LOCUS       NM_001163098            5896 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus trichohyalin (Tchh), mRNA.
ACCESSION   NM_001163098 XM_001000857 XM_036163480 XM_904350
VERSION     NM_001163098.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5896)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5896)
  AUTHORS   Chen,G.D., Fatima,I., Xu,Q., Rozhkova,E., Fessing,M.Y.,
            Mardaryev,A.N., Sharov,A.A., Xu,G.L. and Botchkarev,V.A.
  TITLE     DNA dioxygenases Tet2/3 regulate gene promoter accessibility and
            chromatin topology in lineage-specific loci to control epithelial
            differentiation
  JOURNAL   Sci Adv 9 (2), eabo7605 (2023)
   PUBMED   36630508
REFERENCE   3  (bases 1 to 5896)
  AUTHORS   Nguyen,M.B., Cohen,I., Kumar,V., Xu,Z., Bar,C., Dauber-Decker,K.L.,
            Tsai,P.C., Marangoni,P., Klein,O.D., Hsu,Y.C., Chen,T.,
            Mikkola,M.L. and Ezhkova,E.
  TITLE     FGF signalling controls the specification of hair placode-derived
            SOX9 positive progenitors to Merkel cells
  JOURNAL   Nat Commun 9 (1), 2333 (2018)
   PUBMED   29899403
  REMARK    Erratum:[Nat Commun. 2018 Jul 17;9(1):2854. PMID: 30018293]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5896)
  AUTHORS   Sardella,C., Winkler,C., Quignodon,L., Hardman,J.A., Toffoli,B.,
            Giordano Attianese,G.M.P., Hundt,J.E., Michalik,L., Vinson,C.R.,
            Paus,R., Desvergne,B. and Gilardi,F.
  TITLE     Delayed Hair Follicle Morphogenesis and Hair Follicle Dystrophy in
            a Lipoatrophy Mouse Model of Pparg Total Deletion
  JOURNAL   J Invest Dermatol 138 (3), 500-510 (2018)
   PUBMED   28964716
REFERENCE   5  (bases 1 to 5896)
  AUTHORS   Nishiguchi,Y., Ohmoto,M., Koki,J., Enomoto,T., Kominami,R.,
            Matsumoto,I. and Hirota,J.
  TITLE     Bcl11b/Ctip2 is required for development of lingual papillae in
            mice
  JOURNAL   Dev Biol 416 (1), 98-110 (2016)
   PUBMED   27287879
REFERENCE   6  (bases 1 to 5896)
  AUTHORS   Kobielak,K., Pasolli,H.A., Alonso,L., Polak,L. and Fuchs,E.
  TITLE     Defining BMP functions in the hair follicle by conditional ablation
            of BMP receptor IA
  JOURNAL   J Cell Biol 163 (3), 609-623 (2003)
   PUBMED   14610062
REFERENCE   7  (bases 1 to 5896)
  AUTHORS   Takebe,K., Oka,Y., Radisky,D., Tsuda,H., Tochigui,K., Koshida,S.,
            Kogo,K. and Hirai,Y.
  TITLE     Epimorphin acts to induce hair follicle anagen in C57BL/6 mice
  JOURNAL   FASEB J 17 (14), 2037-2047 (2003)
   PUBMED   14597673
REFERENCE   8  (bases 1 to 5896)
  AUTHORS   Steinert,P.M., Parry,D.A. and Marekov,L.N.
  TITLE     Trichohyalin mechanically strengthens the hair follicle: multiple
            cross-bridging roles in the inner root shealth
  JOURNAL   J Biol Chem 278 (42), 41409-41419 (2003)
   PUBMED   12853460
  REMARK    GeneRIF: Trichohyalin is a multi-functional cross-bridging protein
            that functions in the inner root sheath and other specialized
            epithelial tissues
REFERENCE   9  (bases 1 to 5896)
  AUTHORS   Kaufman,C.K., Zhou,P., Pasolli,H.A., Rendl,M., Bolotin,D.,
            Lim,K.C., Dai,X., Alegre,M.L. and Fuchs,E.
  TITLE     GATA-3: an unexpected regulator of cell lineage determination in
            skin
  JOURNAL   Genes Dev 17 (17), 2108-2122 (2003)
   PUBMED   12923059
REFERENCE   10 (bases 1 to 5896)
  AUTHORS   Steinert,P.M., Kartasova,T. and Marekov,L.N.
  TITLE     Biochemical evidence that small proline-rich proteins and
            trichohyalin function in epithelia by modulation of the
            biomechanical properties of their cornified cell envelopes
  JOURNAL   J Biol Chem 273 (19), 11758-11769 (1998)
   PUBMED   9565599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC123859.4.
            
            On or before Dec 22, 2021 this sequence version replaced
            XM_036163480.1, NM_001163098.1.
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164137,
                              SAMN04095721 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-52                AC123859.4         42234-42285         c
            53-213              AC123859.4         40582-40742         c
            214-5896            AC123859.4         33974-39656         c
FEATURES             Location/Qualifiers
     source          1..5896
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.51 cM"
     gene            1..5896
                     /gene="Tchh"
                     /gene_synonym="AHF; Thh"
                     /note="trichohyalin"
                     /db_xref="GeneID:99681"
                     /db_xref="MGI:MGI:2177944"
     exon            1..52
                     /gene="Tchh"
                     /gene_synonym="AHF; Thh"
                     /inference="alignment:Splign:2.1.0"
     exon            53..213
                     /gene="Tchh"
                     /gene_synonym="AHF; Thh"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..4875
                     /gene="Tchh"
                     /gene_synonym="AHF; Thh"
                     /note="hair follicle protein AHF"
                     /codon_start=1
                     /product="trichohyalin"
                     /protein_id="NP_001156570.1"
                     /db_xref="CCDS:CCDS50980.1"
                     /db_xref="GeneID:99681"
                     /db_xref="MGI:MGI:2177944"
                     /translation="MSPLIRSIVDITEVFNQYASQSCDGASLSKKDLKNLLERELGDV
                     LQRPHDPETIDLTLELLDRDCNGRVDFNEFLLFLFKIAQACYYALDQAAELGEKRALP
                     NEKRNLSQDRRQEDQRRFEPRSRQLDEEPGRRSWQKRREQEERAEEQRLEQRYRQHRD
                     EEQRLQRRELQELEERLAEKEPLGWSKGRDAEEFSEVEEQQRQERQELKGKGQTEERR
                     LQKRRQEELREPLLRRDLELRREQELRREQELRQEQRREQELRREQELRQELRREQEL
                     NRRQELRREQELRREQELRQELRREQELRREQELRQELRREQELRREQELRQELRREQ
                     ELRREQELRQELRREQELRREQELRQELAEEDELTRIREPDESITQRWQWQLENEADA
                     RQNKVYSRPSRQEQRLRQELGERQLREQEEQRRDLQQERPAEEARQRNQWERPQRAEE
                     RLEQEQRFRDREEQRFREEKLQRAELQDSLLDEEQRRLQEERREPNRSRQLREESQRR
                     RTLYAKPSQRQRREEELREERLLQEEQRQQRERKHRREEDLQQEEKRLQQDEEQLQRE
                     RRRLQRERQYQEEDLQQEEERLQQEEERLQRERRRLQQERQYQEEDLQRLRDEDQRRD
                     LKWQWQPRKENEVRSNRLFTKRRGDEEPIQQLEDSQERERRQDRRPLQDEEEEKRELE
                     QERRRRQQRDRQILEEEQFQREHQREARRRDETFQEEEQLQGESRRRQQEREGKFLEE
                     ERQLRTEREEQRRRQEQEREFQEEEEHLQEREKELRQECDRKSREQERRQQREEEQLR
                     RQERDQRFRREQERHLEREEEQLRDRPSRREQERHQEREEEQLRDRPSRREQERHQER
                     EEEQLRDRPSRREQERHQEREEEQLRDRPFRREQERRLEREEEQLRDRPSRREQERHQ
                     EREEEQLRDRPSRREQERRLEREEEQLRDRSFRREQELRRDRKFHEEEERREELEEEQ
                     RGQERDRLRVEEQLRGQREEEQRRRQECDRKLHRELEVRQELEEERLRDRKLRREQEL
                     RRDRKFHEEEERRHEEFEEKQLRLQEPDRRFRREQELRQECVEEERLRDSKIRREQEL
                     RREREEERLRDRKIRRDQELRQGLEEEQLRRQELDRKFREEQELDQELEEERLRDRKI
                     RREQELRREQELRREQEFRREQELRREQEFRREQELRQEREEERLRDRKIRRDQELRQ
                     GLEEEQLRRQERDRKVREEQELDQELEEERLRDRKIRREQELRREQELRREQEFRREQ
                     GLRREREEERLRDRKIRRDQELRQGLEEEQLRRQERDRKFREEQELGQELEEERLRDR
                     KIRREQELRREREQEQRRRLEREEEQQRLHEREEEQRRRQEREQEQQRCLEREEEQFR
                     FEEQQRRRQEREQQLRQERDRRVLEEEELRQEREELLHRQVGGRKFREEERLRLEREE
                     QQRRLQERDNRRFREEVELRQEREGQQLRQERDRKFREVEELRQEEQRRRQERDRKFR
                     EEKHPREEREEQQLRREKRDGQYLAEEQFARDTIRRQEQELRQEEEQRRRQERERKFQ
                     EEQIRRRQEEQRRRQILEPGTRQFANVPVRSSPLYEYIQEQRSQYRP"
     exon            214..5896
                     /gene="Tchh"
                     /gene_synonym="AHF; Thh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5878..5883
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tchh"
                     /gene_synonym="AHF; Thh"
                     /note="hexamer: AATAAA"
     polyA_site      5896
                     /gene="Tchh"
                     /gene_synonym="AHF; Thh"
                     /note="major polyA site"
ORIGIN      
        1 acacttgcca gcagtgtcag tgagcacttg acttcttctt ctggtgaagt gggtttactt
       61 gaattttaag aaaaaatgtc tccacttata agaagcattg tcgatatcac tgaagttttc
      121 aatcaatatg catcacaaag ttgtgatgga gcatcactta gcaagaaaga cctgaaaaac
      181 ctccttgaga gagaacttgg agatgtcctt cagagaccac atgaccctga gacgatagac
      241 ctgaccctag aacttctgga tcgcgactgc aacgggcgtg ttgatttcaa cgaattcctc
      301 ctgttccttt tcaagattgc tcaagcttgc tattatgctc tcgatcaggc cgcagagcta
      361 ggcgagaaga gagccctgcc caatgaaaag aggaacctgt cacaagatcg caggcaagaa
      421 gaccaaagga gattcgagcc ccgaagcaga caactggacg aagaacctgg gcgccgaagc
      481 tggcagaaga gacgtgagca ggaggagcgc gctgaggagc agcggctgga gcagcgctac
      541 aggcagcacc gcgatgaaga gcagagactg caaaggcgag aactgcaaga actggaggaa
      601 cgccttgcag agaaagagcc gcttggctgg agtaagggtc gtgacgcgga ggagttttct
      661 gaggtagagg aacagcaaag gcaagagagg caggaactca agggcaaggg ccaaacagaa
      721 gagagaaggc tgcagaagcg caggcaagaa gagctacgcg aacccctgct aaggcgcgat
      781 ctggagttga ggcgcgaaca agagctaagg cgcgagcagg agttgaggca ggaacagagg
      841 cgcgagcagg agctaaggcg cgagcaggag ctgaggcaag agctgaggcg cgagcaggag
      901 ctgaatcgaa ggcaggagct gaggcgcgaa caagagctaa ggcgcgagca ggagctgagg
      961 caggagctga ggcgcgagca ggagctaagg cgcgagcagg agttgaggca ggaactgagg
     1021 cgcgagcaag agctaaggcg cgagcaggag ttgaggcagg aactgaggcg cgagcaagag
     1081 ctaaggcgcg agcaggagtt gaggcaggaa ctgaggcgtg agcaagagct aagacgcgag
     1141 caagagctga ggcaggagct ggctgaggag gacgagctga cgcggatccg ggaacccgac
     1201 gagagcatta cccagaggtg gcagtggcag ctcgaaaacg aggcagacgc ccgtcagaac
     1261 aaggtctact ctaggcctag caggcaggag cagaggcttc gccaggagct gggggagcgt
     1321 cagctccggg agcaggagga gcagcgccgc gacctccaac aggagcgtcc cgctgaggag
     1381 gcgcgccagc gcaaccagtg ggagaggccg cagcgggcgg aggagcgcct ggagcaggag
     1441 cagcggttcc gcgacaggga ggagcagcgc ttccgggagg agaagctgca acgagcagag
     1501 ctccaggaca gcctcctaga tgaagaacag aggcgactcc aggaggaacg ccgagagcca
     1561 aacaggagcc ggcaactgag ggaagaaagc cagaggcgcc gcacactgta cgccaaaccc
     1621 agccagaggc agcgtaggga ggaggagcta cgcgaggaac ggctgttgca agaagagcag
     1681 cgccagcagc gggagaggaa acaccgcagg gaggaggatc tgcagcagga ggaaaagcgg
     1741 ctgcagcaag acgaagagca actgcagcga gaaaggaggc gcctgcagcg ggagaggcag
     1801 tatcaggagg aggacctgca acaggaggaa gagcggctgc agcaggagga agagcggctg
     1861 cagagagaaa gaaggcgcct gcagcaggaa aggcagtatc aggaggagga cctgcagcgg
     1921 ctgcgggatg aagatcagcg cagggatctg aaatggcagt ggcaaccaag gaaagaaaat
     1981 gaagttcgta gtaacaggct cttcaccaaa cgcagagggg atgaggaacc catccagcag
     2041 ctggaagatt ctcaggagcg agagagacgt caggatcggc ggcctctgca agacgaagag
     2101 gaagagaaga gagagctgga gcaggagagg aggcgtcgac agcagcgcga ccgtcagatc
     2161 ctagaggaag agcagtttca gcgagagcac caacgggaag ccagaagacg agatgagacg
     2221 ttccaggagg aagaacagct ccagggagaa tcgagaagac ggcaacagga gagagagggc
     2281 aagttccttg aggaggaaag gcagctgcgg acagaacggg aagagcagag gcggcgtcaa
     2341 gaacaagaga gagaattcca agaggaggag gagcacctcc aagaacgcga gaaagaactt
     2401 cggcaggaat gcgacagaaa atctcgtgaa caagagcgcc gccagcagcg tgaggaagag
     2461 cagctgaggc gtcaggagcg ggaccagaga ttccgtcggg aacaagaacg ccacctggaa
     2521 cgtgaggaag agcagctgcg ggacagacca tcccgccggg aacaagaacg ccaccaggaa
     2581 cgtgaggaag agcagctgcg ggacagacca tcccgccggg aacaagaacg ccaccaggaa
     2641 cgtgaggaag agcagctgcg ggacagacca tcccgccggg aacaagaacg ccaccaggaa
     2701 cgtgaggaag agcagctgcg ggacagacca ttccgccggg aacaagaacg ccgcctggag
     2761 cgtgaggaag agcagctgcg ggacagacca tcccgccggg aacaagaacg ccaccaggaa
     2821 cgtgaggaag agcagctgcg ggacagacca tcccgccggg aacaagaacg ccgcctggag
     2881 cgtgaggaag agcagctgcg ggacagatca ttccgccggg agcaagagct cagacgggac
     2941 agaaaattcc atgaggaaga agagcgccgc gaggaactgg aggaagagca gcgtggccaa
     3001 gagcgggacc gtttgagggt ggaggagcag cttcgcggac agcgagagga agagcagcgc
     3061 cgccgccagg aatgtgacag aaaattacac cgggaactag aggtccgcca ggaactggag
     3121 gaagagcggc tgcgggacag aaagctccgc agggaacaag agctcaggcg cgacagaaaa
     3181 ttccatgagg aagaagagcg ccgtcatgag gagttcgagg aaaagcagct gcgcctccag
     3241 gaaccggaca gaagattccg ccgggaacaa gagctccgtc aggaatgcgt cgaggaagag
     3301 cggctgcggg acagtaagat ccgccgggag caagagctcc gccgggagcg cgaagaagag
     3361 cggctgaggg acagaaagat ccgccgggac caagaactcc gccagggact ggaggaagag
     3421 cagctgaggc gccaggaact tgacagaaaa ttccgtgagg aacaagagct cgaccaagaa
     3481 ctggaggaag agcggctgcg ggacagaaag atccgccggg agcaagagct ccgccgggag
     3541 caagagctcc gccgggagca agagttccgc cgggagcaag agctccgccg ggagcaagag
     3601 ttccgccggg agcaagagct ccgccaggag cgcgaggaag agcggctgag ggacagaaag
     3661 atccgccggg accaagaact ccgccaggga ctggaggaag agcagctgag gcgccaggaa
     3721 cgtgacagaa aagtccgtga ggaacaagag ctcgaccaag aactggagga agagcggctg
     3781 cgggacagaa agatccgccg ggagcaagag ctccgcagag agcaagagct ccgccgggag
     3841 caagagttcc gccgggagca agggctccgc cgggagcgcg aggaagagcg gctgagggac
     3901 agaaagatcc gccgggacca agaactccgc cagggactgg aggaagagca gctgaggcgc
     3961 caggaacgtg acagaaaatt ccgtgaggaa caagagctcg gccaagaact ggaggaagag
     4021 cggctgcggg acagaaagat ccgccgggag caagagctcc gccgggaacg cgagcaagag
     4081 cagcggcgcc gcctggagcg tgaggaagag cagcagcgtc tccatgagcg tgaggaagag
     4141 cagcggcgcc gccaggagcg cgagcaagag cagcagcggt gcctggagcg tgaggaggaa
     4201 caatttcgct ttgaggagca gcagcgccgc cgccaggaac gcgagcaaca gttgagacag
     4261 gagcgcgaca gaagagtcct tgaggaagaa gagcttcgtc aggaaaggga ggagctgctg
     4321 caccgccagg tgggtggcag gaaattccgg gaagaggagc gactccgcct ggaaagagag
     4381 gaacagcagc gtcgtctcca ggagcgtgac aacagaagat tccgcgagga agtagagctc
     4441 aggcaagaaa gggaagggca gcagcttcgc caagagcgtg acagaaaatt ccgtgaggta
     4501 gaagagcttc gccaggaaga acagcgccgc cgccaggagc gtgacaggaa attccgggaa
     4561 gagaaacacc cacgcgagga acgcgaggaa cagcagttgc gcagggagaa gcgagatggt
     4621 caatacctgg ctgaggagca gtttgccagg gatacgattc gtcgccagga acaagaacta
     4681 cgtcaagaag aggaacaaag acgtcgccaa gagcgggaga gaaaattcca agaagagcaa
     4741 atccgtcgta ggcaagagga gcagaggcgc cgccaaatcc tggagcctgg tacacgccag
     4801 tttgccaatg tcccagtgcg ttccagccct ctctatgagt acatccagga gcagaggtct
     4861 caataccgcc cttaaaagat gctgcaaaca tcctggcacc agccaaagct tcaagcaaaa
     4921 gaaaatgaga aacactaggg tatccagcga taactcaagt gtttctggtt gtgggaaaac
     4981 tctctgatct tagaatgtgt cttttcttac agaatcttaa actatactaa tttcatttcc
     5041 tttaattcct gtctttcatt cttccacagg tagttctttt ttgcaagatg tctttgttct
     5101 ttagtgaaga tatgatgtgc acttttaaaa ctaagccatt taattttttg aacgaatttt
     5161 ctttgaggag cacattggtt tattgccttc ttaaataaca agaataatgc aagcaatctg
     5221 atattcaaag taattgaatc gctactttta gtggtggatc attttatcta aagctttcat
     5281 tttatgagtt caagttgaca ttttctttgg cttaaatttt gtctttacct ccaaatggtt
     5341 ttcttaggtt ttgttgcaaa attatgacag attccatcag caggctgaaa cttagatccc
     5401 tcagataatg taggaggaag aggatttatg cagaaaataa tatatgaagt cagttcataa
     5461 ctgaacaaat cttgttaaga gaaatgcttg acagaaaatt ataatttggc attatatttt
     5521 ttatattttg catcatctaa aatctcatga agtgaaagca aggtggtcct caaacaactc
     5581 aaatttaaaa ctgtagttgt agcactctgt tccatttccc caagtcttat tgagtttgag
     5641 aatttttcta cttttgtaca ttttggttta gagggaacct actcaagatt ctgtaaacat
     5701 ttgtcttgtt tgggtccaat aaaagttcac agagtgatgg caaaaggaaa agggaaatgt
     5761 atgaacagag gacaaatttc tagaggtctc tttattatac ttagatgctc acagtacttt
     5821 gaggctttat actacctgga agacattctt gttcaaataa ttggactgtt aaaaatcaat
     5881 aaatgtttgg caaata
//
