LOCUS       NM_146174               4257 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus TRPM8 channel-associated factor 2 (Tcaf2), mRNA.
ACCESSION   NM_146174
VERSION     NM_146174.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4257)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4257)
  AUTHORS   Gkika,D., Lemonnier,L., Shapovalov,G., Gordienko,D., Poux,C.,
            Bernardini,M., Bokhobza,A., Bidaux,G., Degerny,C., Verreman,K.,
            Guarmit,B., Benahmed,M., de Launoit,Y., Bindels,R.J., Fiorio Pla,A.
            and Prevarskaya,N.
  TITLE     TRP channel-associated factors are a novel protein family that
            regulates TRPM8 trafficking and activity
  JOURNAL   J Cell Biol 208 (1), 89-107 (2015)
   PUBMED   25559186
  REMARK    GeneRIF: Report novel TRP channel-associated factors that modulate
            TRPM8 activity.
REFERENCE   3  (bases 1 to 4257)
  AUTHORS   Nagamachi,A., Matsui,H., Asou,H., Ozaki,Y., Aki,D., Kanai,A.,
            Takubo,K., Suda,T., Nakamura,T., Wolff,L., Honda,H. and Inaba,T.
  TITLE     Haploinsufficiency of SAMD9L, an endosome fusion facilitator,
            causes myeloid malignancies in mice mimicking human diseases with
            monosomy 7
  JOURNAL   Cancer Cell 24 (3), 305-317 (2013)
   PUBMED   24029230
REFERENCE   4  (bases 1 to 4257)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC011487.1.
            
            Sequence Note: This sequence has been modified as follows: removed
            39 bp suspected to be vector contamination from the 3' end.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC011487.1, AK131169.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4257              BC011487.1         1-4257
FEATURES             Location/Qualifiers
     source          1..4257
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="FVB/N"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 20.82 cM"
     gene            1..4257
                     /gene="Tcaf2"
                     /gene_synonym="Fam115c"
                     /note="TRPM8 channel-associated factor 2"
                     /db_xref="GeneID:232748"
                     /db_xref="MGI:MGI:2385258"
     exon            1..162
                     /gene="Tcaf2"
                     /gene_synonym="Fam115c"
                     /inference="alignment:Splign:2.1.0"
     exon            163..799
                     /gene="Tcaf2"
                     /gene_synonym="Fam115c"
                     /inference="alignment:Splign:2.1.0"
     CDS             177..2936
                     /gene="Tcaf2"
                     /gene_synonym="Fam115c"
                     /note="protein FAM115C; family with sequence similarity
                     115, member C; TRP channel-associated factor 2"
                     /codon_start=1
                     /product="TRPM8 channel-associated factor 2"
                     /protein_id="NP_666286.1"
                     /db_xref="CCDS:CCDS20075.1"
                     /db_xref="GeneID:232748"
                     /db_xref="MGI:MGI:2385258"
                     /translation="MATTPDAAFEALMNGVTSWDLPKEFTPSELLLIGEAAFPVMVND
                     KGQVLIAVSFYGQGRLVVVSHESYLMHAGLAPFLLNAVSWLCPSPGTPIEVHSSLASL
                     VNILRGSGINALVQPEPGEALGVYCIDAYNDTLTKKLVQFVKRGGGLLIGGQAWNWAS
                     QHGSDKVLFSFPGNKVTSVAGVYFTDVYGDINRFKVSKKIPKIPLYIRCWEELRHDQD
                     QLLDGISMLDVRTGGVPSQLLVHGSLAFPLGLDNSFLSCFLAAAHYGRGRVVLAAHEA
                     MLCAPKMEPFLLNAIRWLSRGQEDNIGVNTRLKNLNSLLLKHGLKCSLESHLTDDMCV
                     YCCAAYSDQEAKKIQEFVAEGGGLLIGGQSWWWASQNPGSSALGSFPGNVILNTFGLS
                     ILPRTVSPGCFPILHIDIRNYHFRGALSEFQAMLNHKEGNLEKRYSGKLGVDGAGFLQ
                     IPAQGVPAYLSVHRILRKILRQAGLPAVSKSNPVSSHSYEAAILQLATELAHSGSDCS
                     QIAHNLSSQTCSSNLSSSEHPITVEINGTNPGDRDVWMSTGLYLLEGQSTEISVSEPA
                     ASAGLKVQIGCHTDDLTFAIKLFRAPVVTYQCCMNRTQRSVSCLWGGLLYIIVPKGCQ
                     LGPVSVTITNAVPAPYYKLGKTSLEEWKSCIQKNLGPWGELATDNVILTVPTASLKTL
                     ENPEPLLQLWDEMMQAVARLASQPFPFQRPERIVADVQLSAGWMHSGYPIMCHMESVQ
                     ELVSLANIRSKGLWGPIHELGHNQQCRGWEFPPHTTEATCNLWSVYVHETVLGIPRAQ
                     AHPQLKPEEREKRIKEHLQKGAPLQNWNVWTALETYLQLQEVFGWEPFITLFAEYQTI
                     FYIPEDNECKMNIWLKLFSEKVQKNLVPFFEAWGWPIQKDVAEDLACYPSWEDHPLRM
                     YMGSE"
     exon            800..1794
                     /gene="Tcaf2"
                     /gene_synonym="Fam115c"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1892
                     /gene="Tcaf2"
                     /gene_synonym="Fam115c"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..2106
                     /gene="Tcaf2"
                     /gene_synonym="Fam115c"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2346
                     /gene="Tcaf2"
                     /gene_synonym="Fam115c"
                     /inference="alignment:Splign:2.1.0"
     exon            2347..2684
                     /gene="Tcaf2"
                     /gene_synonym="Fam115c"
                     /inference="alignment:Splign:2.1.0"
     exon            2685..4257
                     /gene="Tcaf2"
                     /gene_synonym="Fam115c"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcgacagt cagccggcag caacctctgt ggtctgaatt ttctgtcctg gtttgttccg
       61 gtgtggggct gagtgtccga gcactaagac gacgctggga ggaaatcctt aaagtgccag
      121 aaggctactg gacgccgttc ccaacagtgt atctgctcac agcaacgggc agaaccatgg
      181 caacaactcc cgatgctgct tttgaggccc tcatgaatgg agtgaccagc tgggatctcc
      241 ctaaagaatt cactcccagt gaactccttc ttattgggga ggcagccttc ccagtgatgg
      301 tgaatgacaa gggccaggtg ctcattgctg tttctttcta tggccaaggc cgcctggtgg
      361 tcgtatccca tgagagctac ctgatgcatg ctggcttggc tccttttctt ctcaatgcag
      421 tgagctggct ctgcccctcc ccagggactc ccattgaagt gcattcttcc ttagcatcac
      481 tagttaacat cctacgtggc tctgggataa atgccttggt tcagcctgag cctggagagg
      541 ctctgggagt ttattgcatt gatgcctaca acgacacctt gaccaagaag ctggtccagt
      601 ttgtgaagcg tggtggaggc ttgctcattg gaggtcaggc ctggaattgg gccagtcagc
      661 atggcagtga caaggtgcta ttcagtttcc ctgggaacaa ggtgacaagt gtggctggag
      721 tctacttcac agatgtctat ggagatataa accggttcaa agtctctaag aagataccca
      781 agatcccact gtatatcagg tgttgggagg agctcagaca tgaccaggac cagcttctgg
      841 atggaatctc tatgttggat gtcaggactg ggggtgtccc ctcacagctg ttggtgcatg
      901 ggtccctggc cttccctctg gggctcgata actccttcct tagctgcttc ctagcagctg
      961 ctcactatgg ccgtggtcgt gtggtgttgg ctgcacatga ggccatgctc tgcgctccta
     1021 agatggaacc ctttttgctc aatgctatac gctggttgtc cagaggtcag gaagataata
     1081 ttggggtgaa cacacgtctc aagaatctga attccctatt gttgaagcat ggcttgaaat
     1141 gcagtctgga gtcccatttg accgatgata tgtgtgtcta ctgctgtgca gcttatagtg
     1201 accaggaggc caagaaaata caggagtttg tagcagaggg tggagggttg ctcattggtg
     1261 gtcagtcctg gtggtgggct tcccagaacc caggcagctc tgctttaggt agtttccctg
     1321 ggaatgtcat cctcaatact tttggcctca gcattttgcc tcggacagtc agcccaggct
     1381 gttttcctat ccttcatata gatataagaa actatcactt tcgaggggct ctttctgagt
     1441 tccaagctat gttgaaccac aaggagggga acttggaaaa gaggtattcg ggaaagttgg
     1501 gagtagatgg agcaggcttt ctccagattc ctgcacaggg agttcctgct tacttatctg
     1561 tgcaccggat cctgaggaag atactgcgac aggcaggcct cccagctgtg agcaagagta
     1621 atccagtgtc cagtcactcc tatgaggctg cgatactcca gctagccaca gagctggcac
     1681 actctgggag tgattgctcc cagatagcac ataaccttag cagtcagacc tgctcctcca
     1741 atctctcctc ctcagaacac cccattaccg tggagatcaa tggaaccaat ccaggtgacc
     1801 gtgatgtctg gatgagcact gggctctacc tcctggaagg acaaagcacc gagatctctg
     1861 tctctgaacc tgctgcctct gcaggtctga aggtgcagat tggatgtcac actgatgacc
     1921 ttacctttgc cataaagctg tttcgagccc ctgtggtaac ttaccagtgc tgtatgaaca
     1981 gaacccaacg gtcagtctcc tgcctctggg gtggtctcct gtacatcatt gtgcccaaag
     2041 gctgtcaact gggccctgtg tctgttacca tcacgaatgc agtgcctgcc ccatactaca
     2101 agctaggtaa gacatcactg gaggagtgga agagctgcat ccagaagaac ctaggcccct
     2161 ggggagagct ggccacagac aatgtcatcc tgacagtgcc aactgcaagc ctcaagactc
     2221 tggagaatcc agagcctctg ctccaactct gggatgagat gatgcaggct gtggccaggc
     2281 tggcaagcca gcccttccct ttccaaagac ctgagagaat tgtcgctgat gtgcagctct
     2341 cagccggctg gatgcattca ggatacccca tcatgtgcca catggagtct gtgcaagagc
     2401 tagtcagttt ggcaaacata agaagtaagg gcctgtgggg acccatccat gagctgggcc
     2461 acaatcagca gtgcaggggt tgggagttcc ccccacatac aactgaggcc acctgcaatc
     2521 tctggtcagt ctatgttcat gagaccgtcc tggggattcc cagggctcag gcccaccctc
     2581 aactgaaacc tgaagaaaga gagaagagaa ttaaagaaca ccttcagaag ggagcacccc
     2641 tgcaaaactg gaatgtctgg acagcactgg agacatatct gcagctccaa gaggtctttg
     2701 ggtgggaacc gttcatcacc ctctttgctg aataccaaac cattttttac atccctgaag
     2761 acaatgagtg caagatgaac atatggctga agttgttctc tgaaaaagtg cagaagaacc
     2821 tggttccttt ctttgaagcc tggggctggc ctatccagaa ggatgtggct gaagacctgg
     2881 cctgctatcc ttcctgggag gatcaccccc tgaggatgta catggggagc gagtagtagg
     2941 ggccatggag ccggctgggg tggggaaagg gcattggggt ggggtgaaat gggtgagata
     3001 aggcatagta ctagcttcac ggccttaact atttttctca ctgtttgact ttaaaatata
     3061 ttttgaatgt ccctttccac atcccatcag cacatcccaa tttcagggac catttcctca
     3121 gataccacca gtatcccctg gcagatgctt tgtacatgaa aaacattaag aagatacttg
     3181 ctacatgaaa ggtcactaaa gtctcctgac acagaaggaa cagtcagtgc atgtcctaag
     3241 acctgcatac agcgttttct ctgagttcca tggataatct tccaccagct aatatcttct
     3301 tatcatagag gagaaaatgg catggatgtt aaacaacttc tttagtcaag actgagaaga
     3361 gaaagtgtca gatttcacag atgtccataa cagcgataga ttgtagatct tatcctcaac
     3421 agattgataa tgttaaccaa aatttgccca agagatagat gaaggtttgt gctctttatt
     3481 tgctttccta tgttcattac tgaattttga ctaaatatca aattgaatct ctaaatcttt
     3541 ttcgcaatta atcttccctt tacctcaaga ttcatctgcc ttgagaggaa accagccttg
     3601 gaaaaatatt taaaccaagg aagttcattt cccaaactgg tggcattctt aattataatt
     3661 ggagggggtg actagggagc taattaaagc tggaattaat gggttatcta agagaccaaa
     3721 ccaagtccta accttgtaca caccacttct ctgtaggatg tagagccctg tgatggtgtc
     3781 ttctcattcc tgaggagaga ccctggctcc gcctcttgtt tttatgcttt tggtaaattt
     3841 ttctgtggct gtaataccca cagattatgc ttgtatacgt aaaaacattt ttttctgctt
     3901 acaattttat agttctgtat ttacaaatct tatttaggag aaaatattga agaatagtga
     3961 tctcagacaa agtctgaaaa agcatgagtg ggggaggagt tatgaagtcc catccctagt
     4021 tagagatctg ttagcagtct atggctgctg ggaggagagt cggctttctt cagctttgtg
     4081 gtccctaaga ggctacctat gccgtacacc agcacacata taggcagcac tatgggcttt
     4141 gaaatgaaca catgaattta ggaggggata gatatgtggg gataggggat gaatgaggac
     4201 atgggaaatg gttttgatca aagcacctta tatacatgta tagaattctc aactaat
//
