LOCUS       NM_026486               2735 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus tectonic family member 2 (Tctn2), mRNA.
ACCESSION   NM_026486 XM_917131 XM_924700
VERSION     NM_026486.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2735)
  AUTHORS   Li,X., Xiao,S., Li,F., Fang,K., Wen,J. and Gong,H.
  TITLE     Max interacting protein 1 induces IL-17-producing T
            helper/regulatory T imbalance in osteoarthritis by upregulating
            tectonic family member 2
  JOURNAL   Tissue Cell 78, 101906 (2022)
   PUBMED   36049372
  REMARK    GeneRIF: Max interacting protein 1 induces IL-17-producing T
            helper/regulatory T imbalance in osteoarthritis by upregulating
            tectonic family member 2.
REFERENCE   2  (bases 1 to 2735)
  AUTHORS   Abrams,S.R. and Reiter,J.F.
  TITLE     Ciliary Hedgehog signaling regulates cell survival to build the
            facial midline
  JOURNAL   Elife 10, e68558 (2021)
   PUBMED   34672258
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2735)
  AUTHORS   Nandadasa,S., Szafron,J.M., Pathak,V., Murtada,S.I., Kraft,C.M.,
            O'Donnell,A., Norvik,C., Hughes,C., Caterson,B., Domowicz,M.S.,
            Schwartz,N.B., Tran-Lundmark,K., Veigl,M., Sedwick,D.,
            Philipson,E.H., Humphrey,J.D. and Apte,S.S.
  TITLE     Vascular dimorphism ensured by regulated proteoglycan dynamics
            favors rapid umbilical artery closure at birth
  JOURNAL   Elife 9, e60683 (2020)
   PUBMED   32909945
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2735)
  AUTHORS   Hasenpusch-Theil,K., Laclef,C., Colligan,M., Fitzgerald,E.,
            Howe,K., Carroll,E., Abrams,S.R., Reiter,J.F.,
            Schneider-Maunoury,S. and Theil,T.
  TITLE     A transient role of the ciliary gene Inpp5e in controlling direct
            versus indirect neurogenesis in cortical development
  JOURNAL   Elife 9, e58162 (2020)
   PUBMED   32840212
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2735)
  AUTHORS   Wang,B., Zhang,Y., Dong,H., Gong,S., Wei,B., Luo,M., Wang,H.,
            Wu,X., Liu,W., Xu,X., Zheng,Y. and Sun,M.
  TITLE     Loss of Tctn3 causes neuronal apoptosis and neural tube defects in
            mice
  JOURNAL   Cell Death Dis 9 (5), 520 (2018)
   PUBMED   29725084
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2735)
  AUTHORS   Chih,B., Liu,P., Chinn,Y., Chalouni,C., Komuves,L.G., Hass,P.E.,
            Sandoval,W. and Peterson,A.S.
  TITLE     A ciliopathy complex at the transition zone protects the cilia as a
            privileged membrane domain
  JOURNAL   Nat Cell Biol 14 (1), 61-72 (2011)
   PUBMED   22179047
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2735)
  AUTHORS   Garcia-Gonzalo,F.R., Corbit,K.C., Sirerol-Piquer,M.S.,
            Ramaswami,G., Otto,E.A., Noriega,T.R., Seol,A.D., Robinson,J.F.,
            Bennett,C.L., Josifova,D.J., Garcia-Verdugo,J.M., Katsanis,N.,
            Hildebrandt,F. and Reiter,J.F.
  TITLE     A transition zone complex regulates mammalian ciliogenesis and
            ciliary membrane composition
  JOURNAL   Nat Genet 43 (8), 776-784 (2011)
   PUBMED   21725307
  REMARK    GeneRIF: Loss of Tctn2 is associated with ciliopathies.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2735)
  AUTHORS   Sang,L., Miller,J.J., Corbit,K.C., Giles,R.H., Brauer,M.J.,
            Otto,E.A., Baye,L.M., Wen,X., Scales,S.J., Kwong,M.,
            Huntzicker,E.G., Sfakianos,M.K., Sandoval,W., Bazan,J.F.,
            Kulkarni,P., Garcia-Gonzalo,F.R., Seol,A.D., O'Toole,J.F., Held,S.,
            Reutter,H.M., Lane,W.S., Rafiq,M.A., Noor,A., Ansar,M., Devi,A.R.,
            Sheffield,V.C., Slusarski,D.C., Vincent,J.B., Doherty,D.A.,
            Hildebrandt,F., Reiter,J.F. and Jackson,P.K.
  TITLE     Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy
            disease genes and pathways
  JOURNAL   Cell 145 (4), 513-528 (2011)
   PUBMED   21565611
REFERENCE   9  (bases 1 to 2735)
  AUTHORS   Jerome-Majewska,L.A., Achkar,T., Luo,L., Lupu,F. and Lacy,E.
  TITLE     The trafficking protein Tmed2/p24beta(1) is required for
            morphogenesis of the mouse embryo and placenta
  JOURNAL   Dev Biol 341 (1), 154-166 (2010)
   PUBMED   20178780
REFERENCE   10 (bases 1 to 2735)
  AUTHORS   Reiter,J.F. and Skarnes,W.C.
  TITLE     Tectonic, a novel regulator of the Hedgehog pathway required for
            both activation and inhibition
  JOURNAL   Genes Dev 20 (1), 22-27 (2006)
   PUBMED   16357211
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK031829.1 and AK014476.1.
            
            On Oct 26, 2007 this sequence version replaced NM_026486.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031829.1, AK012720.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-941               AK031829.1         2-942
            942-2735            AK014476.1         908-2701
FEATURES             Location/Qualifiers
     source          1..2735
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 63.68 cM"
     gene            1..2735
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /note="tectonic family member 2"
                     /db_xref="GeneID:67978"
                     /db_xref="MGI:MGI:1915228"
     exon            1..208
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..2229
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /note="tectonic-2"
                     /codon_start=1
                     /product="tectonic-2 precursor"
                     /protein_id="NP_080762.1"
                     /db_xref="GeneID:67978"
                     /db_xref="MGI:MGI:1915228"
                     /translation="MGSLSPLSLLWGLLLLQGVLRPLRGDPVFIPPFIRMSSPEVRAT
                     LVGGSEDVAVSLSLLQVEEGVLPVPTCGGRRNETVDWNVTVSPRESTLEVTIRWKRGL
                     DWCSADETASFSEPPCVLQMLLVSASHNASCLAHLLIQVEIYPNTSVTHNASENMTVI
                     PNQVYQPLGPCPCDLTAKACDIQCCCDQDCQPEVRELFAQSCFSGVFGGHVSPPSHHH
                     CAVSTTHQTPDWFPLLCVQSPPSTSPFLGHFYHGATSPRHSPGFEAHLHFDLRDFADA
                     SYKQGDPIMTTEGYFTIPQVSLAGQCLQDAPVAFLRNFDSVCTMDLEVHQGRDEIVLE
                     NMKIRTTGGPVTPTVTYEEAIDLDKFITSPDTVLSVGSAPRNVNVEEHYVFRWQNNSI
                     SGLDITVIRAEISAQQRGMMTQRFTVKFLSHHSGGEKEFSGNPGYQLGKPVRALHTAG
                     MNVSTLHLWQPAGRGLCTAAALRPILFGENAFSGCLLEVGIKENCTQLRENVLQRLDL
                     LTQATHVARRGNSDYSDLSDGWLEIIRAEAPDTGADLPLSSVNGVCPEVPARLSIRIL
                     TAEAGSVEGVAQREILAVETRFSTVTWQYQCGLTCEDKADLLPLSASVEFINVPAQMP
                     HPPTRFQINFTEYDCTRNELCWPQLLYPLTQYYQGEPQSQCVAKGLMLLSLLMLAILL
                     RHPWVRMCKARDSAAIYH"
     exon            209..316
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            317..393
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            394..589
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            590..690
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            691..887
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1011
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1153
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1219
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1354
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1355..1432
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1510
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1622
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1729
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..1886
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..2012
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2101
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2735
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2427..2432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /note="hexamer: AATAAA"
     polyA_site      2455
                     /gene="Tctn2"
                     /gene_synonym="4432405B04Rik; Tect2"
                     /note="major polyA site"
ORIGIN      
        1 tcattgattg gtggttgcca tggctgcagg catttagctt ggcaatatgg cgtcggctgg
       61 tcggcgaagg ccgccacttt ttctcttcca ggctattctg ggtttctgag gcaggccggc
      121 ccgggtatgg gctctctgtc accgctcagc ctcctgtggg gactcctcct gctgcagggc
      181 gtcctgaggc cgctgcgcgg ggacccggtt ttcatcccac ctttcatccg gatgtccagc
      241 cctgaggtcc gagcgaccct ggtcggaggc agcgaggatg tcgctgtgtc tctgagtctg
      301 ctgcaggtcg aggaaggagt gttgccagtt cctacttgtg gcggccgccg caatgagaca
      361 gtggattgga atgtgactgt gagcccccga gagagcacgc tggaagtgac cataaggtgg
      421 aagaggggtc tagactggtg ctccgcagac gagacagcct cattctcaga gcccccgtgt
      481 gttctgcaga tgctgctagt ttcagcctcc cacaatgcat cctgcttagc acatctgctc
      541 atccaggtgg agatttatcc caacacatct gtaacccaca acgcatcaga gaacatgact
      601 gtcattccta accaagtcta tcagcccctg ggtccctgcc cgtgtgactt aacagccaag
      661 gcctgtgaca ttcaatgctg ctgtgaccag gactgtcagc cagaagtaag agagctgttt
      721 gcacagtcct gcttctccgg cgtgtttgga gggcacgtca gccctccgtc ccatcatcac
      781 tgcgctgtca gcactactca ccagactcct gactggtttc ccctcctgtg tgtgcagtcg
      841 ccaccctcta cctcgccgtt ccttggtcac ttctaccacg gtgccacttc ccccagacat
      901 tcccccggct ttgaagccca tttgcacttc gacctaagag acttcgcgga tgccagttac
      961 aagcaaggag atcccattat gaccacggag gggtatttta ccatccccca ggtgtctcta
     1021 gctgggcagt gtctacagga tgctcctgtg gctttcctga ggaattttga cagtgtatgt
     1081 accatggacc tggaagtgca ccaaggacga gatgaaattg tcctcgagaa catgaaaatc
     1141 cgcacaacag gaggtccggt cacaccaaca gtaacctatg aggaagccat tgacctggac
     1201 aagttcatca ccagcccgga cacagtttta agtgtcggat cggcccccag aaacgtgaat
     1261 gtggaagaac attatgtctt cagatggcaa aataattcca tcagcggcct agacatcaca
     1321 gtcatcaggg cagaaatcag tgcccagcag agaggaatga tgacccagag attcacagtg
     1381 aagtttttaa gccatcacag tggtggtgag aaggaatttt ctggaaatcc aggttaccag
     1441 cttggcaagc cggtccgagc cctgcatacc gctgggatga acgtcagcac actgcacctc
     1501 tggcagccag ctggaagggg cctgtgcaca gcagccgctc tcagacccat tttgtttgga
     1561 gaaaatgcct tctctggctg cctgctggaa gttgggatta aggagaactg tacccagctc
     1621 agagagaatg tccttcagag actggatttg ctgacacaag caacgcacgt ggcgaggaga
     1681 ggcaactcgg actacagtga tctgagtgac ggctggctgg agatcatacg tgccgaagcc
     1741 cctgatacag gtgccgacct gcccttgagc agcgtgaatg gcgtgtgccc agaagttcca
     1801 gcccggctct ccatccgcat tctcactgct gaagctggct ctgtggaagg ggtggctcag
     1861 cgggagatcc tggctgtgga gacaaggttt tccacagtga cctggcagta ccagtgtggg
     1921 ctcacttgtg aggacaaggc cgaccttctc cctctcagtg cctctgttga gttcattaat
     1981 gtccctgcgc agatgcccca cccccctacg agattccaga tcaacttcac agagtacgac
     2041 tgtacccgga atgagctgtg ttggccccaa cttctgtacc ctctgaccca gtattatcaa
     2101 ggggagcccc agtctcagtg tgtggccaaa ggcctgatgc tgctgtcact cctcatgctg
     2161 gccatcctcc tcaggcaccc ctgggtcagg atgtgcaaag cccgggactc agctgccatc
     2221 taccattaag tttcctggaa gactcagggc atccactcag cggctcctca tcggcccttg
     2281 cgcctctctg aaacctgtca gtttgagaca ggtctctcca catatccctg gcttgcttct
     2341 aagctcacag agatctgcct gtctctgcct ctggagtgct ggattaaagg catgttccac
     2401 catgcctgga ctctctgaac cattttaata aacagaatgt ctatttttgt agaaatccct
     2461 agtgttaagt gaacgtgagc caaatatcta gatgtttaga gtggctccgg attatcactc
     2521 tcgattctag ctggttgcag gggaatcgag ggtgtcctaa gtgtcagaga cttaagccca
     2581 gcacggattt ctaatcatgg ggttttatgt ttgaccagac ttgattgatg caagcaggta
     2641 agcataaaga aaagactgat tactatcaca tattccagag aaagagttag aaaatgcttt
     2701 atataggctt ttaaattaaa attgaatttt atatt
//
