LOCUS       NM_001136091            2700 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus T cell, immune regulator 1, ATPase, H+ transporting,
            lysosomal V0 protein A3 (Tcirg1), transcript variant 2, mRNA.
ACCESSION   NM_001136091
VERSION     NM_001136091.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2700)
  AUTHORS   Nakanishi-Matsui,M., Matsumoto,N., Sun-Wada,G.H. and Wada,Y.
  TITLE     Role of the Cytosolic Domain of the a3 Subunit of V-ATPase in the
            Interaction with Rab7 and Secretory Lysosome Trafficking in
            Osteoclasts
  JOURNAL   Biol Pharm Bull 47 (1), 339-344 (2024)
   PUBMED   38296463
REFERENCE   2  (bases 1 to 2700)
  AUTHORS   Sun-Wada,G.H. and Wada,Y.
  TITLE     The a subunit isoforms of vacuolar-type proton ATPase exhibit
            differential distribution in mouse perigastrulation embryos
  JOURNAL   Sci Rep 12 (1), 13590 (2022)
   PUBMED   35948619
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2700)
  AUTHORS   Matsumoto,N., Sekiya,M., Sun-Wada,G.H., Wada,Y. and
            Nakanishi-Matsui,M.
  TITLE     The lysosomal V-ATPase a3 subunit is involved in localization of
            Mon1-Ccz1, the GEF for Rab7, to secretory lysosomes in osteoclasts
  JOURNAL   Sci Rep 12 (1), 8455 (2022)
   PUBMED   35589873
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2700)
  AUTHORS   Nishikawa,K., Seno,S., Yoshihara,T., Narazaki,A., Sugiura,Y.,
            Shimizu,R., Kikuta,J., Sakaguchi,R., Suzuki,N., Takeda,N.,
            Semba,H., Yamamoto,M., Okuzaki,D., Motooka,D., Kobayashi,Y.,
            Suematsu,M., Koseki,H., Matsuda,H., Yamamoto,M., Tobita,S., Mori,Y.
            and Ishii,M.
  TITLE     Osteoclasts adapt to physioxia perturbation through DNA
            demethylation
  JOURNAL   EMBO Rep 22 (12), e53035 (2021)
   PUBMED   34661337
REFERENCE   5  (bases 1 to 2700)
  AUTHORS   Zhang,D., Lin,L., Yang,B., Meng,Z. and Zhang,B.
  TITLE     Knockdown of Tcirg1 inhibits large-osteoclast generation by
            down-regulating NFATc1 and IP3R2 expression
  JOURNAL   PLoS One 15 (8), e0237354 (2020)
   PUBMED   32790690
  REMARK    GeneRIF: Knockdown of Tcirg1 inhibits large-osteoclast generation
            by down-regulating NFATc1 and IP3R2 expression.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2700)
  AUTHORS   Nakamura,I., Takahashi,N., Udagawa,N., Moriyama,Y., Kurokawa,T.,
            Jimi,E., Sasaki,T. and Suda,T.
  TITLE     Lack of vacuolar proton ATPase association with the cytoskeleton in
            osteoclasts of osteosclerotic (oc/oc) mice
  JOURNAL   FEBS Lett 401 (2-3), 207-212 (1997)
   PUBMED   9013888
REFERENCE   7  (bases 1 to 2700)
  AUTHORS   Li,Y.P., Chen,W. and Stashenko,P.
  TITLE     Molecular cloning and characterization of a putative novel human
            osteoclast-specific 116-kDa vacuolar proton pump subunit
  JOURNAL   Biochem Biophys Res Commun 218 (3), 813-821 (1996)
   PUBMED   8579597
REFERENCE   8  (bases 1 to 2700)
  AUTHORS   Udagawa,N., Sasaki,T., Akatsu,T., Takahashi,N., Tanaka,S.,
            Tamura,T., Tanaka,H. and Suda,T.
  TITLE     Lack of bone resorption in osteosclerotic (oc/oc) mice is due to a
            defect in osteoclast progenitors rather than the local
            microenvironment provided by osteoblastic cells
  JOURNAL   Biochem Biophys Res Commun 184 (1), 67-72 (1992)
   PUBMED   1567458
REFERENCE   9  (bases 1 to 2700)
  AUTHORS   Marks,S.C. Jr., Seifert,M.F. and Lane,P.W.
  TITLE     Osteosclerosis, a recessive skeletal mutation on chromosome 19 in
            the mouse
  JOURNAL   J Hered 76 (3), 171-176 (1985)
   PUBMED   3998439
REFERENCE   10 (bases 1 to 2700)
  AUTHORS   Seifert,M.F. and Marks,S.C. Jr.
  TITLE     Morphological evidence of reduced bone resorption in the
            osteosclerotic (oc) mouse
  JOURNAL   Am J Anat 172 (2), 141-153 (1985)
   PUBMED   3976544
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ057829.1, AB022322.1 and BE987533.1.
            
            On Nov 17, 2009 this sequence version replaced NM_001136091.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 3. All three variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF218253.1, BC085234.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                CJ057829.1         2-94
            94-2686             AB022322.1         1-2593
            2687-2700           BE987533.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..2700
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.62 cM"
     gene            1..2700
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /note="T cell, immune regulator 1, ATPase, H+
                     transporting, lysosomal V0 protein A3"
                     /db_xref="GeneID:27060"
                     /db_xref="MGI:MGI:1350931"
     exon            1..115
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            116..236
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..2624
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /EC_number="7.1.2.1"
                     /note="osteosclerotic; V-ATPase a3; ATPase, H+
                     transporting, lysosomal I"
                     /codon_start=1
                     /product="V-type proton ATPase 116 kDa subunit a 3"
                     /protein_id="NP_001129563.1"
                     /db_xref="CCDS:CCDS29401.1"
                     /db_xref="GeneID:27060"
                     /db_xref="MGI:MGI:1350931"
                     /translation="MGSMFRSEEVALVQLLLPTGSAYNCVSQLGELGLVEFRDLNESV
                     SAFQRRFVVDVRRCEELEKTFTFLREEVQRAGLTLAPPEGTLPAPPPRDLLRIQEETD
                     RLAQELRDVRGNQQALRAQLHQLRLHSAVLGQSHSPPVAADHTEGPFSETTPLLPGTR
                     GPHSDLKVNFVAGAVEPYKAAALERLLWRACRGFLIASFRETEGQLEDPVTGEPATWM
                     TFVISYWGEQIGQKIRKITDCFHCHVFPYLEQEEARFRTLQQLQQQSQELQEVLGETD
                     RFLSQVLGRVQQLLPPWQVQIHKMKAVYLTLNQCSVNTTHKCLIAEVWCAARDLPTVQ
                     QALQSGSSEEGVSAVAHRIPCQDMPPTLIRTNRFTSSFQGIVDAYGVGRYREVNPAPY
                     TIITFPFLFAVMFGDVGHGLLMFLFALAMVLTENRPAVKAAQNEIWQTFFGGRYLLLL
                     MGLFSVYTGFIYNECFSRATTIFPSGWSVAAMANQSGWSDEYLSQHSMLTLNPNITGV
                     FLGPYPFGIDPIWSLATNHLSFLNSFKMKMSVILGVTHMAFGVFLSIFNHVHFGQAHR
                     LLLETLPELIFLLGLFGYLVFLIVYKWVNVSAASASSAPSILIHFINMFLFSQNPTNH
                     LLFHGQEVVQYVLVVLALATVPILLLGTPLYLLRQHRHRRNTQRRPAGQQDEDTDKLL
                     ASPDASTLENSWSPDEEKAGSPGDEETEFVPSEIFMHQAIHTIEFCLGCISNTASYLR
                     LWALSLAHAQLSEVLWAMVMRIGLGMGREIGVAAVVLVPVFAAFAVLTVAILLVMEGL
                     SAFLHALRLHWVEFQNKFYSGTGYKLSPFTFTVDSD"
     exon            237..315
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            316..536
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..625
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..752
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            753..835
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            836..929
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1142
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1143..1287
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1427
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1585
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1586..1676
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1795
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..2009
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2141
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2142..2249
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2250..2367
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2368..2545
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     exon            2546..2688
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2664..2669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /note="hexamer: AATAAA"
     polyA_site      2688
                     /gene="Tcirg1"
                     /gene_synonym="ATP6a3; Atp6i; ATP6N1C; oc; OC-116; OPTB1;
                     Stv1; TIRC7; Vph1"
                     /note="major polyA site"
ORIGIN      
        1 gtgggcaggc cgtcacaggc cacacccact ccggtatttc gaagctggag tgagctgcac
       61 tggccggagg gcgggctcag atcctaagcc gaagttgagc gaagagtcca cctgggatca
      121 tgggctctat gttccggagt gaagaggtgg ccttggtcca gctcctgttg cccacagggt
      181 ctgcttacaa ctgtgtgagc cagcttggtg agctgggcct cgtggagttc agagacctca
      241 acgaatccgt gagcgccttc cagagacgct tcgtggtaga cgtccggcgc tgcgaggaac
      301 tggagaagac gtttaccttc ttgcgggaag aagtgcagcg ggcaggtctg acgctggccc
      361 cacctgaggg gacactgcca gcaccacctc cccgagacct gctgcgcatc caggaggaaa
      421 cggatcgctt ggcccaggag cttcgggatg ttcgtggcaa tcagcaggca ctgcgggccc
      481 agctgcacca gctgcggctt cactcggctg tgctgggcca gagccacagc ccgccggtgg
      541 cagctgacca tactgaagga cccttctctg agacaacacc cctgcttcca ggcacccggg
      601 ggccacattc agacctgaag gtcaattttg tggcaggtgc tgtggagccc tacaaggctg
      661 cggccctgga gcgcctgctg tggagagctt gccgcggctt cctcattgcc agctttcggg
      721 agactgaggg gcagctggag gacccagtga cgggtgagcc tgcaacttgg atgacctttg
      781 tcatctccta ctggggtgag cagatcggac agaagatccg aaagatcaca gactgcttcc
      841 actgtcatgt cttcccatac ctggagcagg aggaagcccg gttcaggacc ttgcagcagc
      901 tgcagcagca aagccaggag cttcaggaag tcctggggga gacagaccgg ttcctgagcc
      961 aggtgttggg ccgggtgcag cagctgctgc ccccatggca ggtgcagatc cacaagatga
     1021 aggcagtgta cctgaccctc aaccagtgca gtgtgaacac cacacacaag tgcctcatcg
     1081 cggaggtctg gtgtgccgcg agggacctgc ccactgtgca gcaggcgctg cagagcggct
     1141 caagtgagga aggagtgagt gctgtcgctc accgcatccc ctgccaggac atgcctccaa
     1201 ccctcatcag gaccaaccgc ttcacctcca gcttccaggg cattgtggat gcctatggtg
     1261 tgggccgcta cagggaagtt aaccctgctc cctacaccat catcacattc ccctttctct
     1321 tcgctgtgat gtttggcgat gtggggcacg gactgctcat gtttctcttt gccctggcca
     1381 tggtcctcac tgaaaaccgt ccagctgtga aggctgcaca aaacgagatc tggcagacct
     1441 tctttggggg tcgataccta ctcctgctca tgggtctgtt ctccgtctac actggcttca
     1501 tctacaatga gtgcttcagc cgagccacca ctattttccc ctcaggttgg agtgtggctg
     1561 ccatggccaa ccagtcaggc tggagtgacg agtatctgtc ccagcactcc atgctcaccc
     1621 tgaaccctaa catcactggt gtcttccttg gaccatatcc ctttggcatt gacccgatct
     1681 ggagcctggc cacgaaccac ctgagctttc tcaactcctt caagatgaag atgtctgtca
     1741 tccttggggt cacgcacatg gcctttgggg tgttcctcag catcttcaac cacgtgcact
     1801 ttggccaggc ccaccggcta ctgctggaga ccttgcctga gctcatcttc ctgctgggtc
     1861 tctttggcta ccttgtgttc ctcattgtct acaagtgggt gaatgtctca gctgctagcg
     1921 cctcctcggc ccccagtatc ctcattcact tcatcaatat gttcctcttc tctcaaaacc
     1981 ccaccaatca tctgctcttc catgggcagg aagtggtaca gtacgtgctg gtggtcctgg
     2041 ctttggctac cgttcctatc ctgttgctgg gcacaccctt gtacctgctg cgccagcacc
     2101 gccacagaag aaacactcag agaaggccag caggccagca ggatgaggac acggacaagc
     2161 ttctggcctc ccctgatgca tccaccttgg agaacagctg gagccctgat gaggagaagg
     2221 ctgggagccc aggggatgaa gaaactgagt ttgtcccttc tgagatcttc atgcaccaag
     2281 caatccacac cattgagttc tgcctgggct gcatctccaa cacagcctcc tacttgcgtc
     2341 tctgggccct gagcctggcc catgcccagc tgtctgaggt cctgtgggcc atggtgatgc
     2401 gcataggcct gggcatgggc cgagagatcg gcgtggcagc tgtggtgctg gtccctgtgt
     2461 ttgctgcctt tgctgtgttg actgtggcca tcctgttagt gatggagggg ctctcagcct
     2521 tcctgcatgc cctgcggttg cactgggtgg agttccagaa caagttctat tcaggcaccg
     2581 gctacaagct cagccccttc accttcactg tggacagtga ctagctaccc actgcaatcc
     2641 ctgcttctcc gaagtgggac aggaataaag agctggctgg cccaggaaaa aaaaaaaaaa
//
