LOCUS       NM_001142924            3454 bp    mRNA    linear   ROD 14-JAN-2025
DEFINITION  Mus musculus transcription factor 7 like 2, T cell specific, HMG
            box (Tcf7l2), transcript variant 8, mRNA.
ACCESSION   NM_001142924
VERSION     NM_001142924.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3454)
  AUTHORS   Hudacova,E., Abaffy,P., Kaplan,M.M., Krausova,M., Kubista,M. and
            Machon,O.
  TITLE     Single-cell transcriptomic resolution of osteogenesis during
            craniofacial morphogenesis
  JOURNAL   Bone 190, 117297 (2025)
   PUBMED   39461490
REFERENCE   2  (bases 1 to 3454)
  AUTHORS   Dudukcu,O., Raj,D.D.A., van de Haar,L.L., Grossouw,L.M.,
            Linders,L.E., Garritsen,O., Adolfs,Y., van Kronenburg,N.C.H.,
            Broekhoven,M.H., Kapteijns,T.H.W., Meye,F.J. and Pasterkamp,R.J.
  TITLE     Molecular diversity and migration of GABAergic neurons in the
            developing ventral midbrain
  JOURNAL   iScience 27 (11), 111239 (2024)
   PUBMED   39569362
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3454)
  AUTHORS   Bugacov,H., Der,B., Briantseva,B.M., Guo,Q., Kim,S., Lindstrom,N.O.
            and McMahon,A.P.
  TITLE     Dose-dependent responses to canonical Wnt transcriptional complexes
            in the regulation of mammalian nephron progenitors
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39250420
REFERENCE   4  (bases 1 to 3454)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 3454)
  AUTHORS   Tran,H.N., Nguyen,Q.H. and Jeong,Y.
  TITLE     Dbx1 is a dorsal midbrain-specific determinant of GABAergic neuron
            fate and regulates differentiation of the dorsal midbrain into the
            inferior and superior colliculi
  JOURNAL   Front Cell Dev Biol 12, 1336308 (2024)
   PUBMED   38344749
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3454)
  AUTHORS   Lee,Y.J., Swencki,B., Shoichet,S. and Shivdasani,R.A.
  TITLE     A possible role for the high mobility group box transcription
            factor Tcf-4 in vertebrate gut epithelial cell differentiation
  JOURNAL   J Biol Chem 274 (3), 1566-1572 (1999)
   PUBMED   9880534
REFERENCE   7  (bases 1 to 3454)
  AUTHORS   Ogawa,S., Goto,W., Orimo,A., Hosoi,T., Ouchi,Y., Muramatsu,M. and
            Inoue,S.
  TITLE     Molecular cloning of a novel RING finger-B box-coiled coil (RBCC)
            protein, terf, expressed in the testis
  JOURNAL   Biochem Biophys Res Commun 251 (2), 515-519 (1998)
   PUBMED   9792805
REFERENCE   8  (bases 1 to 3454)
  AUTHORS   Cho,E.A. and Dressler,G.R.
  TITLE     TCF-4 binds beta-catenin and is expressed in distinct regions of
            the embryonic brain and limbs
  JOURNAL   Mech Dev 77 (1), 9-18 (1998)
   PUBMED   9784592
REFERENCE   9  (bases 1 to 3454)
  AUTHORS   Korinek,V., Barker,N., Moerer,P., van Donselaar,E., Huls,G.,
            Peters,P.J. and Clevers,H.
  TITLE     Depletion of epithelial stem-cell compartments in the small
            intestine of mice lacking Tcf-4
  JOURNAL   Nat Genet 19 (4), 379-383 (1998)
   PUBMED   9697701
REFERENCE   10 (bases 1 to 3454)
  AUTHORS   Korinek,V., Barker,N., Willert,K., Molenaar,M., Roose,J.,
            Wagenaar,G., Markman,M., Lamers,W., Destree,O. and Clevers,H.
  TITLE     Two members of the Tcf family implicated in Wnt/beta-catenin
            signaling during embryogenesis in the mouse
  JOURNAL   Mol Cell Biol 18 (3), 1248-1256 (1998)
   PUBMED   9488439
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CA750374.1, AK048536.1, AC118695.10 and AI451561.1.
            
            On Sep 8, 2016 this sequence version replaced NM_001142924.1.
            
            Transcript Variant: This variant (8) uses an alternate 5' UTR and
            5' coding region, compared to variant 1. The resulting isoform (8)
            has a substantially shorter and distinct N-terminus, compared to
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK048536.1, SRR7974084.14000.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164136
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-189               CA750374.1         1-189
            190-2526            AK048536.1         3-2339
            2527-3424           AC118695.10        178113-179010       c
            3425-3454           AI451561.1         4-33                c
FEATURES             Location/Qualifiers
     source          1..3454
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 51.59 cM"
     gene            1..3454
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /note="transcription factor 7 like 2, T cell specific, HMG
                     box"
                     /db_xref="GeneID:21416"
                     /db_xref="MGI:MGI:1202879"
     exon            1..317
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..1214
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /note="isoform 8 is encoded by transcript variant 8;
                     T-cell-specific transcription factor 4; HMG box
                     transcription factor 4; HMG box transcription factor
                     TCF7L2"
                     /codon_start=1
                     /product="transcription factor 7-like 2 isoform 8"
                     /protein_id="NP_001136396.1"
                     /db_xref="CCDS:CCDS50474.1"
                     /db_xref="GeneID:21416"
                     /db_xref="MGI:MGI:1202879"
                     /translation="MSNKVPVVQHPHHVHPLTPLITYSNEHFTPGNPPPHLPADVDPK
                     TGIPRPPHPPDISPYYPLSPGTVGQIPHPLGWLVPQQGQPVYPITTGGFRHPYPTALT
                     VNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQESSQSDVGSLHSSKHQDSKKEE
                     EKKKPHIKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHALSREEQAKYYE
                     LARKERQLHMQLYPGWSARDNYGKKKKRKRDKQPGETNEHSECFLNPCLSLPPITDLS
                     APKKCRARFGLDQQNNWCGPCSL"
     exon            318..450
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            451..553
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            554..640
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            641..766
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            767..926
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            927..1034
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1035..1083
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1134
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1207
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..1232
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..3454
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3431..3436
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /note="hexamer: AATAAA"
     polyA_site      3454
                     /gene="Tcf7l2"
                     /gene_synonym="Tcf-4; Tcf4; TCF4B; TCF4E"
                     /note="major polyA site"
ORIGIN      
        1 ttgaatgctg ggttgggggg aaagagaaga gtgaaaaagc cctgcctttt tatatatata
       61 tataacgccc cctccctctt ttgggggtgg attgttgtgg aaccgaccgg gggagatccc
      121 cgttattgtg cgcttcgctg tgaatggaac tgtgcctgag tatccggcgc ggcacggctg
      181 ctgcgggctg ctcctgggag ctgcgggctc tgtgcgggct gcagggcggg tgctgccctc
      241 cagcgggccc gggccatccg cgcggcagca tgcctgcgag ccagcagcgg caaggacagc
      301 gcggcgaccc ctagatgtcg aacaaagtac cggtggtgca acacccccac catgtccacc
      361 cactcacgcc tctcatcacg tacagcaatg aacacttcac cccgggaaat ccacctccgc
      421 acttaccagc tgacgtagac cccaaaacag gaatcccaag gcctccgcac cctccagata
      481 tctctccata ttacccgctg tcgcccggca ccgtaggaca aatcccccat ccgctaggat
      541 ggttagtacc acagcaaggt cagcctgtgt acccaatcac gacaggagga ttcagacacc
      601 cctaccccac agcgctgaca gtcaacgcat ctatgtctag gttccctccc catatggtcc
      661 ctccccatca cactctgcac acgaccggca tccctcaccc ggccatcgtc acaccgacag
      721 tcaagcagga atcctcccag agtgacgtcg gctcactcca cagctcaaag catcaggact
      781 ccaaaaagga agaagagaag aagaagcccc acataaagaa gccccttaat gcattcatgt
      841 tgtatatgaa agagatgaga gcgaaggtgg tggccgaatg cacattgaaa gagagtgcag
      901 ccatcaacca gattctcggg cgcaggtggc acgccctgtc cagggaagaa caggcaaaat
      961 actacgagct ggcccggaag gaacgacagc ttcacatgca gctgtaccct ggctggtctg
     1021 cacgggataa ctatgggaag aagaagaaga gaaaaagaga caagcagccg ggggaaacca
     1081 acgaacacag cgaatgtttc ctaaatcctt gcctttcgct tcctccgatc acagacctga
     1141 gcgctcctaa gaaatgccga gcgcgctttg gccttgatca acagaataac tggtgcggcc
     1201 cctgcagtct ttgaatttgg aatattatga tggagaaaaa aaaagtgcgt tcgctacata
     1261 caaggtgaag gcagctgcct cagcccaccc tcttcagatg gaagcttact agactcgcct
     1321 cccccctcac cgcatctgct aggctcccct ccccaagacg ccaagtcaca gactgagcag
     1381 acccagccgc tctcgctgtc cctgaagcct gatcctctgg cccacctgtc catgatgcct
     1441 ccgccacccg cgctcctgtt ggccgaagct gcccacggca aggcctctgc cctctgtccc
     1501 aatggggctc tggacctgcc acctgccgct ctgcagccgt ccatggtccc ttcctcatcg
     1561 ctcgcacaac catcaacttc ttccttacat tcccacaact cgctggctgg aacgcaaccc
     1621 cagcctctgt ctctggtgac caagtcttta gaatagctcc gcctcctcgt cctccatgcc
     1681 cctgcttgat tgaagtgttt ccttctggtt cttggttcgc ccttccccgc ttggaaagct
     1741 tttgttttgt actctttaat tttgtgccgc cgtggctaca tgagttaatg tttatggagt
     1801 tcattggtca atatttgacc cattcttatt tcaatttctc cttttaaata tgtagatgag
     1861 aaaaacctca tgattctacc aaaattttta tcaacagctg tttaaagtct ttgtagcgtt
     1921 taaaaaatat attatatata cataactgtt atgtagttcg gatagcttag ttttaaaaga
     1981 ctgatttaaa aaacaaaaag aaaaaaaaga gagagaagca attttgaagc accctccaga
     2041 aggagttggt tctgtgttat ttgtattaaa tacgagcttg cgaaccaatc actttacacc
     2101 ttggtattta aaccacgagg gcacaaggaa tgcagtgccg tttctttctt tctttttttc
     2161 tttctttttt ttttcctccc agtgtgaaac aacttttacc ttgatgttac ttgttattgt
     2221 ttaaatgtac agaaacaaag ggttaaaatg tgttaatata ccttgttcca tggtgttgtt
     2281 cttttggggg ggaggggaca ccactcaaca atgaatggaa tcaacactgt tggaccagta
     2341 gtatttattg ctttagaggt tgcttgctgt acctgtatgt ccgtccaatt ttaaatatgt
     2401 tttccctttt ttttgaaact gtgtaaagtc ccccccaacc ttagcgtaag catcttatat
     2461 ataacaactc atttgtacaa ggtttttaag tttatatata aaatgtgtat atattttttt
     2521 gtttcctttt tttttttttt ttggcgtacg ttcgttcgtt cgtttgtttg tttctgtata
     2581 aaacccagat gccaccaaat ggacattgac attcgcatta aggatcagta gcattaacaa
     2641 aacttgcttt aaaagccatt ctgtaaaaca agacttgaac attagcgaga gggtctgagc
     2701 agccgtctga gcagccgtgg gaactgcccc gtttccccct tgacctccta gtcaactgcc
     2761 ctgtgctctt agaacatgga ctgaccgtgt gcaaaacttt tatgtgccaa aattctcagt
     2821 gactttagct ttctccctcc tttttgatgc tgtactttct gttcgccatg ttttgctgtg
     2881 atgttacata gatagatttg tatgtagttt taatgtcacc tataacaaaa tgtgtttggt
     2941 agcagactgt ccagaaagca ttttaaatga agaggtctaa acccttaagg gccaaaaaaa
     3001 atcctgtata ttagattact cttaaatgaa aaagaaaaaa agaaaaaaaa aaaccccagc
     3061 tgccgctttt atgtatgcat attacataca agtaggtagt gacctttaaa aacaagaaaa
     3121 cctaggcatg ccgatgttgt aaaatgctgt ataaagctga gacctgttcc ttcagtgcca
     3181 tcgtagttga catgaagcga ttgtaaaact gtctccggtt ttctctggtt tattaaaatg
     3241 ctaactataa cattttcttt tctttttttt tttttgtgaa tactttgaat gtctccctaa
     3301 cagttgtggt gttgctgttc tgttcgatgc ttattccaag ttcatttttt tgaatggttt
     3361 tgaagccatt ttgtaatgaa ttaaatgtcc atgctgtaca gtacctgtag catgcctgcc
     3421 gttctggatt aataaaagca acttagtatg tgca
//
