LOCUS       NM_013686               2499 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus t-complex protein 1 (Tcp1), transcript variant 1,
            mRNA.
ACCESSION   NM_013686
VERSION     NM_013686.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2499)
  AUTHORS   Cuellar,J., Vallin,J., Svanstrom,A., Maestro-Lopez,M.,
            Bueno-Carrasco,M.T., Ludlam,W.G., Willardson,B.M., Valpuesta,J.M.
            and Grantham,J.
  TITLE     The Molecular Chaperone CCT Sequesters Gelsolin and Protects it
            from Cleavage by Caspase-3
  JOURNAL   J Mol Biol 434 (5), 167399 (2022)
   PUBMED   34896365
  REMARK    GeneRIF: The Molecular Chaperone CCT Sequesters Gelsolin and
            Protects it from Cleavage by Caspase-3.
REFERENCE   2  (bases 1 to 2499)
  AUTHORS   Chen,J., Kaw,K., Lu,H., Fagnant,P.M., Chattopadhyay,A., Duan,X.Y.,
            Zhou,Z., Ma,S., Liu,Z., Huang,J., Kamm,K., Stull,J.T.,
            Kwartler,C.S., Trybus,K.M. and Milewicz,D.M.
  TITLE     Resistance of Acta2R149C/+ mice to aortic disease is associated
            with defective release of mutant smooth muscle alpha-actin from the
            chaperonin-containing TCP1 folding complex
  JOURNAL   J Biol Chem 297 (6), 101228 (2021)
   PUBMED   34600884
  REMARK    GeneRIF: Resistance of Acta2(R149C/+) mice to aortic disease is
            associated with defective release of mutant smooth muscle
            alpha-actin from the chaperonin-containing TCP1 folding complex.
REFERENCE   3  (bases 1 to 2499)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2499)
  AUTHORS   Andergassen,D., Muckenhuber,M., Bammer,P.C., Kulinski,T.M.,
            Theussl,H.C., Shimizu,T., Penninger,J.M., Pauler,F.M. and
            Hudson,Q.J.
  TITLE     The Airn lncRNA does not require any DNA elements within its locus
            to silence distant imprinted genes
  JOURNAL   PLoS Genet 15 (7), e1008268 (2019)
   PUBMED   31329595
  REMARK    Erratum:[PLoS Genet. 2020 Oct 21;16(10):e1009151. doi:
            10.1371/journal.pgen.1009151.. PMID: 33085675]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2499)
  AUTHORS   Gopal,S., Perez,E. Jr., Xia,A.Y., Knowlton,J.J., Cerqueira,F.,
            Dermody,T.S. and Upton,J.W.
  TITLE     Murine cytomegalovirus M72 promotes acute virus replication in vivo
            and is a substrate of the TRiC/CCT complex
  JOURNAL   Virology 522, 92-105 (2018)
   PUBMED   30029015
  REMARK    GeneRIF: The authors identify and confirm interaction of M72 with
            the eukaryotic chaperonin tailless complex protein -1 (TCP-1) ring
            complex (TRiC) or chaperonin containing tailless complex
            polypeptide 1 (CCT). Accumulating biochemical evidence indicates
            M72 forms homo-oligomers and is a substrate of TRiC/CCT
REFERENCE   6  (bases 1 to 2499)
  AUTHORS   Kubota,H., Willison,K., Ashworth,A., Nozaki,M., Miyamoto,H.,
            Yamamoto,H., Matsushiro,A. and Morita,T.
  TITLE     Structure and expression of the gene encoding mouse t-complex
            polypeptide (Tcp-1)
  JOURNAL   Gene 120 (2), 207-215 (1992)
   PUBMED   1383093
REFERENCE   7  (bases 1 to 2499)
  AUTHORS   Morita,T., Kubota,H., Murata,K., Nozaki,M., Delarbre,C.,
            Willison,K., Satta,Y., Sakaizumi,M., Takahata,N., Gachelin,G. et
            al.
  TITLE     Evolution of the mouse t haplotype: recent and worldwide
            introgression to Mus musculus
  JOURNAL   Proc Natl Acad Sci U S A 89 (15), 6851-6855 (1992)
   PUBMED   1495973
REFERENCE   8  (bases 1 to 2499)
  AUTHORS   Kubota,H., Morita,T., Satta,Y., Nozaki,M. and Matsushiro,A.
  TITLE     Nucleotide sequence of a mouse Tcp-1 pseudogene: a nucleotide
            record for a t complex gene carried by an ancestor of the mouse
  JOURNAL   Mamm Genome 2 (4), 246-251 (1992)
   PUBMED   1543916
REFERENCE   9  (bases 1 to 2499)
  AUTHORS   Sertic,J., Zaleska-Rutczynska,Z., Vincek,V., Nadeau,J.H.,
            Figueroa,F. and Klein,J.
  TITLE     Mapping of six DNA markers on mouse chromosome 17
  JOURNAL   Mamm Genome 2 (2), 138-142 (1992)
   PUBMED   1347473
REFERENCE   10 (bases 1 to 2499)
  AUTHORS   Silver,L.M., Artzt,K. and Bennett,D.
  TITLE     A major testicular cell protein specified by a mouse T/t complex
            gene
  JOURNAL   Cell 17 (2), 275-284 (1979)
   PUBMED   455464
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN725473.1, AK166966.1 and AK149611.1.
            
            On Mar 19, 2014 this sequence version replaced NM_013686.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform 1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149611.1, SRR1660817.209624.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               CN725473.1         1-280
            281-1986            AK166966.1         169-1874
            1987-2499           AK149611.1         1852-2364
FEATURES             Location/Qualifiers
     source          1..2499
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.72 cM"
     gene            1..2499
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /note="t-complex protein 1"
                     /db_xref="GeneID:21454"
                     /db_xref="MGI:MGI:98535"
     exon            1..301
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /inference="alignment:Splign:2.1.0"
     CDS             238..1908
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-complex protein 1 subunit alpha A; T-complex protein 1
                     subunit alpha B; t-complex polypeptide 1; TCP-1-A;
                     TCP-1-B; CCT-alpha; TCP-1-alpha; tailless complex
                     polypeptide 1A; tailless complex polypeptide 1B"
                     /codon_start=1
                     /product="T-complex protein 1 subunit alpha isoform 1"
                     /protein_id="NP_038714.2"
                     /db_xref="CCDS:CCDS28397.1"
                     /db_xref="GeneID:21454"
                     /db_xref="MGI:MGI:98535"
                     /translation="MEGPLSVFGDRSTGEAVRSQNVMAAASIANIVKSSFGPVGLDKM
                     LVDDIGDVTITNDGATILKLLEVEHPAAKVLCELADLQDKEVGDGTTSVVIIAAELLK
                     NADELVKQKIHPTSVISGYRLACKEAVRYINENLIINTDELGRDCLINAAKTSMSSKI
                     IGINGDYFANMVVDAVLAVKYTDARGQPRYPVNSVNILKAHGRSQIESMLINGYALNC
                     VVGSQGMPKRIVNAKIACLDFSLQKTKMKLGVQVVITDPEKLDQIRQRESDITKERIQ
                     KILATGANVILTTGGIDDMYLKYFVEAGAMAVRRVLKRDLKHVAKASGASILSTLANL
                     EGEETFEVTMLGQAEEVVQERICDDELILIKNTKARTSASIILRGANDFMCDEMERSL
                     HDALCVVKRVLELKSVVPGGGAVEAALSIYLENYATSMGSREQLAIAEFARSLLVIPN
                     TLAVNAAQDSTDLVAKLRAFHNEAQVNPERKNLKWIGLDLVHGKPRDNKQAGVFEPTI
                     VKVKSLKFATEAAITILRIDDLIKLHPESKDDKHGSYENAVHSGALDD"
     exon            302..387
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /inference="alignment:Splign:2.1.0"
     exon            388..516
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /inference="alignment:Splign:2.1.0"
     exon            517..614
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /inference="alignment:Splign:2.1.0"
     exon            615..725
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /inference="alignment:Splign:2.1.0"
     exon            726..907
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1034
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1210
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1334
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1527
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..1691
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..2499
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1970..1975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /note="hexamer: ATTAAA"
     polyA_site      1989
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /note="major polyA site"
     regulatory      2475..2480
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
                     /note="hexamer: AATAAA"
     polyA_site      2494
                     /gene="Tcp1"
                     /gene_synonym="c-cpn; CCT; Cct1; Ccta; p63; Tcp-1; Tp63;
                     TRic"
ORIGIN      
        1 cggcgttttc agtttttcgc cccgcccagc cctcgtctgt caatccctac cgctttcccg
       61 gcagaccttg cggttggtgg agcgtggaga gcgcgcaggg cgtgttaccc agcaggcccc
      121 gcggcatcgc tcgggccttt ccacgccgtg gtccccgccg tggtggccgt taaacggtct
      181 cagagcggag ctatcggttg tctgcggccg tagtgagctt tgcttcgttt cctgaagatg
      241 gagggtcctt tgtccgtgtt cggggaccgc agcactgggg aggcggtccg ctcccagaat
      301 gttatggctg cagcttctat tgccaacatt gttaaaagtt cttttgggcc agttggcttg
      361 gataaaatgt tggtggatga tattggtgat gtaaccatta ctaacgatgg tgccaccatc
      421 ctgaagttac tggaggtaga acatcccgca gccaaagttc tgtgtgagct ggctgacctg
      481 caagacaaag aagttggaga tggaactacc tcagtggtaa tcattgcagc ggagcttctg
      541 aaaaatgcag atgagctagt caaacagaaa attcatccaa catcagttat tagtggctat
      601 cgtcttgcct gcaaggaagc ggtgcgttat atcaatgaga acctgattat taacacagac
      661 gaacttggaa gagactgtct gatcaatgct gctaagacat ccatgtcatc caaaattatt
      721 ggaataaatg gtgattactt tgctaatatg gtagtagatg ctgtgcttgc tgttaaatac
      781 acagatgcca gaggccagcc tcgctatcca gtcaattctg ttaatattct gaaagcccat
      841 gggagaagtc agatagaaag catgctgatc aatggctatg cgctcaattg tgtggttgga
      901 tctcagggca tgcccaagag aatagttaat gcaaaaattg cttgtcttga cttcagcctg
      961 cagaaaacaa aaatgaagct tggtgtacag gtggttatta cagaccctga gaaattggac
     1021 caaattagac agagagaatc ggatatcacc aaggagagaa ttcagaagat cctggcaact
     1081 ggtgccaatg ttattctaac cactggtggc attgatgata tgtatctcaa gtattttgtg
     1141 gaagctggtg ccatggctgt taggagagtt ttaaaacgag acctgaagca tgttgcaaaa
     1201 gcttctggag caagtatcct gtctacgctg gccaatttgg aaggcgaaga aacttttgaa
     1261 gtgacgatgt tgggacaagc ggaagaggtc gtacaggaga gaatttgtga tgatgagctg
     1321 atcttaatca aaaatactaa ggctcgtaca tctgcttcaa tcatcttacg aggagcaaat
     1381 gatttcatgt gtgatgaaat ggagcgctct ttacatgatg ctctttgtgt ggtgaagaga
     1441 gttttggagt tgaaatctgt ggtcccaggt ggaggtgctg tagaagctgc cctgtccata
     1501 tacctggaaa actatgcaac aagcatggga tctcgggaac agcttgctat tgcagagttt
     1561 gcaagatctc tgcttgtgat tcctaataca ctggcagtga atgctgccca ggactccacc
     1621 gacctggttg ccaagttaag agcttttcac aatgaggctc aagtgaaccc ggaacgtaaa
     1681 aatctaaagt ggattggtct tgatttggtc catgggaaac cacgagacaa caagcaagca
     1741 ggggtgtttg aaccaaccat agttaaagtg aagagcctga agttcgcaac agaggctgca
     1801 atcaccatcc ttcggattga tgatctgata aaattacacc cagaaagcaa agacgataaa
     1861 cacggaagtt atgaaaatgc tgttcactct ggagcccttg atgactgatt ggatttccct
     1921 cttatttata acagtgtcag gtgcaatgcc gtagccttgg gtgtctcaca ttaaagtaca
     1981 gcaagctgac cacctgggtt cctgtcctca gtttggtcct ctggtttccc tttctgctta
     2041 gtgttgcact gatttaacaa gaactgtcca aggtggtggc tgtcatgcag ttcaccctct
     2101 ctgaacacac attgcgactc ccatcccacc cccaatgcac agggctgcaa caccacgggt
     2161 cccgcccact ctctccaggg tgtgcagcaa ggtcactaga atcctgcagc cagatgctcc
     2221 cagaggatgg cccaaggcaa tggctcctcc attgatgttg acctatagag aagaagagcc
     2281 taagtcagtc ctctgtgaac tgactgtttt atatgtctcc ccgcagtgtt atgctagcaa
     2341 accatccttt caaactcaac tttcactgta aaccttagga ataaataggc ctatgtgaca
     2401 cctcctgggt ttctctgtgt ggctctggcc ttcgtggaac tcactctgta gaccaggctg
     2461 gcctctaact cagaaataaa tctgcctgcc tttgcctct
//
