LOCUS       NM_001039153            4087 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus tectonic family member 1 (Tctn1), transcript variant
            1, mRNA.
ACCESSION   NM_001039153
VERSION     NM_001039153.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4087)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4087)
  AUTHORS   Truong,H.M., Cruz-Colon,K.O., Martinez-Marquez,J.Y., Willer,J.R.,
            Travis,A.M., Biswas,S.K., Lo,W.K., Bolz,H.J. and Pearring,J.N.
  TITLE     The tectonic complex regulates membrane protein composition in the
            photoreceptor cilium
  JOURNAL   Nat Commun 14 (1), 5671 (2023)
   PUBMED   37704658
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4087)
  AUTHORS   Wang,B., Zhang,Y., Dong,H., Gong,S., Wei,B., Luo,M., Wang,H.,
            Wu,X., Liu,W., Xu,X., Zheng,Y. and Sun,M.
  TITLE     Loss of Tctn3 causes neuronal apoptosis and neural tube defects in
            mice
  JOURNAL   Cell Death Dis 9 (5), 520 (2018)
   PUBMED   29725084
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4087)
  AUTHORS   Wang,C., Li,J., Meng,Q. and Wang,B.
  TITLE     Three Tctn proteins are functionally conserved in the regulation of
            neural tube patterning and Gli3 processing but not ciliogenesis and
            Hedgehog signaling in the mouse
  JOURNAL   Dev Biol 430 (1), 156-165 (2017)
   PUBMED   28800946
  REMARK    GeneRIF: These results suggest that Tctn1, Tctn2, and Tctn3 are
            functionally divergent with respect to their role in ciliogenesis
            and Hedgehog signaling but conserved in neural tube patterning and
            Gli3 processing.
REFERENCE   5  (bases 1 to 4087)
  AUTHORS   Kurogi,S., Sekimoto,T., Funamoto,T., Ota,T., Nakamura,S., Nagai,T.,
            Nakahara,M., Yoshinobu,K., Araki,K., Araki,M. and Chosa,E.
  TITLE     Development of an efficient screening system to identify novel bone
            metabolism-related genes using the exchangeable gene trap
            mutagenesis mouse models
  JOURNAL   Sci Rep 7, 40692 (2017)
   PUBMED   28106071
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4087)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   7  (bases 1 to 4087)
  AUTHORS   Reiter,J.F. and Skarnes,W.C.
  TITLE     Tectonic, a novel regulator of the Hedgehog pathway required for
            both activation and inhibition
  JOURNAL   Genes Dev 20 (1), 22-27 (2006)
   PUBMED   16357211
  REMARK    GeneRIF: During neural tube development, mouse Tectonic is required
            for formation of the most ventral cell types and for full Hedgehog
            (Hh) pathway activation. Tectonic plays an additional role in
            repressing Hh pathway activity.
REFERENCE   8  (bases 1 to 4087)
  AUTHORS   Taniwaki,T., Haruna,K., Nakamura,H., Sekimoto,T., Oike,Y.,
            Imaizumi,T., Saito,F., Muta,M., Soejima,Y., Utoh,A., Nakagata,N.,
            Araki,M., Yamamura,K. and Araki,K.
  TITLE     Characterization of an exchangeable gene trap using pU-17 carrying
            a stop codon-beta geo cassette
  JOURNAL   Dev Growth Differ 47 (3), 163-172 (2005)
   PUBMED   15840001
REFERENCE   9  (bases 1 to 4087)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 4087)
  AUTHORS   Araki,K., Imaizumi,T., Sekimoto,T., Yoshinobu,K., Yoshimuta,J.,
            Akizuki,M., Miura,K., Araki,M. and Yamamura,K.
  TITLE     Exchangeable gene trap using the Cre/mutated lox system
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 45 (5), 737-750 (1999)
   PUBMED   10512203
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DQ278867.1, AK138661.1, AK036568.1, DV657549.1, AC127266.4,
            CX202489.1 and AW121310.1.
            
            On Apr 18, 2014 this sequence version replaced NM_001039153.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the supported protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ278867.1, AK036568.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 DQ278867.1         2-3
            3-20                AK138661.1         2-19
            21-2042             AK036568.1         3-2024
            2043-2278           AK138661.1         1967-2202
            2279-2778           DV657549.1         1-500               c
            2779-3460           AC127266.4         45991-46672
            3461-4066           CX202489.1         1-606
            4067-4087           AW121310.1         1-21                c
FEATURES             Location/Qualifiers
     source          1..4087
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5"
     gene            1..4087
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /note="tectonic family member 1"
                     /db_xref="GeneID:654470"
                     /db_xref="MGI:MGI:3603820"
     exon            1..323
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1873
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /note="tectonic-1"
                     /codon_start=1
                     /product="tectonic-1 precursor"
                     /protein_id="NP_001034242.2"
                     /db_xref="CCDS:CCDS39254.1"
                     /db_xref="GeneID:654470"
                     /db_xref="MGI:MGI:3603820"
                     /translation="MGSRGLPPLLLVLLNCYTSSSTQVIAIPAAATPAVTKEDLNSTK
                     ATPTTLQPSLSPRTPGTPRAPERSGPRPTPVTDVAALCVCDLLPAQCDVNCCCDPDCS
                     PADFSIFSACSVPVVTGDRQFCSQKAAFYSMNLTADPPHRDFKLIDQINPSVFCIHIS
                     NYKPALSFANPEVPDENNFDRLMQTSGGFTLSAESAVPSTAASDGPQPTKYEYGAPLQ
                     TAGASSGSFLKLPSPLTSSLCADQNPAAFLVSQAFECSRRVDIEQCEGMEALSMAHYS
                     SPAILRVPNSMTQVSIKIQSVMYRSLNHTLTQLEGHGVLRPSLVSTGQDRLCSNVVLQ
                     VKYSLLYTATGQIHEAGLSLVLGTLSSAVSLLQQKFEIHFIQHGTKPVPLSGNPGYRV
                     GLPLAAGFQPQKGSGIIQTTNRQGQFTILRSTSQQDCLASEGLRTPVLFGYNVQSGCQ
                     LRLTGTIPCGLLAQKVQDLLRGQAFPDYVAAFGNSRAQDVQDWVPVHFVTYSSNMKGS
                     CQLPVALAIEVKWTKYGSLLNPQARIVNVTAQLVSVPEPLPGPERTVVISTAVTFVDV
                     SAPAEAGFRAPPTINARLPFSFFFPFV"
     exon            324..444
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /inference="alignment:Splign:2.1.0"
     exon            445..575
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..727
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /inference="alignment:Splign:2.1.0"
     exon            728..827
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /inference="alignment:Splign:2.1.0"
     exon            828..937
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /inference="alignment:Splign:2.1.0"
     exon            938..958
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /inference="alignment:Splign:2.1.0"
     exon            959..1093
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1219
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /inference="alignment:Splign:2.1.0"
     exon            1220..1305
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /inference="alignment:Splign:2.1.0"
     exon            1306..1446
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1609
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1729
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /inference="alignment:Splign:2.1.0"
     exon            1730..4070
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2044
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /note="major polyA site"
     regulatory      4050..4055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /note="hexamer: AATAAA"
     polyA_site      4069
                     /gene="Tctn1"
                     /gene_synonym="4930565B19Rik; G730031O11Rik; Tect1"
                     /note="major polyA site"
ORIGIN      
        1 gccctttccc gtgataccta gcgctaggct gtgactgttg cccgggcaac agacgggcct
       61 agctccccgg cgcgggctac tctgctaggc catggggtcg cggggtctcc cgccgctcct
      121 gctggtgctc ctaaactgct acacctcttc gagcacccag gtcattgcca tcccggctgc
      181 ggccacccca gcagtgacga aggaggatct caattccacc aaggccaccc ccaccactct
      241 gcagccctcc ctgtcgccta ggaccccggg aactcccagg gcaccggagc gctctggccc
      301 caggcctacc ccggtcacgg acgttgctgc tctgtgtgtc tgcgacctgc ttccggcaca
      361 gtgtgatgtc aactgctgtt gcgaccctga ctgcagccct gcagatttca gcatcttctc
      421 tgcctgctca gtcccagttg tcacgggtga caggcagttt tgtagtcaga aggcagcctt
      481 ctactcaatg aatttgacag cagacccacc tcaccgtgac tttaaactca ttgatcagat
      541 caatccttcc gtcttctgca tccatatttc aaactacaag cctgcactgt cttttgctaa
      601 tccagaagtg cctgatgaaa acaattttga cagactgatg cagacatcag gtggctttac
      661 actgagtgcc gaatccgctg ttccttccac agccgcatca gatggcccac agcccactaa
      721 atacgagtat ggagcccctc tgcagactgc aggagcatct tcagggtcat ttctgaaact
      781 gccctcgcct ctcacgtcat ctctgtgtgc agatcagaac cccgcagcgt tcctggtgag
      841 ccaggccttc gaatgcagcc gaagggtgga catagaacag tgtgaaggaa tggaagccct
      901 cagcatggct cattacagca gccctgccat tctgagggta cctaattcaa tgacacaggt
      961 ctccatcaag atccagtctg taatgtatcg gtctctgaat cacacactga cgcagttaga
     1021 aggccatggt gtcctgcggc catctctggt cagcactggg caagacagac tctgcagcaa
     1081 cgttgttctc caggtgaagt acagtctgct gtacacagcc acaggccaga tccacgaagc
     1141 cggcctctcc ctcgttctgg ggacactgag cagcgctgtg agtctcctgc agcagaagtt
     1201 tgagattcac tttattcagc atggcaccaa gcctgttcct ctcagcggca accctggtta
     1261 cagggtggga ctcccgctgg ctgctggctt tcagcctcag aagggatctg ggattattca
     1321 gacaacgaac agacaaggcc aatttactat tcttcgtagc acgagccagc aggattgcct
     1381 tgccagcgag gggcttcgca cccctgtgct atttggctac aatgtgcagt ctggctgtca
     1441 gctcaggttg acaggcacca tcccttgtgg gcttctggca cagaaggtgc aggacctgct
     1501 gagaggccag gccttccctg actatgtggc tgcctttggg aactcccggg cccaggatgt
     1561 gcaggactgg gtgcctgtgc actttgtcac ctactcctcc aacatgaagg gctcttgcca
     1621 gcttccggtg gctttggcta tagaagtgaa atggactaag tatgggtccc tgctgaaccc
     1681 ccaggccagg atagtaaatg tcactgccca gctcgtctca gttccagagc ccctcccagg
     1741 gcctgagagg accgtggtca tttccactgc agtgacattt gtggatgtgt cagcccctgc
     1801 agaggcaggc ttccgagccc cacccaccat caacgccagg ctacccttca gcttcttctt
     1861 cccgtttgtg tgatgagctg accccgcagg agtacccatc ctgaagatct tcccttccgc
     1921 ggcagtgcgc acctgggccc taggcgcaag aggacatgaa cctagctgcc gcctcccctt
     1981 gctgttaccc ttcaagcagc cctctgctct actccactgc cttttaaaac tctcagaaac
     2041 tttactctgc tgggctgtgg tgttgggtca gatgggtcca gcaccctgca catacaggtc
     2101 aaagggcacg gccctctggg agatgagcgg gaacagagtg tgacgtggca gtgcatggag
     2161 agcctcctcg tcagtgcatc atccctggtc tagtgggagt tgttttcaga atgcctgttg
     2221 gcatttgaga ggtacaaacc agcaaggagc tatgtaaaac tgtgtgccca caagggggtt
     2281 gtatcccaag attgtgctaa ttacagggcc ctcagggcag ccttgggacc ctgccatgtg
     2341 ctggctgtat aactggtggg ctggtgtggg ctgccaccga ggagagaatg tggtgggtga
     2401 gccctgggaa ggagagggct tattttacac attaattgta cagtaactga aagagctgct
     2461 agtgggtaca gagccagttt gaagctgatg gtacagctgg atgctgcaga ggagggactg
     2521 ggtaccatga tggctcccct agggaggcag caggagaagc tggggacatt ctagtagaga
     2581 aaggttttcc agagtgagct ggttcggggt gcgggctcca gctcctttca ggatgtgcat
     2641 taagttggct ttacaagccc agcctccttg atcatttttg agcgacagtg gagtccagct
     2701 tgagaaaagg ttggtgcgat gatccctttg ctgcaagcgt agggcgtgga cgccaaggag
     2761 acagcagtac cagtgaagat gtgtccccag catcccgggg tgcaagccaa ggcagagatg
     2821 gagactggac tttgcaccac aggctggctc tctggccaca gcccagctac tccaggcgga
     2881 gtgtctggaa ggctagttca cgtccccgag aagtccattc tgtttcaaca gcttgttgag
     2941 ccgctcaatt tcttgttcct attgtaaaag cagacaaaca ctgggtggtg accttctgag
     3001 ctacattccc ccaggcccgg ggctgcagac agctaagtgg cattctggct gctgatggga
     3061 gcgagtggct ttcaaaaggg ccctgggcag caatagcagg cacaagatgc ccagaggagg
     3121 gactggacct ggctcttgga ggagcccaag ttaagctgaa aggaccaaga agagggaact
     3181 ataggcgtgg ggtcaacatg gactggaggg gacagcagtg aaaccactcg agtctcacct
     3241 tctcggagca gctgaattcc agatgctgga tcttggtggc cagttggata tttatctgct
     3301 ttagccttaa gatctgccgt tctgagcgtg tcttcacgga gatgatgatg cctgggtggg
     3361 agggaggggt tagggttcat aaagctcaac ttttaaacat gtgtgagaca ggggtgggga
     3421 gtggatgcgt gtgcaccaca gagtgcctga ggatgacaca gtacagcatg caggaagtcc
     3481 atctccttcc accaggcgtg tcctacggct taatctcagg tcatcaagcc tagcagcaag
     3541 tgtcagccct gagacttgtg ttctgattca cacatatact tggagcatgc agagagaact
     3601 gtcactgggc agactcaaca aggcaggcaa gatcgatact tctgagctca agagtaggcc
     3661 gctaggcagt atctccctgt ggcccgcaag ggtgccaact ctagaggcta gctgtgttcc
     3721 tgtccctcaa ggacacgtgt ccctagcagt aactgaaagt tgcttgtctt ccctggtcag
     3781 cgtccagagt gtgaagataa aacagccaga agttaaagca gggacccacc ctgtagcaca
     3841 gccttgacct gctgacttgg gatatcctgc acaaccccag tgacccacag ctcctgaccc
     3901 gatggcagtg ctggccctca gatgcagacc cagagaggcc caggcgtgca acagttacct
     3961 gccccagctg cagggggggt ttctagcccc tctcagccaa ggcacaccct cagggagccc
     4021 actcactgtg gctgcactat gttatgttta ataaatcttt tacatctgtc aaaaaaaaaa
     4081 aaaaaaa
//
