LOCUS       NM_026260               2741 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus tectonic family member 3 (Tctn3), transcript variant
            1, mRNA.
ACCESSION   NM_026260
VERSION     NM_026260.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2741)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2741)
  AUTHORS   Yang,Y., Paivinen,P., Xie,C., Krup,A.L., Makela,T.P., Mostov,K.E.
            and Reiter,J.F.
  TITLE     Ciliary Hedgehog signaling patterns the digestive system to
            generate mechanical forces driving elongation
  JOURNAL   Nat Commun 12 (1), 7186 (2021)
   PUBMED   34893605
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2741)
  AUTHORS   Wang,B., Zhang,Y., Dong,H., Gong,S., Wei,B., Luo,M., Wang,H.,
            Wu,X., Liu,W., Xu,X., Zheng,Y. and Sun,M.
  TITLE     Loss of Tctn3 causes neuronal apoptosis and neural tube defects in
            mice
  JOURNAL   Cell Death Dis 9 (5), 520 (2018)
   PUBMED   29725084
  REMARK    GeneRIF: results show that Tctn3 KO disrupts the Shh signaling
            pathway and neural tube patterning, resulting in abnormal embryonic
            development, cellular apoptosis, and prenatal death in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2741)
  AUTHORS   Wang,C., Li,J., Meng,Q. and Wang,B.
  TITLE     Three Tctn proteins are functionally conserved in the regulation of
            neural tube patterning and Gli3 processing but not ciliogenesis and
            Hedgehog signaling in the mouse
  JOURNAL   Dev Biol 430 (1), 156-165 (2017)
   PUBMED   28800946
  REMARK    GeneRIF: These results suggest that Tctn1, Tctn2, and Tctn3 are
            functionally divergent with respect to their role in ciliogenesis
            and Hedgehog signaling but conserved in neural tube patterning and
            Gli3 processing.
REFERENCE   5  (bases 1 to 2741)
  AUTHORS   Nedelko,T., Kollmus,H., Klawonn,F., Spijker,S., Lu,L., Hessman,M.,
            Alberts,R., Williams,R.W. and Schughart,K.
  TITLE     Distinct gene loci control the host response to influenza H1N1
            virus infection in a time-dependent manner
  JOURNAL   BMC Genomics 13, 411 (2012)
   PUBMED   22905720
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2741)
  AUTHORS   Garcia-Gonzalo,F.R., Corbit,K.C., Sirerol-Piquer,M.S.,
            Ramaswami,G., Otto,E.A., Noriega,T.R., Seol,A.D., Robinson,J.F.,
            Bennett,C.L., Josifova,D.J., Garcia-Verdugo,J.M., Katsanis,N.,
            Hildebrandt,F. and Reiter,J.F.
  TITLE     A transition zone complex regulates mammalian ciliogenesis and
            ciliary membrane composition
  JOURNAL   Nat Genet 43 (8), 776-784 (2011)
   PUBMED   21725307
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2741)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   8  (bases 1 to 2741)
  AUTHORS   Reiter,J.F. and Skarnes,W.C.
  TITLE     Tectonic, a novel regulator of the Hedgehog pathway required for
            both activation and inhibition
  JOURNAL   Genes Dev 20 (1), 22-27 (2006)
   PUBMED   16357211
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166063.4 and AC142101.4.
            
            On Jul 24, 2018 this sequence version replaced NM_026260.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ278871.1, BC027335.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-307               AC166063.4         57916-58222         c
            308-431             AC166063.4         57642-57765         c
            432-550             AC166063.4         57285-57403         c
            551-681             AC166063.4         55193-55323         c
            682-790             AC166063.4         54893-55001         c
            791-906             AC166063.4         54683-54798         c
            907-942             AC166063.4         54211-54246         c
            943-1023            AC166063.4         53617-53697         c
            1024-1149           AC166063.4         53269-53394         c
            1150-1257           AC166063.4         52217-52324         c
            1258-1352           AC166063.4         51694-51788         c
            1353-1506           AC166063.4         51297-51450         c
            1507-1644           AC166063.4         48796-48933         c
            1645-2326           AC166063.4         42852-43533         c
            2327-2741           AC142101.4         1-415
FEATURES             Location/Qualifiers
     source          1..2741
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 34.25 cM"
     gene            1..2741
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /note="tectonic family member 3"
                     /db_xref="GeneID:67590"
                     /db_xref="MGI:MGI:1914840"
     exon            1..307
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..1875
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; tectonic-3"
                     /codon_start=1
                     /product="tectonic-3 isoform 1 precursor"
                     /protein_id="NP_080536.2"
                     /db_xref="CCDS:CCDS29804.1"
                     /db_xref="GeneID:67590"
                     /db_xref="MGI:MGI:1914840"
                     /translation="MCTLQLHLLLLVVLMLSETARPQPSSTARAFPTSWGLEPVTPEV
                     PTSAPPDSSESPTPWTLSMPVNATTDPFPALPICVCDLTPGTCDLNCCCDKDCDLLHP
                     RTVFSFCLPGSVRSSSWVCVDNSLMFRSNSPFPSRVFTDSSGTTQFCVRVNNSKANYF
                     QKLQTVNATNFQALAAEFGGQSFPSMPPETQPPVLFYRAGDPILTYYPSWSVVSLLRQ
                     PAAVGAGGLCAESNPAGFLESKSTTCPRFFRDLASSCTSEPALDAASYYNFRVLKVPR
                     GVTDLQNMKFQVPVTLASQASPPLLAGNTCQNIVSQVVYEIETNGTFGIQKVSVSFRQ
                     TNLTVKPGVSLQQDFIVHFRAFQQRKAAAPAAPRSGNPGYLTGKPLLVLTGDTSHSMT
                     LLQSEGNGLCSAKRHAVQFGVNAVSGCQLRPREVNCSHLQEEVYQTLHGRPRPEHVAV
                     FGNADPAQRGGWTRILSRDCSVSAVNCTSCCLIPVSLEIQVLWAHLGLQSNPQAHVAG
                     ARFLYQCKSVQEHQRGIEVSLTTLVNFVDITQKPEPPRDQPRIDWKLPFDFFFPFKAA
                     LSRGASVQKDSLVLILCVLLLGLLNSQTK"
     exon            308..431
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /inference="alignment:Splign:2.1.0"
     exon            432..550
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /inference="alignment:Splign:2.1.0"
     exon            551..681
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /inference="alignment:Splign:2.1.0"
     exon            682..790
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /inference="alignment:Splign:2.1.0"
     exon            791..906
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /inference="alignment:Splign:2.1.0"
     exon            907..942
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1023
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1149
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1257
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1352
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1506
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /inference="alignment:Splign:2.1.0"
     exon            1507..1644
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..2741
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2720..2725
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /note="hexamer: CATAAA"
     polyA_site      2741
                     /gene="Tctn3"
                     /gene_synonym="4930521E07Rik; Tect3"
                     /note="major polyA site"
ORIGIN      
        1 gaagtacgcg actcttcttc ccagggctcc tgggacgtat ctggagaccc aggctcctgt
       61 cgcaccgctc tgcggccagg ctgccttatg tgcaccctgc agctgcacct gctgctgctg
      121 gtggtcctga tgctttctga gaccgcccga ccgcagccct cctccacagc ccgggctttc
      181 cccacctcct ggggcctgga gccagtgacg cccgaagtgc caacctcagc tcctccggat
      241 tcgtctgaga gtccgactcc ctggactcta tcgatgcccg tgaacgcgac caccgacccc
      301 tttccagctt taccgatctg tgtctgtgac ttgactccgg gtacctgcga tttaaactgc
      361 tgctgtgaca aggactgcga tcttctccat cccagaacag tcttttcctt ctgtcttcct
      421 ggtagtgtaa gatcttcaag ttgggtatgt gtggacaact ctcttatgtt caggagcaac
      481 tccccgttcc cttccagagt tttcacggac tccagtggaa cgacacagtt ttgtgtccgt
      541 gtgaacaact caaaagcaaa ctatttccag aagctccaaa cagtcaatgc aaccaacttc
      601 caggccctgg ctgcagagtt cggaggccag tccttccctt caatgccacc agaaacccag
      661 ccgccagtac tattctatag ggctggggat cccatcctga cctactaccc gagctggtct
      721 gtggtgagct tactgaggca gcctgcagcg gtgggagctg ggggactttg tgccgagagc
      781 aaccctgcag gtttcctaga gagtaaaagc acaacgtgtc ctcgtttctt cagggacctg
      841 gccagtagct gcacctcgga gccagccctg gatgctgcct cttactataa cttcagagtc
      901 ttgaaggttc caagaggtgt gactgatctt cagaatatga agttccaggt tcctgtgacg
      961 cttgcctcac aagccagccc tcctctgttg gctggaaaca catgtcagaa tatcgtttcc
     1021 caggtcgtct acgagataga gaccaatggg acctttggga tccagaaagt ctctgtcagc
     1081 ttccgacaga ccaacctgac tgtcaagcca ggggtctcct tacagcaaga cttcatcgtt
     1141 cacttcaggg catttcaaca gagaaaggcc gctgctcctg ctgctccgag aagtgggaat
     1201 cctggctacc tcactgggaa gccactctta gtgctaactg gtgacacaag tcactcgatg
     1261 accctgttgc agagcgaggg taatgggctt tgctctgcta agagacacgc agtacagttt
     1321 ggagtgaacg cagtatctgg gtgccagtta agacccagag aggtgaactg cagccacttg
     1381 caggaggagg tttatcagac tctgcacgga aggcccagac cggagcacgt tgccgtcttt
     1441 ggcaacgctg acccagccca gagaggaggg tggaccagga tcctcagcag agactgcagc
     1501 gtttcagcag ttaactgcac ttcctgctgt ctgataccag tgtccctgga gatccaggtg
     1561 ttgtgggcac atctaggact tcagtccaac ccacaagctc atgtggccgg agccagattc
     1621 ctgtaccaat gcaagtctgt acaggagcac cagagaggaa tagaagtatc tttgacgact
     1681 cttgtgaact ttgtggacat tacccagaag ccagagcctc ctagggatca acccagaata
     1741 gactggaagc tgccattcga tttcttcttt cccttcaaag cggcgttgag cagaggggcc
     1801 agtgtgcaga aagactctct cgttctcatc ctgtgtgtct tactacttgg acttctcaac
     1861 tcacagacca agtgaagaaa gaaaagaatc cggtttcatt tttccctatg ggaaacaaag
     1921 acagcctact tatcttggct aaataggtcc tcatgattac tcatgattat aggagggaat
     1981 ttagggaaac aggacctaac gaaaaggaat ttttttcttt ccattttctc actatgtcgt
     2041 cttggttggc ctagaactcc caatgtagac caggctggtc tcaggcgcac agagattttc
     2101 ccctttgcct ctgcctccag agtgctggat taaaggcacg tgctatcacg cccagccagg
     2161 aatctttatg aactgaagat ggtacgctag aaaagtgact acaagtattc catcttcata
     2221 gctctcctct tggggggctc ctcggacctc cagatacaca ctgggttctc tgcgtctaaa
     2281 gctgggcagg ccaagagccc ccatctcttc aggttgtgtt tgccaggatc tcataggcgc
     2341 atgctcctgc atcatccaga gtgaactcag agaggctggc ccctgcatta gtgctgacaa
     2401 ttcaagccgg gaaactgctg gctctgtgtt ttgtctggct cttttgccaa agttatagcc
     2461 acacccttta cccagacctg agttagaaaa gtagttcttt ctactcgttt cccaaagtga
     2521 atggcgtcct atgtcctttt ctcactagca aatgactcca ccagtccttt ctgtcctccc
     2581 ctactttgtg gtgtggtgta atagaagtga ctgagagctc tcttctgtta tgtccagtag
     2641 cgtggcagaa gttgacacct catgatagac accctgagga tttttatgta tatgaggttt
     2701 aaaggggaac tgggactctc ataaactgta tttgaatcag g
//
