LOCUS       NM_001164149            2920 bp    mRNA    linear   ROD 05-OCT-2024
DEFINITION  Mus musculus transcription factor 3 (Tcf3), transcript variant 3,
            mRNA.
ACCESSION   NM_001164149
VERSION     NM_001164149.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2920)
  AUTHORS   Liu,B., He,Y., Wu,X., Lin,Z., Ma,J., Qiu,Y., Xiang,Y., Kong,F.,
            Lai,F., Pal,M., Wang,P., Ming,J., Zhang,B., Wang,Q., Wu,J., Xia,W.,
            Shen,W., Na,J., Torres-Padilla,M.E., Li,J. and Xie,W.
  TITLE     Mapping putative enhancers in mouse oocytes and early embryos
            reveals TCF3/12 as key folliculogenesis regulators
  JOURNAL   Nat Cell Biol 26 (6), 962-974 (2024)
   PUBMED   38839978
  REMARK    GeneRIF: Mapping putative enhancers in mouse oocytes and early
            embryos reveals TCF3/12 as key folliculogenesis regulators.
REFERENCE   2  (bases 1 to 2920)
  AUTHORS   Parriott,G., Hegermiller,E., Morman,R.E., Frank,C., Saygin,C.,
            Stock,W., Bartom,E.T. and Kee,B.L.
  TITLE     Loss of thymocyte competition underlies the tumor suppressive
            functions of the E2a transcription factor in T-ALL
  JOURNAL   Leukemia 38 (3), 491-501 (2024)
   PUBMED   38155245
REFERENCE   3  (bases 1 to 2920)
  AUTHORS   Talley,M.J., Nardini,D., Ehrman,L.A., Lu,Q.R. and Waclaw,R.R.
  TITLE     Distinct requirements for Tcf3 and Tcf12 during oligodendrocyte
            development in the mouse telencephalon
  JOURNAL   Neural Dev 18 (1), 5 (2023)
   PUBMED   37684687
  REMARK    GeneRIF: Distinct requirements for Tcf3 and Tcf12 during
            oligodendrocyte development in the mouse telencephalon.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2920)
  AUTHORS   Boast,B., Goel,S., Gonzalez-Granado,L.I., Niemela,J., Stoddard,J.,
            Edwards,E.S.J., Seneviratne,S., Spensberger,D.,
            Quesada-Espinosa,J.F., Allende,L.M., McDonnell,J., Haseley,A.,
            Lesmana,H., Walkiewicz,M.A., Muhammad,E., Bosco,J.J.,
            Fleisher,T.A., Cohen,S., Holland,S.M., van Zelm,M.C., Enders,A.,
            Kuehn,H.S. and Rosenzweig,S.D.
  TITLE     TCF3 haploinsufficiency defined by immune, clinical, gene-dosage,
            and murine studies
  JOURNAL   J Allergy Clin Immunol 152 (3), 736-747 (2023)
   PUBMED   37277074
  REMARK    GeneRIF: TCF3 haploinsufficiency defined by immune, clinical,
            gene-dosage, and murine studies.
REFERENCE   5  (bases 1 to 2920)
  AUTHORS   Lin,Y., Zhan,M. and Xu,B.
  TITLE     Exportin XPO7 acts as an oncogenic factor in prostate cancer via
            upregulation of TCF3
  JOURNAL   J Cancer Res Clin Oncol 149 (10), 7663-7677 (2023)
   PUBMED   37000263
  REMARK    GeneRIF: Exportin XPO7 acts as an oncogenic factor in prostate
            cancer via upregulation of TCF3.
REFERENCE   6  (bases 1 to 2920)
  AUTHORS   Zhuang,Y., Kim,C.G., Bartelmez,S., Cheng,P., Groudine,M. and
            Weintraub,H.
  TITLE     Helix-loop-helix transcription factors E12 and E47 are not
            essential for skeletal or cardiac myogenesis, erythropoiesis,
            chondrogenesis, or neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 89 (24), 12132-12136 (1992)
   PUBMED   1465450
REFERENCE   7  (bases 1 to 2920)
  AUTHORS   Nielsen,A.L., Pallisgaard,N., Pedersen,F.S. and Jorgensen,P.
  TITLE     Murine helix-loop-helix transcriptional activator proteins binding
            to the E-box motif of the Akv murine leukemia virus enhancer
            identified by cDNA cloning
  JOURNAL   Mol Cell Biol 12 (8), 3449-3459 (1992)
   PUBMED   1321336
REFERENCE   8  (bases 1 to 2920)
  AUTHORS   Hainaut,P., Castellazzi,M., Gonzales,D., Clausse,N., Hilgers,J. and
            Crepin,M.
  TITLE     A congenic line of the BALB/c mouse strain with the endogenous
            mouse mammary tumor virus proviral gene Mtv-3: tissue-specific
            expression and correlation with resistance to mouse mammary tumor
            virus infection and tumorigenesis
  JOURNAL   Cancer Res 50 (12), 3754-3760 (1990)
   PUBMED   2160325
REFERENCE   9  (bases 1 to 2920)
  AUTHORS   Walker,M.D., Park,C.W., Rosen,A. and Aronheim,A.
  TITLE     A cDNA from a mouse pancreatic beta cell encoding a putative
            transcription factor of the insulin gene
  JOURNAL   Nucleic Acids Res 18 (5), 1159-1166 (1990)
   PUBMED   2181401
REFERENCE   10 (bases 1 to 2920)
  AUTHORS   Murre,C., McCaw,P.S., Vaessin,H., Caudy,M., Jan,L.Y., Jan,Y.N.,
            Cabrera,C.V., Buskin,J.N., Hauschka,S.D., Lassar,A.B. et al.
  TITLE     Interactions between heterologous helix-loop-helix proteins
            generate complexes that bind specifically to a common DNA sequence
  JOURNAL   Cell 58 (3), 537-544 (1989)
   PUBMED   2503252
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152062.6.
            
            On Mar 13, 2020 this sequence version replaced NM_001164149.1.
            
            Transcript Variant: This variant (3) has two alternate splice sites
            in the coding region, compared to variant 1. The resulting isoform
            (3) lacks two internal aa, compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156265.1, AK017617.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-316               AC152062.6         3484-3799
            317-448             AC152062.6         6051-6182
            449-521             AC152062.6         9376-9448
            522-595             AC152062.6         15714-15787
            596-674             AC152062.6         15953-16031
            675-742             AC152062.6         17031-17098
            743-875             AC152062.6         17520-17652
            876-925             AC152062.6         18304-18353
            926-1028            AC152062.6         19479-19581
            1029-1186           AC152062.6         19649-19806
            1187-1322           AC152062.6         19894-20029
            1323-1381           AC152062.6         20330-20388
            1382-1460           AC152062.6         20481-20559
            1461-1534           AC152062.6         21193-21266
            1535-1690           AC152062.6         21599-21754
            1691-1817           AC152062.6         21831-21957
            1818-1950           AC152062.6         23782-23914
            1951-2186           AC152062.6         24057-24292
            2187-2920           AC152062.6         26845-27578
FEATURES             Location/Qualifiers
     source          1..2920
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2920
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /note="transcription factor 3"
                     /db_xref="GeneID:21423"
                     /db_xref="MGI:MGI:98510"
     exon            1..316
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            317..448
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..2329
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /note="isoform 3 is encoded by transcript variant 3;
                     transcription factor E2-alpha; transcription factor A1;
                     immunoglobulin enhancer-binding factor E12/E47;
                     transcription factor E2a"
                     /codon_start=1
                     /product="transcription factor E2-alpha isoform 3"
                     /protein_id="NP_001157621.1"
                     /db_xref="CCDS:CCDS48630.1"
                     /db_xref="GeneID:21423"
                     /db_xref="MGI:MGI:98510"
                     /translation="MMNQSQRMAPVGSDKELSDLLDFSMMFPLPVANGKSRPASLGGT
                     QFAGSGLEDRPSSGSWGSSDQNSSSFDPSRTYSEGAHFSDSHSSLPPSTFLGAGLGGK
                     GSERNAYATFGRDTSVGTLSQAGFLPGELSLSSPGPLSPSGIKSSSQYYPSFPSNPRR
                     RAADGGLDTQPKKVRKVPPGLPSSVYPPSSGDSYSRDAAAYPSAKTPSSAYPSPFYVA
                     DGSLHPSAELWSTPSQVGFGPMLGDGSSPLPLAPGSSSVGSGTFGGLQQQDRMGYQLH
                     GSEVNGSLPAVSSFSAAPGTYSGTSGHTPPVSGAAAESLLGTRGTTASSSGDALGKAL
                     ASIYSPDHSSNNFSPSPSTPVGSPQGLPGTSQWPRAGAPSALSPNYDAGLHGLSKMED
                     RLDEAIHVLRSHAVGTASDLHGLLPGHGALTTSFTGPMSLGGRHAGLVGGSHPEEGLT
                     SGASLLHNHASLPSQPSSLPDLSQRPPDSYSGLGRAGTTAGASEIKREEKEDEEIASV
                     ADAEEDKKDLKVPRTRTSPDEDEDDLLPPEQKAEREKERRVANNARERLRVRDINEAF
                     KELGRMCQLHLSSEKPQTKLLILHQAVAVILSLEQQVRERNLNPKAACLKRREEEKVS
                     GVVGDPQLALSAAHPGLGEAHNPAGHL"
     exon            449..521
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            522..595
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            596..674
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            675..742
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            743..875
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            876..925
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            926..1028
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1029..1186
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1187..1322
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1323..1381
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1460
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1534
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1690
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1691..1817
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1818..1950
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2186
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2920
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2835..2840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /note="hexamer: TATAAA"
     polyA_site      2868
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /note="major polyA site"
     regulatory      2900..2905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /note="hexamer: ATTAAA"
     polyA_site      2920
                     /gene="Tcf3"
                     /gene_synonym="A1; ALF2; bHLHb21; E12; E12/E47; E2A; E47;
                     KA1; ME2; Pan1; Pan2; TCF-3; Tcfe2a; VDIR"
                     /note="major polyA site"
ORIGIN      
        1 atgtctcccg ccgcaggaag atgaggcagc gccggcggct gcgggcgtag cgggccaccg
       61 cgggccaccg ccgcgcgccg ccgcctctgc tacagtccct tcccgcgggg cctgctctga
      121 gagaagctcg agagagacca ggcgacgcga acgcgagtgg ggaggaggaa ggacgcgcga
      181 ccccgagccc tgcgcgctcc cgccgcccac gcgcgaccct cggggacgcg cccgccaccc
      241 ttttgtcccc ggggtccccg agggcggtgg gcagcaggga gccccggtgc acccggtgca
      301 tgcccccgcc cagcagggct gtctctagat ctgggggacg caccccagtt ccaacacctg
      361 ctgtcctggg tggatgatga accagtctca gagaatggca cccgtgggct ctgacaagga
      421 actgagtgac ctcctggact tcagcatgat gttcccgcta cctgtggcca atgggaagag
      481 ccggcccgcc tccctcgggg gaacccagtt tgcaggctca ggactggagg accgacccag
      541 ctcaggctcc tggggcagca gtgaccagaa cagttcttcc tttgacccta gccggacata
      601 cagcgaaggt gcccacttca gtgactccca cagcagcctg ccgccttcca cgttcctagg
      661 agctgggctt ggaggcaagg gcagtgagcg gaatgcctat gccacctttg ggagagacac
      721 cagtgttggc accttgagtc aggctggctt cctgccaggt gagctgagcc tcagcagtcc
      781 cgggccactg tccccatcgg gcatcaagag cagctcccag tattacccct cattccccag
      841 caaccctcgt cggagagctg cagatggtgg cctggatact cagccgaaga aggtccggaa
      901 ggttccgcct ggtctccctt cctcggtgta tccgcccagc tcaggtgaca gctacagcag
      961 ggatgctgca gcctacccct ccgccaagac ccccagcagc gcttacccct cccccttcta
     1021 cgtggcagat ggcagcctgc acccatcagc tgagctctgg agtacgccta gccaggtggg
     1081 ctttgggccc atgctaggtg acggctcttc ccctctgccc cttgcaccgg gcagcagctc
     1141 cgtgggcagt ggtacctttg ggggcctcca gcagcaggat cgcatgggct accagctgca
     1201 tggatctgag gttaatggct cgctcccagc tgtatccagc ttttcggctg cccctggcac
     1261 ttacagtggg acttccggcc acacgccccc tgtgagtggg gccgcagctg aaagcctcct
     1321 aggcacccga gggactacag ccagcagctc aggggatgcc cttgggaagg cactggcctc
     1381 gatctactcc ccggatcact ccagcaataa tttctcacct agcccctcaa cgcctgtggg
     1441 ttcaccccag ggcctgccag ggacatcaca gtggccccgg gcaggagcgc ccagtgcctt
     1501 atcccccaac tacgatgcag gtctccatgg cctgagcaag atggaggacc gcttggacga
     1561 ggccatccat gtcctgcgaa gccacgctgt tggcaccgct agcgatctcc atgggctttt
     1621 gcctggccat ggcgcactga ccacgagctt caccggcccc atgtcactgg gcgggcggca
     1681 tgccggcctg gtcgggggaa gccatcctga ggagggcctc acaagtgggg ccagtctttt
     1741 gcataaccat gccagcctcc ccagccagcc cagttccctc cctgacctct cacagagacc
     1801 tcccgactcc tatagtggac tcgggagggc aggcacaaca gcgggtgcca gcgagatcaa
     1861 gcgggaggag aaagaggatg aggaaatcgc atcagtagcc gacgccgaag aggacaagaa
     1921 ggacctgaag gtcccacgca cgcgcaccag cccagacgag gacgaggacg accttctccc
     1981 cccagagcag aaggcggagc gggagaagga gcgccgggtg gccaataatg cccgagagcg
     2041 cctgcgggtc cgcgacatca atgaggcctt taaggagctc ggccgcatgt gccagctgca
     2101 cctcagcagc gagaagccgc agaccaaact gctcatcctg caccaggccg tggccgtcat
     2161 cctcagcctg gagcagcagg tgcgagaacg caacctgaac cccaaagcag cctgcttgaa
     2221 gcggagggag gaggagaagg tgtctggcgt ggtcggggac ccacagctgg ccctgtcagc
     2281 cgcccacccg ggcctgggtg aggcccacaa cccagccggg cacctgtgag ccgtcacagc
     2341 ttcttcgttg gaccagggac caccatatct ctgcccgggg tgcatcagga cggttctgga
     2401 tgagacaggt ctccatcgaa gcatgagcag agagagggct ctggggacac ttcagggcct
     2461 ggggagggtg gcactgaaca gctccctgct tggccccagt gaccaagcag aaaagttcct
     2521 tcctctcggt taaccagaac tggaaacaaa gcagcatgct cccttttcaa aaaggaaaga
     2581 aagatgcctt aactatgtaa gacggaagag tcggaccgtg ccctggcagg gcggcctggg
     2641 actggcttct acttcagagc caccagcaca tcgtgcctaa gcatttttcg tttttttaaa
     2701 ggagaataaa ggaacattag ttttcagatt ttttttttaa atgtagacaa aagttagcaa
     2761 gaacgaggcc ttccgtgtct tttttttttc ccttagcttt tttttccgta tgttttgtaa
     2821 gcaacaaatt tttgtataaa agtctcatgt ctgtttctgt ttctagaatt tatcgtcata
     2881 tttcatggtc tacaaggtta ttaaagtagc attcaaaaga
//
