LOCUS       NM_011542               1247 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus transcription elongation factor A (SII), 3 (Tcea3),
            mRNA.
ACCESSION   NM_011542
VERSION     NM_011542.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1247)
  AUTHORS   Ge,Y., Li,S., Hu,X.Y., Tong,H.L., Li,S.F. and Yan,Y.Q.
  TITLE     TCEA3 promotes differentiation of C2C12 cells via an Annexin
            A1-mediated transforming growth factor-beta signaling pathway
  JOURNAL   J Cell Physiol 234 (7), 10554-10565 (2019)
   PUBMED   30623413
  REMARK    GeneRIF: which is located in the cytoplasm and also promotes cell
            differentiation. Collectively, our results indicate that TCEA3
            promotes cell differentiation by interacting with ANXA1 and
            affecting transforming growth factor-b signaling pathways
REFERENCE   2  (bases 1 to 1247)
  AUTHORS   Kazim,N., Adhikari,A. and Davie,J.
  TITLE     The transcription elongation factor TCEA3 promotes the activity of
            the myogenic regulatory factors
  JOURNAL   PLoS One 14 (6), e0217680 (2019)
   PUBMED   31158246
  REMARK    GeneRIF: TCEA3 is a required co-factor for myogenic regulatory
            factors driven gene expression during myogenesis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1247)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   4  (bases 1 to 1247)
  AUTHORS   Park,K.S., Cha,Y., Kim,C.H., Ahn,H.J., Kim,D., Ko,S., Kim,K.H.,
            Chang,M.Y., Ko,J.H., Noh,Y.S., Han,Y.M., Kim,J., Song,J., Kim,J.Y.,
            Tesar,P.J., Lanza,R., Lee,K.A. and Kim,K.S.
  TITLE     Transcription elongation factor Tcea3 regulates the pluripotent
            differentiation potential of mouse embryonic stem cells via the
            Lefty1-Nodal-Smad2 pathway
  JOURNAL   Stem Cells 31 (2), 282-292 (2013)
   PUBMED   23169579
  REMARK    GeneRIF: Tcea3 critically regulates pluripotent differentiation of
            mouse embryonic stem cells as a molecular rheostat of
            Lefty1-Nodal-Smad2 signaling.
REFERENCE   5  (bases 1 to 1247)
  AUTHORS   Cha,Y., Heo,S.H., Ahn,H.J., Yang,S.K., Song,J.H., Suh,W. and
            Park,K.S.
  TITLE     Tcea3 regulates the vascular differentiation potential of mouse
            embryonic stem cells
  JOURNAL   Gene Expr 16 (1), 25-30 (2013)
   PUBMED   24397209
  REMARK    GeneRIF: Vascular endothelial growth factor A and VEGFC, major
            transcription factors that regulate vasculogenesis, are activated
            in Tcea3 knocked down mESCs
REFERENCE   6  (bases 1 to 1247)
  AUTHORS   Taira,Y., Kubo,T. and Natori,S.
  TITLE     Molecular cloning of cDNA and tissue-specific expression of the
            gene for SII-K1, a novel transcription elongation factor SII
  JOURNAL   Genes Cells 3 (5), 289-296 (1998)
   PUBMED   9685180
REFERENCE   7  (bases 1 to 1247)
  AUTHORS   Freund,C., Horsford,D.J. and McInnes,R.R.
  TITLE     Transcription factor genes and the developing eye: a genetic
            perspective
  JOURNAL   Hum Mol Genet 5 Spec No, 1471-1488 (1996)
   PUBMED   8875254
  REMARK    Review article
REFERENCE   8  (bases 1 to 1247)
  AUTHORS   Yeh,C.H. and Shatkin,A.J.
  TITLE     A HeLa-cell-encoded p21 is homologous to transcription elongation
            factor SII
  JOURNAL   Gene 143 (2), 285-287 (1994)
   PUBMED   8206389
REFERENCE   9  (bases 1 to 1247)
  AUTHORS   Kanai,A., Kuzuhara,T., Sekimizu,K. and Natori,S.
  TITLE     Heterogeneity and tissue-specific expression of eukaryotic
            transcription factor S-II-related protein mRNA
  JOURNAL   J Biochem 109 (5), 674-677 (1991)
   PUBMED   1917889
REFERENCE   10 (bases 1 to 1247)
  AUTHORS   Hirashima,S., Hirai,H., Nakanishi,Y. and Natori,S.
  TITLE     Molecular cloning and characterization of cDNA for eukaryotic
            transcription factor S-II
  JOURNAL   J Biol Chem 263 (8), 3858-3863 (1988)
   PUBMED   3346229
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK007437.1 and AK002319.1.
            
            On May 8, 2009 this sequence version replaced NM_011542.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK002319.1, AK007437.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1238              AK007437.1         7-1244
            1239-1247           AK002319.1         1223-1231
FEATURES             Location/Qualifiers
     source          1..1247
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 68.34 cM"
     gene            1..1247
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /note="transcription elongation factor A (SII), 3"
                     /db_xref="GeneID:21401"
                     /db_xref="MGI:MGI:1196908"
     exon            1..161
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1136
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /note="tissue-specific transcription factor S-II;
                     transcription elongation factor TFIIS.h; transcription
                     elongation factor S-II protein 3"
                     /codon_start=1
                     /product="transcription elongation factor A protein 3"
                     /protein_id="NP_035672.1"
                     /db_xref="CCDS:CCDS18803.1"
                     /db_xref="GeneID:21401"
                     /db_xref="MGI:MGI:1196908"
                     /translation="MGLEEELLRIAKKLEKMVSRKKTEGALDLLKKLNSCQMSIQLLQ
                     TTRIGVAVNGVRKHCSDKEVVSLAKVLIKNWKRLLDSPRTTKGEREEREKAKKEKGLG
                     CSDWKPEAGLSPPRKKGGGEPKTRRDSVDSRSSTTSSPKRPSLERSNSSKSKVETPTT
                     PSSPSTPTFAPAVCLLAPCYLTGDSVRDKCVEMLSAALKAEDNFKDYGVNCDKLASEI
                     EDHIYQELKSTDMKYRNRVRSRISNLKDPRNPGLRRNVLSGAISPELIAKMTAEEMAS
                     DELRELRNAMTQEAIREHQMAKTGGTTTDLLRCSKCKKKNCTYNQVQTRSADEPMTTF
                     VLCNECGNRWKFC"
     exon            162..224
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            225..330
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            331..469
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..532
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..696
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            697..753
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..908
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            909..1055
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1127
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /inference="alignment:Splign:2.1.0"
     exon            1128..1247
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1217
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /note="major polyA site"
     regulatory      1224..1229
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /note="hexamer: AATAAA"
     polyA_site      1246
                     /gene="Tcea3"
                     /gene_synonym="S-II; SII-K1"
                     /note="major polyA site"
ORIGIN      
        1 gagtgtccgg tgtgtttgcg gcccttgcgg ctcgcgcctt ggcgcccgct gctgccctgc
       61 gcccctaacc ccgccgtgcg ttgtggacca acatgggcct ggaagaggag ctgttgagga
      121 tcgccaaaaa gctggagaag atggtgtccc ggaagaagac ggaaggggcc ctggaccttc
      181 tgaagaagct gaacagttgc cagatgtcca tccagctgct acagaccacc aggatcggag
      241 tggcagtcaa cggagtccgc aagcactgct cagacaagga agtggtgtcc ttggccaaag
      301 tcctcattaa aaactggaag cggctgctgg actcccccag aaccaccaaa ggagaaagag
      361 aagaaagaga aaaagcgaag aaggagaaag gacttggctg ttcagactgg aaaccagaag
      421 caggcctttc tccaccaagg aagaaaggag ggggagagcc caaaactagg agagactctg
      481 tagactccag gtcatccacc acctcctctc caaaaaggcc ttcgctggaa agatccaaca
      541 gcagcaaatc taaagtggaa actcccacga cccccagcag cccctcaact cccacctttg
      601 cccccgctgt ctgtctcctg gccccctgct acctcaccgg ggactctgtc cgggacaaat
      661 gtgtggagat gctgtcagca gctctgaagg cagaagacaa tttcaaggac tatggagtca
      721 actgtgacaa gctggcctca gaaatagaag accatatcta tcaagaactc aagagcacag
      781 acatgaagta ccggaaccgt gtgcgcagcc gcatcagcaa cctgaaggac cccaggaacc
      841 caggcctgag gcggaatgtg ctcagtgggg ccatttcccc agagctcatt gccaagatga
      901 cagcggagga aatggccagt gatgagctga gggagctgag gaacgccatg actcaagagg
      961 ccatccgtga gcaccagatg gcgaagacag gcggcaccac cactgacctc ttgcggtgta
     1021 gcaagtgcaa gaagaagaat tgtacctata accaggtgca gacacgcagt gctgatgagc
     1081 ccatgaccac ttttgtctta tgcaatgaat gtgggaatcg ctggaagttc tgctgacgga
     1141 accacccaca aggatggcag aggataaggt gaagaagacc cagcaggaag cacagaccac
     1201 gtgacccaga gcaaaaataa ataaataaat acaaattcaa atgacag
//
