LOCUS       NM_001082976            5313 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus tandem C2 domains, nuclear (Tc2n), transcript variant
            2, mRNA.
ACCESSION   NM_001082976
VERSION     NM_001082976.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5313)
  AUTHORS   Fukuda,M. and Mikoshiba,K.
  TITLE     Tac2-N, an atypical C-type tandem C2 protein localized in the
            nucleus
  JOURNAL   FEBS Lett 503 (2-3), 217-218 (2001)
   PUBMED   11526914
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK136558.1, AK016683.1, AC125355.4 and EH095356.1.
            
            On Nov 2, 2013 this sequence version replaced NM_001082976.1.
            
            Transcript Variant: This variant (2) has an alternate 5' UTR exon,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK136558.1, SRR14995047.810761.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-749               AK136558.1         2-750
            750-1726            AK016683.1         1434-2410
            1727-5002           AC125355.4         112657-115932       c
            5003-5313           EH095356.1         22-332              c
FEATURES             Location/Qualifiers
     source          1..5313
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 51.26 cM"
     gene            1..5313
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /note="tandem C2 domains, nuclear"
                     /db_xref="GeneID:74413"
                     /db_xref="MGI:MGI:1921663"
     exon            1..122
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /inference="alignment:Splign:2.1.0"
     exon            123..235
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1638
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /note="membrane targeting (tandem) C2 domain containing 1;
                     tandem C2 protein in nucleus; membrane targeting tandem C2
                     domain-containing protein 1"
                     /codon_start=1
                     /product="tandem C2 domains nuclear protein"
                     /protein_id="NP_001076445.1"
                     /db_xref="CCDS:CCDS36524.1"
                     /db_xref="GeneID:74413"
                     /db_xref="MGI:MGI:1921663"
                     /translation="MAAEFIKSCCRGCLYGETEKQKFSVDRDFKASASSSQNTIGIPP
                     LTSVLVKPQVGCNEDYLLSKLPCDGKEVQFVVPRFKLSYIQPRTQGIPSHLDELEGSA
                     RASFGDQKTELCSSFYHGPSYDVYNPCYMYQHFSPDLSRRFLPHCETKQLYGSVCDLR
                     TSKLPGSSGLSKSMLDLTTSSQRFIQRHDSFSSVPSSSSSRKNSQGSNRSLDTITLSG
                     DERDLGRLNVKLFYNSSAEQIWITVLQCRDISWPSSYGDTPTISIKGILTLSKPVHFK
                     SSAKEGSNAIEFMETFVFAIKLQNLQAVRLAFKIQTQTPKKKTIGECSLSLRTLSTQE
                     MEYSLEIIAPSKISVCQAELELGTCFQAVNSRIQLQILEAQYLPSSSTPLTLSFFVKV
                     GMFSSGELIYKKKTRLLKASSGRVKWGETMIFPLIQTEKEIVFLIKLYSRSSVRRKHF
                     VGQLWISEDSNNIEAVNQWKETITNPEKVVIKWHKLNPS"
     exon            236..466
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /inference="alignment:Splign:2.1.0"
     exon            467..634
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /inference="alignment:Splign:2.1.0"
     exon            635..726
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /inference="alignment:Splign:2.1.0"
     exon            727..802
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /inference="alignment:Splign:2.1.0"
     exon            803..903
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1020
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1021..1212
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1213..1327
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1527
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /inference="alignment:Splign:2.1.0"
     exon            1528..5287
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5138..5143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /note="hexamer: AATAAA"
     polyA_site      5169
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /note="major polyA site"
     regulatory      5264..5269
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
                     /note="hexamer: AATAAT"
     polyA_site      5283
                     /gene="Tc2n"
                     /gene_synonym="4933406D09Rik; Mtac2d1; Tac2-N"
ORIGIN      
        1 agttacaggt aggcagccgg agcggtggga ctcctccttg gcggtgggtg ccgcgagggc
       61 gcccgcccct cgagagccct gagtgaaggc gccgggagga gcgccagacc gcggcgacgc
      121 aggttgatat caaaattgga agttttctag ttattagaaa ttgaaagtat ggcagcagaa
      181 tttataaaga gttgctgtag aggatgtctc tatggtgaaa cagaaaagca gaagttttct
      241 gtggacagag actttaaagc atcagcctca agtagccaaa ataccattgg tatccctcca
      301 ttgacttctg ttctagtaaa gcctcaagtt ggctgtaatg aagattattt gctttccaaa
      361 ttaccatgtg atggtaaaga agtacaattt gtggtgccca ggtttaaatt atcttatatt
      421 cagcctagga cacaaggaat tccttcacat ctggatgaac tggaaggatc tgctagagca
      481 tcttttggag atcaaaagac agaactttgt agttcattct accatggacc cagctatgat
      541 gtgtataatc catgctatat gtatcaacac ttttcacctg atttaagtag gcgctttctt
      601 cctcattgtg aaacaaaaca gttatatgga tctgtttgtg atttaaggac cagtaaactt
      661 cctggttcct ctgggctaag caaatctatg cttgatctta caacttcatc tcagcgattc
      721 atccagagac atgactcatt ttccagtgtt cctagtagtt cttcttcaag aaaaaattct
      781 cagggcagta acagaagcct ggatacaatt accctatcag gagatgaaag agacttgggg
      841 agattgaatg tgaaattatt ttataattct tcagcagagc agatctggat cacagttttg
      901 cagtgcagag atataagttg gccctctagt tatggagaca ctcccacaat ttctataaaa
      961 ggaattttaa cattgtccaa accagtgcat ttcaaatctt cagccaaaga aggttccaat
     1021 gctattgaat ttatggaaac atttgtattt gctattaaac tacaaaatct ccaagctgtg
     1081 agacttgcat ttaagattca aacccagact cccaagaaga aaaccattgg agagtgttct
     1141 ctttcactca gaactcttag tacccaggaa atggagtact cgttggaaat aatagcacct
     1201 tcaaaaattt ctgtttgcca agcagaactt gaactgggga cttgttttca agcagtaaat
     1261 agcaggattc agctgcaaat tcttgaggca caataccttc caagttcatc aacacctttg
     1321 actttgagtt tttttgtgaa agtggggatg tttagctcag gagagctgat ttacaagaag
     1381 aagacacgct tattgaaggc ctccagtgga agagtaaaat ggggagaaac tatgattttt
     1441 ccacttatac agactgaaaa agaaattgtt tttcttatta aactttatag tcggagctct
     1501 gtaagaagaa aacattttgt aggccagctc tggataagtg aagacagtaa taatattgaa
     1561 gcagtgaatc aatggaaaga gaccattaca aatccggaaa aggttgttat caagtggcac
     1621 aagttaaatc catcttgaag acgttgggca ttaaattgct gaagagacag cttgacattc
     1681 ttttagaaga aacataattt ttaaaatttg taatgagtcc tttcaggtac acaaagtgaa
     1741 cgaaatgttt taaaatggtg ccaaaatatg ataaaagggt agtagcattt ggccaactta
     1801 atgaattata caatctataa aaatatcaat cctagataag tatcttttta aagtactatt
     1861 agacatttac aagactttac ctcttttcca gtgctagaca tgattaatta gatcttggtt
     1921 atactgttta tagcttatat gtatttttct cacagcaaaa atgaatagaa ccattccatt
     1981 acttttttcc tgtatatgaa gaaaattggt accctgtact tacaatttat ttatgttatt
     2041 gcatagccat tttataaact gcttatttct tggagaatta gagagttatt tatatttttc
     2101 aaagaataaa taaagcttgg atctaggagg attgcttggt ggaaaaggag cttgtcccca
     2161 cactgaaaat ttgagttcca tccctgcaat gcaatatgat ggaaggagag aaccaattcc
     2221 ttcatattgt tcattgtcat tcacatgtag accatcaaca cacacacaca cacacacaca
     2281 cacacacaca cacacacaca cacacacaaa taaataataa ataagtaaaa agattaattg
     2341 aagttaaact taaagtcaat tttgccttct catttttaac ctttttttgt agttaaaata
     2401 ttttacattt ggataactta atttagcaaa attaaattag cttaaatagc aaatttagta
     2461 ttttatgatc agtagttctt tgtttcaatt ttttatgtaa attacttgtt ctataatcca
     2521 caatgttaaa gtattttccc actttgataa ccataccagc taacaatgta taggatacaa
     2581 atatgtttct actataggct tctttcaggt acatattaga acttagcata tgaagattat
     2641 ttctgcttgg atgggcataa gcgtgtggct aaaacaaaat aattttatga agaaacaagc
     2701 aacagtttct aatcttactt tatttttacc aaaaagtaaa caatggatct atgttcctga
     2761 tccttgtctc tctgttcccc ttgtctgcct gcctgcctct ctctttgttc cacatatttt
     2821 aggccagagg aatcacttat tatgatgtag gaataacctc ttaaactcta gttcttttat
     2881 aataacataa tggttgaagg aggctttatt tttaataact agaattttca ttgtttttaa
     2941 tgttttattt taattcctaa agttaatata tgtaatttat ttaattttgt tataatgatc
     3001 taattattaa ttttaagcat agatgtaata taaatttgat tcccaggatc ctagacatct
     3061 tagataagtc aatacaaaga aaacttgatt taaaagaact ttcagggggg ctggtgagat
     3121 ggctcagttg gtaagagtac ccgactgctc ttccgaaggt tcagagttca aatcccaaca
     3181 accacatggt ggctcacaac catctgtaac gagatctgac accctcttct ggagtgtctg
     3241 aggacagcta cagtgtactt tacgtataat aaataaataa atcttaaaaa aaaaaaagaa
     3301 ctttcaggta ggaaagtatt agtaggtgaa gatttctagt gttttaatca ctttttactt
     3361 aagcatattt tagctgaaga tgcattgaat gtaaacgtat atattttttg tgttcttgaa
     3421 attgttatat gaaagtgtag atgcaaacac tgttgtgtta ataggcattc ttggagagaa
     3481 aaacaattag gagccaataa caataactga aataatatac aaaaataatt tcctttgtat
     3541 ttgcttaggc tcttcttgtc ctgtacttgt aacaaggaaa agggaactaa aatgatactg
     3601 ggaatgcagc tggaaaccaa ttaaacttca caataggagg gagattattc atttataaac
     3661 tatatcactc tctatatata ttaaacacac acatatgtgt gcatctctat atatgtacac
     3721 acatgtatgt acacacatat gtgtatatgt gtgtgtatgt gtgtatatat atgtacatat
     3781 atatgtgtgt gtatgtgtat atatgtatac atacacacac acacacatat atatatatca
     3841 cagaaagtta tggaccattt taaaatatca ctatttgtca ttgatttagt tttacacaat
     3901 actattctcc agtaacgttt cttctttttc catttctttc atttcttttc tctcttcttt
     3961 tactaaattg gcacacttgt ttacttctca ggttttgcaa acatccttaa tatgttggta
     4021 tggcaaatgc atttcaattc aaatagcaac tgcaagttga tatgcagaag aacagaagta
     4081 atgtggtctg gaattaattt gctcaattgc ttacaagcaa tatgctatgt atgaaaagat
     4141 taccaaatta caggtattaa attctaaatg atttaacagt ttattatgat ttattctatt
     4201 taacaaccta gggagtttga agccattgga aactccagtg gcaagttcag gtgcagttgg
     4261 gagttcagga atctcaatgg agctattagt gtagcagact tgtgggtaaa atatatgcat
     4321 ctctcaatag caaatgtgaa agactctcta aaatggacct cagtgacttc attctccaca
     4381 agctgtcctg gcccactcag catatccttt attgttccat gatattaagg catgtctgct
     4441 tttttttttt ttttaataat aaatccatga ccacctgaag gttttaactt ggtatgcacg
     4501 gcattaaggc tttcacagcc accataggta ttttctcctc catccattat gttattataa
     4561 actattactt tgatgccata ggaactttct tagtttttcc tacacattct gggacactgg
     4621 cagaaataac ttcttccaga ttatagttgc tttgtgcaac aggaaggaga tcagtcaaca
     4681 atggatttat aaactctcag ataacacaga aagttacatc tcatgtccaa aaatgacctt
     4741 attacttggc cctaatttag ttttgcatga atttttaaag caggaatcat aaatggccca
     4801 agtgtcttaa ttcaaattct tacctgactg tggagaagaa atcattgtga tttttgaaca
     4861 cacataatta tggtttaaaa acaaactaac ctgaatttgt ttgaatatag tttttcaact
     4921 ttctctgata ctaataaact catcagccag ttggaaattg ctttccagaa aaaattctca
     4981 ttgcttatat gttcatatat ttgtacatgt ataaaagatt tcaaaaactt ggaataagtt
     5041 tagaccattc ttaataagga tattaatgga tatttaaagt gcctgtcttt tcagtgtttg
     5101 gaaatttatt tagtgtttct tcagggcgta tcaaatcaat aaaatgtcca tgtctgtgat
     5161 gactaggaag atgttcttct attttctttc tcttgctgca taacctgtct tattcagaac
     5221 taaatttcaa atgtgaacag ttttagctga accactgaat taaaataatt atgaactatg
     5281 aaatataaaa aaaaaaaaaa aaaaaaaaaa aaa
//
