LOCUS       NM_011536               3210 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus T-box 4 (Tbx4), transcript variant 1, mRNA.
ACCESSION   NM_011536 XM_001002538 XM_006532780
VERSION     NM_011536.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3210)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   2  (bases 1 to 3210)
  AUTHORS   Chen,K.Q., Kawakami,H., Anderson,A., Corcoran,D., Soni,A.,
            Nishinakamura,R. and Kawakami,Y.
  TITLE     Sall genes regulate hindlimb initiation in mouse embryos
  JOURNAL   Genetics 227 (1) (2024)
   PUBMED   38386912
REFERENCE   3  (bases 1 to 3210)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 3210)
  AUTHORS   Qiu,C., Martin,B.K., Welsh,I.C., Daza,R.M., Le,T.M., Huang,X.,
            Nichols,E.K., Taylor,M.L., Fulton,O., O'Day,D.R., Gomes,A.R.,
            Ilcisin,S., Srivatsan,S., Deng,X., Disteche,C.M., Noble,W.S.,
            Hamazaki,N., Moens,C.B., Kimelman,D., Cao,J., Schier,A.F.,
            Spielmann,M., Murray,S.A., Trapnell,C. and Shendure,J.
  TITLE     A single-cell time-lapse of mouse prenatal development from
            gastrula to birth
  JOURNAL   Nature 626 (8001), 1084-1093 (2024)
   PUBMED   38355799
REFERENCE   5  (bases 1 to 3210)
  AUTHORS   Lin,S.M., Rue,R., Mukhitov,A.R., Goel,A., Basil,M.C.,
            Obraztsova,K., Babu,A., Crnkovic,S., Ledwell,O.A., Ferguson,L.T.,
            Planer,J.D., Nottingham,A.N., Vanka,K.S., Smith,C.J., Cantu,E. 3rd,
            Kwapiszewska,G., Morrisey,E.E., Evans,J.F. and Krymskaya,V.P.
  TITLE     Hyperactive mTORC1 in lung mesenchyme induces endothelial cell
            dysfunction and pulmonary vascular remodeling
  JOURNAL   J Clin Invest 134 (4), e172116 (2023)
   PUBMED   38127441
  REMARK    GeneRIF: Hyperactive mTORC1 in lung mesenchyme induces endothelial
            cell dysfunction and pulmonary vascular remodeling.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3210)
  AUTHORS   Agulnik,S.I., Garvey,N., Hancock,S., Ruvinsky,I., Chapman,D.L.,
            Agulnik,I., Bollag,R., Papaioannou,V. and Silver,L.M.
  TITLE     Evolution of mouse T-box genes by tandem duplication and cluster
            dispersion
  JOURNAL   Genetics 144 (1), 249-254 (1996)
   PUBMED   8878690
REFERENCE   7  (bases 1 to 3210)
  AUTHORS   Chapman,D.L., Garvey,N., Hancock,S., Alexiou,M., Agulnik,S.I.,
            Gibson-Brown,J.J., Cebra-Thomas,J., Bollag,R.J., Silver,L.M. and
            Papaioannou,V.E.
  TITLE     Expression of the T-box family genes, Tbx1-Tbx5, during early mouse
            development
  JOURNAL   Dev Dyn 206 (4), 379-390 (1996)
   PUBMED   8853987
REFERENCE   8  (bases 1 to 3210)
  AUTHORS   Gibson-Brown,J.J., Agulnik,S.I., Chapman,D.L., Alexiou,M.,
            Garvey,N., Silver,L.M. and Papaioannou,V.E.
  TITLE     Evidence of a role for T-box genes in the evolution of limb
            morphogenesis and the specification of forelimb/hindlimb identity
  JOURNAL   Mech Dev 56 (1-2), 93-101 (1996)
   PUBMED   8798150
REFERENCE   9  (bases 1 to 3210)
  AUTHORS   Zhang,L., Chase,M.B. and Shen,R.F.
  TITLE     Molecular cloning and expression of murine thromboxane synthase
  JOURNAL   Biochem Biophys Res Commun 194 (2), 741-748 (1993)
   PUBMED   7688225
REFERENCE   10 (bases 1 to 3210)
  AUTHORS   Namba,T., Sugimoto,Y., Hirata,M., Hayashi,Y., Honda,A., Watabe,A.,
            Negishi,M., Ichikawa,A. and Narumiya,S.
  TITLE     Mouse thromboxane A2 receptor: cDNA cloning, expression and
            northern blot analysis
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1197-1203 (1992)
   PUBMED   1375456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592465.8.
            
            On or before Jun 19, 2019 this sequence version replaced
            XM_006532780.2, NM_011536.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB221665.1, AY075134.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849387, SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AL592465.8         16493-16688
            197-400             AL592465.8         20186-20389
            401-495             AL592465.8         20983-21077
            496-615             AL592465.8         28619-28738
            616-763             AL592465.8         29876-30023
            764-916             AL592465.8         41233-41385
            917-1005            AL592465.8         42062-42150
            1006-1241           AL592465.8         42232-42467
            1242-3210           AL592465.8         44255-46223
FEATURES             Location/Qualifiers
     source          1..3210
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.42 cM"
     gene            1..3210
                     /gene="Tbx4"
                     /gene_synonym="3930401C23"
                     /note="T-box 4"
                     /db_xref="GeneID:21387"
                     /db_xref="MGI:MGI:102556"
     exon            1..196
                     /gene="Tbx4"
                     /gene_synonym="3930401C23"
                     /inference="alignment:Splign:2.1.0"
     exon            197..400
                     /gene="Tbx4"
                     /gene_synonym="3930401C23"
                     /inference="alignment:Splign:2.1.0"
     CDS             200..1858
                     /gene="Tbx4"
                     /gene_synonym="3930401C23"
                     /note="isoform a is encoded by transcript variant 1; T-box
                     transcription factor TBX4; T-box protein 4"
                     /codon_start=1
                     /product="T-box transcription factor TBX4 isoform a"
                     /protein_id="NP_035666.2"
                     /db_xref="CCDS:CCDS25196.1"
                     /db_xref="GeneID:21387"
                     /db_xref="MGI:MGI:102556"
                     /translation="MLQDKGLSESEEAFRAPGPALGEASNTSTTNAPEPALATPGLSG
                     AALSSPPGQGADVAAAAAAAAEQTIENIKVGLHEKELWKKFHEAGTEMIITKAGRRMF
                     PSYKVKVTGMNPKTKYILLIDIVPADDHRYKFCDNKWMVAGKAEPAMPGRLYVHPDSP
                     ATGAHWMRQLVSFQKLKLTNNHLDPFGHIILNSMHKYQPRLHIVKADENNAFGSKNTA
                     FCTHVFPETSFISVTSYQNHKITQLKIENNPFAKGFRGSDDSDLRVARLQSKEYPVIS
                     KSIMRQRLVSSQLSAKPDVSPLHSAHQALQHYQYENGAHMQFAAAEPQDLPLNTFPTQ
                     RDSSLFYHCLKRRDSARHLDLPCKRSYLETPSSVGDDHYFRSPPPYDQQMLSPSYCSE
                     VTPREACMYSSSGPEIAGVSAVDDLPPPPLSCNMWTSVSPYTSYSVQTMETVPYQPFP
                     AHFTATTVMPRLPTIAAQSAQPPGNAHFSVYNQLSQSQVRERGPSASFPRERGLPGMC
                     ERKPPSPHLNTANEFLYSQSFSLTRESSLQYHSGMGTVENWTDG"
     exon            401..495
                     /gene="Tbx4"
                     /gene_synonym="3930401C23"
                     /inference="alignment:Splign:2.1.0"
     exon            496..615
                     /gene="Tbx4"
                     /gene_synonym="3930401C23"
                     /inference="alignment:Splign:2.1.0"
     exon            616..763
                     /gene="Tbx4"
                     /gene_synonym="3930401C23"
                     /inference="alignment:Splign:2.1.0"
     exon            764..916
                     /gene="Tbx4"
                     /gene_synonym="3930401C23"
                     /inference="alignment:Splign:2.1.0"
     exon            917..1005
                     /gene="Tbx4"
                     /gene_synonym="3930401C23"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1241
                     /gene="Tbx4"
                     /gene_synonym="3930401C23"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..3210
                     /gene="Tbx4"
                     /gene_synonym="3930401C23"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcccca aagtgcagcc tcggagatca agggcccgct ctacacccgg gatgtgctgg
       61 gccccgaggg cgcagcaggc agccggacgg tgacccagag gcccaggcag actccctgcg
      121 gtcccgttcc tctaggacct gagctggttg cagacctggg gccgcaggag cctccgcatg
      181 ctgcggcgca gttagggaga tgctgcagga taagggcctg tccgagagcg aggaggcctt
      241 cagggccccg ggcccagctc tcggggaggc cagcaacact agcaccacca acgcccccga
      301 acccgcgctg gccacgccgg gccttagtgg agcagcgctc agcagcccac cgggccaggg
      361 cgccgacgtc gccgccgccg ccgctgccgc cgcggagcag accatcgaga acatcaaggt
      421 ggggctgcat gagaaggagc tgtggaagaa gttccacgag gcaggcacgg agatgatcat
      481 caccaaggcc ggcaggagga tgttccccag ctacaaggta aaagtcacag gcatgaaccc
      541 caagaccaag tacatacttc tcatcgacat cgtccccgca gatgaccatc gctacaagtt
      601 ctgtgacaac aaatggatgg tcgcagggaa ggctgagccg gccatgccag gaagacttta
      661 tgtgcacccg gattctcctg ccaccggggc tcactggatg cggcagttgg tctctttcca
      721 gaagctgaag ctgacaaaca accacctgga cccctttggc catatcatcc tcaactccat
      781 gcataagtac cagccaaggc tgcacatcgt taaggccgac gagaacaatg cttttggctc
      841 caaaaacaca gccttttgca cccacgtgtt cccagagacc tccttcatct ctgtgacctc
      901 ctaccagaac cacaagatca cccagctgaa aattgagaac aacccttttg ccaagggatt
      961 ccggggcagc gatgacagtg acctgcgtgt ggcccggttg cagagcaagg agtatcccgt
     1021 gatctccaaa agcatcatga ggcagaggct cgtttccagc caactctcgg ctaagccaga
     1081 tgtcagcccc ctgcacagcg cacaccaggc cctgcagcac taccagtatg agaatggggc
     1141 ccacatgcag tttgctgctg cagagcccca ggacctgccc ctcaacacct tcccaactca
     1201 gagggactcc agcctcttct accactgcct gaagcgtaga gacagtgccc gccacctgga
     1261 cttgccctgc aagcgatcct acctggaaac cccctcttca gtgggggacg atcactattt
     1321 ccgttctccc cctccctacg accagcagat gctgagccct tcttattgca gtgaggtgac
     1381 ccccagagaa gcctgtatgt actcgagttc ggggcctgag atcgcagggg tgtcagccgt
     1441 ggacgacctg cccccacccc cactgagctg taacatgtgg acgtcggtgt cgccatacac
     1501 cagctacagc gttcagacca tggagactgt gccttaccag cccttccccg cacactttac
     1561 tgccaccaca gtgatgcctc ggctgcccac catcgccgcc cagagcgccc agccaccagg
     1621 aaatgcccac tttagtgtgt acaatcagct atcccagtct caggtccgag agcgggggcc
     1681 ctctgcttcc ttccctagag agcgtggcct ccctgggatg tgtgagagga agccaccctc
     1741 acctcacctg aacactgcca acgagttcct ctactcacag agcttctcct tgacccggga
     1801 gtcatcctta cagtatcatt cagggatggg gactgtggag aactggaccg atggatgacg
     1861 agactacctg tatccttaac agccccaggg ccatgtcaat ccagtgttaa tctctgtggg
     1921 tggccagcac tgccaagaaa catggaaagg tatttcagaa tgtgtgtgtg tgtgtgtgtg
     1981 tgtgtgtgtg gtgtgtgcgc gtgcttgaac ttctacacac atgtggtcag agagcatctg
     2041 tcttctgaca tgcaactaag gccaaaacaa gaaaaaaatg caattatcta agaagtgact
     2101 ttggctacag gagccgagtc caccattagc tgacatctct tggcatgccc tgggtgggat
     2161 agaagtagag ggctcaggag tcacctggag ctttctgaaa tgtactttgg ttttactcag
     2221 gggccaagtg agatctctgg cacagggagg gcctttcttt tgcctgggta ggggtggggt
     2281 atccatgctt accatagact ccctggtctt ccaccagcac ggggagctgc cactttgggg
     2341 aacagaagca cccccttccc ttagcttctg gagattgtgt tgatactacc tgagccttag
     2401 agtgttttga gagtggagtt ggcctggact tggattcttg aagccccagg gtctgaagca
     2461 tgactttcaa aaaggagtca tgcgccatca cctcatgatt cgtacagagt ccctcccctc
     2521 ccagtgctag catgtggcct ccctctcagc ctgggagaca ccgtctgcat cccaggatgg
     2581 gcagtcagac gccccttacc cggcagtgtc ccttggagat ctcactggac tgatgtcaca
     2641 tatccgctgg actggctctg ctcccagaaa acctacatac atgcctggag cgaggatgcc
     2701 ggctggcaga agatggacag ctgagagaaa gtacttgagt gttcaagctc agaggagcat
     2761 atcatccctt cagagtaggg aggggagtat ccttggtcca tcagcatcac acgtcaccag
     2821 aacgtcaggg cggccggtat gaactctgga gatcactaaa ctctttgcat gctgaatagc
     2881 tatttatata ttatataaat aaataaatat ataaataaat atatatctca caaatgcggg
     2941 ccacatgtca aattcagctt tgcttttttt acaaataaac ttactgaaaa caaatgctga
     3001 aggaagtatt tggaaagaca tctatttaaa tttttattac gtttgatgtt aaagataaaa
     3061 catatatata tattataaat gcacactgca gataaagctt tattagaaaa cacactagct
     3121 gacaggcggt atgaaacttc aagtgttttt gatatatagc atggacattt tgttttgcat
     3181 attggaacat aaagccatct tacaactgtg
//
