LOCUS       NM_001331146            4196 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus transcription factor 7 like 2, T cell specific, HMG
            box (Tcf7l2), transcript variant 21, mRNA.
ACCESSION   NM_001331146 XM_006526862
VERSION     NM_001331146.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4196)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   2  (bases 1 to 4196)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4196)
  AUTHORS   Bugacov,H., Der,B., Briantseva,B.M., Guo,Q., Kim,S., Lindstrom,N.O.
            and McMahon,A.P.
  TITLE     Dose-dependent responses to canonical Wnt transcriptional complexes
            in the regulation of mammalian nephron progenitors
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39250420
REFERENCE   4  (bases 1 to 4196)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4196)
  AUTHORS   Tran,H.N., Nguyen,Q.H. and Jeong,Y.
  TITLE     Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron
            fate and regulates differentiation of the dorsal midbrain into the
            inferior and superior colliculi
  JOURNAL   Front Cell Dev Biol 12, 1336308 (2024)
   PUBMED   38344749
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4196)
  AUTHORS   Lee,Y.J., Swencki,B., Shoichet,S. and Shivdasani,R.A.
  TITLE     A possible role for the high mobility group box transcription
            factor Tcf-4 in vertebrate gut epithelial cell differentiation
  JOURNAL   J Biol Chem 274 (3), 1566-1572 (1999)
   PUBMED   9880534
REFERENCE   7  (bases 1 to 4196)
  AUTHORS   Ogawa,S., Goto,W., Orimo,A., Hosoi,T., Ouchi,Y., Muramatsu,M. and
            Inoue,S.
  TITLE     Molecular cloning of a novel RING finger-B box-coiled coil (RBCC)
            protein, terf, expressed in the testis
  JOURNAL   Biochem Biophys Res Commun 251 (2), 515-519 (1998)
   PUBMED   9792805
REFERENCE   8  (bases 1 to 4196)
  AUTHORS   Cho,E.A. and Dressler,G.R.
  TITLE     TCF-4 binds beta-catenin and is expressed in distinct regions of
            the embryonic brain and limbs
  JOURNAL   Mech Dev 77 (1), 9-18 (1998)
   PUBMED   9784592
REFERENCE   9  (bases 1 to 4196)
  AUTHORS   Korinek,V., Barker,N., Moerer,P., van Donselaar,E., Huls,G.,
            Peters,P.J. and Clevers,H.
  TITLE     Depletion of epithelial stem-cell compartments in the small
            intestine of mice lacking Tcf-4
  JOURNAL   Nat Genet 19 (4), 379-383 (1998)
   PUBMED   9697701
REFERENCE   10 (bases 1 to 4196)
  AUTHORS   Korinek,V., Barker,N., Willert,K., Molenaar,M., Roose,J.,
            Wagenaar,G., Markman,M., Lamers,W., Destree,O. and Clevers,H.
  TITLE     Two members of the Tcf family implicated in Wnt/beta-catenin
            signaling during embryogenesis in the mouse
  JOURNAL   Mol Cell Biol 18 (3), 1248-1256 (1998)
   PUBMED   9488439
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC157916.2, AC137148.14 and AC118695.10.
            
            On Sep 8, 2016 this sequence version replaced XM_006526862.3.
            
            Transcript Variant: This variant (21) encodes the longest protein
            (isoform 20).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.301488.1,
                                           SRR1660811.96553.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-721               AC157916.2         116472-117192
            722-788             AC157916.2         117438-117504
            789-913             AC157916.2         117735-117859
            914-982             AC157916.2         129676-129744
            983-1084            AC137148.14        112112-112213       c
            1085-1217           AC137148.14        21422-21554         c
            1218-1320           AC137148.14        19296-19398         c
            1321-1407           AC137148.14        17332-17418         c
            1408-1533           AC137148.14        12498-12623         c
            1534-1693           AC137148.14        10933-11092         c
            1694-1801           AC137148.14        10359-10466         c
            1802-1850           AC137148.14        6033-6081           c
            1851-1901           AC137148.14        5397-5447           c
            1902-1974           AC137148.14        3928-4000           c
            1975-4196           AC118695.10        178083-180304       c
FEATURES             Location/Qualifiers
     source          1..4196
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.59 cM"
     gene            1..4196
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /note="transcription factor 7 like 2, T cell specific, HMG
                     box"
                     /db_xref="GeneID:21416"
                     /db_xref="MGI:MGI:1202879"
     exon            1..721
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     CDS             533..2398
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /note="isoform 20 is encoded by transcript variant 21;
                     T-cell-specific transcription factor 4; HMG box
                     transcription factor 4; HMG box transcription factor
                     TCF7L2"
                     /codon_start=1
                     /product="transcription factor 7-like 2 isoform 20"
                     /protein_id="NP_001318075.1"
                     /db_xref="GeneID:21416"
                     /db_xref="MGI:MGI:1202879"
                     /translation="MPQLNGGGGDDLGANDELISFKDEGEQEEKNSENSSAERDLADV
                     KSSLVNESETNQNSSSDSEAERRPPPRSESFRDKSRESLEEAAKRQDGGLFKGPPYPG
                     YPFIMIPDLTSPYLPNGSLSPTARTLHFQSGSTHYSAYKTIEHQIAIQYLQMKWPLLD
                     VQAGSLQSRQTLKDARSPSPAHIVSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPP
                     HLPADVDPKTGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGF
                     RHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSS
                     KHQDSKKEEEKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALS
                     REEQAKYYELARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCL
                     SLPPITDLSAPKKCRARFGLDQQNNWCGPCRRKKKCVRYIQGEGSCLSPPSSDGSLLD
                     SPPPSPHLLGSPPQDAKSQTEQTQPLSLSLKPDPLAHLSMMPPPPALLLAEAAHGKAS
                     ALCPNGALDLPPAALQPSMVPSSSLAQPSTSSLHSHNSLAGTQPQPLSLVTKSLE"
     exon            722..788
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            789..913
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            914..982
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1084
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1217
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1218..1320
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1321..1407
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1533
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1693
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..1801
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1802..1850
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1901
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..1974
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1975..4196
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4173..4178
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /note="hexamer: AATAAA"
     polyA_site      4196
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /note="major polyA site"
ORIGIN      
        1 ctcgccctgt caataatctc cgctcccaga ctactccgtt cctccggatt tcgatccccc
       61 tttttctatc tgtcaatcag cgccgccttt gaactgaaaa gctcagtcta acttcaactc
      121 actcaaatcc gagcggcacg agatccttcg gtgtcttcgg cttccccccc ctttgctctt
      181 atatctgact tcttcttgtt gttgttgttg ttttttttac cccctttttt atttattatt
      241 attttttttt tttgcacatt gatcggatcc ttgggaacga gagaaaaaaa gaaacccaaa
      301 ctcacgcgtg cagaagatct ccccccttcc cctcccctcc tccctctttt cccctcccca
      361 ggagagaaag accccaaagc aggaaaaaaa aaagttaacc ttggactcgt ctttttcttg
      421 cagtattttt ttggggggga ctcgcaaaac tttttttttt tttttttttt tttttttgct
      481 ttttttcctc cttcattttt cttccaaaat tgctgctgct ggtgggtgaa aaatgccgca
      541 gctgaacggc ggtggaggag atgacctagg cgctaacgac gagctgatct ccttcaaaga
      601 cgaaggcgag caggaggaga agaactcgga aaactcctcg gcggaaaggg atttagccga
      661 tgtcaagtcc tcgctggtca atgaatcaga gacgaatcaa aacagctcct ccgattccga
      721 ggcggaaaga cggcctccgc ctcgctccga aagtttccga gataaatccc gggaaagttt
      781 ggaagaagcg gccaagaggc aagatggagg gctctttaag gggccaccgt atcccggcta
      841 ccccttcatc atgatccccg acctgacgag cccctacctc cccaacggat cgctctcgcc
      901 caccgcccga accctccatt ttcaatccgg cagcactcat tactctgcgt acaaaacgat
      961 tgaacaccag attgcaattc agtatcttca gatgaaatgg ccactgcttg atgtccaagc
     1021 aggaagcctc cagagcagac aaaccctcaa ggatgctcgt tcgccgtcgc cagcacacat
     1081 cgtttcgaac aaagtaccgg tggtgcaaca cccccaccat gtccacccac tcacgcctct
     1141 catcacgtac agcaatgaac acttcacccc gggaaatcca cctccgcact taccagctga
     1201 cgtagacccc aaaacaggaa tcccaaggcc tccgcaccct ccagatatct ctccatatta
     1261 cccgctgtcg cccggcaccg taggacaaat cccccatccg ctaggatggt tagtaccaca
     1321 gcaaggtcag cctgtgtacc caatcacgac aggaggattc agacacccct accccacagc
     1381 gctgacagtc aacgcatcta tgtctaggtt ccctccccat atggtccctc cccatcacac
     1441 tctgcacacg accggcatcc ctcacccggc catcgtcaca ccgacagtca agcaggaatc
     1501 ctcccagagt gacgtcggct cactccacag ctcaaagcat caggactcca aaaaggaaga
     1561 agagaagaag aagccccaca taaagaagcc ccttaatgca ttcatgttgt atatgaaaga
     1621 gatgagagcg aaggtggtgg ccgaatgcac attgaaagag agtgcagcca tcaaccagat
     1681 tctcgggcgc aggtggcacg ccctgtccag ggaagaacag gcaaaatact acgagctggc
     1741 ccggaaggaa cgacagcttc acatgcagct gtaccctggc tggtctgcac gggataacta
     1801 tgggaagaag aagaagagaa aaagagacaa gcagccgggg gaaaccaacg aacacagcga
     1861 atgtttccta aatccttgcc tttcgcttcc tccgatcaca gacctgagcg ctcctaagaa
     1921 atgccgagcg cgctttggcc ttgatcaaca gaataactgg tgcggcccct gcaggagaaa
     1981 aaaaaagtgc gttcgctaca tacaaggtga aggcagctgc ctcagcccac cctcttcaga
     2041 tggaagctta ctagactcgc ctcccccctc accgcatctg ctaggctccc ctccccaaga
     2101 cgccaagtca cagactgagc agacccagcc gctctcgctg tccctgaagc ctgatcctct
     2161 ggcccacctg tccatgatgc ctccgccacc cgcgctcctg ttggccgaag ctgcccacgg
     2221 caaggcctct gccctctgtc ccaatggggc tctggacctg ccacctgccg ctctgcagcc
     2281 gtccatggtc ccttcctcat cgctcgcaca accatcaact tcttccttac attcccacaa
     2341 ctcgctggct ggaacgcaac cccagcctct gtctctggtg accaagtctt tagaatagct
     2401 ccgcctcctc gtcctccatg cccctgcttg attgaagtgt ttccttctgg ttcttggttc
     2461 gcccttcccc gcttggaaag cttttgtttt gtactcttta attttgtgcc gccgtggcta
     2521 catgagttaa tgtttatgga gttcattggt caatatttga cccattctta tttcaatttc
     2581 tccttttaaa tatgtagatg agaaaaacct catgattcta ccaaaatttt tatcaacagc
     2641 tgtttaaagt ctttgtagcg tttaaaaaat atattatata tacataactg ttatgtagtt
     2701 cggatagctt agttttaaaa gactgattta aaaaacaaaa agaaaaaaaa gagagagaag
     2761 caattttgaa gcaccctcca gaaggagttg gttctgtgtt atttgtatta aatacgagct
     2821 tgcgaaccaa tcactttaca ccttggtatt taaaccacga gggcacaagg aatgcagtgc
     2881 cgtttctttc tttctttttt tctttctttt ttttttcctc ccagtgtgaa acaactttta
     2941 ccttgatgtt acttgttatt gtttaaatgt acagaaacaa agggttaaaa tgtgttaata
     3001 taccttgttc catggtgttg ttcttttggg ggggagggga caccactcaa caatgaatgg
     3061 aatcaacact gttggaccag tagtatttat tgctttagag gttgcttgct gtacctgtat
     3121 gtccgtccaa ttttaaatat gttttccctt ttttttgaaa ctgtgtaaag tcccccccaa
     3181 ccttagcgta agcatcttat atataacaac tcatttgtac aaggttttta agtttatata
     3241 taaaatgtgt atatattttt ttgtttcctt tttttttttt ttttggcgta cgttcgttcg
     3301 ttcgtttgtt tgtttctgta taaaacccag atgccaccaa atggacattg acattcgcat
     3361 taaggatcag tagcattaac aaaacttgct ttaaaagcca ttctgtaaaa caagacttga
     3421 acattagcga gagggtctga gcagccgtct gagcagccgt gggaactgcc ccgtttcccc
     3481 cttgacctcc tagtcaactg ccctgtgctc ttagaacatg gactgaccgt gtgcaaaact
     3541 tttatgtgcc aaaattctca gtgactttag ctttctccct cctttttgat gctgtacttt
     3601 ctgttcgcca tgttttgctg tgatgttaca tagatagatt tgtatgtagt tttaatgtca
     3661 cctataacaa aatgtgtttg gtagcagact gtccagaaag cattttaaat gaagaggtct
     3721 aaacccttaa gggccaaaaa aaatcctgta tattagatta ctcttaaatg aaaaagaaaa
     3781 aaagaaaaaa aaaaacccca gctgccgctt ttatgtatgc atattacata caagtaggta
     3841 gtgaccttta aaaacaagaa aacctaggca tgccgatgtt gtaaaatgct gtataaagct
     3901 gagacctgtt ccttcagtgc catcgtagtt gacatgaagc gattgtaaaa ctgtctccgg
     3961 ttttctctgg tttattaaaa tgctaactat aacattttct tttctttttt tttttttgtg
     4021 aatactttga atgtctccct aacagttgtg gtgttgctgt tctgttcgat gcttattcca
     4081 agttcatttt tttgaatggt tttgaagcca ttttgtaatg aattaaatgt ccatgctgta
     4141 cagtacctgt agcatgcctg ccgttctgga ttaataaaag caacttagta tgtgca
//
