LOCUS       NM_011539               1959 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus thromboxane A synthase 1, platelet (Tbxas1),
            transcript variant 1, mRNA.
ACCESSION   NM_011539
VERSION     NM_011539.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1959)
  AUTHORS   Chueh,T.H., Cheng,Y.H., Chen,K.H. and Chien,C.T.
  TITLE     Thromboxane A2 Synthase and Thromboxane Receptor Deletion Reduces
            Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis, Autophagy and
            Pyroptosis
  JOURNAL   Thromb Haemost 120 (2), 329-343 (2020)
   PUBMED   31785598
  REMARK    GeneRIF: Thromboxane A2 Synthase and Thromboxane Receptor Deletion
            Reduces Ischaemia/Reperfusion-Evoked Inflammation, Apoptosis,
            Autophagy and Pyroptosis.
REFERENCE   2  (bases 1 to 1959)
  AUTHORS   Chiang,C.Y., Chien,C.Y., Qiou,W.Y., Chang,C., Yu,I.S., Chang,P.Y.
            and Chien,C.T.
  TITLE     Genetic Depletion of Thromboxane A2/Thromboxane-Prostanoid Receptor
            Signalling Prevents Microvascular Dysfunction in
            Ischaemia/Reperfusion Injury
  JOURNAL   Thromb Haemost 118 (11), 1982-1996 (2018)
   PUBMED   30300909
  REMARK    GeneRIF: this study shows that genetic depletion of Thromboxane
            A2/Thromboxane-Prostanoid Receptor signaling prevents microvascular
            dysfunction in ischemia reperfusion injury
REFERENCE   3  (bases 1 to 1959)
  AUTHORS   Pai,C.H., Yen,C.T., Chen,C.P., Yu,I.S., Lin,S.W. and Lin,S.R.
  TITLE     Lack of Thromboxane Synthase Prevents Hypertension and Fetal Growth
            Restriction after High Salt Treatment during Pregnancy
  JOURNAL   PLoS One 11 (3), e0151617 (2016)
   PUBMED   26974824
  REMARK    GeneRIF: the administration of salted drinking water (2.7% NaCl) to
            wild-type mice resulted in elevated placental TXA2 synthase (TXAS)
            and plasma thromboxane A2, but not prostacyclin, levels, which was
            also found in clinical preeclampsia placenta samples.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1959)
  AUTHORS   Liu,M., Saeki,K., Matsunobu,T., Okuno,T., Koga,T., Sugimoto,Y.,
            Yokoyama,C., Nakamizo,S., Kabashima,K., Narumiya,S., Shimizu,T. and
            Yokomizo,T.
  TITLE     12-Hydroxyheptadecatrienoic acid promotes epidermal wound healing
            by accelerating keratinocyte migration via the BLT2 receptor
  JOURNAL   J Exp Med 211 (6), 1063-1078 (2014)
   PUBMED   24821912
REFERENCE   5  (bases 1 to 1959)
  AUTHORS   Matsunobu,T., Okuno,T., Yokoyama,C. and Yokomizo,T.
  TITLE     Thromboxane A synthase-independent production of
            12-hydroxyheptadecatrienoic acid, a BLT2 ligand
  JOURNAL   J Lipid Res 54 (11), 2979-2987 (2013)
   PUBMED   24009185
  REMARK    GeneRIF: 12-HHT is produced by both TxAS-dependent and
            TxAS-independent pathways in vitro and in vi
REFERENCE   6  (bases 1 to 1959)
  AUTHORS   Carver,E.A., Issel-Tarver,L., Rine,J., Olsen,A.S. and Stubbs,L.
  TITLE     Location of mouse and human genes corresponding to conserved canine
            olfactory receptor gene subfamilies
  JOURNAL   Mamm Genome 9 (5), 349-354 (1998)
   PUBMED   9545490
REFERENCE   7  (bases 1 to 1959)
  AUTHORS   Zhang,L., Xiao,H., Schultz,R.A. and Shen,R.F.
  TITLE     Genomic organization, chromosomal localization, and expression of
            the murine thromboxane synthase gene
  JOURNAL   Genomics 45 (3), 519-528 (1997)
   PUBMED   9367676
REFERENCE   8  (bases 1 to 1959)
  AUTHORS   Brady,K.P., Rowe,L.B., Her,H., Stevens,T.J., Eppig,J.,
            Sussman,D.J., Sikela,J. and Beier,D.R.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   9  (bases 1 to 1959)
  AUTHORS   Kuwamoto,S., Inoue,H., Tone,Y., Izumi,Y. and Tanabe,T.
  TITLE     Inverse gene expression of prostacyclin and thromboxane synthases
            in resident and activated peritoneal macrophages
  JOURNAL   FEBS Lett 409 (2), 242-246 (1997)
   PUBMED   9202154
REFERENCE   10 (bases 1 to 1959)
  AUTHORS   Zhang,L., Chase,M.B. and Shen,R.F.
  TITLE     Molecular cloning and expression of murine thromboxane synthase
  JOURNAL   Biochem Biophys Res Commun 194 (2), 741-748 (1993)
   PUBMED   7688225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC154016.2 and AC125327.4.
            
            On Aug 8, 2022 this sequence version replaced NM_011539.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029014.1, L18868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-237               AC154016.2         8803-9039           c
            238-331             AC125327.4         80262-80355
            332-384             AC125327.4         83598-83650
            385-481             AC125327.4         113841-113937
            482-598             AC125327.4         132972-133088
            599-687             AC125327.4         149612-149700
            688-836             AC125327.4         152759-152907
            837-967             AC125327.4         154689-154819
            968-1282            AC125327.4         159360-159674
            1283-1374           AC125327.4         203076-203167
            1375-1512           AC125327.4         212659-212796
            1513-1675           AC125327.4         215413-215575
            1676-1959           AC125327.4         216016-216299
FEATURES             Location/Qualifiers
     source          1..1959
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 17.85 cM"
     gene            1..1959
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /note="thromboxane A synthase 1, platelet"
                     /db_xref="GeneID:21391"
                     /db_xref="MGI:MGI:98497"
     exon            1..237
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1750
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /EC_number="5.3.99.5"
                     /EC_number="4.2.1.152"
                     /note="isoform 1 is encoded by transcript variant 1;
                     thromboxane-A synthase; TXA synthase; cytochrome P450 5A1;
                     thromboxane synthase; hydroperoxy icosatetraenoate
                     dehydratase"
                     /codon_start=1
                     /product="thromboxane-A synthase isoform 1"
                     /protein_id="NP_035669.3"
                     /db_xref="CCDS:CCDS20018.1"
                     /db_xref="GeneID:21391"
                     /db_xref="MGI:MGI:98497"
                     /translation="MEVLGLLKFEVSGTIVTVTLLVALLALLKWYSMSAFSRLEKLGI
                     RHPKPSPFVGNLMFFRQGFWESQLELRERYGPLCGYYLGRRMHVVISEPDMIKQVLVE
                     NFSNFSNRMASGLEPKMVADSVLLLRDRRWEEVRGALMSSFSPEKLDEMTPLISQACE
                     LLVAHLKRYAASRDAFNIQRCYCCYTIDVVASVAFGTQVDSQNSPEDPFVQHCRRAST
                     FCIPRPLLVLILSFPSIMVPLARILPNKNRDELNGFFNTLIRNVIALRDQQAAEERRR
                     DFLQMVLDAQHSMNSVGVEGFDMVPESLSSSECTKEPPQRCHPTSTSKPFTVDEIVGQ
                     AFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPAPEYHSLQEGLPY
                     LDMVISETLRMYPPAFRFTREAAQDCEVLGQRIPAGTVLEIAVGALHHDPEHWPNPET
                     FDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQVLHKFRFEASPET
                     QVPLQLESKSALGPKNGVYIKIVSR"
     exon            238..331
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /inference="alignment:Splign:2.1.0"
     exon            332..384
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /inference="alignment:Splign:2.1.0"
     exon            385..481
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /inference="alignment:Splign:2.1.0"
     exon            482..598
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /inference="alignment:Splign:2.1.0"
     exon            599..687
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /inference="alignment:Splign:2.1.0"
     exon            688..836
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /inference="alignment:Splign:2.1.0"
     exon            837..967
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1282
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /inference="alignment:Splign:2.1.0"
     exon            1283..1374
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /inference="alignment:Splign:2.1.0"
     exon            1375..1512
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /inference="alignment:Splign:2.1.0"
     exon            1513..1675
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1959
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1938..1943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /note="hexamer: AATAAA"
     polyA_site      1959
                     /gene="Tbxas1"
                     /gene_synonym="CYP5; CYP5A1; THAS; TS; TXAS; TXS"
                     /note="major polyA site"
ORIGIN      
        1 acttttgggg gactcacttg atgggatgtt cagctgacta cctacttctt tctccaccac
       61 ctatatacag atcaggactc ctataagggc aggagagcag caccctcttt cctcctgagg
      121 accacccctc cggggtctcc gaggaaaaat ggaagtgttg gggcttctca agtttgaagt
      181 cagtggtacc atagtgactg tgactctgct cgtggctctc ttggccctcc tgaaatggta
      241 ctccatgtca gctttctcaa gactggagaa gttgggcatc aggcacccca agccttctcc
      301 ttttgttgga aacttgatgt ttttccgcca gggtttttgg gagagccaat tggaactccg
      361 agagcgatac gggcctctgt gtgggtacta tcttggccgt cggatgcacg ttgtcatttc
      421 agagccagac atgatcaagc aggtgttggt tgagaacttc agtaactttt ccaacagaat
      481 ggcctcaggt ctggaaccca agatggtagc agacagtgtc ctgttgttac gtgacagaag
      541 atgggaggaa gtcaggggtg ccctgatgtc ttcattcagt cctgaaaagt tggatgagat
      601 gacacctctc atcagccaag cctgtgaact tctcgtggct cacttaaaac gctatgcagc
      661 atccagggac gcattcaaca tccagaggtg ttactgctgt tacaccatag atgtggtggc
      721 cagtgtggcc tttggcaccc aggtggactc ccagaattct ccagaagatc cctttgtgca
      781 acactgccgg cgtgcttcca ccttctgtat ccccaggcct ctcctggtat taatcttatc
      841 atttccatcc ataatggtcc cattggcccg gattctgccc aataagaacc gagatgaact
      901 gaatggcttt tttaacacac tcattaggaa tgtgattgcc ttacgggacc agcaagcagc
      961 agaagagagg cggagagact tcctgcagat ggtgctggat gcccagcact ccatgaactc
     1021 tgtgggcgtg gaaggctttg acatggtccc agaatccctg tcctcttctg agtgcacaaa
     1081 ggaaccaccc caaaggtgcc atcctacctc cacatctaag cctttcactg tggatgaaat
     1141 tgtgggccag gccttcctct tcctcattgc gggccatgag gtcatcacaa acacgctgtc
     1201 cttcatcaca tacctgctgg ccacccaccc tgactgccag gagaggcttc tgaaagaggt
     1261 ggacctcttc atggggaagc acccagcccc tgagtaccac agcctgcagg aaggtctgcc
     1321 gtatctggac atggtgattt cagagaccct gaggatgtac ccaccagctt tcaggttcac
     1381 acgggaggca gcacaggact gtgaggtgct gggacaacgt atccctgcag gtacagtgct
     1441 ggagatagct gtgggtgccc tacaccatga cccagagcac tggccgaatc ctgagacctt
     1501 tgaccctgaa aggttcacag cagaggcccg gcttcagcgg aggccgttca catacctgcc
     1561 ctttggagct ggccccagga gctgcctcgg agtgcggctg ggcctgctgg tggtcaagct
     1621 gacaatactc caggtcctac acaagttccg ctttgaagcc agccctgaga ctcaggttcc
     1681 acttcagcta gaatccaaat ctgccctagg ccccaaaaat ggagtctaca tcaagattgt
     1741 gtcacgctga tatagaaggc acgtgggaaa gaggaagcac tttgtaatgg taacatctgc
     1801 acatcgctgc aggagggcac ccgggattca gatgaaagcc tcgtgtggag atggagagtt
     1861 tataggaata tatatcttag ggtgatcaaa agggcacatg gcatgtgagc ctactttgtc
     1921 acaattccta aatgtttaat aaatgtttac catgcttca
//
