LOCUS       NM_029992               2886 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus trichoplein, keratin filament binding (Tchp), mRNA.
ACCESSION   NM_029992
VERSION     NM_029992.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2886)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2886)
  AUTHORS   Yamakawa,D., Katoh,D., Kasahara,K., Shiromizu,T., Matsuyama,M.,
            Matsuda,C., Maeno,Y., Watanabe,M., Nishimura,Y. and Inagaki,M.
  TITLE     Primary cilia-dependent lipid raft/caveolin dynamics regulate
            adipogenesis
  JOURNAL   Cell Rep 34 (10), 108817 (2021)
   PUBMED   33691104
REFERENCE   3  (bases 1 to 2886)
  AUTHORS   Martello,A., Lauriola,A., Mellis,D., Parish,E., Dawson,J.C.,
            Imrie,L., Vidmar,M., Gammoh,N., Mitic,T., Brittan,M., Mills,N.L.,
            Carragher,N.O., D'Arca,D. and Caporali,A.
  TITLE     Trichoplein binds PCM1 and controls endothelial cell function by
            regulating autophagy
  JOURNAL   EMBO Rep 21 (7), e48192 (2020)
   PUBMED   32337819
REFERENCE   4  (bases 1 to 2886)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2886)
  AUTHORS   Inaba,H., Goto,H., Kasahara,K., Kumamoto,K., Yonemura,S., Inoko,A.,
            Yamano,S., Wanibuchi,H., He,D., Goshima,N., Kiyono,T., Hirotsune,S.
            and Inagaki,M.
  TITLE     Ndel1 suppresses ciliogenesis in proliferating cells by regulating
            the trichoplein-Aurora A pathway
  JOURNAL   J Cell Biol 212 (4), 409-423 (2016)
   PUBMED   26880200
  REMARK    GeneRIF: Ndel1 acts as a novel upstream regulator of the
            trichoplein-Aurora A pathway to inhibit primary cilia assembly.
REFERENCE   6  (bases 1 to 2886)
  AUTHORS   Veleri,S., Manjunath,S.H., Fariss,R.N., May-Simera,H., Brooks,M.,
            Foskett,T.A., Gao,C., Longo,T.A., Liu,P., Nagashima,K.,
            Rachel,R.A., Li,T., Dong,L. and Swaroop,A.
  TITLE     Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal
            appendages on the mother centriole during cilia biogenesis
  JOURNAL   Nat Commun 5, 4207 (2014)
   PUBMED   24947469
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 2886)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   8  (bases 1 to 2886)
  AUTHORS   Fassan,M., D'Arca,D., Letko,J., Vecchione,A., Gardiman,M.P.,
            McCue,P., Wildemore,B., Rugge,M., Shupp-Byrne,D., Gomella,L.G.,
            Morrione,A., Iozzo,R.V. and Baffa,R.
  TITLE     Mitostatin is down-regulated in human prostate cancer and
            suppresses the invasive phenotype of prostate cancer cells
  JOURNAL   PLoS One 6 (5), e19771 (2011)
   PUBMED   21573075
  REMARK    GeneRIF: MITOSTATIN may acts as a tumor suppressor gene in prostate
            cancer.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 2886)
  AUTHORS   Ibi,M., Zou,P., Inoko,A., Shiromizu,T., Matsuyama,M., Hayashi,Y.,
            Enomoto,M., Mori,D., Hirotsune,S., Kiyono,T., Tsukita,S., Goto,H.
            and Inagaki,M.
  TITLE     Trichoplein controls microtubule anchoring at the centrosome by
            binding to Odf2 and ninein
  JOURNAL   J Cell Sci 124 (Pt 6), 857-864 (2011)
   PUBMED   21325031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU512279.1, AK020912.1, AK159947.1 and BC043048.1.
            
            On May 23, 2007 this sequence version replaced NM_029992.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159947.1, SRR7974084.17705.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BU512279.1         1-38
            39-684              AK020912.1         2-647
            685-1677            AK159947.1         646-1638
            1678-2886           BC043048.1         1943-3151
FEATURES             Location/Qualifiers
     source          1..2886
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     gene            1..2886
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /note="trichoplein, keratin filament binding"
                     /db_xref="GeneID:77832"
                     /db_xref="MGI:MGI:1925082"
     exon            1..182
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             183..1676
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /note="mitostatin; mitochondrial protein with oncostatic
                     activity"
                     /codon_start=1
                     /product="trichoplein keratin filament-binding protein"
                     /protein_id="NP_084268.2"
                     /db_xref="CCDS:CCDS51624.1"
                     /db_xref="GeneID:77832"
                     /db_xref="MGI:MGI:1925082"
                     /translation="MALPTLPSYWSSRKHMDLRQRQHQQEDQFRQQWEQNSRYFRTWD
                     IHNSKQIEWSSKISYQRSMHAYHCEKMKEEKRKILELRRERLRELLLEEQDLLAAELD
                     ELRLSMGLREQRLREQHQDLKSAREEQRKLIAERLLYEHWKKNNPKLRELELDLHKKH
                     VINSWATQKEEKKQQEATEKQENKRLENQYAAARREAEARMRVEEERRQLEGRLQAEA
                     LRQQMEELKQKEMEATKLKKEQENLLRQRWELERLEEERRQMAALRRKTELGRFLKHQ
                     YNAQLNRRTQEIQEELEVDGRILQALLEKEGELQQVELARREQARADAAWMKQVIEEQ
                     LQLEKAREAELQQLLREEAKEMWEKREAEWAREQVARDRLMSEVLTGRQQQILEKIEQ
                     NRRAQEETLKHREKLIRSLEEGKQLAQRAKEESEELKLARKQELEAQVAERQGQEWEA
                     ARQEEEEEEEARQAEEHSNALLQQEAKTMAEKGYQPKLHGHLRIAWD"
     exon            183..367
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            368..578
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            579..635
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            636..704
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            705..878
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            879..991
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1058
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1231
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1313
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1499
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1643
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..2863
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2841..2846
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /note="hexamer: AGTAAA"
     polyA_site      2863
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /note="major polyA site"
ORIGIN      
        1 cgggaggaag tttgtccatc gccgtgctcc gttgtcccgc gggctgcccg gcaaccggcg
       61 aggaaacggc tggcgtctgt gcagtgggcg cctggggacc ctcggagcga gcgggcgcgt
      121 gatcgagcta aggccggcga cccttctccg cgaacttcgg acacggagtg catgagtcag
      181 agatggctct ccccacgttg ccctcttatt ggtccagccg gaaacacatg gatcttcgcc
      241 agcgccagca tcagcaggag gaccagtttc gccagcagtg ggaacagaac agtcgctatt
      301 tcaggacctg ggacatccac aactcgaaac agatcgaatg gagctccaag atctcctacc
      361 agcggagcat gcacgcctac cattgtgaga agatgaagga ggagaagagg aagattctgg
      421 agctccggcg ggagaggctc agagagcttc tcctggagga acaggacttg ctggctgcgg
      481 agctggatga gctcaggctg agcatgggcc tgcgggagca aaggctccgc gagcagcacc
      541 aggacctgaa gtcagcccga gaagaacaga ggaagctgat tgctgaacga cttttatatg
      601 aacactggaa gaagaacaac cccaaacttc gagagcttga gttggacctt cacaagaagc
      661 acgtgataaa ttcttgggca acacagaaag aagaaaaaaa acagcaagaa gccacagaga
      721 agcaggagaa caagcggttg gagaaccagt acgcagcagc ccgccgggaa gccgaggcga
      781 ggatgagagt cgaggaggag aggaggcagc tagaggggcg cctgcaggcc gaggcgctgc
      841 gccagcagat ggaggagctg aagcagaagg agatggaggc aaccaaactg aagaaggaac
      901 aggagaacct gctgaggcag cgctgggagc tggaaaggct ggaggaggaa aggaggcaga
      961 tggccgccct ccggcgcaag acagagctgg ggcgcttctt gaaacatcag tacaacgcgc
     1021 agctcaacag gcgcacccag gagatccagg aggagctgga ggtagatggg cggatcctgc
     1081 aggccctcct ggagaaggaa ggcgagttgc agcaggtgga actggccagg cgggagcaag
     1141 cccgggccga tgcggcctgg atgaagcagg tcatcgagga gcaactgcag ctggagaaag
     1201 cacgggaggc agagctgcag cagctgctga gggaggaggc caaggagatg tgggagaaga
     1261 gagaggccga gtgggcccga gagcaggtcg cgcgggacag actgatgagt gaggttctga
     1321 ccgggaggca gcagcagatc ctggagaaga ttgaacagaa ccggcgggca caggaggaga
     1381 ccctcaaaca cagggagaaa ctcatcagga gtctcgagga ggggaagcag ttagctcagc
     1441 gagccaagga ggagagtgaa gagctgaagt tggccaggaa gcaggagctg gaagcccagg
     1501 ttgcagagcg ccagggccag gaatgggaag cagcccggca ggaggaggag gaagaggagg
     1561 aggccaggca ggcggaagag cactccaatg ctttgctgca gcaggaggcg aagaccatgg
     1621 cagagaaggg ctatcagccc aagcttcacg gacacctcag aattgcttgg gactgacgtt
     1681 gagcacagag aagcaaaccg actcactacc gctccagaca gttgtacggt gttggtgctg
     1741 gccagtgctc agggtgctgc tagctagttg agccatacct gtcaggcaca tcatgggcca
     1801 tagatgtcag gatgccatgg gtgtgcagcg tcccctgaga gcccttctca ccccgacagg
     1861 ccttggcttc agtgccacca gagatcagga atgctttata agtacatgtt agagttagtc
     1921 taagaagaag tcatgttccc tgacagacag gagtaccatg acaggaatac gtaggttcct
     1981 ctcatctcac ctgtagctgt cagctcaggg aggaccagcc acagagagga gggagctgtt
     2041 taggttttca aattgctgtt cagaagttat tctattgagg gctcataggt cttggtgcag
     2101 ttattgccag ttatgagctg tgtagcccca aggcccatgt gtgtactgtg gaagagctgg
     2161 cagtctggag agccggtgac aaaggcgccc ttgtttggaa gtgttgtgag ggctacccct
     2221 aggggttggg ggttctcagc gtggagtact taaccttcca cttgtgtggt cctctgccca
     2281 gctccacacc accaagaaga aaagaatcct acagagcact tgagcccaac atgtgccacc
     2341 ccgaaagagt cctcaaggtc acttggttgg ctagccgaca aaggcagagg cttgactagg
     2401 gacctcctgt gtctgtggaa gcccagtgtg cagccccatg ggaattaagt gcccagagag
     2461 acatgtgacc ctggagaaat ggcatgagac tcggaatcac agatgagctt gtccccactg
     2521 ttagatccca atacaagtgg ccatgggtcc tcatggcgac agtcgggttg ttatggcttg
     2581 tatctttccg tagccttcct cgagttggct ttcaccccta tattccagat tctgcccact
     2641 ctagctgaat atacggtgtt gttcctggtt atgggaaccg agagtttgcc tgggctctga
     2701 gggctgtatc acttcccttc catcacggaa ccggttctca gcctgtttca tttcctgctg
     2761 aggtccttgg atgtggcccc cagctctgtt tccactacac atttgtgagc actcgccctc
     2821 gtcaaatgct cactaactga agtaaagctc tatctcagta tcaaaaaaaa aaaaaaaaaa
     2881 aaaaaa
//
