LOCUS       NM_053085               4101 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Mus musculus transcription factor 23 (Tcf23), mRNA.
ACCESSION   NM_053085
VERSION     NM_053085.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4101)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4101)
  AUTHORS   Minisy,F.M., Shawki,H.H., Fujita,T., Moustafa,A.M., Sener,R.,
            Nishio,Y., Shimada,I.S., Saitoh,S., Sugiura-Ogasawara,M. and
            Oishi,H.
  TITLE     Transcription Factor 23 is an Essential Determinant of Murine Term
            Parturition
  JOURNAL   Mol Cell Biol 44 (8), 316-333 (2024)
   PUBMED   39014976
  REMARK    GeneRIF: Transcription Factor 23 is an Essential Determinant of
            Murine Term Parturition.
REFERENCE   3  (bases 1 to 4101)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   4  (bases 1 to 4101)
  AUTHORS   Kommagani,R., Szwarc,M.M., Kovanci,E., Creighton,C.J.,
            O'Malley,B.W., Demayo,F.J. and Lydon,J.P.
  TITLE     A murine uterine transcriptome, responsive to steroid receptor
            coactivator-2, reveals transcription factor 23 as essential for
            decidualization of human endometrial stromal cells
  JOURNAL   Biol Reprod 90 (4), 75 (2014)
   PUBMED   24571987
  REMARK    GeneRIF: transcription factor 23 (Tcf23), a basic-helix-loop-helix
            transcription factor, is a new progesterone-induced target gene
            that requires SRC-2 for full induction.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4101)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4101)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   7  (bases 1 to 4101)
  AUTHORS   Stevens,J.D., Roalson,E.H. and Skinner,M.K.
  TITLE     Phylogenetic and expression analysis of the basic helix-loop-helix
            transcription factor gene family: genomic approach to cellular
            differentiation
  JOURNAL   Differentiation 76 (9), 1006-1022 (2008)
   PUBMED   18557763
REFERENCE   8  (bases 1 to 4101)
  AUTHORS   Tachibana,M., Narumi,O., Muguruma,K., Yamamoto,I., Shinkai,Y. and
            Yokota,Y.
  TITLE     Genomic organization and chromosomal mapping of the basic
            helix-loop-helix factor OUT (Tcf23/TCF23)
  JOURNAL   Cytogenet Cell Genet 94 (1-2), 23-25 (2001)
   PUBMED   11701948
  REMARK    GeneRIF: genomic organization and chromosome 2 mapping
REFERENCE   9  (bases 1 to 4101)
  AUTHORS   Narumi,O., Mori,S., Boku,S., Tsuji,Y., Hashimoto,N., Nishikawa,S.
            and Yokota,Y.
  TITLE     OUT, a novel basic helix-loop-helix transcription factor with an
            Id-like inhibitory activity
  JOURNAL   J Biol Chem 275 (5), 3510-3521 (2000)
   PUBMED   10652346
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC109606.11.
            
            On Nov 17, 2006 this sequence version replaced NM_053085.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF142405.1, AK030277.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-321               AC109606.11        192495-192815
            322-564             AC109606.11        193893-194135
            565-4101            AC109606.11        197300-200836
FEATURES             Location/Qualifiers
     source          1..4101
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 16.9 cM"
     gene            1..4101
                     /gene="Tcf23"
                     /gene_synonym="2010002O16Rik; bHLHa24; Out"
                     /note="transcription factor 23"
                     /db_xref="GeneID:69852"
                     /db_xref="MGI:MGI:1934960"
     exon            1..321
                     /gene="Tcf23"
                     /gene_synonym="2010002O16Rik; bHLHa24; Out"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..732
                     /gene="Tcf23"
                     /gene_synonym="2010002O16Rik; bHLHa24; Out"
                     /note="basic helix-loop-helix transcription factor OUT;
                     TCF-23; ovary, uterus and testis protein"
                     /codon_start=1
                     /product="transcription factor 23"
                     /protein_id="NP_444315.1"
                     /db_xref="CCDS:CCDS19168.1"
                     /db_xref="GeneID:69852"
                     /db_xref="MGI:MGI:1934960"
                     /translation="MSQEATEAPAMPGEGHGHNKAKARWLLGTDRKRSRINRTRQDLW
                     EDTSWSNHRLSRATSAPRGTRARGTAHGRSEASPENAARERTRVKTLRQAFLALQAAL
                     PAVPPDTKLSKLDVLVLATSYIAHLTRTLGHELPGPAWPPFVRGLRYLHPLKKWPMRS
                     RLYAGGLGCSDLDSTTAITTGQRCKDAELGSQDSVAAESLLTSPAFGNK"
     exon            322..564
                     /gene="Tcf23"
                     /gene_synonym="2010002O16Rik; bHLHa24; Out"
                     /inference="alignment:Splign:2.1.0"
     exon            565..4101
                     /gene="Tcf23"
                     /gene_synonym="2010002O16Rik; bHLHa24; Out"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3817..3822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcf23"
                     /gene_synonym="2010002O16Rik; bHLHa24; Out"
                     /note="hexamer: AATAAA"
     polyA_site      3836
                     /gene="Tcf23"
                     /gene_synonym="2010002O16Rik; bHLHa24; Out"
                     /note="major polyA site"
     regulatory      4074..4079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcf23"
                     /gene_synonym="2010002O16Rik; bHLHa24; Out"
                     /note="hexamer: AATAAA"
     polyA_site      4101
                     /gene="Tcf23"
                     /gene_synonym="2010002O16Rik; bHLHa24; Out"
                     /note="major polyA site"
ORIGIN      
        1 tggctggatg gccaccctgt cagggcgagc ttgagcccaa ggctcccttg ggtactgtgt
       61 ccctgctcta gggcctacag cctcatactt catgatagcg gcatgtcaca ggaggccaca
      121 gaggcaccag caatgccagg agaagggcat ggtcataata aggccaaggc acggtggctt
      181 ctaggcactg acaggaagag gagtcgcatc aacaggacaa ggcaggacct gtgggaggac
      241 actagctgga gcaatcacag actgagcaga gccacctctg cccctcgagg gaccagagct
      301 aggggaacag ctcatggcag gagtgaggcc agcccggaga acgcagcacg ggaacggact
      361 cgggtgaaga cgcttcgtca ggcctttctg gccctgcagg ctgctctgcc cgcagtgcca
      421 cccgacacca agctttccaa gttggatgtg ctcgtgctgg ccacaagcta cattgcccac
      481 ctcacccgga ccctcggcca tgagttgcct ggccctgcct ggcctccctt cgtgcgtgga
      541 ctccgttact tgcacccgct aaagaagtgg cccatgcgat ctcgtctcta tgcaggaggc
      601 ttgggatgct ctgacctcga ttccaccaca gctatcacga ccggccaaag atgcaaggat
      661 gcagagctgg ggtctcaaga ctctgtagcc gcagaaagtc tcctgacctc tccagctttt
      721 ggtaacaaat gaccaccatg atcatcctat tctcttagac ggtgcctctg cttaaggacc
      781 tggattttct gcctgcttta cttgtcttcc ccttgactcc cagcctttgg atttgtctca
      841 ggctcaagtt tcaagttcag gcttggcttc cagcaggcag aagaagcagt aatgacatca
      901 gtaatagaga gtccccagga aacccaggat ggagttcatt cacctttggc tcgtctatgg
      961 cagtgacagg aagtgacaga gaaaccgagg ttgacatggt tcagtcaagt tagggaatca
     1021 catccccctc ccccagggct cttcaagaca agaaggcagg aagacagaaa ttgctctgcc
     1081 aatacagcgt ggggttagga cagcagtagc ccctggtgct catgggcata gcagggtgcc
     1141 tgaagggctt ttggaagcag taagtatgaa cacgtctggg gtcaggtcac aaagccagac
     1201 aggaagctaa agaatggagt gatttctttt tgaaatttcc cgacgagatg tttattcaac
     1261 atcaaagagt ttagagtcct tctctctgga atatggtctc tccagtggtc ccttgtcacc
     1321 gccttcctgc accagggccc tgctgccttt cacatttcag cagatgaagc ccccagactt
     1381 acatggctga caatccaggg aaatttagct agtccaagct atctagggtc agatcatttt
     1441 atcccacagg cagctctgcc tttgctcaaa gaggcagcca ctcacagccc tgcctgtaaa
     1501 ggacagcaat ccttccagct ttatctcctt gatggcccaa gataaagcag gtgcatcact
     1561 ctcccggtgt gataagcagt gtctcccccc ccccccaccc tcatgttagt atgttagaaa
     1621 catcatctca cagggcttcg gcaagattcc tgtaccatca gcgatggggg ctttattggt
     1681 tttggtacaa tctgtgcatt tctatatatc agctcccaag gccaacttct ttccataggc
     1741 attgacatcc caggcttgcc ccaattcctg gtacaaggtg tcaaaagttt tctagagctt
     1801 tagtggcatt tgtccttgac cctgaagaaa taactggaga ccaaccatac actaaggtgg
     1861 gctttgcaag tcaggtatag tttcaggttg gtccctgggg tctgaacata gcaggaactg
     1921 cctgcctctc aaattttagt cactgaggcc aagtcgagtc ccagcaggct gctcatgagt
     1981 tgagtggagg ctctgacagg ctgggaggga ctgggcctgc tcctccatag ggatgacccc
     2041 ctaaggcatc caggaaaggg ggattgatgg ggtgactcag caagctgggg tggaggtaga
     2101 agacagaacg tcccagcctc agctgcatgg gctgtgggag agcagctgga ctatggctgg
     2161 gagccatggc ggacagcctc agccaaggcc aaacccataa atctgcctgg tcccacattt
     2221 ctcctagggg accctgagaa cttgtagaga gctgatccag cagctggaca gggccaagca
     2281 ggggcagcga ccaggtgtgg gagagcagga gccgtgttcc taacaagacc ataaaagccc
     2341 agtctgggtg ttctattttt aaaaccagat ggcagcatct ccctggttga gttggagggt
     2401 ggtaaaaagg agcgggcatg atttcttccc agtcggtagc atacgatctg tgtctgggca
     2461 ggctggggac tggctttggg tacctgctgg gagtctgctc atagcttaaa gcatctccca
     2521 gtaactgagg agagtttgat ctggagcttg aagtgtccac actgtccaga ctcaggcttt
     2581 tgcctccttc cacaaaccct tcagggctga ccacataaca caaccccggt ggagaatctg
     2641 aggagggaaa ggaggatgaa gttggcagag ggccaggtaa agaacaagtc ccaccaggaa
     2701 gggtgttttg ctttgttttg ttttgttttg ttttcttgac atggctcatt gtgtagccca
     2761 ggctgccttt gaacttgaaa tccttctgcc tcagcaagga ttatgggctc ataggcctat
     2821 accactctgc ccaattagga caaatttgga agtctgttcc cagagaatct gtttttcccc
     2881 actgactagg acagtcacct ggcctgagga ggcaaagggg ctggctgtgg ggaggggacc
     2941 aaaggaacac ccaggggcat gactggggcc tcaccctccc tgaccagcac aaggcttcca
     3001 tgggcaacac catgctggag actggggtct ctaagccaag ctgaaccagg aatggatccc
     3061 tttgtttcca cagcagagga agaagagcac ctgctgactg gagttctatg ctcgcctgtg
     3121 gtggggaggc agtagaagaa gctgaaatct gtctccaaca atagctattg ttccctaggc
     3181 acaaggatgt atagggaaga gtatgcaaaa gttaaggagc acagacagcc agtggtgtat
     3241 gtgtgccctg gtgagtcaga ggggtggccc ctgtgaccct agtccagttt tcttcctgtc
     3301 cctctcaggg tgaggtgcag gtagagtgaa gagggagatt tccctgttgc cctcctccaa
     3361 tggctaacct tggctgtcaa cttctttgga ctgagagatg aagagcgggt tagtaaagtg
     3421 ggcctctggc tttgtctgtg agggctttta cctcctgaat ggcttagtcc atggatggat
     3481 aaactgggca tggtggtgca tgccttcaat cctagcactc aggagacaga ggcaggagga
     3541 tctttgtgag ttggagacca gccaggccaa ccagtgagac actatctcaa aaaaaaaaaa
     3601 ttagactagt gggtggtggt agaattgtgg acaggctggg gctatgtgtt tcgggccgtg
     3661 tattgcccct gactccctcc atgtcgctgc cgcacccctg acatgacatt acatgagaaa
     3721 aagagccgtc ccttccacat actcctgata ccatgatgtt ttgcacaaag ccatgacacc
     3781 aagaagctat ggactgtctc tgagattttg gatcaaaata aatctttcct acttgacatt
     3841 gtttctatcc tgaattaggt cacagcaatg tggactctaa cggagagtga aaagatcaag
     3901 atggtttcta agaaataatc cctttttctc ctgggaagac cctggctagg atgaattaga
     3961 taatgtcggc ctctcccttt cataatacta gccctggaag cttattcaat tctagatcaa
     4021 gggagggcaa gtcagggcca gtagaccaaa tccaaccttt acttgtttgt atgaataaag
     4081 ttttattggg atagccctgt a
//
