LOCUS       NM_001079822            2882 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus transcription factor 7 like 1 (T cell specific, HMG
            box) (Tcf7l1), transcript variant 1, mRNA.
ACCESSION   NM_001079822
VERSION     NM_001079822.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2882)
  AUTHORS   Bugacov,H., Der,B., Briantseva,B.M., Guo,Q., Kim,S., Lindstrom,N.O.
            and McMahon,A.P.
  TITLE     Dose-dependent responses to canonical Wnt transcriptional complexes
            in the regulation of mammalian nephron progenitors
  JOURNAL   Development 151 (18) (2024)
   PUBMED   39250420
REFERENCE   2  (bases 1 to 2882)
  AUTHORS   Yu,Y., Liu,L., Cao,J., Huang,R., Duan,Q. and Ye,S.D.
  TITLE     Tbl1 promotes Wnt-beta-catenin signaling-induced degradation of the
            Tcf7l1 protein in mouse embryonic stem cells
  JOURNAL   J Cell Sci 137 (9) (2024)
   PUBMED   38639717
  REMARK    GeneRIF: Tbl1 promotes Wnt-beta-catenin signaling-induced
            degradation of the Tcf7l1 protein in mouse embryonic stem cells.
REFERENCE   3  (bases 1 to 2882)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2882)
  AUTHORS   Zinina,V.V., Sauer,M., Nigmatullina,L., Kreim,N. and Soshnikova,N.
  TITLE     TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small
            Intestine
  JOURNAL   Cells 12 (11), 1452 (2023)
   PUBMED   37296573
  REMARK    GeneRIF: TCF7L1 Controls the Differentiation of Tuft Cells in Mouse
            Small Intestine.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2882)
  AUTHORS   Mitsiadis,T.A., Pagella,P., Gomes Rodrigues,H., Tsouknidas,A.,
            Ramenzoni,L.L., Radtke,F., Mehl,A. and Viriot,L.
  TITLE     Notch Signaling Pathway in Tooth Shape Variations throughout
            Evolution
  JOURNAL   Cells 12 (5), 761 (2023)
   PUBMED   36899896
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2882)
  AUTHORS   Nagai,K.
  TITLE     Molecular evolution of Sry and Sox gene
  JOURNAL   Gene 270 (1-2), 161-169 (2001)
   PUBMED   11404013
REFERENCE   7  (bases 1 to 2882)
  AUTHORS   Galceran,J., Miyashita-Lin,E.M., Devaney,E., Rubenstein,J.L. and
            Grosschedl,R.
  TITLE     Hippocampus development and generation of dentate gyrus granule
            cells is regulated by LEF1
  JOURNAL   Development 127 (3), 469-482 (2000)
   PUBMED   10631168
REFERENCE   8  (bases 1 to 2882)
  AUTHORS   DasGupta,R. and Fuchs,E.
  TITLE     Multiple roles for activated LEF/TCF transcription complexes during
            hair follicle development and differentiation
  JOURNAL   Development 126 (20), 4557-4568 (1999)
   PUBMED   10498690
REFERENCE   9  (bases 1 to 2882)
  AUTHORS   Galceran,J., Farinas,I., Depew,M.J., Clevers,H. and Grosschedl,R.
  TITLE     Wnt3a-/--like phenotype and limb deficiency in Lef1(-/-)Tcf1(-/-)
            mice
  JOURNAL   Genes Dev 13 (6), 709-717 (1999)
   PUBMED   10090727
REFERENCE   10 (bases 1 to 2882)
  AUTHORS   Korinek,V., Barker,N., Willert,K., Molenaar,M., Roose,J.,
            Wagenaar,G., Markman,M., Lamers,W., Destree,O. and Clevers,H.
  TITLE     Two members of the Tcf family implicated in Wnt/beta-catenin
            signaling during embryogenesis in the mouse
  JOURNAL   Mol Cell Biol 18 (3), 1248-1256 (1998)
   PUBMED   9488439
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153613.9, BC128305.1 and AC125039.4.
            
            On Oct 26, 2013 this sequence version replaced NM_001079822.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC128305.1, SRR11927932.2232096.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-93                AC153613.9         156638-156730
            94-1981             BC128305.1         1-1888
            1982-2882           AC125039.4         101740-102640       c
FEATURES             Location/Qualifiers
     source          1..2882
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 32.27 cM"
     gene            1..2882
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /note="transcription factor 7 like 1 (T cell specific, HMG
                     box)"
                     /db_xref="GeneID:21415"
                     /db_xref="MGI:MGI:1202876"
     exon            1..336
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             94..1893
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     T-cell factor 3; transcription factor 7-like 2 (T-cell
                     specific, HMG box); HMG box transcription factor 3"
                     /codon_start=1
                     /product="transcription factor 7-like 1 isoform 1"
                     /protein_id="NP_001073290.1"
                     /db_xref="CCDS:CCDS39517.1"
                     /db_xref="GeneID:21415"
                     /db_xref="MGI:MGI:1202876"
                     /translation="MPQLGGGRGGGAGGGGGGSGAGATSGGDDLGANDELIPFQDEGG
                     EEQEPSSDSASAQRDLDEVKSSLVNESENQSSSSDSEAERRPQPARDAFQKPRDYFAE
                     VRRPQDGAFFKGPAYPGYPFLMIPDLSSPYLSNGPLSPGGARTYLQMKWPLLDVPSSA
                     TVKDTRSPSPAHLYGDPARWMVPPTFRSNKVPVVQHPHHMHPLTPLITYSNDHFSPAS
                     PPTHLSPEIDPKTGIPRPPHPSELSPYYPLSPGAVGQIPHPLGWLVPQQGQPMYSLPP
                     GGFRHPYPALAMNASMSSLVSSRFPHMVAPAHPGLPTSGIPHPAIVSPIVKQEPAAPS
                     LSPAVSAKSPVTVKKEEEKKPHVKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILG
                     RKWHNLSREEQAKYYELARKERQLHAQLYPTWSARDNYGKKKKRKREKQLSQTQSQQQ
                     IQEAEGALASKSKKPCIQYLPPEKPCDSPASSHGSTLDSPATPSAALASPAAPAATHS
                     EQAQPLSLTTKPEARAQLALHSAAFLSAKAAASNSSQMGSQPPLLSRPLPLGSMPAAL
                     LTSPPTFPATLHAHQALPVLQAQPLSLVTKSAH"
     exon            337..400
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            401..528
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            529..612
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            613..654
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            655..787
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            788..890
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            891..974
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1115
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1275
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1383
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1384..1459
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..2882
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2857..2862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /note="hexamer: AATAAA"
     polyA_site      2875
                     /gene="Tcf7l1"
                     /gene_synonym="bHLHb21; Tcf-3; Tcf3"
                     /note="major polyA site"
ORIGIN      
        1 gagccgggcc agcgagaggg agggaggggc gccgggccgg gccaggcagg gcgcggggct
       61 ccgagcgcag cggccccggc ccgtggcccc accatgcccc agctcggtgg tggccgcggt
      121 ggcggcgccg gcgggggagg cggtggctcc ggagccgggg caaccagtgg aggggacgac
      181 ctcggagcga acgacgagct gatccccttc caggacgagg ggggcgaaga gcaagagccg
      241 agcagcgaca gcgcttcggc gcagagggat ctggatgagg tcaagtcgtc cctggtcaac
      301 gaatcggaga atcagagcag tagctcggac tccgaggcgg agaggcgccc gcagcccgcc
      361 cgggacgctt tccagaagcc gcgcgactat ttcgccgaag tgagaaggcc ccaggatggc
      421 gcttttttta agggacctgc gtatcctggg taccccttcc tgatgattcc agacctgagc
      481 agcccgtacc tctccaacgg acccctgtct cctggtggag cgcgcaccta cctacagatg
      541 aaatggcccc tcctcgatgt cccctccagt gctacagtca aggacacaag gtcgccatct
      601 ccagcacact tgtatgggga tcctgcccgt tggatggtgc ctcccacatt caggtccaac
      661 aaagttcctg ttgttcagca ccctcatcac atgcacccgc tgacacctct catcacctac
      721 agcaacgacc acttctcccc tgcgtcccct cccacgcatc tgtccccaga gatcgaccca
      781 aagacaggaa tcccccggcc ccctcatcca tctgagctgt caccgtatta cccactgtct
      841 ccaggagctg tcggacaaat cccccatccc ctcggctggc tcgtcccaca gcaagggcag
      901 cccatgtact ctctccctcc gggtggtttc cggcatcctt accctgccct cgccatgaac
      961 gcttcaatgt ccagcctggt ctcaagccgg ttcccacaca tggtggctcc tgcccatcct
     1021 ggtctgccca cctcaggaat cccccaccct gccatcgtct cccccattgt gaagcaggag
     1081 ccagcagccc ccagcctgag ccctgcagtg agtgcgaaat ccccagttac ggtgaagaag
     1141 gaagaggaga agaaacctca cgtgaaaaag cccctgaatg ccttcatgtt gtatatgaag
     1201 gagatgaggg ccaaggtggt ggccgagtgt accctgaagg aaagtgcagc cattaaccaa
     1261 atcctgggaa gaaagtggca caacctgtca agagaagaac aggccaaata ctatgagctt
     1321 gcccggaaag aacggcagct tcacgcgcag ctctacccaa cctggtcagc ccgggacaac
     1381 tatgggaaga agaagaagag gaagagagaa aagcagctgt cacagacaca gtctcagcag
     1441 caaatccaag aggcagaggg tgctctggcc tctaagagca agaagccatg cattcagtac
     1501 ctgccccctg agaagccttg tgatagccct gcgtcttccc atggcagcac gctggactcc
     1561 cctgcgacgc cctccgcagc cttggcctca ccagctgccc ctgcggctac ccactccgag
     1621 caagcgcagc ccctgtcgct caccaccaaa ccggaggccc gggcccagct ggctctccac
     1681 tccgctgcct tcctgtcggc taaggcggcc gccagcaact ccagccagat gggcagccag
     1741 cccccactcc tatccaggcc cttgcccttg ggctctatgc ccgccgctct gctgacctct
     1801 ccccctactt tcccagctac gctccatgcc caccaggccc tccccgtgct acaggcccag
     1861 cctctttcct tggtcaccaa gtctgcccac taagctgccc ccggttctat gcaggctgtc
     1921 tcgggactcc aagtagtaat gattcagagg agaggaaggg ggaaacacaa aggaagcatt
     1981 attggtcaat atttgaccac tctggactgt tctgtaaagt gactggtaac agcagtgcct
     2041 taccactgta gatataacca gtagctgatc ttcaggcttt tttaaaaaaa aaaaaaaaaa
     2101 aaaaaaggag aaaacataaa caaaacaaag cctgcccctc tcccctcccc aaaaaaaacc
     2161 atccttcaca agaaagcact gaaaagcagt gtgttgctcc ctccccttgc gctgtggtgg
     2221 gtatacctgg gcgggagata tctctctacc tcttctcttc ctgactctct gccctccttt
     2281 ccgtcgtcgc tgccagcccc acttgcccta gctcccccac cgtatcagca acatgaccag
     2341 gcctggagtt ctagcctgac acccttctct ccaggtcagt cctgttgccc tcgcccaaat
     2401 gtttgtcctg tgttcagcgc cagttcaacc ccctctgtcc tctgcccagt gtaaggttgt
     2461 ggccacgtgt gaccatagtt tcccaccatc atcccctctc cctcttcggg ccccaatggc
     2521 ctggactcca gcttggggtg gggtccttct gaaatggtcc ccccccctgc atttaaaggg
     2581 actcaaggtg cctaccactg ccttcaagaa gtctgttcct ctctgctgcc cagtcacgtt
     2641 ttctttcccg cctcgcagta tcagagtggc aggcaggccc cagtccccga tgtctggctc
     2701 ctgtcacctc catctgtgct agtacaatcc gcagaagctc caagaccctc tgccccttcc
     2761 cccaccacca cctcacaagc tttttctgtg tgtatttcat tttgttttta tggtttttgg
     2821 aacaatttaa actcccagtt tattttcaca agagaaaata aaattacagt tgcaagaccg
     2881 tc
//
