LOCUS       NM_026931               1775 bp    mRNA    linear   ROD 08-JUN-2024
DEFINITION  Mus musculus transcriptional and immune response regulator (Tcim),
            mRNA.
ACCESSION   NM_026931
VERSION     NM_026931.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1775)
  AUTHORS   Narayanan,R., Pham,L., Kerimoglu,C., Watanabe,T., Castro
            Hernandez,R., Sokpor,G., Ulmke,P.A., Kiszka,K.A., Tonchev,A.B.,
            Rosenbusch,J., Seong,R.H., Teichmann,U., Frahm,J., Fischer,A.,
            Bonn,S., Stoykova,A., Staiger,J.F. and Tuoc,T.
  TITLE     Chromatin Remodeling BAF155 Subunit Regulates the Genesis of Basal
            Progenitors in Developing Cortex
  JOURNAL   iScience 4, 109-126 (2018)
   PUBMED   30240734
REFERENCE   2  (bases 1 to 1775)
  AUTHORS   Jang,H., Kim,M., Lee,S., Kim,J., Woo,D.C., Kim,K.W., Song,K. and
            Lee,I.
  TITLE     Adipose tissue hyperplasia with enhanced adipocyte-derived stem
            cell activity in Tc1(C8orf4)-deleted mice
  JOURNAL   Sci Rep 6, 35884 (2016)
   PUBMED   27775060
  REMARK    GeneRIF: These data support that Tc1 is a novel regulator for
            adipose stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1775)
  AUTHORS   Heise,I., Fisher,S.P., Banks,G.T., Wells,S., Peirson,S.N.,
            Foster,R.G. and Nolan,P.M.
  TITLE     Sleep-like behavior and 24-h rhythm disruption in the Tc1 mouse
            model of Down syndrome
  JOURNAL   Genes Brain Behav 14 (2), 209-216 (2015)
   PUBMED   25558895
  REMARK    GeneRIF: Tc1 mice express sleep-related phenotypes that are
            comparable with those seen in Down syndrome patients
REFERENCE   4  (bases 1 to 1775)
  AUTHORS   Lui,J.H., Nowakowski,T.J., Pollen,A.A., Javaherian,A.,
            Kriegstein,A.R. and Oldham,M.C.
  TITLE     Radial glia require PDGFD-PDGFRbeta signalling in human but not
            mouse neocortex
  JOURNAL   Nature 515 (7526), 264-268 (2014)
   PUBMED   25391964
REFERENCE   5  (bases 1 to 1775)
  AUTHORS   Jung,Y., Kim,M., Soh,H., Lee,S., Kim,J., Park,S., Song,K. and
            Lee,I.
  TITLE     TC1(C8orf4) regulates hematopoietic stem/progenitor cells and
            hematopoiesis
  JOURNAL   PLoS One 9 (6), e100311 (2014)
   PUBMED   24937306
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1775)
  AUTHORS   Gineste,C., De Winter,J.M., Kohl,C., Witt,C.C., Giannesini,B.,
            Brohm,K., Le Fur,Y., Gretz,N., Vilmen,C., Pecchi,E., Jubeau,M.,
            Cozzone,P.J., Stienen,G.J., Granzier,H., Labeit,S.,
            Ottenheijm,C.A., Bendahan,D. and Gondin,J.
  TITLE     In vivo and in vitro investigations of heterozygous nebulin
            knock-out mice disclose a mild skeletal muscle phenotype
  JOURNAL   Neuromuscul Disord 23 (4), 357-369 (2013)
   PUBMED   23375831
REFERENCE   7  (bases 1 to 1775)
  AUTHORS   Wang,Y.D., Bian,G.H., Lv,X.Y., Zheng,R., Sun,H., Zhang,Z., Chen,Y.,
            Li,Q.W., Xiao,Y., Yang,Q.T., Ai,J.Z., Wei,Y.Q. and Zhou,Q.
  TITLE     TC1 (C8orf4) is involved in ERK1/2 pathway-regulated G(1)- to
            S-phase transition
  JOURNAL   BMB Rep 41 (10), 733-738 (2008)
   PUBMED   18959821
  REMARK    GeneRIF: TC1 was involved in the mitogen-activated ERK1/2 signaling
            pathway and positively regulated G(1)- to S-phase transition of the
            cell cycle.[TC1]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC164300.3.
            
            On Feb 9, 2019 this sequence version replaced NM_026931.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK007441.1, BC016562.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1775              AC164300.3         191587-193361       c
FEATURES             Location/Qualifiers
     source          1..1775
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 12.47 cM"
     gene            1..1775
                     /gene="Tcim"
                     /gene_synonym="1110065B09Rik; 1810011O10Rik"
                     /note="transcriptional and immune response regulator"
                     /db_xref="GeneID:69068"
                     /db_xref="MGI:MGI:1916318"
     exon            1..1775
                     /gene="Tcim"
                     /gene_synonym="1110065B09Rik; 1810011O10Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..371
                     /gene="Tcim"
                     /gene_synonym="1110065B09Rik; 1810011O10Rik"
                     /note="thyroid cancer-1; protein C8orf4 homolog"
                     /codon_start=1
                     /product="transcriptional and immune response regulator"
                     /protein_id="NP_081207.1"
                     /db_xref="CCDS:CCDS22194.1"
                     /db_xref="GeneID:69068"
                     /db_xref="MGI:MGI:1916318"
                     /translation="MKAKPSHQATSMSSSLRVSPSIHGYHFDTAARKKAVGNIFENID
                     QESLQRLFRNSGDKKAEERAKIIFAIDQDLEEKTRALMALKKRTKDKLLQFLKLRKYS
                     IKVH"
     regulatory      1313..1318
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcim"
                     /gene_synonym="1110065B09Rik; 1810011O10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1332
                     /gene="Tcim"
                     /gene_synonym="1110065B09Rik; 1810011O10Rik"
                     /note="major polyA site"
     regulatory      1745..1750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcim"
                     /gene_synonym="1110065B09Rik; 1810011O10Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1767
                     /gene="Tcim"
                     /gene_synonym="1110065B09Rik; 1810011O10Rik"
ORIGIN      
        1 aacagactcc cctggaagtg cccaagctga gccgtggaag acccacatcg atgaaagcca
       61 agccaagcca tcaagccacc agcatgtcct cgtctcttcg agtaagcccg tccatccacg
      121 gctaccactt cgacacagcc gctcgcaaga aagctgtggg caacatcttt gagaacatag
      181 accaggagtc cctgcagagg ctcttcagga actccggaga caagaaggca gaggagcggg
      241 ccaagatcat ttttgccatc gaccaagatt tggaggagaa aactcgagcc ctcatggccc
      301 tgaagaagag gacaaaagac aagcttcttc agtttctcaa actgcggaaa tattccatca
      361 aggtacactg agcacagcag gctgggcaag agcgtatcca ccaatggacc tttaaagacc
      421 cagtgagcct gccagctctg gcacgggcag tgtcccgcga aaaggcttga gagcttcctc
      481 cgacaggacc ccgaggatgg aaagggacat acataactca ccagctacac agacttgcaa
      541 ctcattgcag ccctgagctg tcccactggg agccaagtgc cttcagcagg cgttgagaac
      601 tctcacagca ggaaaggaca tagcctgaga ggatggaggc actgaccaga acactgcgtt
      661 tgtggggact gagtgcacgc acccagggcc gttggcaagg ccctaagact aaactcaaac
      721 ctaacttggt ttttgttctt gttgttcggt ttattatttt gttttctttt ttcttttctt
      781 ccttttttct ttttttaaat attgaagtgg ggagggaggg aagagaagga atatgaagca
      841 taagtggttt actgaagttt tgtgtgtttt tttttttaaa tctgaatgtt taaaaatgtg
      901 gctaaatctc cgtgctgttt attggtcaag atttttagag atcagtaatt gtctgcttgc
      961 attgaataca atggctaaga cagtgcaccc cctgctgtta aagtcaaaga actggatgcc
     1021 tggcccagcc cagtaaaacc ccacagcatg ggctatgttt ctacaggatt tgtacacact
     1081 tcaaaatggt ttgcacaaag ctgaaataat ggggcccttc ataaatccga aggactgtga
     1141 acaactttcg aatgtgcttt ttaaaactct ctgactaatg ctaaaatcta atctaattaa
     1201 atgtcctcca gacactgtag taagcattag gaaatgaata tgggggattt tagaaggatg
     1261 ctgtgggttt tttaaaatta tttattatgc attgtaagtg atacatagcc ctaataaatt
     1321 attatcaact tagcttctct ttgctctgtg gtgatccgtc cccaagggaa aaatatagga
     1381 tggtaaattt tgatcattgt aaacttttct aggggttgac tctaaatctt ccagagtagc
     1441 tttatgctga ttgccaaact tttccaaaac aagttacagc gccaagtgtc tacagagcct
     1501 tctccccgcc cccattttaa acttcatggc atagagtttc ccacagagta atttggcaat
     1561 attgctttta tatatccata atctatcttc atttttcgtg aaatttctcc tctgtcacta
     1621 cagcagatac atacccattt atttcttcct aaacggtatg ttttgaagtt cgagtgaatt
     1681 atgatgaagt ttctgtgggt cattataaca ttaatatctc tctccttatt ccagtataat
     1741 ttataataaa gcatttctaa aaaggcataa gccaa
//
