LOCUS       NM_011538               1731 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus T-box 6 (Tbx6), mRNA.
ACCESSION   NM_011538
VERSION     NM_011538.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1731)
  AUTHORS   Hung,Y.S., Lin,W.M., Wang,Y.C., Kuo,W.C., Chen,Y.Y., Fann,M.J.,
            Yu,J.Y. and Wong,Y.H.
  TITLE     Protogenin facilitates trunk-to-tail HOX code transition via
            modulating GDF11/SMAD2 signaling in mammalian embryos
  JOURNAL   Commun Biol 7 (1), 1669 (2024)
   PUBMED   39702818
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1731)
  AUTHORS   Oh,S.A., Jeon,J., Je,S.Y., Kim,S., Jung,J. and Ko,H.W.
  TITLE     TMEM132A regulates Wnt/beta-catenin signaling through stabilizing
            LRP6 during mouse embryonic development
  JOURNAL   Cell Commun Signal 22 (1), 482 (2024)
   PUBMED   39385148
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1731)
  AUTHORS   Feng,X., Ye,Y., Zhang,J., Zhang,Y., Zhao,S., Mak,J.C.W., Otomo,N.,
            Zhao,Z., Niu,Y., Yonezawa,Y., Li,G., Lin,M., Li,X., Cheung,P.W.H.,
            Xu,K., Takeda,K., Wang,S., Xie,J., Kotani,T., Choi,V.N.T.,
            Song,Y.Q., Yang,Y., Luk,K.D.K., Lee,K.S., Li,Z., Li,P.S.,
            Leung,C.Y.H., Lin,X., Wang,X., Qiu,G., Watanabe,K., Wu,Z.,
            Posey,J.E., Ikegawa,S., Lupski,J.R., Cheung,J.P.Y., Zhang,T.J.,
            Gao,B. and Wu,N.
  CONSRTM   DISCO (Deciphering disorders Involving Scoliosis and COmorbidities)
            study group; Japanese Early Onset Scoliosis Research Group
  TITLE     Core planar cell polarity genes VANGL1 and VANGL2 in predisposition
            to congenital vertebral malformations
  JOURNAL   Proc Natl Acad Sci U S A 121 (18), e2310283121 (2024)
   PUBMED   38669183
REFERENCE   4  (bases 1 to 1731)
  AUTHORS   Pappas,M.P., Kawakami,H., Corcoran,D., Chen,K.Q., Scott,E.P.,
            Wong,J., Gearhart,M.D., Nishinakamura,R., Nakagawa,Y. and
            Kawakami,Y.
  TITLE     Sall4 regulates posterior trunk mesoderm development by promoting
            mesodermal gene expression and repressing neural genes in the
            mesoderm
  JOURNAL   Development 151 (5) (2024)
   PUBMED   38345319
REFERENCE   5  (bases 1 to 1731)
  AUTHORS   Sampath Kumar,A., Tian,L., Bolondi,A., Hernandez,A.A., Stickels,R.,
            Kretzmer,H., Murray,E., Wittler,L., Walther,M., Barakat,G.,
            Haut,L., Elkabetz,Y., Macosko,E.Z., Guignard,L., Chen,F. and
            Meissner,A.
  TITLE     Spatiotemporal transcriptomic maps of whole mouse embryos at the
            onset of organogenesis
  JOURNAL   Nat Genet 55 (7), 1176-1185 (2023)
   PUBMED   37414952
REFERENCE   6  (bases 1 to 1731)
  AUTHORS   Chapman,D.L. and Papaioannou,V.E.
  TITLE     Three neural tubes in mouse embryos with mutations in the T-box
            gene Tbx6
  JOURNAL   Nature 391 (6668), 695-697 (1998)
   PUBMED   9490412
REFERENCE   7  (bases 1 to 1731)
  AUTHORS   Davis,T.L., Tremblay,K.D. and Bartolomei,M.S.
  TITLE     Imprinted expression and methylation of the mouse H19 gene are
            conserved in extraembryonic lineages
  JOURNAL   Dev Genet 23 (2), 111-118 (1998)
   PUBMED   9770268
REFERENCE   8  (bases 1 to 1731)
  AUTHORS   Chapman,D.L., Agulnik,I., Hancock,S., Silver,L.M. and
            Papaioannou,V.E.
  TITLE     Tbx6, a mouse T-Box gene implicated in paraxial mesoderm formation
            at gastrulation
  JOURNAL   Dev Biol 180 (2), 534-542 (1996)
   PUBMED   8954725
REFERENCE   9  (bases 1 to 1731)
  AUTHORS   Agulnik,S.I., Garvey,N., Hancock,S., Ruvinsky,I., Chapman,D.L.,
            Agulnik,I., Bollag,R., Papaioannou,V. and Silver,L.M.
  TITLE     Evolution of mouse T-box genes by tandem duplication and cluster
            dispersion
  JOURNAL   Genetics 144 (1), 249-254 (1996)
   PUBMED   8878690
REFERENCE   10 (bases 1 to 1731)
  AUTHORS   Theiler,K. and Varnum,D.S.
  TITLE     Development of rib-vertebrae: a new mutation in the house mouse
            with accessory caudal duplications
  JOURNAL   Anat Embryol (Berl) 173 (1), 111-116 (1985)
   PUBMED   4073528
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            U57331.1, BF607954.1, AI152111.1 and AW047428.1.
            
            On Jun 18, 2004 this sequence version replaced NM_011538.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY654733.1, ERR3363658.5049482.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-212               U57331.1           1-212
            213-377             BF607954.1         248-412
            378-490             U57331.1           378-490
            491-605             BF607954.1         526-640
            606-1014            U57331.1           606-1014
            1015-1110           AI152111.1         59-154
            1111-1133           U57331.1           1110-1132
            1134-1164           AI152111.1         178-208
            1165-1424           U57331.1           1163-1422
            1425-1731           AW047428.1         1-307               c
FEATURES             Location/Qualifiers
     source          1..1731
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.25 cM"
     gene            1..1731
                     /gene="Tbx6"
                     /gene_synonym="rv"
                     /note="T-box 6"
                     /db_xref="GeneID:21389"
                     /db_xref="MGI:MGI:102539"
     exon            1..142
                     /gene="Tbx6"
                     /gene_synonym="rv"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..1335
                     /gene="Tbx6"
                     /gene_synonym="rv"
                     /note="T-box protein 6; rib-vertebrae"
                     /codon_start=1
                     /product="T-box transcription factor TBX6"
                     /protein_id="NP_035668.2"
                     /db_xref="CCDS:CCDS21843.1"
                     /db_xref="GeneID:21389"
                     /db_xref="MGI:MGI:102539"
                     /translation="MYHPRELYPSLGTGYRLGHPQPGADSTFPPALTEGYRYPDLDTS
                     KLDCFLSGIEAAPHTLAAAAPLPLLPSALGPETAPPPPEALHSLPGVSLSLENQELWK
                     EFSAVGTEMIITKAGRRMFPACRVSVTGLDPEARYLFLLDVVPVDGARYRWQGQHWEP
                     SGKAEPRLPDRVYIHPDSPATGAHWMRQPVSFHRVKLTNSTLDPHGHLILHSMHKYQP
                     RIHLVRATQLCSQHWGGVASFRFPETTFISVTAYQNPRITQLKIAANPFAKGFRENGR
                     NCKRERDARVKRKLRGPEPVATEACGSGDTPGGPCDSTLGGDIRDSDPEQAPTPQEAA
                     SASAPPCGGPSAEAYLLHPAAFHGAPSHLPARTPSFAEAPDPGRPAPYSAAFLDLQPG
                     PGGSAYQAAPSVPSFAPHFIQGGPFPLPYPGPGGYLDMGSKPMY"
     exon            143..377
                     /gene="Tbx6"
                     /gene_synonym="rv"
                     /inference="alignment:Splign:2.1.0"
     exon            378..645
                     /gene="Tbx6"
                     /gene_synonym="rv"
                     /inference="alignment:Splign:2.1.0"
     exon            646..792
                     /gene="Tbx6"
                     /gene_synonym="rv"
                     /inference="alignment:Splign:2.1.0"
     exon            793..863
                     /gene="Tbx6"
                     /gene_synonym="rv"
                     /inference="alignment:Splign:2.1.0"
     exon            864..937
                     /gene="Tbx6"
                     /gene_synonym="rv"
                     /inference="alignment:Splign:2.1.0"
     exon            938..1121
                     /gene="Tbx6"
                     /gene_synonym="rv"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1715
                     /gene="Tbx6"
                     /gene_synonym="rv"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1695..1700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbx6"
                     /gene_synonym="rv"
     polyA_site      1715
                     /gene="Tbx6"
                     /gene_synonym="rv"
ORIGIN      
        1 cacaaggcca gaagaaacta caacatgtac catccacgag agttgtaccc ctccctgggg
       61 actggctacc gtctgggaca cccccagcct ggggcagact ccaccttccc acctgccctg
      121 acagagggtt accgctaccc tgatttggat acttctaaac tggattgctt cctctctggg
      181 atcgaggcag ctccccacac tctggctgca gccgctcctt tgccccttct cccatctgct
      241 ctgggccccg agacagcacc gccaccccca gaggcccttc actcgcttcc tggggtcagc
      301 ctgagcttgg agaaccagga actgtggaag gaattcagcg ctgtggggac agagatgatc
      361 atcaccaagg ctggcaggcg catgttccct gcttgccgag tatcagtcac tggcctggac
      421 ccagaggccc gctacttgtt tcttctggat gtggttccag tggatggggc ccgataccgc
      481 tggcagggcc agcactggga gccaagtggc aaggctgaac cccgcctacc cgaccgtgtc
      541 tacattcacc ctgactctcc tgccactggt gcccactgga tgcggcagcc cgtatccttc
      601 catcgtgtta agctcaccaa cagcacactg gacccccatg gccacctgat cttgcactcg
      661 atgcacaagt accagcctcg catccacctg gtgagagcca cccaactatg cagccaacac
      721 tgggggggtg tggcctcctt ccgatttcct gagaccacat tcatctctgt gacagcctac
      781 cagaacccta ggatcacaca gctgaagatc gcagccaatc cctttgccaa aggtttccga
      841 gaaaatggca gaaactgtaa gagggagcgg gatgcccgtg tgaagaggaa acttcggggc
      901 ccagagccag tggccacaga ggcctgtggg agtggggata caccaggggg tccctgtgac
      961 tccaccctgg gtggggacat tcgggactca gatccagagc aggccccaac cccccaggaa
     1021 gctgcttctg cctcagctcc tccatgtggg ggccccagtg ctgaggccta ccttctacac
     1081 cctgccgctt ttcatggcgc ccccagtcac ctaccagcca ggacccccag cttcgctgag
     1141 gctccagacc ctgggcgccc agccccctac tcagctgcat ttctggacct acagcctgga
     1201 ccagggggct ctgcctatca ggcagctcca tctgtaccat cctttgcccc acacttcatc
     1261 caagggggtc ccttccctct accgtaccca ggacctggag gttatctgga catgggatcc
     1321 aagccaatgt actgagcctc ggtgtagtaa ccctatgcca tcttcccttg atcctccagc
     1381 tcccttcccc cagcctggta gcatccgcat tgaagtggta tccccctccc ccccaccaaa
     1441 tggctggctt gggcctctct tccacccttt agttcacacc ttgatttcac tccaccccct
     1501 ctggcttcaa agctcaggca aggcagctct gagtccagct ggggcctgct tcccctcagc
     1561 tctcacctta gtgcgaatgg agggagcctc tgcctggcca aatggggctc ccagcccagt
     1621 acccccacct cctgggggcc ttgttactag tgcaagccat gccaatttgt tctcaggatc
     1681 agagtatttt tgttaataaa actccaaaga cattaaaaaa aaaaaaaaaa a
//
