LOCUS       NM_001355768            5258 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus TRPM8 channel-associated factor 1 (Tcaf1), transcript
            variant 1, mRNA.
ACCESSION   NM_001355768 XM_006506751
VERSION     NM_001355768.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5258)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5258)
  AUTHORS   Gkika,D., Lemonnier,L., Shapovalov,G., Gordienko,D., Poux,C.,
            Bernardini,M., Bokhobza,A., Bidaux,G., Degerny,C., Verreman,K.,
            Guarmit,B., Benahmed,M., de Launoit,Y., Bindels,R.J., Fiorio Pla,A.
            and Prevarskaya,N.
  TITLE     TRP channel-associated factors are a novel protein family that
            regulates TRPM8 trafficking and activity
  JOURNAL   J Cell Biol 208 (1), 89-107 (2015)
   PUBMED   25559186
  REMARK    GeneRIF: Report novel TRP channel-associated factors that modulate
            TRPM8 activity.
REFERENCE   3  (bases 1 to 5258)
  AUTHORS   Okazaki,N., F-Kikuno,R., Ohara,R., Inamoto,S., Koseki,H.,
            Hiraoka,S., Saga,Y., Seino,S., Nishimura,M., Kaisho,T., Hoshino,K.,
            Kitamura,H., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: IV. The complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (3), 205-218 (2004)
   PUBMED   15368895
REFERENCE   4  (bases 1 to 5258)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014379.1, AK132148.1 and BM117796.2.
            
            On Sep 27, 2017 this sequence version replaced XM_006506751.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132148.1, AK083917.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AK014379.1         1-63
            64-4803             AK132148.1         2-4741
            4804-5258           BM117796.2         1-455               c
FEATURES             Location/Qualifiers
     source          1..5258
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 20.84 cM"
     gene            1..5258
                     /gene="Tcaf1"
                     /gene_synonym="2810407D09Rik; 3321401G04Rik;
                     A230020K05Rik; Fam115a"
                     /note="TRPM8 channel-associated factor 1"
                     /db_xref="GeneID:77574"
                     /db_xref="MGI:MGI:1914665"
     exon            1..157
                     /gene="Tcaf1"
                     /gene_synonym="2810407D09Rik; 3321401G04Rik;
                     A230020K05Rik; Fam115a"
                     /inference="alignment:Splign:2.1.0"
     exon            158..791
                     /gene="Tcaf1"
                     /gene_synonym="2810407D09Rik; 3321401G04Rik;
                     A230020K05Rik; Fam115a"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2946
                     /gene="Tcaf1"
                     /gene_synonym="2810407D09Rik; 3321401G04Rik;
                     A230020K05Rik; Fam115a"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM115A; family with sequence similarity 115,
                     member A; TRP channel-associated factor 1"
                     /codon_start=1
                     /product="TRPM8 channel-associated factor 1 isoform 1"
                     /protein_id="NP_001342697.1"
                     /db_xref="GeneID:77574"
                     /db_xref="MGI:MGI:1914665"
                     /translation="MATPSAAFEALMNGVTSWDIPEDSVPCELLLIGEASFPIMVNDV
                     GQVLVAASSYGRGRMVVASHEDFLLESQLFVFLVNAVGWLRSSPNSAIGVHSSLAPLV
                     KILESCGIESKIEPEVNDSLGVYCIDAYNETMTDKLVQFVKRGGGLLIGGEAWDWDTQ
                     GDDDRVLFAFPGNLVTSVAGVYFTDNKADTSFFKVSKKMPKIPILVRCDDDLSDDRDE
                     LLRGIIDLDITNSDCFPSQLLVHGSLAFPLGLDTYHGCVIAAARYGRGRVVVTGHKVL
                     FTVGKLGPFLLNAVRWLDGGRKGKIVVQTELRTLSGLLAVGGIDTSIEPHLTSDASVY
                     CFEPTSDVGVKELQEFVAEGGGLFVGTQAWWWAFKNPGVSPLARFPGNLLLNAFGISI
                     TSQSLNPGPFRTPKIGTRTYHFRSTLAEFQVIMGRKRGNVEKGWLAKLGPDGATFLQI
                     PAEEIPAYMSVHRLLRKLLSRYRLPVATRENPVINDCCRGAMLSLATGLAHSGSDLSL
                     LIPEIEDVYSSRYLRPSASPITVNVNCTNPGTRYCWMSTGLYIPGRQVIDVSVPESAA
                     SADLKIQIGCHTDDLTRASKLFRGPLVINRCCLDKPTKSITCLWGGLLYIIVPQNSKL
                     GSVPLTVKGAVRAPFYKLGETSKEEWKRRLLEYPGPWGELATDNIILTVPTANLRTLE
                     NPEPLLRLWDEMMQAVAKLGGETFPLRLPQRIVADVQISVGWMHAGYPIMCHLESVQE
                     LINEKLIRTKGLWGPVHELGRNQQRQEWEFPPHTTEATCNLWCVYVHETVLGIPRSRA
                     NIALWPPVREKRVRIYLSKGPSVKHWNAWTALETYLQLQEAFGWEPFIRLFTEYRNQT
                     TSSSPPSDNVDKMNLWVKMFSQQVQRNLAPFFEAWGWPIQKEVATSLAYLPEWKENIM
                     KLYLLTQMPH"
     exon            792..1786
                     /gene="Tcaf1"
                     /gene_synonym="2810407D09Rik; 3321401G04Rik;
                     A230020K05Rik; Fam115a"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1884
                     /gene="Tcaf1"
                     /gene_synonym="2810407D09Rik; 3321401G04Rik;
                     A230020K05Rik; Fam115a"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2098
                     /gene="Tcaf1"
                     /gene_synonym="2810407D09Rik; 3321401G04Rik;
                     A230020K05Rik; Fam115a"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2338
                     /gene="Tcaf1"
                     /gene_synonym="2810407D09Rik; 3321401G04Rik;
                     A230020K05Rik; Fam115a"
                     /inference="alignment:Splign:2.1.0"
     exon            2339..2676
                     /gene="Tcaf1"
                     /gene_synonym="2810407D09Rik; 3321401G04Rik;
                     A230020K05Rik; Fam115a"
                     /inference="alignment:Splign:2.1.0"
     exon            2677..2936
                     /gene="Tcaf1"
                     /gene_synonym="2810407D09Rik; 3321401G04Rik;
                     A230020K05Rik; Fam115a"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..5258
                     /gene="Tcaf1"
                     /gene_synonym="2810407D09Rik; 3321401G04Rik;
                     A230020K05Rik; Fam115a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3291..3296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tcaf1"
                     /gene_synonym="2810407D09Rik; 3321401G04Rik;
                     A230020K05Rik; Fam115a"
                     /note="hexamer: AATAAA"
     polyA_site      3318
                     /gene="Tcaf1"
                     /gene_synonym="2810407D09Rik; 3321401G04Rik;
                     A230020K05Rik; Fam115a"
                     /note="major polyA site"
ORIGIN      
        1 attgcttgct cccccttctc tgccagtgac tttccacgtc ccccatccac tggtccaccg
       61 cctattccct tgcaggcctg aagcttcttc cccttgggta gcttcctcct ttgctgttgt
      121 gcctccgaat cagcacttca gggaacagcg acgcagaaaa ccaacagaac catggcaact
      181 ccctctgctg cctttgaggc ccttatgaat ggagtaacga gttgggatat ccccgaggat
      241 tctgttccat gtgaactgct tcttattgga gaggcttcat ttcctataat ggtgaatgac
      301 gtgggccagg tcctcgttgc cgcctcttcc tatggcagag gccgcatggt ggtagcatct
      361 catgaggact tcttgctgga aagccagctc tttgtctttc ttgtcaatgc tgttgggtgg
      421 cttcgttcct cccctaactc agccattggt gtgcactcat ctttagcacc attggtgaaa
      481 attctcgaga gctgtggaat agagtcaaag attgagccag aagtcaatga ctccctgggg
      541 gtttactgca ttgatgccta caatgaaacc atgacagata agctagtcca gtttgtgaaa
      601 cgtggagggg gcttgctcat aggaggcgaa gcatgggatt gggataccca gggtgatgat
      661 gatagagttc tgttcgcatt tcctgggaat ctggtgacca gtgtggctgg tgtgtacttc
      721 actgacaaca aagcagacac aagtttcttt aaagtctcca agaagatgcc taagataccc
      781 atcttagttc gttgtgatga cgacctctca gatgacagag atgagcttct gcgtggcata
      841 atagacctgg acatcaccaa ctcggactgc ttcccatccc agctactagt tcatgggtct
      901 ttggcttttc ctttggggct agatacctac catggctgtg tgatagctgc agctcgctat
      961 ggccggggtc gggtagttgt aactggtcat aaggttttat ttactgtggg taaactcggc
     1021 ccctttttgc tcaatgctgt ccgctggctg gatggtggcc gcaaaggcaa gattgtggta
     1081 cagacagagc tgagaacact aagtggtctg ctcgcagtag ggggtataga caccagcatt
     1141 gagccccacc tgaccagtga cgcaagtgtc tattgttttg aacccacaag cgatgtgggg
     1201 gttaaggaac tacaggagtt tgtagcagag ggtggtgggc tgtttgttgg aactcaagcc
     1261 tggtggtggg cttttaagaa cccaggagtg tcccctctgg ctcgattccc aggaaacctg
     1321 ctcctcaatg cctttggtat cagcatcaca agccagagtc tcaatccagg acctttccgt
     1381 acccctaaaa taggaacaag gacctatcac ttccgctcta ccctagcaga gttccaggtg
     1441 ataatgggca ggaagagagg gaatgtggag aagggctggc tagccaagct aggcccagat
     1501 ggggcaactt tcctgcagat tcctgcagaa gagatccctg cttacatgtc tgtgcacaga
     1561 ctcctgagga agctgctgag ccgctatcgg cttccagtgg caaccagaga gaacccggtc
     1621 atcaatgact gttgtagggg agccatgctt tccctggcca caggtctggc ccactctgga
     1681 agtgacctct cactgctgat cccagaaatt gaagacgtgt acagcagccg ctacctgcgc
     1741 ccctcagcgt ctcccatcac cgtgaatgtc aattgcacta atccaggcac tcgatattgc
     1801 tggatgagca ccggactcta catacctgga aggcaagtca tagatgtctc cgtgcctgag
     1861 agtgctgcct ctgctgacct gaagatacaa attggctgtc atactgatga tctgacaagg
     1921 gccagcaagc tgttccgagg cccccttgtg attaaccggt gttgcttgga caaacccacg
     1981 aaatcaatca cctgcctctg gggtggtctc ctctatatca ttgtgcctca gaatagcaaa
     2041 ctgggttctg tgccccttac agtgaagggg gctgttcgtg ctccattcta caagctaggg
     2101 gagacatcca aggaagaatg gaagaggcgt ctcctggaat atccaggtcc atggggagaa
     2161 ctggccactg acaacatcat cctgactgtg cccactgcaa atcttcgaac gctggagaat
     2221 cctgagccac tgctccgcct ctgggatgag atgatgcagg ctgtggctaa gctgggaggc
     2281 gagaccttcc ctttgcgtct gccacagagg atagtggctg atgttcagat ctcagtaggc
     2341 tggatgcacg cagggtaccc catcatgtgc catctggagt cagtgcagga actcatcaac
     2401 gagaagctca tccggaccaa ggggctctgg ggccctgtgc atgagctggg ccgcaatcag
     2461 cagaggcagg agtgggagtt ccccccacat actacggaag ccacgtgcaa cctgtggtgt
     2521 gtttacgtgc atgaaacggt cctgggcata ccccgaagcc gtgccaatat tgcgctatgg
     2581 cctccagttc gggagaagag agtccgaatc tacttgagca agggacccag tgtgaaacac
     2641 tggaacgcct ggactgcgtt ggaaacgtac ctacagctcc aagaggcctt tggttgggag
     2701 ccatttattc gtctcttcac cgagtacaga aaccagacaa catcgagctc gccgccctca
     2761 gacaacgtcg acaaaatgaa tctatgggtc aagatgttct cccagcaagt gcagaggaat
     2821 ctggctccat tctttgaggc ctggggctgg cctatccaga aggaagtggc tacaagctta
     2881 gcctatctgc ccgaatggaa agagaatata atgaaattgt acctcctcac acagatgccc
     2941 cactgaaact gaagtccagg aatacaaaag aaaactgaga cctctcagca aaggagacta
     3001 aaagcatttg gttggagaag atctcaacaa atttcaggaa gagagaaagt aaatgaagag
     3061 aaataatgat cgggaaacat ggcggtccat ttcagacaga atatactgat ccgaacactg
     3121 gaaccccaaa gagacttgag cactagaaaa ctctagctac taaataatta taccagttgt
     3181 aaattgaccc ccagtctact cagccccgac ccttgtacat agaaaacaga aaacctacca
     3241 ctgaaactag tgaaactgtt attgttactg ttgtttgaat aaagaaatca aataaaccac
     3301 ctgaggagag gtaaaaaatt agtgctccaa aggatattct ttccatggaa ataagtgccc
     3361 cactagcctg tcaggtaatt ttcttctcag aggtgacacc cttactcaca ccctaaaagc
     3421 ccacagcttc taggtatagc agacatttgc tggagaaaca ggactcattt aacgagctga
     3481 tagttaacaa agattctcag catggatttc ctgatagaat ttttcataca tcgaagggtc
     3541 caaggaagaa gcataaagaa aataaccact tagacataaa aagcttgagg aattataaac
     3601 taatggaagc ataatttata aggaaaaatc tgtaaaattc tgaccatttc tccaagagag
     3661 acttgaggtg cattactaag agaaaatcct gaacattgta aaagcaaaac gagatggcca
     3721 taaattttca tcatatagac tggaaaacaa gatagaatga atctttccag acatgcatca
     3781 aaatgaaata tcacacaatt gaaaagaagg aaagggaaac agacaatcac tgtgtaactc
     3841 ttaggagttt ccagaaggca gcacagaaag cctggacagt gagagaataa gaaagacttg
     3901 aggaacagca gagggacggc acccagtacc aaccacatct aggcagggtc ctaaagaaaa
     3961 gtggaaacag gagggctaga aggaacatgt tgaaagtgcc cagggaaggg aaagaggctg
     4021 aaccaaacct gagaattcta gcagtgctga atgctagaag tcaaagaacc aatggttgac
     4081 ttttgaaaac ttttgttccc agaattccat atagtacaga ctgtcaagag taatataaaa
     4141 agaaaaacat ttttggcagg gaagtcttta gaaactctcc ctcccccctt tgtaccctta
     4201 ttaaggaagt tttccattta aaagaaaact ttctttccat atatatgtgg aagaaagtcc
     4261 aaaaaagaaa aggaaagaag atctggagac agtggccctc actcagggtg tctctgtcta
     4321 gagtggtaga tatcagaaga gagcactacc ctgggctctg tgaagaatat gccagagtag
     4381 cactgaggag atgggacatt tggagatatg aaaagcatgc agtctttaat cacaaaaatt
     4441 aaacagaatg tcaagaaatt tgggctgagc catgaaggaa aatagaatgg gataggattt
     4501 caaagtctcg tggagtatga gaagagactg attgggcact ggcagtaggt atgtttcctt
     4561 tcctttgata tgggtatcat ggcattggga gtgtagagaa aattaagttt cttccacttg
     4621 gcttggtaaa agtattttaa tagcccaaat aatgtataga tgccacttat agatcttcaa
     4681 tggtttgatc agcctatcaa caaagactga aaggtttaat gttacactca tatcagagat
     4741 agaaagggat gttgatcagt tgatgcacaa aactatagct gaattagttg agagaaggga
     4801 agtaaaagga aaaaaatggg gctacttaaa tattcaaagt gtggatgaaa agctgctgtc
     4861 ttccgataat agaacacagt tgtatggtta gtgtgctggc caatgctata aattagaccc
     4921 tcaaaagaat atctaccaag catttggaga agagtaggca ggagaaaggt ggaggtggtg
     4981 tatgttaaag cattatcttt tgtaatggtg aaagattaaa gatagtctaa tgttaataag
     5041 tcaagagatt attgttcaaa catgttatgt aaaggtagga agttagccaa cagaagatcc
     5101 aaaaatagat attaaaagca tctaagaaat gagactatag aaggagggtg gggtgggaac
     5161 cgtgttttta tttaatgttc cgctgtacta tttaattttt tttttacctt gtgcatgtat
     5221 tatttggaaa agtttataat aaactcaaat aaaacatc
//
