LOCUS       NM_011541               2727 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus transcription elongation factor A (SII) 1 (Tcea1),
            transcript variant 2, mRNA.
ACCESSION   NM_011541
VERSION     NM_011541.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2727)
  AUTHORS   Siametis,A., Stratigi,K., Giamaki,D., Chatzinikolaou,G.,
            Akalestou-Clocher,A., Goulielmaki,E., Luke,B., Schumacher,B. and
            Garinis,G.A.
  TITLE     Transcription stress at telomeres leads to cytosolic DNA release
            and paracrine senescence
  JOURNAL   Nat Commun 15 (1), 4061 (2024)
   PUBMED   38744897
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2727)
  AUTHORS   Yang,T., Cui,H., Wen,M., Zuber,J., Kogan,S.C. and Wei,G.
  TITLE     TCEA1 regulates the proliferative potential of mouse myeloid cells
  JOURNAL   Exp Cell Res 370 (2), 551-560 (2018)
   PUBMED   30009791
  REMARK    GeneRIF: Tcea1 was identified as a gene which can influence the
            proliferative potential, survival and differentiation of myeloid
            cells
REFERENCE   3  (bases 1 to 2727)
  AUTHORS   Park,K.S., Cha,Y., Kim,C.H., Ahn,H.J., Kim,D., Ko,S., Kim,K.H.,
            Chang,M.Y., Ko,J.H., Noh,Y.S., Han,Y.M., Kim,J., Song,J., Kim,J.Y.,
            Tesar,P.J., Lanza,R., Lee,K.A. and Kim,K.S.
  TITLE     Transcription elongation factor Tcea3 regulates the pluripotent
            differentiation potential of mouse embryonic stem cells via the
            Lefty1-Nodal-Smad2 pathway
  JOURNAL   Stem Cells 31 (2), 282-292 (2013)
   PUBMED   23169579
REFERENCE   4  (bases 1 to 2727)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2727)
  AUTHORS   Herriges,J.C., Yi,L., Hines,E.A., Harvey,J.F., Xu,G., Gray,P.A.,
            Ma,Q. and Sun,X.
  TITLE     Genome-scale study of transcription factor expression in the
            branching mouse lung
  JOURNAL   Dev Dyn 241 (9), 1432-1453 (2012)
   PUBMED   22711520
REFERENCE   6  (bases 1 to 2727)
  AUTHORS   Taira,Y., Kubo,T. and Natori,S.
  TITLE     Molecular cloning of cDNA and tissue-specific expression of the
            gene for SII-K1, a novel transcription elongation factor SII
  JOURNAL   Genes Cells 3 (5), 289-296 (1998)
   PUBMED   9685180
REFERENCE   7  (bases 1 to 2727)
  AUTHORS   Sasaki,N., Nagaoka,S., Itoh,M., Izawa,M., Konno,H., Carninci,P.,
            Yoshiki,A., Kusakabe,M., Moriuchi,T., Muramatsu,M., Okazaki,Y. and
            Hayashizaki,Y.
  TITLE     Characterization of gene expression in mouse blastocyst using
            single-pass sequencing of 3995 clones
  JOURNAL   Genomics 49 (2), 167-179 (1998)
   PUBMED   9598303
  REMARK    Erratum:[Genomics 1998 Dec 15;54(3):583]
REFERENCE   8  (bases 1 to 2727)
  AUTHORS   Yeh,C.H. and Shatkin,A.J.
  TITLE     A HeLa-cell-encoded p21 is homologous to transcription elongation
            factor SII
  JOURNAL   Gene 143 (2), 285-287 (1994)
   PUBMED   8206389
REFERENCE   9  (bases 1 to 2727)
  AUTHORS   Kanai,A., Kuzuhara,T., Sekimizu,K. and Natori,S.
  TITLE     Heterogeneity and tissue-specific expression of eukaryotic
            transcription factor S-II-related protein mRNA
  JOURNAL   J Biochem 109 (5), 674-677 (1991)
   PUBMED   1917889
REFERENCE   10 (bases 1 to 2727)
  AUTHORS   Hirashima,S., Hirai,H., Nakanishi,Y. and Natori,S.
  TITLE     Molecular cloning and characterization of cDNA for eukaryotic
            transcription factor S-II
  JOURNAL   J Biol Chem 263 (8), 3858-3863 (1988)
   PUBMED   3346229
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ059479.1, AK136035.1 and BC083127.1.
            
            On May 1, 2009 this sequence version replaced NM_011541.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct N-terminus compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC083127.1, BC061490.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               CJ059479.1         2-108
            108-2456            AK136035.1         1-2349
            2457-2727           BC083127.1         2320-2590
FEATURES             Location/Qualifiers
     source          1..2727
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 1.79 cM"
     gene            1..2727
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /note="transcription elongation factor A (SII) 1"
                     /db_xref="GeneID:21399"
                     /db_xref="MGI:MGI:1196624"
     exon            1..283
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /inference="alignment:Splign:2.1.0"
     CDS             221..1126
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transcription elongation factor A protein 1; transcription
                     elongation factor TFIIS.o; transcription elongation factor
                     S-II protein 1"
                     /codon_start=1
                     /product="transcription elongation factor A protein 1
                     isoform 2"
                     /protein_id="NP_035671.1"
                     /db_xref="CCDS:CCDS35505.1"
                     /db_xref="GeneID:21399"
                     /db_xref="MGI:MGI:1196624"
                     /translation="MEDEVVRIAKKMDKMVQKKNAAGALDLLKELKNIPMTLELLQST
                     RIGMSVNALRKQSTDEEVTSLAKSLIKSWKKLLDGPSTDKDPEEKKKEPAISSQNSPE
                     AREESSSSSNVSSRKDETNARDTYVSSFPRAPSTSDSVRLKCREMLAAALRTGDDYVA
                     IGADEEELGSQIEEAIYQEIRNTDMKYKNRVRSRISNLKDAKNPNLRKNVLCGNIPPD
                     LFARMTAEEMASDELKEMRKNLTKEAIREHQMAKTGGTQTDLFTCGKCKKKNCTYTQV
                     QTRSADEPMTTFVVCNECGNRWKFC"
     exon            284..346
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /inference="alignment:Splign:2.1.0"
     exon            347..452
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /inference="alignment:Splign:2.1.0"
     exon            453..540
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /inference="alignment:Splign:2.1.0"
     exon            541..686
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /inference="alignment:Splign:2.1.0"
     exon            687..743
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /inference="alignment:Splign:2.1.0"
     exon            744..898
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1045
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1046..1117
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..2671
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1320..1325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /note="hexamer: CATAAA"
     polyA_site      1337
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /note="major polyA site"
     regulatory      1501..1506
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /note="hexamer: TATAAA"
     polyA_site      1523
                     /gene="Tcea1"
                     /gene_synonym="S-II"
                     /note="major polyA site"
ORIGIN      
        1 acttctactt tccagtctcc tgcgatcgat tcgtagtgcc tgtgtggcgc gcgcggtgct
       61 tgactggcac ggcctagggg gcggagcgct tatccctgcc gccgcgggcc gggtctgtga
      121 ggaaggccta ggccagcggc ttcgcggctt gtccaacgtc cgcgcagctt ctctcgcttc
      181 ccgtccgctg tggccgggcg aggggaggcc ttccggagcc atggaggacg aggtggttcg
      241 cattgccaag aagatggaca aaatggtgca gaaaaagaat gcggctggcg cattggattt
      301 gctgaaagag cttaagaata ttcccatgac cctagaattg ctacagtcca caagaattgg
      361 aatgtctgtc aatgcccttc gcaagcagag cacagatgaa gaagtcacct ctctagccaa
      421 gtctctcatc aaatcctgga aaaaattatt agatggacca tcaactgata aagaccctga
      481 agaaaagaaa aaagagcctg caatttcatc acagaatagc cctgaagcaa gagaagaaag
      541 tagttccagc agcaatgtaa gcagcagaaa ggatgagaca aatgctcgag atacatatgt
      601 ttcatctttt cctcgggcac caagcacttc tgattctgtg cgattaaaat gtagggagat
      661 gcttgctgca gctcttcgga caggagatga ttatgttgca attggagctg atgaagaaga
      721 actgggatct cagattgagg aagctatata tcaagaaata aggaatacag acatgaaata
      781 caaaaacaga gtacgaagta ggatatcaaa tcttaaagat gcaaagaatc caaatttaag
      841 gaaaaatgtg ctgtgtggga atattcctcc tgatctattt gctagaatga cagcagagga
      901 aatggctagt gatgagctca aagagatgag gaaaaacctg accaaagaag ccatcaggga
      961 gcatcagatg gccaagactg gtgggaccca gactgacttg ttcacttgtg gcaaatgtaa
     1021 aaagaagaac tgcacttata cacaggtgca aactcgtagt gctgatgaac caatgacaac
     1081 atttgttgta tgtaatgaat gtggaaatcg gtggaagttc tgttgagttt ggaagaattg
     1141 gcaaagtatc tggaccatta agaaaaacta attttgtaat tagctttaaa attaagccag
     1201 gcaactcgtt tccttgcaag tgaaatttgt aaacaacata catctcatgg gttggtcttt
     1261 gttgttcacc tgacagtctg tcttaaatgc cttctgtggt ctcagatcag ctgggagacc
     1321 ataaaataat gatataatgt gttgctttgt ttttctcttt cataagttga tgttgcattt
     1381 tattaaatat taacttttta tagcctagaa cacaaaaatt ttgttgatct gttaatgcat
     1441 aaagataaat tgcttttctc attggtatgt acctaaacat gttaaaagga aaaggcataa
     1501 tataaatttt tagagttacc aaatgtagtg tgtattccaa tagtatgtgg ccagcttatc
     1561 aaagttgtgc acacaatttg aactagcata ttactttact cttaattact gtgctcacaa
     1621 agcctcggat ccttggatct cttgcatctg tgactaacca cagtgatcat ttcttttatt
     1681 tctcatacat atataatacc attttttaat agattttact ctgaaaacgg acttggttta
     1741 ttttatttga ctttgtgcta tattttagtt ttatagaact ctgttataat ttcctaagct
     1801 tttcataaag cccaccacag gtatacttct gatgaattgt ccccaatagg aagacatgct
     1861 atgaagaaaa tgttagtatc ttagtagagt tcctggaggc agcatgactg tacttgcact
     1921 tggaaaccta ctgaccaagg attaagcctg agaactgtgt aaatcattaa gctatgctct
     1981 ttgtgtatgg aggttgcaaa aaaaggcacc tcctttagac tgaatctttt gtgctgaaat
     2041 ttttcttaca tgatgatgtc aagccagctg aaatgtaggc tgtagcaaat agttttacaa
     2101 aacatatttc acaattaagt tttacttttt aaatgtgtcc cacttgtttt gctagtaata
     2161 agcagtggtt ttcacatcgt cttcctgaca cagatgttgt aatgcatata gtaaaggcca
     2221 cttttataaa ttaagtgctt ctgcctgtgt tcagactcct gtgtaaaaac cgttgcacaa
     2281 gctttgcact cttctatgct ctgctttgta gaccgtttgt cataacatgg aaaacaatat
     2341 gtccatgtta aaaggattgg tctgccgggc gtggtggccc acacctttaa tcccagaact
     2401 cgggaggcag aggcaggcgg atttctgagt ttgaggccag cctggtctac agagtgagtt
     2461 ccaggacagc cagggctata cagagaaacc ctgtctcaac ccccctcccc cccccaaaaa
     2521 aaagattggt ccatggataa tttctgtcac tttaaaaata aagtacagtt tgaaagaatt
     2581 agtttaaaag taataaggtt aaaatagtcc cacttttaag tgatccattt taaaatttgt
     2641 aaatcaataa agttttttgt tgttaaacat aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2701 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
