LOCUS       NM_203396               3110 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus TRPM8 channel-associated factor 3 (Tcaf3), mRNA.
ACCESSION   NM_203396
VERSION     NM_203396.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3110)
  AUTHORS   Leonard,J.D., Gilmore,D.C., Dileepan,T., Nawrocka,W.I., Chao,J.L.,
            Schoenbach,M.H., Jenkins,M.K., Adams,E.J. and Savage,P.A.
  TITLE     Identification of Natural Regulatory T Cell Epitopes Reveals
            Convergence on a Dominant Autoantigen
  JOURNAL   Immunity 47 (1), 107-117 (2017)
   PUBMED   28709804
REFERENCE   2  (bases 1 to 3110)
  AUTHORS   Gkika,D., Lemonnier,L., Shapovalov,G., Gordienko,D., Poux,C.,
            Bernardini,M., Bokhobza,A., Bidaux,G., Degerny,C., Verreman,K.,
            Guarmit,B., Benahmed,M., de Launoit,Y., Bindels,R.J., Fiorio Pla,A.
            and Prevarskaya,N.
  TITLE     TRP channel-associated factors are a novel protein family that
            regulates TRPM8 trafficking and activity
  JOURNAL   J Cell Biol 208 (1), 89-107 (2015)
   PUBMED   25559186
REFERENCE   3  (bases 1 to 3110)
  AUTHORS   Setiady,Y.Y., Ohno,K., Samy,E.T., Bagavant,H., Qiao,H., Sharp,C.,
            She,J.X. and Tung,K.S.
  TITLE     Physiologic self antigens rapidly capacitate autoimmune
            disease-specific polyclonal CD4+ CD25+ regulatory T cells
  JOURNAL   Blood 107 (3), 1056-1062 (2006)
   PUBMED   16223778
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AY528666.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY528666.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3110
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 20.8 cM"
     gene            1..3110
                     /gene="Tcaf3"
                     /gene_synonym="Eapa2; Fam115e"
                     /note="TRPM8 channel-associated factor 3"
                     /db_xref="GeneID:403088"
                     /db_xref="MGI:MGI:3042585"
     exon            1..719
                     /gene="Tcaf3"
                     /gene_synonym="Eapa2; Fam115e"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2841
                     /gene="Tcaf3"
                     /gene_synonym="Eapa2; Fam115e"
                     /note="experimental autoimmune prostatitis antigen 2;
                     protein FAM115E; family with sequence similarity 115,
                     member E"
                     /codon_start=1
                     /product="TRPM8 channel-associated factor 3"
                     /protein_id="NP_981933.1"
                     /db_xref="CCDS:CCDS20074.1"
                     /db_xref="GeneID:403088"
                     /db_xref="MGI:MGI:3042585"
                     /translation="MATTPDAAFETLMNGVTSWDLPKEPIPSELLLTGESAFPVMVND
                     KGQVLIAASSYGQGRLVVVSHESYLLHDGLVPFLLNVVKWLCPCPGAPIAVHSSLASL
                     VNILGDSGINALVQPEPGEALGVYCIDAYNDALTEKLIQFLKNGGGLLIGGQALNWAA
                     HHGHDKVLSIFPGNQVTSVAGVYFTDISANRDWFKVSKEIPNLRLYVQCEDELEDDQQ
                     QLLKGMSEIYIEAGVIPSQLLVHGQRAFPLGVDNSLNCFLAAARYGRGRVVLGGNESL
                     ILNQTMLPFVLNALHWLMGNQTGRIGLASDMKVLKSMLPNSSFQWSESELLTSDLSVF
                     CCCSLANIDSEEVEEFVAEGGGLLIGAEAWSWGRRNPYSSCMTQYPDNIVLKRFGLGI
                     TSHVAQRGSFPFPNPEGTNYHFRRALSQFESVIYSRGSSLHESWLNKLSQDCFYMFQM
                     THQRISIYDSVKKHALKMIQSKDFPSVTEQYPIARGSSQAFLLSLAYELFKSGVDRSQ
                     LLPPPALLPPTESPITIKISTDNDNSWVSTGLYLPEGQVAQVLLPSEATHAKLKVLIG
                     CHRDNISQARTYFRPPVMTYVYHLTSSQTSISWLYGGLLYIMVPNKYNQDNVSVTIRG
                     AVSAPYFRLGKTTQEEWKNLITHSKAPWGELATDNIILTIPTVNLKELQDPYPLLQLW
                     DKMVRAVAKLAARPFPFQRAERVVLDKQISFGFLHSGYPIMGLISIVEGIISEFKIRS
                     HGIWGVIHELGHNHQKSGWTFPPHTTEALCNLWTIYVHETVLNIPREQAHPSLNPELR
                     RQRIKYHLNKGAPLSNWIMWTALETYLQLQEGFGWEPFIQVFADYRTLSGLPQNNEDK
                     MNLWVKKFSEAVHKNLAPFFEAWGWPVKYAVAKSLASLPEWQENPMKRYTAEGTEGRE
                     "
     exon            720..1684
                     /gene="Tcaf3"
                     /gene_synonym="Eapa2; Fam115e"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1782
                     /gene="Tcaf3"
                     /gene_synonym="Eapa2; Fam115e"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1996
                     /gene="Tcaf3"
                     /gene_synonym="Eapa2; Fam115e"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2236
                     /gene="Tcaf3"
                     /gene_synonym="Eapa2; Fam115e"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2574
                     /gene="Tcaf3"
                     /gene_synonym="Eapa2; Fam115e"
                     /inference="alignment:Splign:2.1.0"
     exon            2575..3110
                     /gene="Tcaf3"
                     /gene_synonym="Eapa2; Fam115e"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtaagact ctgtgaaaac acttcttgat ttcatttatt tagcatctgt tcactcatcc
       61 tgagtctctg cttcctctgc agcagctggc agaaccatgg caacaacccc tgatgctgct
      121 tttgagaccc tcatgaatgg agtgaccagc tgggatcttc ccaaagaacc cattcccagt
      181 gaacttctcc ttactgggga gtcagccttc ccagtgatgg tgaatgacaa gggccaggtg
      241 ctcattgctg cctcttccta tggacaaggc cgcctggtgg tcgtatccca tgagagctac
      301 ctgctgcacg atggcttggt tccatttctt ctcaatgtgg tgaaatggct ctgcccctgc
      361 ccaggggctc ccatagcggt gcattcttcc ttagcatcat tagttaacat cctaggtgat
      421 tctgggataa atgccttggt tcagcctgag cctggagagg ctctgggagt ttattgcatt
      481 gatgcctaca atgatgcctt gactgagaag ctgatccaat tcctgaagaa tggaggaggt
      541 ttgctaattg gaggccaggc tttgaattgg gctgctcacc atggccatga taaagtgcta
      601 tccatttttc ctggaaacca ggtgacaagt gtggctggag tatatttcac tgatatctct
      661 gcgaatagag actggttcaa ggtttctaag gagataccca atctcagact ctatgtccag
      721 tgtgaggatg agctcgagga cgaccagcag cagctcctga aagggatgtc tgagatatac
      781 atcgaggcgg gtgtaatccc ctcccagctg cttgtgcatg gacagcgggc atttcccttg
      841 ggagtagaca attcactcaa ttgctttctt gcagctgccc gctatggccg tggtcgggtg
      901 gtgctggggg gaaatgagag tctcatactt aatcaaacta tgctgccatt tgtgcttaat
      961 gctttacact ggctgatggg gaaccagaca ggcagaattg ggttagcttc agatatgaaa
     1021 gtactgaagt ctatgttacc aaacagcagt ttccagtgga gtgaatcaga acttctaacc
     1081 agtgacttga gcgtgttttg ctgctgctca ctcgccaata tagattccga ggaggtagag
     1141 gaatttgttg cagaaggtgg aggcttgcta attggtgcag aggcctggtc gtggggccgc
     1201 aggaatccat actctagctg tatgactcaa tacccagata acatcgtcct taagcgcttt
     1261 ggccttggta tcactagcca tgtggcccag cgaggcagtt tcccattccc caatcctgaa
     1321 gggacaaact atcactttcg gagagccctg tctcaatttg agtccgtgat ctacagccgg
     1381 gggagtagct tacacgagag ctggctgaat aagctctcac aagattgttt ctacatgttt
     1441 caaatgaccc atcagaggat ttccatctac gactctgtga agaaacatgc tctgaaaatg
     1501 atccaaagca aggactttcc aagtgtgact gaacaatacc cgatcgcaag gggcagctca
     1561 caggcttttc ttctatccct ggcttatgaa ttattcaaat ccggagttga cagatctcag
     1621 ctacttcccc ctcccgcctt actacctcct acagaatctc caataaccat taaaataagc
     1681 acagacaatg acaactcctg ggtgagcact ggactgtact tacctgaagg gcaggttgca
     1741 caagtattac ttcccagtga agctactcat gccaagctga aggtcctcat tggctgccac
     1801 agggacaaca taagccaagc aagaacttac ttccgtcccc ctgtgatgac ctatgtgtac
     1861 cacttaactt catcccagac atccatctcc tggctctatg ggggccttct ctacatcatg
     1921 gtccccaaca aatataatca ggataatgtg tctgtcacca tccgtggggc tgtatctgct
     1981 ccatacttca ggctgggtaa gacgacccag gaggaatgga agaatcttat cacacacagc
     2041 aaagctccgt ggggagaact agccacagac aatatcatcc tgacaattcc aacggtaaac
     2101 ctcaaggagc ttcaggaccc ctatccactg ctccaactct gggacaagat ggtaagggct
     2161 gtagccaagc tggcagcccg gcccttccct tttcagagag ctgagagggt cgtacttgac
     2221 aagcagattt cattcggttt ccttcattct ggatacccca tcatgggcct aattagtata
     2281 gtagaaggca tcatcagcga gttcaaaata agatcacatg gcatttgggg tgtgatacat
     2341 gaactgggcc acaaccatca gaagtctgga tggacttttc cacctcacac caccgaagct
     2401 ttgtgcaatc tctggactat ttatgtgcat gagacagttt taaacatccc cagggagcaa
     2461 gcccatcctt ctctgaatcc tgagcttagg aggcagagga tcaaatacca cctgaacaag
     2521 ggagcacctc tgagcaactg gattatgtgg acagctctag aaacttatct ccagctccag
     2581 gagggctttg ggtgggagcc attcatccag gtctttgctg actaccgaac cctctctggc
     2641 cttcctcaaa acaatgaaga caagatgaat ctgtgggtga agaagttctc tgaggctgtg
     2701 cataagaatc tggcaccttt ctttgaagcc tggggctggc ctgtcaaata tgctgtggct
     2761 aaaagcctag cctctttgcc agagtggcag gaaaacccca tgaaaaggta tacagctgaa
     2821 ggtacagaag gcagagagtg aacacacact atctcttctc tctgggagaa gaatatttat
     2881 gtgatgcaac cgaaaagccc taatgattca agattcaatt ttagggacca cccccgttat
     2941 tagaatcatc ttaattcttt tgtaaggtag agattaaatt acacagcagc tttcaaattt
     3001 tgcaatatag atgactcaat atattgcctc tagattaatc ttaaactgtg agatttgtat
     3061 cttgaccttc ttgtttagca tctttcatgt tctgtttgtt tacaaaagct
//
