LOCUS       NM_011540                948 bp    mRNA    linear   ROD 12-JUN-2024
DEFINITION  Mus musculus titin-cap (Tcap), mRNA.
ACCESSION   NM_011540
VERSION     NM_011540.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 948)
  AUTHORS   Li,C., Warren,D.T., Zhou,C., De Silva,S., Wilson,D.G.S.,
            Garcia-Maya,M., Wheeler,M.A., Meinke,P., Sawyer,G., Ehler,E.,
            Wehnert,M., Rao,L., Zhang,Q. and Shanahan,C.M.
  TITLE     Nesprin-2 is a novel scaffold protein for telethonin and FHL-2 in
            the cardiomyocyte sarcomere
  JOURNAL   J Biol Chem 300 (5), 107254 (2024)
   PUBMED   38569934
  REMARK    GeneRIF: Nesprin-2 is a novel scaffold protein for telethonin and
            FHL-2 in the cardiomyocyte sarcomere.
REFERENCE   2  (bases 1 to 948)
  AUTHORS   Lim,J.Y., Kim,E., Douglas,C.M., Wirianto,M., Han,C., Ono,K.,
            Kim,S.Y., Ji,J.H., Tran,C.K., Chen,Z., Esser,K.A. and Yoo,S.H.
  TITLE     The circadian E3 ligase FBXL21 regulates myoblast differentiation
            and sarcomere architecture via MYOZ1 ubiquitination and NFAT
            signaling
  JOURNAL   PLoS Genet 18 (12), e1010574 (2022)
   PUBMED   36574402
  REMARK    GeneRIF: The circadian E3 ligase FBXL21 regulates myoblast
            differentiation and sarcomere architecture via MYOZ1 ubiquitination
            and NFAT signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 948)
  AUTHORS   Cao,X., Yan,Y., Luo,X., Yang,X., Cui,H., Yang,Y. and Li,H.
  TITLE     Analyses of the circadian clock genes expression in whole embryos
            and maternal major tissues of mice
  JOURNAL   J Mol Histol 53 (2), 473-482 (2022)
   PUBMED   35149920
REFERENCE   4  (bases 1 to 948)
  AUTHORS   Lewis,H.R., Eminaga,S., Gautel,M. and Avkiran,M.
  TITLE     Phosphorylation at Serines 157 and 161 Is Necessary for Preserving
            Cardiac Expression Level and Functions of Sarcomeric Z-Disc Protein
            Telethonin
  JOURNAL   Front Physiol 12, 732020 (2021)
   PUBMED   34566695
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 948)
  AUTHORS   Wirianto,M., Yang,J., Kim,E., Gao,S., Paudel,K.R., Choi,J.M.,
            Choe,J., Gloston,G.F., Ademoji,P., Parakramaweera,R., Jin,J.,
            Esser,K.A., Jung,S.Y., Geng,Y.J., Lee,H.K., Chen,Z. and Yoo,S.H.
  TITLE     The GSK-3beta-FBXL21 Axis Contributes to Circadian TCAP Degradation
            and Skeletal Muscle Function
  JOURNAL   Cell Rep 32 (11), 108140 (2020)
   PUBMED   32937135
  REMARK    GeneRIF: The GSK-3beta-FBXL21 Axis Contributes to Circadian TCAP
            Degradation and Skeletal Muscle Function.
REFERENCE   6  (bases 1 to 948)
  AUTHORS   Frey,N. and Olson,E.N.
  TITLE     Calsarcin-3, a novel skeletal muscle-specific member of the
            calsarcin family, interacts with multiple Z-disc proteins
  JOURNAL   J Biol Chem 277 (16), 13998-14004 (2002)
   PUBMED   11842093
REFERENCE   7  (bases 1 to 948)
  AUTHORS   Moreira,E.S., Wiltshire,T.J., Faulkner,G., Nilforoushan,A.,
            Vainzof,M., Suzuki,O.T., Valle,G., Reeves,R., Zatz,M.,
            Passos-Bueno,M.R. and Jenne,D.E.
  TITLE     Limb-girdle muscular dystrophy type 2G is caused by mutations in
            the gene encoding the sarcomeric protein telethonin
  JOURNAL   Nat Genet 24 (2), 163-166 (2000)
   PUBMED   10655062
REFERENCE   8  (bases 1 to 948)
  AUTHORS   Mason,P., Bayol,S. and Loughna,P.T.
  TITLE     The novel sarcomeric protein telethonin exhibits developmental and
            functional regulation
  JOURNAL   Biochem Biophys Res Commun 257 (3), 699-703 (1999)
   PUBMED   10208846
REFERENCE   9  (bases 1 to 948)
  AUTHORS   Gregorio,C.C., Trombitas,K., Centner,T., Kolmerer,B., Stier,G.,
            Kunke,K., Suzuki,K., Obermayr,F., Herrmann,B., Granzier,H.,
            Sorimachi,H. and Labeit,S.
  TITLE     The NH2 terminus of titin spans the Z-disc: its interaction with a
            novel 19-kD ligand (T-cap) is required for sarcomeric integrity
  JOURNAL   J Cell Biol 143 (4), 1013-1027 (1998)
   PUBMED   9817758
REFERENCE   10 (bases 1 to 948)
  AUTHORS   Valle,G., Faulkner,G., De Antoni,A., Pacchioni,B., Pallavicini,A.,
            Pandolfo,D., Tiso,N., Toppo,S., Trevisan,S. and Lanfranchi,G.
  TITLE     Telethonin, a novel sarcomeric protein of heart and skeletal muscle
  JOURNAL   FEBS Lett 415 (2), 163-168 (1997)
   PUBMED   9350988
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AJ223854.1.
            
            On Jan 27, 2007 this sequence version replaced NM_011540.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ223854.1, AK010167.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-948               AJ223854.1         1-948
FEATURES             Location/Qualifiers
     source          1..948
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 61.75 cM"
     gene            1..948
                     /gene="Tcap"
                     /note="titin-cap"
                     /db_xref="GeneID:21393"
                     /db_xref="MGI:MGI:1330233"
     exon            1..146
                     /gene="Tcap"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..540
                     /gene="Tcap"
                     /note="titin cap protein"
                     /codon_start=1
                     /product="telethonin"
                     /protein_id="NP_035670.2"
                     /db_xref="CCDS:CCDS25346.1"
                     /db_xref="GeneID:21393"
                     /db_xref="MGI:MGI:1330233"
                     /translation="MATSELSCQVSEENQERREAFWAEWKDLTLSTRPEEGCSLHEED
                     TQRHETYHRQGQCQAVVQRSPWLVMRLGILGRGLQEYQLPYQRVLPLPIFTPTKVGAS
                     KEEREETPIQLRELLALETALGGQCVERQDVAEITKQLPPVVPVSKPGPLRRTLSRSM
                     SQEAQRG"
     exon            147..948
                     /gene="Tcap"
                     /inference="alignment:Splign:2.1.0"
     regulatory      928..933
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcap"
                     /note="hexamer: AATAAA"
     polyA_site      945
                     /gene="Tcap"
                     /note="major polyA site"
ORIGIN      
        1 aggagcagga catagcagag ggagcaatca gaaatcatgg ccacttcaga gctgagctgc
       61 caagtgtctg aggagaacca ggaacgcagg gaagccttct gggctgagtg gaaagacctg
      121 actctgtcta cccggccgga agagggatgc tccttgcacg aggaggatac acagaggcat
      181 gagacctacc accggcaggg acagtgtcag gcggtggtac agcgctcacc atggctggtg
      241 atgcgcctgg gtatcctcgg ccgtgggcta caggaatacc agctgccgta ccagcgggtg
      301 ctgcccctac ccatcttcac gcccaccaag gtgggggcct ccaaggagga gcgcgaggag
      361 acccccatcc agcttcggga gctgctggcc ctggagacgg ccctgggcgg ccagtgcgtg
      421 gagcgccagg acgtggctga gatcacaaag cagcttcccc ctgtggtgcc agtcagcaaa
      481 cccgggcccc tgcgccgtac cctgtctcga tccatgtctc aggaagctca gagaggctga
      541 gatggactgt gtgactcaga ctccactgtg tctgtctcag gctaggcact tcctggctag
      601 gacaatggag gagagctgct ggcagtggct gctttgtagt ttgcccagag gtgggagcta
      661 tgggaggagg gagcccgagg ccaggatgcc taggtgtcct gagtccccac agggaaggga
      721 gcgaggatgg cgggcactag gagtggagag ctgagcaccc tcagccccag aagaagagac
      781 aagagatcct ggtgagagga gaggcccctg ggaatggcct gctcgggaac agatggacta
      841 ggagaaggat gtgcaacgct ctggaaagga gggggatgtg aagagggtgg aagtgggcag
      901 gcccccagca ccctctggta gcactgcaat aaatgctcag ccatgttc
//
