LOCUS       NM_011537               3941 bp    mRNA    linear   ROD 31-DEC-2024
DEFINITION  Mus musculus T-box 5 (Tbx5), mRNA.
ACCESSION   NM_011537
VERSION     NM_011537.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3941)
  AUTHORS   Argiro,L., Chevalier,C., Choquet,C., Nandkishore,N., Ghata,A.,
            Baudot,A., Zaffran,S. and Lescroart,F.
  TITLE     Gastruloids are competent to specify both cardiac and skeletal
            muscle lineages
  JOURNAL   Nat Commun 15 (1), 10172 (2024)
   PUBMED   39580459
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3941)
  AUTHORS   Guijarro,C., Song,S., Aigouy,B., Clement,R., Villoutreix,P. and
            Kelly,R.G.
  TITLE     Single-cell morphometrics reveals T-box gene-dependent patterns of
            epithelial tension in the Second Heart field
  JOURNAL   Nat Commun 15 (1), 9512 (2024)
   PUBMED   39496595
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3941)
  AUTHORS   Nord,C., Jones,I., Garcia-Maestre,M., Hagglund,A.C. and Carlsson,L.
  TITLE     Reduced mTORC1-signaling in progenitor cells leads to retinal
            lamination deficits
  JOURNAL   Dev Dyn 253 (10), 922-939 (2024)
   PUBMED   38546215
REFERENCE   4  (bases 1 to 3941)
  AUTHORS   Li,Y., Ma,K., Dong,Z., Gao,S., Zhang,J., Huang,S., Yang,J.,
            Fang,G., Li,Y., Li,X., Welch,C., Griffin,E.L., Ramaswamy,P.,
            Valivullah,Z., Liu,X., Dong,J., Wang,D.W., Du,J., Chung,W.K. and
            Li,Y.
  TITLE     Frameshift variants in C10orf71 cause dilated cardiomyopathy in
            human, mouse, and organoid models
  JOURNAL   J Clin Invest 134 (12), e177172 (2024)
   PUBMED   38950288
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3941)
  AUTHORS   Lozovska,A., Korovesi,A.G., Dias,A., Lopes,A., Fowler,D.A.,
            Martins,G.G., Novoa,A. and Mallo,M.
  TITLE     Tgfbr1 controls developmental plasticity between the hindlimb and
            external genitalia by remodeling their regulatory landscape
  JOURNAL   Nat Commun 15 (1), 2509 (2024)
   PUBMED   38509075
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3941)
  AUTHORS   Agulnik,S.I., Garvey,N., Hancock,S., Ruvinsky,I., Chapman,D.L.,
            Agulnik,I., Bollag,R., Papaioannou,V. and Silver,L.M.
  TITLE     Evolution of mouse T-box genes by tandem duplication and cluster
            dispersion
  JOURNAL   Genetics 144 (1), 249-254 (1996)
   PUBMED   8878690
REFERENCE   7  (bases 1 to 3941)
  AUTHORS   Chapman,D.L., Garvey,N., Hancock,S., Alexiou,M., Agulnik,S.I.,
            Gibson-Brown,J.J., Cebra-Thomas,J., Bollag,R.J., Silver,L.M. and
            Papaioannou,V.E.
  TITLE     Expression of the T-box family genes, Tbx1-Tbx5, during early mouse
            development
  JOURNAL   Dev Dyn 206 (4), 379-390 (1996)
   PUBMED   8853987
REFERENCE   8  (bases 1 to 3941)
  AUTHORS   Gibson-Brown,J.J., Agulnik,S.I., Chapman,D.L., Alexiou,M.,
            Garvey,N., Silver,L.M. and Papaioannou,V.E.
  TITLE     Evidence of a role for T-box genes in the evolution of limb
            morphogenesis and the specification of forelimb/hindlimb identity
  JOURNAL   Mech Dev 56 (1-2), 93-101 (1996)
   PUBMED   8798150
REFERENCE   9  (bases 1 to 3941)
  AUTHORS   Zhang,L., Chase,M.B. and Shen,R.F.
  TITLE     Molecular cloning and expression of murine thromboxane synthase
  JOURNAL   Biochem Biophys Res Commun 194 (2), 741-748 (1993)
   PUBMED   7688225
REFERENCE   10 (bases 1 to 3941)
  AUTHORS   Namba,T., Sugimoto,Y., Hirata,M., Hayashi,Y., Honda,A., Watabe,A.,
            Negishi,M., Ichikawa,A. and Narumiya,S.
  TITLE     Mouse thromboxane A2 receptor: cDNA cloning, expression and
            northern blot analysis
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1197-1203 (1992)
   PUBMED   1375456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC090639.1, BX529547.1 and AI413447.1.
            
            On May 7, 2009 this sequence version replaced NM_011537.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090639.1, AF140427.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               BC090639.1         1-163
            164-3198            BC090639.1         168-3202
            3199-3327           BX529547.1         141-269
            3328-3579           BX529547.1         271-522
            3580-3941           AI413447.1         10-371              c
FEATURES             Location/Qualifiers
     source          1..3941
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.42 cM"
     gene            1..3941
                     /gene="Tbx5"
                     /note="T-box 5"
                     /db_xref="GeneID:21388"
                     /db_xref="MGI:MGI:102541"
     exon            1..615
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            616..800
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            801..895
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1015
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..1163
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1164..1316
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1408
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1635
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
     exon            1636..3941
                     /gene="Tbx5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cacacacaca cacagagaga gagagagaga gagagagaga gagagagaga agagggagcc
       61 agttagagaa gcattttcta tactttgtga gcaccccagc tgagttagtt tgtcagagag
      121 agagagagag agagagagag agagagagag agagagagag agaaagtcat acttcaaatt
      181 ctggaacttt aacccctgaa agcatctctc tgaaaacagc tggctgattc ccaagtctct
      241 ctcaagtctc ccagtttttc ttctctgggg gtgcaagagc agagcaggac actgagatcg
      301 tagggtttag ggatgctccc agatctgcta tttagtcttc tgttcctcta agccgttctg
      361 gagcccgaca acttaaaagt atttggggct agcgaacagc cagcgagcag tggaggaggt
      421 gtgtgctgga ggtgggcagt cgctgggagg ctctagtggt gggtacttct ttgtagcaac
      481 agtagcagct agcttgggca agcaatcccc agcacaaact ccagagacac catgcctgca
      541 cccccacctg gcctccggct ttcctgctaa gaggaagagg ggcggtggcg aatgcatccc
      601 cctgtacaga gcgagaatag aacctcgcgc gggcacagga acccctgcgc accatggccg
      661 atacagatga gggctttggc ctggcgcgca cgcctctgga gcctgattcc aaagacaggt
      721 cttgcgattc gaaacctgag agtgctctgg gggctcccag caagtctcca tcatccccgc
      781 aggctgcctt cacccagcag ggcatggaag gaatcaaggt gtttcttcat gaacgtgaac
      841 tgtggctgaa gttccacgaa gtgggcacag agatgatcat caccaaggca gggaggagaa
      901 tgtttcctag ttacaaagtg aaggtgactg gccttaatcc caaaacgaag tatattcttc
      961 tcatggatat tgttcccgca gacgaccaca gatataaatt tgctgataac aaatggtccg
     1021 taactggcaa agcagagcct gccatgccgg ggcgccttta cgtgcacccg gactccccag
     1081 caaccggagc ccactggatg cgacaacttg tctccttcca gaagctcaaa ctcaccaaca
     1141 accacctgga cccgtttgga cacattatcc tgaactccat gcacaaatac cagccccgat
     1201 tacacatcgt gaaagcagac gaaaataatg ggttcggttc aaagaacact gcgttttgca
     1261 cccacgtctt cccggagaca gcttttatcg ctgtgacttc gtaccagaat cacaagatca
     1321 cacagctgaa aattgagaac aaccccttcg ccaaaggctt tcggggcagt gatgacctgg
     1381 agttacacag gatgtctcgg atgcaaagta aagagtatcc tgtggttccc aggagcacag
     1441 tgaggcacaa agtcacctcc aaccacagcc ccttcagcag cgagacccga gctctctcca
     1501 cctcatccaa tttagggtcc cagtaccagt gtgagaatgg tgtctctggc ccctcccagg
     1561 accttctgcc cccacctaac ccatacccac tggcccagga gcacagccaa atttaccact
     1621 gtaccaagag gaaagatgag gaatgttcca gcacggagca cccctataag aagccgtaca
     1681 tggagacatc ccccagcgag gaagacacct tctatcgctc gggctacccc cagcagcagg
     1741 gcctgagtac ctcttacagg acagagtcgg cccagcggca ggcctgcatg tatgccagct
     1801 ccgctccccc cagcgagccc gtgcctagcc tggaggacat cagctgtaac acatggccca
     1861 gcatgccctc ctatagcagc tgtaccgtca ccaccgtgca gcccatggac cgtcttccct
     1921 accagcactt ctccgctcat ttcacctcgg ggcccctggt ccctcggttg gctggcatgg
     1981 ccaaccatgg ttctccccag ctcggcgaag ggatgtttca gcaccagacc tcagtggccc
     2041 atcagcctgt ggtcaggcag tgcgggcctc agactggcct tcagtctccg ggcggcctcc
     2101 agcccccaga gtttctctac actcacggcg tgcccaggac cctgtccccc catcagtatc
     2161 actcggtaca cggcgtcggc atggtgccag agtggagtga gaatagctaa aggctgacct
     2221 gtgccagaga gggtgtgggg agagagagag agagagagag agagagagag agagagagag
     2281 agagagagaa gtgagggaca gtagtgatga gaaccccgca gatgcgaagc tctagatcgc
     2341 ccgttgtaac ctccatatct ggagctccac agccactgat aagatcagtg ccccgaagcc
     2401 accattccaa aattgtgact cgatgtctca gaaccgatag gagaaacaga aagagtgtcg
     2461 agtcccatcc taccccgcgc ccactctcat ccaaccagga acacatacac agcgccccag
     2521 acatgttccc cgattgtttc tcttgggttc gagaccatat tgcctcgctg agtgttggac
     2581 cccgaccgca cggtgagagg cactctgtgt ctcagtgtta atgttgactt tgttatataa
     2641 taaataataa tatatttttt tcctttggaa ttttcttact gggacccagt cccttgaatg
     2701 gagggagagc agagacagag atgtctcaaa acacgtactt tcggggcttc cctccgataa
     2761 atgagctaaa atgtacatcg gccaccctcc tctaacaaaa aaatacctac ctccgtcatg
     2821 tgagatgtct acgaacgtcg caggggctac ctgctagttt ttggattggg ttttgctttt
     2881 tctccttctg gtttggttct gccttcccca gcgtcgtgga attcagagtt gccttctact
     2941 gagcgtatgg agctaggatg tcgggctcag tctgacaccc tcactcctca gcacctatcg
     3001 tcccagctcc agtctctcca gccgtctgtg gctaaaacgg ggcctagaac tcctcagcct
     3061 ggaaaccttg cttcgataaa ctgaaagagc cctgggtgac acaggaacag aactgtgaca
     3121 cacagcaagg gcgcaagctc ccggcttaca cgttgtaggg gagaagaaag tgaaaataaa
     3181 tatactttgt attaaaaaga aaaaaaaatg aacagtgacg tcagcgtcag ccccaggctg
     3241 gctcaaacct cctctgtgac cctccggata cagagcaaaa cagctccagg tgcctcagga
     3301 gaggaactgt tacctgtgcc tcagcctcca agaaatcccc acccccatcc ccacccccat
     3361 ccccaccccc accccagcgc caatcacctg ggacacaaaa ccacacgcat caaaagcaga
     3421 aaaacagtat taaaaaaaaa gtgtgtaagt acgacattat tgtagggttt ctcagatgta
     3481 atattttact ggtactattt atttataaat aggaattcta attaagtagt aacatgaaac
     3541 ccagcctggg ggctgaccaa gaccttttaa ttttatttgg tactcaaaac tgtgtttgtg
     3601 cgctctctct ctctctctct ctctctttcc tttcttgatt taaaaaaaag gttttgtgtt
     3661 tcttttcttt ctccttcctt ccttcctcct tcccttcttc tttttttttt ttttttaaac
     3721 tgaccctaat aaacagaaca gggtaatcta tgtggctgag aacgtggaag tctgtgagtg
     3781 agtgagtgag tgagtgagtg agtgagtgag tttgtgcatg agcattctat gtgatcttgt
     3841 ctttttatgt tgttaaaggg gggggttggg tgaaaaatca agtactcctt tcttacattt
     3901 gtgcacccat taatgcctaa taaataccat gtgcttaaaa g
//
