LOCUS       NM_009337               1410 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Mus musculus T cell lymphoma breakpoint 1 (Tcl1), transcript
            variant 1, mRNA.
ACCESSION   NM_009337
VERSION     NM_009337.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1410)
  AUTHORS   Pfeuffer,L., Siegert,V., Frede,J., Rieger,L., Trozzo,R., de Andrade
            Kratzig,N., Ring,S., Sarhadi,S., Beck,N., Niedermeier,S.,
            Abril-Gil,M., Elbahloul,M., Remke,M., Steiger,K., Eichner,R.,
            Jellusova,J., Rad,R., Bassermann,F., Winter,C., Ruland,J. and
            Buchner,M.
  TITLE     B-cell intrinsic RANK signaling cooperates with TCL1 to induce
            lineage-dependent B-cell transformation
  JOURNAL   Blood Cancer J 14 (1), 151 (2024)
   PUBMED   39198400
  REMARK    GeneRIF: B-cell intrinsic RANK signaling cooperates with TCL1 to
            induce lineage-dependent B-cell transformation.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1410)
  AUTHORS   Jiang,Q., Stachelscheid,J., Bloehdorn,J., Pacholewska,A., Aszyk,C.,
            Grotenhuijs,F., Muller,T., Onder,O., Wagle,P., Herling,C.D.,
            Kleppe,M., Wang,Z., Coombes,K.R., Robrecht,S., Dalvi,P.S.,
            Plosnita,B., Mayer,P., Abruzzo,L.V., Altmuller,J., Gathof,B.,
            Persigehl,T., Fischer,K., Jebaraj,B., Rienhoff,H.Y., Ecker,R.,
            Zhao,Y., Bruns,C.J., Stilgenbauer,S., Elenitoba-Johnson,K.,
            Hallek,M., Schweiger,M.R., Odenthal,M., Vasyutina,E. and Herling,M.
  TITLE     Oncogenic role and target properties of the lysine-specific
            demethylase KDM1A in chronic lymphocytic leukemia
  JOURNAL   Blood 142 (1), 44-61 (2023)
   PUBMED   37023372
  REMARK    GeneRIF: Oncogenic role and target properties of the
            lysine-specific demethylase KDM1A in chronic lymphocytic leukemia.
REFERENCE   3  (bases 1 to 1410)
  AUTHORS   Weinstock,J.S., Gopakumar,J., Burugula,B.B., Uddin,M.M., Jahn,N.,
            Belk,J.A., Bouzid,H., Daniel,B., Miao,Z., Ly,N., Mack,T.M.,
            Luna,S.E., Prothro,K.P., Mitchell,S.R., Laurie,C.A., Broome,J.G.,
            Taylor,K.D., Guo,X., Sinner,M.F., von Falkenhausen,A.S., Kaab,S.,
            Shuldiner,A.R., O'Connell,J.R., Lewis,J.P., Boerwinkle,E.,
            Barnes,K.C., Chami,N., Kenny,E.E., Loos,R.J.F., Fornage,M., Hou,L.,
            Lloyd-Jones,D.M., Redline,S., Cade,B.E., Psaty,B.M., Bis,J.C.,
            Brody,J.A., Silverman,E.K., Yun,J.H., Qiao,D., Palmer,N.D.,
            Freedman,B.I., Bowden,D.W., Cho,M.H., DeMeo,D.L., Vasan,R.S.,
            Yanek,L.R., Becker,L.C., Kardia,S.L.R., Peyser,P.A., He,J.,
            Rienstra,M., Van der Harst,P., Kaplan,R., Heckbert,S.R.,
            Smith,N.L., Wiggins,K.L., Arnett,D.K., Irvin,M.R., Tiwari,H.,
            Cutler,M.J., Knight,S., Muhlestein,J.B., Correa,A., Raffield,L.M.,
            Gao,Y., de Andrade,M., Rotter,J.I., Rich,S.S., Tracy,R.P.,
            Konkle,B.A., Johnsen,J.M., Wheeler,M.M., Smith,J.G., Melander,O.,
            Nilsson,P.M., Custer,B.S., Duggirala,R., Curran,J.E., Blangero,J.,
            McGarvey,S., Williams,L.K., Xiao,S., Yang,M., Gu,C.C., Chen,Y.I.,
            Lee,W.J., Marcus,G.M., Kane,J.P., Pullinger,C.R., Shoemaker,M.B.,
            Darbar,D., Roden,D.M., Albert,C., Kooperberg,C., Zhou,Y.,
            Manson,J.E., Desai,P., Johnson,A.D., Mathias,R.A., Blackwell,T.W.,
            Abecasis,G.R., Smith,A.V., Kang,H.M., Satpathy,A.T., Natarajan,P.,
            Kitzman,J.O., Whitsel,E.A., Reiner,A.P., Bick,A.G. and Jaiswal,S.
  CONSRTM   NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium
  TITLE     Aberrant activation of TCL1A promotes stem cell expansion in clonal
            haematopoiesis
  JOURNAL   Nature 616 (7958), 755-763 (2023)
   PUBMED   37046083
  REMARK    GeneRIF: Aberrant activation of TCL1A promotes stem cell expansion
            in clonal haematopoiesis.
REFERENCE   4  (bases 1 to 1410)
  AUTHORS   Stachelscheid,J., Jiang,Q., Aszyk,C., Warner,K., Bley,N.,
            Muller,T., Vydzhak,O., Symeonidis,K., Crispatzu,G., Mayer,P.,
            Blakemore,S.J., Goehring,G., Newrzela,S., Hippler,S., Robrecht,S.,
            Kreuzer,K.A., Pallasch,C., Kruger,M., Lechner,A., Fischer,K.,
            Stilgenbauer,S., Beutner,D., Hallek,M., Auguin,D., Huttelmaier,S.,
            Bloehdorn,J., Vasyutina,E. and Herling,M.
  TITLE     The proto-oncogene TCL1A deregulates cell cycle and genomic
            stability in CLL
  JOURNAL   Blood 141 (12), 1425-1441 (2023)
   PUBMED   36179280
  REMARK    GeneRIF: The proto-oncogene TCL1A deregulates cell cycle and
            genomic stability in CLL.
REFERENCE   5  (bases 1 to 1410)
  AUTHORS   Parigger,T., Gassner,F.J., Scherhaufl,C., Bakar,A.A., Hopner,J.P.,
            Hodlmoser,A., Steiner,M., Catakovic,K., Geisberger,R., Greil,R. and
            Zaborsky,N.
  TITLE     Evidence for Non-Cancer-Specific T Cell Exhaustion in the Tcl1
            Mouse Model for Chronic Lymphocytic Leukemia
  JOURNAL   Int J Mol Sci 22 (13), 6648 (2021)
   PUBMED   34206229
  REMARK    GeneRIF: Evidence for Non-Cancer-Specific T Cell Exhaustion in the
            Tcl1 Mouse Model for Chronic Lymphocytic Leukemia.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1410)
  AUTHORS   Bichi,R., Shinton,S.A., Martin,E.S., Koval,A., Calin,G.A.,
            Cesari,R., Russo,G., Hardy,R.R. and Croce,C.M.
  TITLE     Human chronic lymphocytic leukemia modeled in mouse by targeted
            TCL1 expression
  JOURNAL   Proc Natl Acad Sci U S A 99 (10), 6955-6960 (2002)
   PUBMED   12011454
  REMARK    GeneRIF: TCL1 and/or other genes in the TCL1 pathway are
            responsible for the initiation of human chronic lymphocytic
            leukemia.
REFERENCE   7  (bases 1 to 1410)
  AUTHORS   Park,Y.G., Song,C.W., Mori,N., Sugimoto,K., Hong,D.P. and
            Okumoto,M.
  TITLE     Analysis of highly frequent allelic loss region on distal
            chromosome 12 in murine radiation-induced lymphomas
  JOURNAL   Cancer Lett 148 (1), 95-103 (2000)
   PUBMED   10680598
REFERENCE   8  (bases 1 to 1410)
  AUTHORS   Hallas,C., Pekarsky,Y., Itoyama,T., Varnum,J., Bichi,R.,
            Rothstein,J.L. and Croce,C.M.
  TITLE     Genomic analysis of human and mouse TCL1 loci reveals a complex of
            tightly clustered genes
  JOURNAL   Proc Natl Acad Sci U S A 96 (25), 14418-14423 (1999)
   PUBMED   10588720
REFERENCE   9  (bases 1 to 1410)
  AUTHORS   Virgilio,L., Lazzeri,C., Bichi,R., Nibu,K., Narducci,M.G.,
            Russo,G., Rothstein,J.L. and Croce,C.M.
  TITLE     Deregulated expression of TCL1 causes T cell leukemia in mice
  JOURNAL   Proc Natl Acad Sci U S A 95 (7), 3885-3889 (1998)
   PUBMED   9520462
REFERENCE   10 (bases 1 to 1410)
  AUTHORS   Narducci,M.G., Virgilio,L., Engiles,J.B., Buchberg,A.M.,
            Billips,L., Facchiano,A., Croce,C.M., Russo,G. and Rothstein,J.L.
  TITLE     The murine Tcl1 oncogene: embryonic and lymphoid cell expression
  JOURNAL   Oncogene 15 (8), 919-926 (1997)
   PUBMED   9285687
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV653827.1, BC052336.1 and AK163387.1.
            
            On Aug 13, 2009 this sequence version replaced NM_009337.2.
            
            Transcript Variant: This variant (1) encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052336.1, AK163387.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                DV653827.1         1-32
            33-775              BC052336.1         14-756
            776-780             AK163387.1         760-764
            781-1410            BC052336.1         762-1391
FEATURES             Location/Qualifiers
     source          1..1410
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 55.28 cM"
     gene            1..1410
                     /gene="Tcl1"
                     /gene_synonym="Tcl1a"
                     /note="T cell lymphoma breakpoint 1"
                     /db_xref="GeneID:21432"
                     /db_xref="MGI:MGI:1097166"
     exon            1..205
                     /gene="Tcl1"
                     /gene_synonym="Tcl1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..436
                     /gene="Tcl1"
                     /gene_synonym="Tcl1a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-cell leukemia/lymphoma protein 1A; TCL-1; oncogene TCL1;
                     protein p14 TCL1; oncogene TCL-1"
                     /codon_start=1
                     /product="T-cell leukemia/lymphoma protein 1A isoform 1"
                     /protein_id="NP_033363.1"
                     /db_xref="CCDS:CCDS36549.1"
                     /db_xref="GeneID:21432"
                     /db_xref="MGI:MGI:1097166"
                     /translation="MATQRAHRAETPAHPNRLWIWEKHVYLDEFRRSWLPVVIKSNEK
                     FQVILRQEDVTLGEAMSPSQLVPYELPLMWQLYPKDRYRSCDSMYWQILYHIKFRDVE
                     DMLLELIDSESNDE"
     exon            206..376
                     /gene="Tcl1"
                     /gene_synonym="Tcl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            377..446
                     /gene="Tcl1"
                     /gene_synonym="Tcl1a"
                     /inference="alignment:Splign:2.1.0"
     exon            447..1395
                     /gene="Tcl1"
                     /gene_synonym="Tcl1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1371..1376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcl1"
                     /gene_synonym="Tcl1a"
                     /note="hexamer: AATAAA"
     polyA_site      1395
                     /gene="Tcl1"
                     /gene_synonym="Tcl1a"
                     /note="major polyA site"
ORIGIN      
        1 cgcgtttctc atgctcaccg tgtaggaagc agttttatca cggactggca ttgcaatttt
       61 ctgcttcttg ctcttatcgg atgccatggc tacccagcgg gcacacaggg cagagacacc
      121 tgcacacccc aaccgcctgt ggatctggga gaagcacgtg tacttggatg agtttcgtcg
      181 aagctggctg cccgtagtca tcaagagtaa tgaaaaattc caggtgatct tgcgccagga
      241 agatgtcacc ttgggggaag ctatgtcccc cagtcagctg gtgccttacg agctgccttt
      301 aatgtggcaa ctgtacccca aggacaggta ccgaagctgc gactccatgt attggcagat
      361 cctgtaccat atcaagttta gagacgtgga ggacatgttg cttgaactga tagactcgga
      421 gtccaacgat gaataaccca gacccggtcc tgcagctcct gtctgccttg cccaggcctg
      481 gccccacagg ggagatgttg gtacttatgt tctgtctgtt cgctagtcat gtcctttttc
      541 ctctacactg ggctccaaga agaaaactct ggccagacgc tgccccttcc catgctgctg
      601 ttgcctgctc ggctgccttg gttggtccct cagctctgct gactccctgg caaggggctc
      661 cagagaagat cccagttctc ctcacctcct ctaggtgctc agtggtgtct gtgcctctga
      721 tgatcttagc tgattgactc ttccgtcttt ccctttggcc tcacaagaca actagtgtct
      781 ctgacttatg aacttgcctt cttcctcacg ggtccctcag cagtacatac accatgaggg
      841 acaagacctc gtcattggaa tctggccagg ccccagatca gccatcactc aaggtgttgt
      901 gcctgtaccc acctgacctg tgaagcccca cctacccagc aaacataggc tttgattgca
      961 gagcggtgta agacctgaga gctctcttgc ccttccttag aacctaggtg cttgcagcca
     1021 gggatatgca aacctggggc ctatggcctc actagaacaa gaggccaggc agtgggcctg
     1081 gttcagatgg gccctctgat tgcctgtgtg caggcttcct ctctgggtgt tcaggttctg
     1141 tatttagtgt aaacacgtcc tgtcgctgat taaatatttc actcacctaa gttgggccaa
     1201 atcggcttcc atccttgacc gagatgccaa taaatgaggg agagaagact gctccggggt
     1261 ctcccagaga agccagggtc acccagggaa gccttggtct cctagtaaga atgttgaaag
     1321 ggaatgtgtg ggattttatg tggttctatt ttagagatac ggctggattt aataaagctt
     1381 tgtagaactt taaaaaaaaa aaaaaaaaaa
//
