LOCUS       NP_084268                497 aa            linear   ROD 30-APR-2024
DEFINITION  trichoplein keratin filament-binding protein [Mus musculus].
ACCESSION   NP_084268
VERSION     NP_084268.2
DBSOURCE    REFSEQ: accession NM_029992.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 497)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 497)
  AUTHORS   Yamakawa,D., Katoh,D., Kasahara,K., Shiromizu,T., Matsuyama,M.,
            Matsuda,C., Maeno,Y., Watanabe,M., Nishimura,Y. and Inagaki,M.
  TITLE     Primary cilia-dependent lipid raft/caveolin dynamics regulate
            adipogenesis
  JOURNAL   Cell Rep 34 (10), 108817 (2021)
   PUBMED   33691104
REFERENCE   3  (residues 1 to 497)
  AUTHORS   Martello,A., Lauriola,A., Mellis,D., Parish,E., Dawson,J.C.,
            Imrie,L., Vidmar,M., Gammoh,N., Mitic,T., Brittan,M., Mills,N.L.,
            Carragher,N.O., D'Arca,D. and Caporali,A.
  TITLE     Trichoplein binds PCM1 and controls endothelial cell function by
            regulating autophagy
  JOURNAL   EMBO Rep 21 (7), e48192 (2020)
   PUBMED   32337819
REFERENCE   4  (residues 1 to 497)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 497)
  AUTHORS   Inaba,H., Goto,H., Kasahara,K., Kumamoto,K., Yonemura,S., Inoko,A.,
            Yamano,S., Wanibuchi,H., He,D., Goshima,N., Kiyono,T., Hirotsune,S.
            and Inagaki,M.
  TITLE     Ndel1 suppresses ciliogenesis in proliferating cells by regulating
            the trichoplein-Aurora A pathway
  JOURNAL   J Cell Biol 212 (4), 409-423 (2016)
   PUBMED   26880200
  REMARK    GeneRIF: Ndel1 acts as a novel upstream regulator of the
            trichoplein-Aurora A pathway to inhibit primary cilia assembly.
REFERENCE   6  (residues 1 to 497)
  AUTHORS   Veleri,S., Manjunath,S.H., Fariss,R.N., May-Simera,H., Brooks,M.,
            Foskett,T.A., Gao,C., Longo,T.A., Liu,P., Nagashima,K.,
            Rachel,R.A., Li,T., Dong,L. and Swaroop,A.
  TITLE     Ciliopathy-associated gene Cc2d2a promotes assembly of subdistal
            appendages on the mother centriole during cilia biogenesis
  JOURNAL   Nat Commun 5, 4207 (2014)
   PUBMED   24947469
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 497)
  AUTHORS   Nakano,Y., Jahan,I., Bonde,G., Sun,X., Hildebrand,M.S.,
            Engelhardt,J.F., Smith,R.J., Cornell,R.A., Fritzsch,B. and Banfi,B.
  TITLE     A mutation in the Srrm4 gene causes alternative splicing defects
            and deafness in the Bronx waltzer mouse
  JOURNAL   PLoS Genet 8 (10), e1002966 (2012)
   PUBMED   23055939
REFERENCE   8  (residues 1 to 497)
  AUTHORS   Fassan,M., D'Arca,D., Letko,J., Vecchione,A., Gardiman,M.P.,
            McCue,P., Wildemore,B., Rugge,M., Shupp-Byrne,D., Gomella,L.G.,
            Morrione,A., Iozzo,R.V. and Baffa,R.
  TITLE     Mitostatin is down-regulated in human prostate cancer and
            suppresses the invasive phenotype of prostate cancer cells
  JOURNAL   PLoS One 6 (5), e19771 (2011)
   PUBMED   21573075
  REMARK    GeneRIF: MITOSTATIN may acts as a tumor suppressor gene in prostate
            cancer.
            Publication Status: Online-Only
REFERENCE   9  (residues 1 to 497)
  AUTHORS   Ibi,M., Zou,P., Inoko,A., Shiromizu,T., Matsuyama,M., Hayashi,Y.,
            Enomoto,M., Mori,D., Hirotsune,S., Kiyono,T., Tsukita,S., Goto,H.
            and Inagaki,M.
  TITLE     Trichoplein controls microtubule anchoring at the centrosome by
            binding to Odf2 and ninein
  JOURNAL   J Cell Sci 124 (Pt 6), 857-864 (2011)
   PUBMED   21325031
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU512279.1, AK020912.1, AK159947.1 and BC043048.1.
            
            On May 23, 2007 this sequence version replaced NP_084268.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK159947.1, SRR7974084.17705.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..497
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.99 cM"
     Protein         1..497
                     /product="trichoplein keratin filament-binding protein"
                     /note="mitostatin; mitochondrial protein with oncostatic
                     activity"
                     /calculated_mol_wt=60511
     Region          72..457
                     /region_name="Interaction with keratin proteins.
                     /evidence=ECO:0000250|UniProtKB:Q9BT92"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TVW5.2)"
     Region          145..479
                     /region_name="TPH"
                     /note="Trichohyalin-plectin-homology domain; pfam13868"
                     /db_xref="CDD:464007"
     Region          167..188
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TVW5.2)"
     Region          258..424
                     /region_name="Trichohyalin/plectin homology domain.
                     /evidence=ECO:0000250|UniProtKB:Q9BT92"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TVW5.2)"
     Region          441..497
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q3TVW5.2)"
     CDS             1..497
                     /gene="Tchp"
                     /gene_synonym="A930031F18Rik"
                     /coded_by="NM_029992.2:183..1676"
                     /db_xref="CCDS:CCDS51624.1"
                     /db_xref="GeneID:77832"
                     /db_xref="MGI:MGI:1925082"
ORIGIN      
        1 malptlpsyw ssrkhmdlrq rqhqqedqfr qqweqnsryf rtwdihnskq iewsskisyq
       61 rsmhayhcek mkeekrkile lrrerlrell leeqdllaae ldelrlsmgl reqrlreqhq
      121 dlksareeqr kliaerllye hwkknnpklr eleldlhkkh vinswatqke ekkqqeatek
      181 qenkrlenqy aaarreaear mrveeerrql egrlqaealr qqmeelkqke meatklkkeq
      241 enllrqrwel erleeerrqm aalrrktelg rflkhqynaq lnrrtqeiqe elevdgrilq
      301 allekegelq qvelarreqa radaawmkqv ieeqlqleka reaelqqllr eeakemwekr
      361 eaewareqva rdrlmsevlt grqqqileki eqnrraqeet lkhreklirs leegkqlaqr
      421 akeeseelkl arkqeleaqv aerqgqewea arqeeeeeee arqaeehsna llqqeaktma
      481 ekgyqpklhg hlriawd
//
