LOCUS       NP_056564                430 aa            linear   ROD 12-JUN-2025
DEFINITION  transcobalamin-2 precursor [Mus musculus].
ACCESSION   NP_056564
VERSION     NP_056564.1
DBSOURCE    REFSEQ: accession NM_015749.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 430)
  AUTHORS   Panza,P., Kim,H.T., Lautenschlager,T., Piesker,J., Gunther,S.,
            Alayoubi,Y., Cleaver,O., Looso,M. and Stainier,D.Y.R.
  TITLE     The lung microvasculature promotes alveolar type 2 cell
            differentiation via secreted SPARCL1
  JOURNAL   Stem Cell Reports 20 (4), 102451 (2025)
   PUBMED   40118055
REFERENCE   2  (residues 1 to 430)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 430)
  AUTHORS   Boachie,J., Adaikalakoteswari,A., Goljan,I., Samavat,J.,
            Cagampang,F.R. and Saravanan,P.
  TITLE     Intracellular and Tissue Levels of Vitamin B12 in Hepatocytes Are
            Modulated by CD320 Receptor and TCN2 Transporter
  JOURNAL   Int J Mol Sci 22 (6), 3089 (2021)
   PUBMED   33803025
  REMARK    GeneRIF: Intracellular and Tissue Levels of Vitamin B12 in
            Hepatocytes Are Modulated by CD320 Receptor and TCN2 Transporter.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 430)
  AUTHORS   Larimore,J., Zlatic,S.A., Arnold,M., Singleton,K.S., Cross,R.,
            Rudolph,H., Bruegge,M.V., Sweetman,A., Garza,C., Whisnant,E. and
            Faundez,V.
  TITLE     Dysbindin Deficiency Modifies the Expression of GABA Neuron and Ion
            Permeation Transcripts in the Developing Hippocampus
  JOURNAL   Front Genet 8, 28 (2017)
   PUBMED   28344592
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 430)
  AUTHORS   Dutchak,P.A., Laxman,S., Estill,S.J., Wang,C., Wang,Y., Wang,Y.,
            Bulut,G.B., Gao,J., Huang,L.J. and Tu,B.P.
  TITLE     Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1
            Inhibitor NPRL2
  JOURNAL   Cell Rep 12 (3), 371-379 (2015)
   PUBMED   26166573
REFERENCE   6  (residues 1 to 430)
  AUTHORS   Kaupmann,K., Simon-Chazottes,D., Guenet,J.L. and Jockusch,H.
  TITLE     Wobbler, a mutation affecting motoneuron survival and gonadal
            functions in the mouse, maps to proximal chromosome 11
  JOURNAL   Genomics 13 (1), 39-43 (1992)
   PUBMED   1349581
REFERENCE   7  (residues 1 to 430)
  AUTHORS   Bottorff,D. and Stone,J.C.
  TITLE     The murine leukemia inhibition factor gene (Lif) is located on
            proximal chromosome 11, not chromosome 13
  JOURNAL   Mamm Genome 3 (12), 681-684 (1992)
   PUBMED   1477476
REFERENCE   8  (residues 1 to 430)
  AUTHORS   Frankel,W.N., Lee,B.K., Stoye,J.P., Coffin,J.M. and Eicher,E.M.
  TITLE     Characterization of the endogenous nonecotropic murine leukemia
            viruses of NZB/B1NJ and SM/J inbred strains
  JOURNAL   Mamm Genome 2 (2), 110-122 (1992)
   PUBMED   1311971
REFERENCE   9  (residues 1 to 430)
  AUTHORS   Wilson,S.D., Billings,P.R., D'Eustachio,P., Fournier,R.E.,
            Geissler,E., Lalley,P.A., Burd,P.R., Housman,D.E., Taylor,B.A. and
            Dorf,M.E.
  TITLE     Clustering of cytokine genes on mouse chromosome 11
  JOURNAL   J Exp Med 171 (4), 1301-1314 (1990)
   PUBMED   1969921
REFERENCE   10 (residues 1 to 430)
  AUTHORS   DiGirolamo,P.M. and Huennekens,F.M.
  TITLE     Transport of vitamin B12 into mouse leukemia cells
  JOURNAL   Arch Biochem Biophys 168 (2), 386-393 (1975)
   PUBMED   237480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB844284.1, AK147176.1 and AK143761.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147176.1, AK161618.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..430
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.76 cM"
     Protein         1..430
                     /product="transcobalamin-2 precursor"
                     /note="TC-2; TCII; TC II; transcobalamin II"
                     /calculated_mol_wt=45745
     sig_peptide     1..18
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=1859
     mat_peptide     19..430
                     /product="Transcobalamin-2. /id=PRO_0000005565"
                     /note="propagated from UniProtKB/Swiss-Prot (O88968.1)"
                     /calculated_mol_wt=45745
     Region          19..327
                     /region_name="Cobalamin_bind"
                     /note="Eukaryotic cobalamin-binding protein; pfam01122"
                     /db_xref="CDD:460073"
     Region          355..427
                     /region_name="DUF4430"
                     /note="Domain of unknown function (DUF4430); pfam14478"
                     /db_xref="CDD:433979"
     CDS             1..430
                     /gene="Tcn2"
                     /gene_synonym="Tcn-2"
                     /coded_by="NM_015749.3:201..1493"
                     /db_xref="CCDS:CCDS24371.1"
                     /db_xref="GeneID:21452"
                     /db_xref="MGI:MGI:98534"
ORIGIN      
        1 mellkallll sgvfgalaef cvipridsql veklgqrllp wmdrlsseql npsvfvglrl
       61 ssmqagtked lylhslkihy qqcllrstss ddnsscqpkl sggslalyll alranceffg
      121 srkgdrlisq lkwfledekk aighnheghp ntnyyqygls ilalcvhqkr lhdsvvgkll
      181 yavehdyfty qghvsvdtea maglaltcle rfnfnsdlrp ritmaietvr ekilksqape
      241 gyfgniystp lalqmlmtsp asgvglgtac ikagtsllls lqdgafqnpl misqllpiln
      301 hktyldlifp dcqasrvmlv pavedpvhis evisvtlkva salspyeqtf fvfagssled
      361 vlklaqdggg ftygtqasls gpyltsvlgk dagdreywql lrapdtpllq giadykpqdg
      421 etielrlvrw
//
