LOCUS       NM_015749               2061 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus transcobalamin 2 (Tcn2), transcript variant 1, mRNA.
ACCESSION   NM_015749
VERSION     NM_015749.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2061)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2061)
  AUTHORS   Boachie,J., Adaikalakoteswari,A., Goljan,I., Samavat,J.,
            Cagampang,F.R. and Saravanan,P.
  TITLE     Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are
            Modulated by CD320 Receptor and TCN2 Transporter
  JOURNAL   Int J Mol Sci 22 (6), 3089 (2021)
   PUBMED   33803025
  REMARK    GeneRIF: Intracellular and Tissue Levels of Vitamin B12 in
            Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2061)
  AUTHORS   Larimore,J., Zlatic,S.A., Arnold,M., Singleton,K.S., Cross,R.,
            Rudolph,H., Bruegge,M.V., Sweetman,A., Garza,C., Whisnant,E. and
            Faundez,V.
  TITLE     Dysbindin Deficiency Modifies the Expression of GABA Neuron and Ion
            Permeation Transcripts in the Developing Hippocampus
  JOURNAL   Front Genet 8, 28 (2017)
   PUBMED   28344592
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2061)
  AUTHORS   Dutchak,P.A., Laxman,S., Estill,S.J., Wang,C., Wang,Y., Wang,Y.,
            Bulut,G.B., Gao,J., Huang,L.J. and Tu,B.P.
  TITLE     Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1
            Inhibitor NPRL2
  JOURNAL   Cell Rep 12 (3), 371-379 (2015)
   PUBMED   26166573
REFERENCE   5  (bases 1 to 2061)
  AUTHORS   Abonnenc,M., Nabeebaccus,A.A., Mayr,U., Barallobre-Barreiro,J.,
            Dong,X., Cuello,F., Sur,S., Drozdov,I., Langley,S.R., Lu,R.,
            Stathopoulou,K., Didangelos,A., Yin,X., Zimmermann,W.H., Shah,A.M.,
            Zampetaki,A. and Mayr,M.
  TITLE     Extracellular matrix secretion by cardiac fibroblasts: role of
            microRNA-29b and microRNA-30c
  JOURNAL   Circ Res 113 (10), 1138-1147 (2013)
   PUBMED   24006456
REFERENCE   6  (bases 1 to 2061)
  AUTHORS   Kaupmann,K., Simon-Chazottes,D., Guenet,J.L. and Jockusch,H.
  TITLE     Wobbler, a mutation affecting motoneuron survival and gonadal
            functions in the mouse, maps to proximal chromosome 11
  JOURNAL   Genomics 13 (1), 39-43 (1992)
   PUBMED   1349581
REFERENCE   7  (bases 1 to 2061)
  AUTHORS   Bottorff,D. and Stone,J.C.
  TITLE     The murine leukemia inhibition factor gene (Lif) is located on
            proximal chromosome 11, not chromosome 13
  JOURNAL   Mamm Genome 3 (12), 681-684 (1992)
   PUBMED   1477476
REFERENCE   8  (bases 1 to 2061)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
REFERENCE   9  (bases 1 to 2061)
  AUTHORS   Wilson,S.D., Billings,P.R., D'Eustachio,P., Fournier,R.E.,
            Geissler,E., Lalley,P.A., Burd,P.R., Housman,D.E., Taylor,B.A. and
            Dorf,M.E.
  TITLE     Clustering of cytokine genes on mouse chromosome 11
  JOURNAL   J Exp Med 171 (4), 1301-1314 (1990)
   PUBMED   1969921
REFERENCE   10 (bases 1 to 2061)
  AUTHORS   DiGirolamo,P.M. and Huennekens,F.M.
  TITLE     Transport of vitamin B12 into mouse leukemia cells
  JOURNAL   Arch Biochem Biophys 168 (2), 386-393 (1975)
   PUBMED   237480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB844284.1, AK147176.1 and AK143761.1.
            
            On Jul 24, 2008 this sequence version replaced NM_015749.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147176.1, AK161618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                BB844284.1         1-30
            31-1947             AK147176.1         2-1918
            1948-2061           AK143761.1         1916-2029
FEATURES             Location/Qualifiers
     source          1..2061
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.76 cM"
     gene            1..2061
                     /gene="Tcn2"
                     /gene_synonym="Tcn-2"
                     /note="transcobalamin 2"
                     /db_xref="GeneID:21452"
                     /db_xref="MGI:MGI:98534"
     exon            1..69
                     /gene="Tcn2"
                     /gene_synonym="Tcn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            70..264
                     /gene="Tcn2"
                     /gene_synonym="Tcn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            265..457
                     /gene="Tcn2"
                     /gene_synonym="Tcn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            458..627
                     /gene="Tcn2"
                     /gene_synonym="Tcn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            628..789
                     /gene="Tcn2"
                     /gene_synonym="Tcn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            790..962
                     /gene="Tcn2"
                     /gene_synonym="Tcn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1149
                     /gene="Tcn2"
                     /gene_synonym="Tcn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1150..1315
                     /gene="Tcn2"
                     /gene_synonym="Tcn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1431
                     /gene="Tcn2"
                     /gene_synonym="Tcn-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..2061
                     /gene="Tcn2"
                     /gene_synonym="Tcn-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1928..1933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcn2"
                     /gene_synonym="Tcn-2"
                     /note="hexamer: ATTAAA"
     polyA_site      1955
                     /gene="Tcn2"
                     /gene_synonym="Tcn-2"
                     /note="major polyA site"
ORIGIN      
        1 acagtttccc agctctgacc ccgagagtca aagtaagtac tttccaggga ctcctgtgaa
       61 gtgcacccgc agcgtgcttc cggctgttgg aaggacaatt aatcagtgaa gctgcctctt
      121 cctaagcaag acaacagttg cagtcagaca agccctcaag gtgagaccca ggagtctccc
      181 acctcccacc tgtgcctgcc atggagctcc tgaaggcgct gctgctcctt tctggagtct
      241 ttggggctct tgctgaattc tgtgtaatac cacggataga cagccagctg gtagagaagt
      301 tgggtcaacg tcttttacct tggatggatc ggctttcctc agagcagttg aaccccagcg
      361 tcttcgttgg cctgcgactt tccagcatgc aggctgggac caaagaggac ctctaccttc
      421 acagcctcaa gatccattac cagcagtgcc tcctgcggtc cacctccagc gatgataaca
      481 gtagttgcca gcccaaactt tccgggggca gcctggcgct ctacctgctt gctctcaggg
      541 ccaactgcga attcttcggg agccgaaagg gtgacaggtt gatctcacag ctcaagtggt
      601 tcttggagga tgagaagaag gccattgggc acaatcatga aggccacccc aacaccaact
      661 attaccagta tggcctcagc atcctggcac tgtgtgtcca ccagaagcgg ctccatgaca
      721 gcgtggtggg caagctcctg tatgctgttg aacatgacta ctttacctac cagggccacg
      781 tctctgtgga cacagaagcc atggccggct tggccctcac ctgtttggag cgattcaatt
      841 tcaactctga tctgagacca cgaatcacca tggctatcga gacagtgcga gagaaaatcc
      901 tgaagtccca ggcccctgag ggctactttg ggaatatcta tagcacccca ctggcactac
      961 agatgctcat gacatctcct gcatccgggg tagggctggg cacagcgtgc atcaaggcag
     1021 ggacatccct gctgctcagc ctacaggatg gggccttcca aaatcctctg atgatttccc
     1081 agctgctacc catcctgaac cacaagacct acttggatct tatcttccca gactgccagg
     1141 catccagggt catgttggtg ccagctgttg aggaccctgt ccacatctca gaagtcatca
     1201 gcgtcacgct gaaggtcgcc agtgccctgt caccatacga acagacattt tttgtctttg
     1261 ctggatcttc cttggaagat gtcctgaagt tggcacaaga tggcggagga ttcacgtatg
     1321 ggacccaggc ctccttgtca ggcccctacc tgacatctgt actagggaaa gatgctgggg
     1381 accgagaata ttggcagctc ctccgagccc ctgacacacc cctgctgcaa ggcattgctg
     1441 actacaaacc ccaggacggg gaaaccattg agctgcggct agttagatgg tagtcctacg
     1501 atccctcctg atgtcttcac accctgctgc cacctcaagt gcacttggaa caatgccccc
     1561 cagatcacct cagctacctt cccaaagagg atctaagcca ctccccacct gggagcagga
     1621 agggaaaaaa aacctcccct agggaggctg ctagtttgag tttggccctg cctgatccca
     1681 caggtctttc atgaagactg ccccatagcc tgaggaacag gctgctcttg acttcctcta
     1741 cataaagaag tctgctggct atgggtgttg tgagtaccac tgctctggga ccagggtccc
     1801 acaagaagga cctccatggc ctgctgtggc tctgacctgc acacccaacc cctgctctct
     1861 gttatgagag tggtggtccc agtggtcata aggcagcctt tggtcatcgg cagggccatc
     1921 caatacaatt aaagccttga tttacctgac atggacgtag agtcctggtg cctcgtgttc
     1981 atgcatgggg ggagggggag cagagatctc tggggagtta cttgtggtta ctctcctgtg
     2041 tatcacatgg acagttggca t
//
