with
            the T:G mismatch-specific thymine-DNA glycosylase
  JOURNAL   J Biol Chem 273 (33), 20728-20736 (1998)
   PUBMED   9694815
REFERENCE   8  (bases 1 to 3523)
  AUTHORS   De Gregorio,L., Gallinari,P., Gariboldi,M., Manenti,G.,
            Pierotti,M.A., Jiricny,J. and Dragani,T.A.
  TITLE     Genetic mapping of thymine DNA glycosylase (Tdg) gene and of one
            pseudogene in the mouse
  JOURNAL   Mamm Genome 7 (12), 909-910 (1996)
   PUBMED   8995763
REFERENCE   9  (bases 1 to 3523)
  AUTHORS   Neddermann,P., Gallinari,P., Lettieri,T., Schmid,D., Truong,O.,
            Hsuan,J.J., Wiebauer,K. and Jiricny,J.
  TITLE     Cloning and expression of human G/T mismatch-specific thymine-DNA
            glycosylase
  JOURNAL   J Biol Chem 271 (22), 12767-12774 (1996)
   PUBMED   8662714
REFERENCE   10 (bases 1 to 3523)
  AUTHORS   Chevray,P.M. and Nathans,D.
  TITLE     Protein interaction cloning in yeast: identification of mammalian
            proteins that react with the leucine zipper of Jun
  JOURNAL   Proc Natl Acad Sci U S A 89 (13), 5789-5793 (1992)
   PUBMED   1631061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152980.2, BC085471.1 and AK053870.1.
            
            [WARNING] On Mar 30, 2024 this sequence was replaced by
            NM_172552.5.
            
            On Dec 1, 2017 this sequence version replaced NM_172552.3.
            
            Transcript Variant: This variant (3) represents the longer variant
            and encodes the longest isoform (2).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK053870.1, BC085471.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC152980.2         80709-80737         c
            30-3005             BC085471.1         1-2976
            3006-3282           AK053870.1         2934-3210
            3283-3344           AC152980.2         59955-60016         c
            3345-3523           AK053870.1         3273-3451
FEATURES             Location/Qualifiers
     source          1..3523
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3523
                     /gene="Tdg"
                     /gene_synonym="E130317C12Rik; JZA-3; Jza1"
                     /note="thymine DNA glycosylase"
                     /db_xref="GeneID:21665"
                     /db_xref="MGI:MGI:108247"
     exon            1..201
                     /gene="Tdg"
                     /gene_synonym="E130317C12Rik; JZA-3; Jza1"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1444
                     /gene="Tdg"
                     /gene_synonym="E130317C12Rik; JZA-3; Jza1"
                     /EC_number="3.2.2.29"
                     /note="isoform 2 is encoded by transcript variant 2; g/T
                     mismatch-specific thymine DNA glycosylase; C-JUN leucine
                     zipper interactive protein JZA-3"
                     /codon_start=1
                     /product="G/T mismatch-specific thymine DNA glycosylase
                     isoform 2"
                     /protein_id="NP_766140.2"
                     /db_xref="CCDS:CCDS24070.1"
                     /db_xref="GeneID:21665"
                     /db_xref="MGI:MGI:108247"
                     /translation="MDAEAARSYSLEQVQALYSFPFQQMMAEVPNMAVTTGQQVPAVA
                     PNMATVTEQQVPEDAPVQEPAPEAPKRRKRKPRAAEPQEPVEPKKPATSKKSGKSTKS
                     KEKQEKITDAFKVKRKVDRFNGVSEAELLTKTLPDILTFNLDIVIIGINPGLMAAYKG
                     HHYPGPGNHFWKCLFMSGLSEVQLNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKE
                     FREGGRILVQKLQKYQPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETL
                     CYVMPSSSARCAQFPRAQDKVHYYIKLKDLRDQLKGIERNADVQEVQYTFDLQLAQED
                     AKKMAVKEEKYDPGYEAAYGGAYGENPCNGEPCGIASNGLTAHSAEPRGEAAPSDVPN
                     GQWMAQSFAEQIPSFNNCGTREQEEESHA"
     exon            202..377
                     /gene="Tdg"
                     /gene_synonym="E130317C12Rik; JZA-3; Jza1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..619
                     /gene="Tdg"
                     /gene_synonym="E130317C12Rik; JZA-3; Jza1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..689
                     /gene="Tdg"
                     /gene_synonym="E130317C12Rik; JZA-3; Jza1"
                     /inference="alignment:Splign:2.1.0"
     exon            690..825
                     /gene="Tdg"
                     /gene_synonym="E130317C12Rik; JZA-3; Jza1"
                     /inference="alignment:Splign:2.1.0"
     exon            826..908
                     /gene="Tdg"
                     /gene_synonym="E130317C12Rik; JZA-3; Jza1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1003
                     /gene="Tdg"
                     /gene_synonym="E130317C12Rik; JZA-3; Jza1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1175
                     /gene="Tdg"
                     /gene_synonym="E130317C12Rik; JZA-3; Jza1"
                     /inference="alignment:Splign:2.1.0"
     exon            1176..1301
                     /gene="Tdg"
                     /gene_synonym="E130317C12Rik; JZA-3; Jza1"
                     /inference="alignment:Splign:2.1.0"
     exon            1302..3523
                     /gene="Tdg"
                     /gene_synonym="E130317C12Rik; JZA-3; Jza1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggaggggga cggaagtgcg ctggggactc gccgcggtga tgtagcagcg tgggaggggc
       61 cgaggccagc gccgtccatc caccggccgc cccgatcctg tggtgagtcc gcgcgctgag
      121 cggcagagcg ggcgcccgtg ggctcggcag gagtggccgt accctcggcg gcgccgccat
      181 ggacgcagag gccgcgcgca gctattctct ggagcaagtt caagctttgt attcatttcc
      241 atttcaacaa atgatggcag aagttcctaa catggcagtc acgactggac agcaggtgcc
      301 agcagtagct cctaacatgg caaccgtgac agaacagcag gtgcccgaag acgctcctgt
      361 ccaggaacct gcaccagaag ctccaaagag aaggaaaagg aaacccagag cagcagagcc
      421 ccaggaacca gtggagccca aaaaacctgc tacgtcgaag aaatccggca agtctacaaa
      481 atcaaaggaa aagcaggaga aaatcacaga cgcgtttaaa gtgaaaagga aagtggaccg
      541 cttcaacggc gtctctgaag ctgagcttct gaccaagact cttcctgaca ttttgacctt
      601 caatctggat attgtgatca ttggcattaa cccgggatta atggctgctt acaaaggaca
      661 tcactaccct gggcctggaa atcacttctg gaagtgtctg ttcatgtcgg ggctgagtga
      721 ggtgcagctg aatcacatgg atgaccacac cttacccggc aagtacggca tcggattcac
      781 caacatggtg gaacggacga cgccgggcag caaggatctg tctagtaaag agttccggga
      841 aggagggcgc atcctggtgc agaaactgca gaaatatcag ccacgaatag cggtgtttaa
      901 tggaaaatgt atttatgaaa ttttcagtaa agaagttttt ggagtaaagg ttaagaactt
      961 ggaatttggg cttcaacccc acaagatccc agacacagaa actctgtgct acgtcatgcc
     1021 gtcgtccagc gccagatgtg ctcagtttcc ccgggcccag gacaaagttc attactacat
     1081 taagctgaag gacttgagag accaactgaa aggcattgaa cgcaacgcgg acgttcagga
     1141 agtgcagtat acatttgacc tgcagcttgc gcaagaggac gcaaagaaga tggctgttaa
     1201 ggaagaaaag tatgatccag gctatgaggc agcttacggc ggtgcctatg gggaaaaccc
     1261 atgtaatggg gaaccttgtg gcattgcttc aaatgggcta acagctcaca gtgcggagcc
     1321 gagaggagaa gcggccccca gcgatgttcc gaatgggcag tggatggcac agtcgtttgc
     1381 agagcagatc ccttctttta ataattgtgg gacccgagag caggaagaag agagccacgc
     1441 ttaggaaggg tgcctctcag ctcgggctca gggctgcagt tctaatgcag acctcaggac
     1501 ggagagcctc agtgtgctaa ctgaggggct ttagtgttaa tggtccttta cgctagtggt
     1561 gtaattatat atggagcagt tatatggtag agtcaactgt atgaatctat gtagtttgga
     1621 aaggaaaaat agggtgtttt gtacttgagt tttgtatttt aactacccat cattccagct
     1681 ttttatatac tatatttcat ttatgaagaa accggttttc tctgaggagt cacttcaatc
     1741 tgtaatttta aaaaagcaac agtcggaata tttatagttg attcttcact gtgcatacct
     1801 atatatgccc ttatcccttt aaatgcctaa gtagggcatg ctactaagaa tcaagctggt
     1861 gaaaggcaga tgtgcctatc tctgttggaa gccgactaac cctccgccct ccgtggactc
     1921 gaagctggag gtggactcag aaccctctgg gttgcagtca cacgcagacc cccttactct
     1981 cccagtagtg tgtgtggcag ttgcttggta gtagaaacct agtggggcct gagccctgcc
     2041 gttggcctct gcctcttgtg gttcctgaga aggcagtaga acctggacag ttgccacccc
     2101 tctgttttac tgaatccccc gtcagtgttc atcactgttg tgattttatc ccgacatgga
     2161 aagcgctaag aaatgaactt tccagttagc cacgcgctgc tgcaggtgtt tgataatcct
     2221 gtttaaactg gtgctgtgta catgggatgt actgatacag aacttctctt ctagggaaag
     2281 ctaatcattt gtcaatgatt taaaaattat tgtcactact gttgattact gtggactaag
     2341 tgagcctcgt gaaagagctg attggaattt gtacctttgt ggctgctcat gcattttcca
     2401 tggtgctaca gacagcctgc ccgggctggt ggctaggaaa cgtgcgtgtt cagcgatgcc
     2461 tagcgctctc actcctgagc actctgactt ggtgcccacc cctggcgcgt gctggtttgg
     2521 cagtatgaaa tgcccacgag ggttttgtat ctcacaaagg ttatgtagcc tgttctgtga
     2581 acaatgaggg aagcagtctc ttggtggaaa ttttaacatg cctttagctg tggcagtgat
     2641 gggctttctt tttccttctg tctgggtcag gttgtgcaca agtcatgtta tttggaaggt
     2701 gcactgcact gctgtttaca tgggcatttt atgcgggtgc tttgaagtgc cttgcatcag
     2761 ggattaggat caattgaatt ctttttttca tgggactatg taaagcatgt agtattgcct
     2821 tggtatgtaa ctattgtagt tttaccatgg agaaatacct ttaaattata actctggaga
     2881 gcagccatga ggaccctctg tacttcctgg tgcttttcct taacatggtg ggtgagtagc
     2941 gagtgcgggg caccctgtac atggcagggt ggggcgttct cattaaataa tactgagatt
     3001 ttaaacatgc gcagtctgag cgtttttaca ataaacatta agaatggcta tgcttagtat
     3061 acaggttttc ctccagcagg atttaatggt attcctcccc actggaaacc tgaggatggc
     3121 ttactttctc ttacatgtca catgacaaaa atcacaaaag cttgaatagt ttatttttac
     3181 agattctaca tttttttaat ttataatttt gtaaaagaca agactagcaa cctgttttta
     3241 agaaagaaaa ccctgcagcc agatgtggtg gcccaggcct tcagttccag tacttaggag
     3301 gcaaagacat gaggatcttt gtgagtttga agttgtgagt tccaatttat ccagggatat
     3361 agagaaagac cctgtttgtt tgtttgtttg tttttgaggc agcgtttctc tccgtagcct
     3421 tggctgtcct gaaactcact gtatagacca ggctggcctc gaactcacag attaaactct
     3481 ttctgcctcc tgagtgctga gattaaaggt atgtgccgcc acc
//
