LOCUS       NM_001313981            2695 bp    mRNA    linear   ROD 08-NOV-2023
DEFINITION  Mus musculus transcription factor 7, T cell specific (Tcf7),
            transcript variant 1, mRNA.
ACCESSION   NM_001313981
VERSION     NM_001313981.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2695)
  AUTHORS   Chen D, Li K, Pan L, Wu Y, Chen M, Zhang X, Xu J and Lou T.
  TITLE     TCF7 and LEF-1 downregulation in sepsis promotes immune suppression
            by inhibiting CD4+ T cell proliferation
  JOURNAL   Microb Pathog 184, 106362 (2023)
   PUBMED   37741305
  REMARK    GeneRIF: TCF7 and LEF-1 downregulation in sepsis promotes immune
            suppression by inhibiting CD4[+] T cell proliferation.
REFERENCE   2  (bases 1 to 2695)
  AUTHORS   Yakou MH, Ghilas S, Tran K, Liao Y, Afshar-Sterle S, Kumari A,
            Schmid K, Dijkstra C, Inguanti C, Ostrouska S, Wilcox J, Smith M,
            Parathan P, Allam A, Xue HH, Belz GT, Mariadason JM, Behren A,
            Drummond GR, Ruscher R, Williams DS, Pal B, Shi W, Ernst M, Raghu D
            and Mielke LA.
  TITLE     TCF-1 limits intraepithelial lymphocyte antitumor immunity in
            colorectal carcinoma
  JOURNAL   Sci Immunol 8 (88), eadf2163 (2023)
   PUBMED   37801516
  REMARK    GeneRIF: TCF-1 limits intraepithelial lymphocyte antitumor immunity
            in colorectal carcinoma.
REFERENCE   3  (bases 1 to 2695)
  AUTHORS   Zheng M, Yao C, Ren G, Mao K, Chung H, Chen X, Hu G, Wang L, Luan
            X, Fang D, Li D, Zhong C, Lu X, Cannon N, Zhang M, Bhandoola A,
            Zhao K, O'Shea JJ and Zhu J.
  TITLE     Transcription factor TCF-1 regulates the functions, but not the
            development, of lymphoid tissue inducer subsets in different
            tissues
  JOURNAL   Cell Rep 42 (8), 112924 (2023)
   PUBMED   37540600
  REMARK    GeneRIF: Transcription factor TCF-1 regulates the functions, but
            not the development, of lymphoid tissue inducer subsets in
            different tissues.
REFERENCE   4  (bases 1 to 2695)
  AUTHORS   Belanger S, Haupt S, Faliti CE, Getzler A, Choi J, Diao H,
            Karunadharma PP, Bild NA, Pipkin ME and Crotty S.
  TITLE     The Chromatin Regulator Mll1 Supports T Follicular Helper Cell
            Differentiation by Controlling Expression of Bcl6, LEF-1, and TCF-1
  JOURNAL   J Immunol 210 (11), 1752-1760 (2023)
   PUBMED   37074193
  REMARK    GeneRIF: The Chromatin Regulator Mll1 Supports T Follicular Helper
            Cell Differentiation by Controlling Expression of Bcl6, LEF-1, and
            TCF-1.
REFERENCE   5  (bases 1 to 2695)
  AUTHORS   Hofland T, Danelli L, Cornish G, Donnarumma T, Hunt DM, de Carvalho
            LPS and Kassiotis G.
  TITLE     CD4+ T cell memory is impaired by species-specific cytotoxic
            differentiation, but not by TCF-1 loss
  JOURNAL   Front Immunol 14, 1168125 (2023)
   PUBMED   37122720
  REMARK    GeneRIF: CD4[+] T cell memory is impaired by species-specific
            cytotoxic differentiation, but not by TCF-1 loss.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2695)
  AUTHORS   Kingsmore SF, Watson ML and Seldin MF.
  TITLE     Genetic mapping of the T lymphocyte-specific transcription factor 7
            gene on mouse chromosome 11
  JOURNAL   Mamm Genome 6 (5), 378 (1995)
   PUBMED   7626895
REFERENCE   7  (bases 1 to 2695)
  AUTHORS   van de Wetering M, Oosterwegel M, Holstege F, Dooyes D,
            Suijkerbuijk R, Geurts van Kessel A and Clevers H.
  TITLE     The human T cell transcription factor-1 gene. Structure,
            localization, and promoter characterization
  JOURNAL   J Biol Chem 267 (12), 8530-8536 (1992)
   PUBMED   1569101
REFERENCE   8  (bases 1 to 2695)
  AUTHORS   Sawada S and Littman DR.
  TITLE     Identification and characterization of a T-cell-specific enhancer
            adjacent to the murine CD4 gene
  JOURNAL   Mol Cell Biol 11 (11), 5506-5515 (1991)
   PUBMED   1922061
REFERENCE   9  (bases 1 to 2695)
  AUTHORS   De Simone V, De Magistris L, Lazzaro D, Gerstner J, Monaci P,
            Nicosia A and Cortese R.
  TITLE     LFB3, a heterodimer-forming homeoprotein of the LFB1 family, is
            expressed in specialized epithelia
  JOURNAL   EMBO J 10 (6), 1435-1443 (1991)
   PUBMED   1673925
REFERENCE   10 (bases 1 to 2695)
  AUTHORS   Oosterwegel M, van de Wetering M, Dooijes D, Klomp L, Winoto A,
            Georgopoulos K, Meijlink F and Clevers H.
  TITLE     Cloning of murine TCF-1, a T cell-specific transcription factor
            interacting with functional motifs in the CD3-epsilon and T cell
            receptor alpha enhancers
  JOURNAL   J Exp Med 173 (5), 1133-1142 (1991)
   PUBMED   1827138
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL645862.14, AK037616.1 and
            AW545274.1.
            
            [WARNING] On Jan 23, 2024 this sequence was replaced by
            NM_001313981.2.
            
            Summary: This gene encodes a transcription factor which is a member
            of the T-cell specific transcription factor family. The encoded
            protein is distinct from the hepatic transcription factor,
            transcription factor 1, which is also referred to by the symbol
            Tcf1. Several alternatively spliced transcript variants of this
            gene have been described, but the full-length nature of some of
            these variants has not been determined. [provided by RefSeq, Sep
            2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X61385.1, SRR11927936.2719810.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AL645862.14        99643-99729         c
            88-154              AL645862.14        99427-99493         c
            155-2374            AK037616.1         20-2239
            2375-2695           AW545274.1         1-321               c
FEATURES             Location/Qualifiers
     source          1..2695
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 31.86 cM"
     gene            1..2695
                     /gene="Tcf7"
                     /gene_synonym="TCF-1; Tcf1"
                     /note="transcription factor 7, T cell specific"
                     /db_xref="GeneID:21414"
                     /db_xref="MGI:MGI:98507"
     exon            1..87
                     /gene="Tcf7"
                     /gene_synonym="TCF-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            88..154
                     /gene="Tcf7"
                     /gene_synonym="TCF-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            155..279
                     /gene="Tcf7"
                     /gene_synonym="TCF-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1095
                     /gene="Tcf7"
                     /gene_synonym="TCF-1; Tcf1"
                     /note="T-cell-specific transcription factor 1"
                     /codon_start=1
                     /product="transcription factor 7"
                     /protein_id="NP_001300910.1"
                     /db_xref="CCDS:CCDS24670.1"
                     /db_xref="GeneID:21414"
                     /db_xref="MGI:MGI:98507"
                     /translation="MYKETVYSAFNLLMPYPPASGAGQHPQPQPPLHNKPGQPPHGVP
                     QLSPLYEHFSSPHPTPAPADISQKQGVHRPLQTPDLSGFYSLTSGSMGQLPHTVSWPS
                     PPLYPLSPSCGYRQHFPAPTAAPGAPYPRFTHPSLMLGSGVPGHPAAIPHPAIVPSSG
                     KQELQPYDRNLKTQAEPKAEKEAKKPVIKKPLNAFMLYMKEMRAKVIAECTLKESAAI
                     NQILGRRWHALSREEQAKYYELARKERQLHMQLYPGWSARDNYGKKKRRSREKHQEST
                     TGGKRNAFGTYPEKAAAPAPFLPMTVL"
     exon            280..391
                     /gene="Tcf7"
                     /gene_synonym="TCF-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            392..482
                     /gene="Tcf7"
                     /gene_synonym="TCF-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            483..575
                     /gene="Tcf7"
                     /gene_synonym="TCF-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            576..695
                     /gene="Tcf7"
                     /gene_synonym="TCF-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            696..858
                     /gene="Tcf7"
                     /gene_synonym="TCF-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            859..966
                     /gene="Tcf7"
                     /gene_synonym="TCF-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1015
                     /gene="Tcf7"
                     /gene_synonym="TCF-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..2695
                     /gene="Tcf7"
                     /gene_synonym="TCF-1; Tcf1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgaatgagt ccgaaggcgc ggccgcaggc gccggggtcc cgggtcccgg cgtccgagta
       61 catggagaag ccgagggagc gcccgaggcc ctgggacggg agcacacttc gcagagactt
      121 ttcccggaca aacttccaga gtccctagag gacggcctga aggccccgga gtgtgccagt
      181 ggcatgtaca aagagactgt ctactctgcc ttcaatctgc tcatgcccta cccaccggcc
      241 tccggagcag ggcagcatcc gcagcctcaa cccccgctgc ataacaagcc cggccagcct
      301 ccacatggcg tcccccagct ttctccactc tacgaacatt tcagcagtcc acaccccacc
      361 cctgcaccag cggacatcag ccagaagcaa ggagttcaca ggccgctgca gacccccgat
      421 ctctctggat tttattctct gacctcaggc agcatgggac agctccccca tactgtgagc
      481 tggcccagtc ctcctctcta ccccctgtcc ccttcctgcg gatatagaca gcacttccct
      541 gcccccactg cagcccctgg cgccccctat cccaggttca cccacccatc cttgatgctg
      601 ggatctggtg tacctggaca cccagcagcc atccctcacc cggccattgt gccctcctca
      661 gggaagcagg agctgcagcc atatgataga aacctgaaaa cacaggcaga acccaaggca
      721 gagaaggagg ctaagaagcc agtcatcaag aaacccctca atgcgttcat gctttacatg
      781 aaggagatga gagccaaggt cattgctgag tgcacactca aggagagcgc tgccatcaac
      841 cagatcctgg gtcgcaggtg gcatgcacta tctcgagaag agcaggccaa gtactatgaa
      901 ctggcccgca aggaaaggca gctgcacatg cagctatacc cgggctggtc cgcgcgggat
      961 aactacggaa agaagaagag gcggtcaagg gaaaaacatc aagaatccac cacaggagga
     1021 aaaagaaatg cattcggtac ttacccggag aaggccgctg ccccagcccc gttccttccg
     1081 atgacagtgc tctaggctgt ccccggtccc cagctcccca ggactcaccc tcgtatcttc
     1141 tgttgccctc cttccccaca gaactgcttg ctagcccagt ggagccagca ccaacattct
     1201 caggtcgctc tgcagctctc actcttccag cccctaagtc tccaaagacc ccccacagca
     1261 ccctccagaa tccacagata cagcaacaag aatctcagag acaggcagcc taacagcctt
     1321 ggttgctagg cacagaacac ctggcttgct ccaggggccc acccctaact caggaggagg
     1381 caacatgacc agctcccatg gaaccagcta ggggtcctct taaggtgatg aagatttcaa
     1441 aggctgcaca actccctgaa ccaggggcca tcaattcaag aggtggggga ttagatctat
     1501 gtagatgtat catcttaagg ggatcctgcc gcctctgaca gccatatctc ttgttattgc
     1561 tggctggacc tccctattgg cctaggaggt tttgtttgct gtaggtcaga tgggttggac
     1621 tgatctcttc agctgcctac cctacaaatg cttctcctgc cctctgccac accctcccca
     1681 tgccaatact tcttggacca agaatacctg gtttgtcaca caaaataact ctgtggtcaa
     1741 ccagccacaa gtctaaacaa taatgcttct ctcttaaacc gagaagttct gtttacaaaa
     1801 accagctgct gttcataagc tgggccggag gaagcggctc cctgtgttct caggcgcttg
     1861 caagaggagg gactaggata cgtttaggcc tttcaacctt ggcaccaact acctactggt
     1921 gggcaatagt cagctttcat ttcaatcttt cccaagaagc tcaccagcat taacaactag
     1981 tcaatatagt tggcctaaac ccagtgtgca cccttcctat caggctcttc ccagttccat
     2041 ttccagctca tctgagtcag ctcctgggca gctgtgagag ggcaaacccc aaacccccaa
     2101 cagccagagc ctatcagcat tgagaaccgg ccagcttcag tttctctgtg gggctgcagg
     2161 aagaaatgtt actactaaag caaggaaccc ataaaacctc tctgtggtgg acatggttcc
     2221 ttgccacatt ctagaaactc tttttgagcc aaacttaacc ctgagccttg aaaaacaagt
     2281 tttttgtttg tttgttttaa cttttttttt ttcattctcg ctgtagatag cctgaatcca
     2341 aagaaaacca aaaggggtta tccaagtatt ccacacaaaa acaaaacaaa aaacccttta
     2401 gtgttcctac tttagtcact catttctcaa tccaaagatc atgtttctaa cgtagtgttg
     2461 aaagtcttga gaaagtctgg ccaagtgtgg tagtgtgcac ctataacccc agcacttgcg
     2521 agatagaggc agggggacct ctgtgaattc caagacaacc agggctgtat agaagacctt
     2581 ttctcaaaaa gaaaaactgt tgtatccaaa atatttttgt attgtaatgc attaccatag
     2641 aaaagctttt ttaacaatga gaataaagaa tctttttact tggtttttca aagtc
//
