LOCUS       NP_035666                552 aa            linear   ROD 12-JUN-2025
DEFINITION  T-box transcription factor TBX4 isoform a [Mus musculus].
ACCESSION   NP_035666 XP_001002538 XP_006532843
VERSION     NP_035666.2
DBSOURCE    REFSEQ: accession NM_011536.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 552)
  AUTHORS   Yamaguchi,H., Tran,L.T., Bi,J., Urayama,A., Yutzey,K.E., Mishina,Y.
            and Komatsu,Y.
  TITLE     Enhanced BMP signaling in cranial neural crest cells induces
            aberrant chondrogenesis by upregulating Tbx20 expression during
            craniofacial development
  JOURNAL   Biochem Biophys Res Commun 765, 151834 (2025)
   PUBMED   40273622
REFERENCE   2  (residues 1 to 552)
  AUTHORS   Maldonado-Velez,G., Mickler,E.A., Cook,T.G. and Aldred,M.A.
  TITLE     Loss of Tbx4 Affects Postnatal Lung Development and Predisposes to
            Pulmonary Hypertension
  JOURNAL   Am J Respir Cell Mol Biol (2025) In press
   PUBMED   40106779
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (residues 1 to 552)
  AUTHORS   Lozovska,A., Casaca,A., Novoa,A., Kuo,Y.Y., Jurberg,A.D.,
            Martins,G.G., Hadjantonakis,A.K. and Mallo,M.
  TITLE     Tgfbr1 regulates lateral plate mesoderm and endoderm reorganization
            during the trunk to tail transition
  JOURNAL   Elife 13, 94290 (2025)
   PUBMED   39874182
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 552)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   5  (residues 1 to 552)
  AUTHORS   Chen,K.Q., Kawakami,H., Anderson,A., Corcoran,D., Soni,A.,
            Nishinakamura,R. and Kawakami,Y.
  TITLE     Sall genes regulate hindlimb initiation in mouse embryos
  JOURNAL   Genetics 227 (1) (2024)
   PUBMED   38386912
REFERENCE   6  (residues 1 to 552)
  AUTHORS   Agulnik,S.I., Garvey,N., Hancock,S., Ruvinsky,I., Chapman,D.L.,
            Agulnik,I., Bollag,R., Papaioannou,V. and Silver,L.M.
  TITLE     Evolution of mouse T-box genes by tandem duplication and cluster
            dispersion
  JOURNAL   Genetics 144 (1), 249-254 (1996)
   PUBMED   8878690
REFERENCE   7  (residues 1 to 552)
  AUTHORS   Chapman,D.L., Garvey,N., Hancock,S., Alexiou,M., Agulnik,S.I.,
            Gibson-Brown,J.J., Cebra-Thomas,J., Bollag,R.J., Silver,L.M. and
            Papaioannou,V.E.
  TITLE     Expression of the T-box family genes, Tbx1-Tbx5, during early mouse
            development
  JOURNAL   Dev Dyn 206 (4), 379-390 (1996)
   PUBMED   8853987
REFERENCE   8  (residues 1 to 552)
  AUTHORS   Gibson-Brown,J.J., Agulnik,S.I., Chapman,D.L., Alexiou,M.,
            Garvey,N., Silver,L.M. and Papaioannou,V.E.
  TITLE     Evidence of a role for T-box genes in the evolution of limb
            morphogenesis and the specification of forelimb/hindlimb identity
  JOURNAL   Mech Dev 56 (1-2), 93-101 (1996)
   PUBMED   8798150
REFERENCE   9  (residues 1 to 552)
  AUTHORS   Zhang,L., Chase,M.B. and Shen,R.F.
  TITLE     Molecular cloning and expression of murine thromboxane synthase
  JOURNAL   Biochem Biophys Res Commun 194 (2), 741-748 (1993)
   PUBMED   7688225
REFERENCE   10 (residues 1 to 552)
  AUTHORS   Namba,T., Sugimoto,Y., Hirata,M., Hayashi,Y., Honda,A., Watabe,A.,
            Negishi,M., Ichikawa,A. and Narumiya,S.
  TITLE     Mouse thromboxane A2 receptor: cDNA cloning, expression and
            northern blot analysis
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1197-1203 (1992)
   PUBMED   1375456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL592465.8.
            
            On or before Jun 19, 2019 this sequence version replaced
            XP_006532843.1, NP_035666.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AB221665.1, AY075134.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849387, SAMN01164133 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.42 cM"
     Protein         1..552
                     /product="T-box transcription factor TBX4 isoform a"
                     /note="T-box transcription factor TBX4; T-box protein 4"
                     /calculated_mol_wt=60970
     Region          1..50
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P70325.3)"
     Region          72..256
                     /region_name="T-box_TBX4_5-like"
                     /note="DNA-binding domain of T-box transcription factor 4
                     and 5, and related T-box proteins; cd20189"
                     /db_xref="CDD:410315"
     Site            order(99..100,177,180,193..194,233,235,241,244..245,
                     248..254)
                     /site_type="DNA binding"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410315"
     Site            order(119,126..127,146,149,151,153,155,159..160,200,202,
                     205,217..219)
                     /site_type="other"
                     /note="homodimer interface [polypeptide binding]"
                     /db_xref="CDD:410315"
     Site            order(158..160,168)
                     /site_type="other"
                     /note="NKX2.5 interface [polypeptide binding]"
                     /db_xref="CDD:410315"
     Site            514
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (P70325.3)"
     CDS             1..552
                     /gene="Tbx4"
                     /gene_synonym="3930401C23"
                     /coded_by="NM_011536.3:200..1858"
                     /note="isoform a is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS25196.1"
                     /db_xref="GeneID:21387"
                     /db_xref="MGI:MGI:102556"
ORIGIN      
        1 mlqdkglses eeafrapgpa lgeasntstt napepalatp glsgaalssp pgqgadvaaa
       61 aaaaaeqtie nikvglheke lwkkfheagt emiitkagrr mfpsykvkvt gmnpktkyil
      121 lidivpaddh rykfcdnkwm vagkaepamp grlyvhpdsp atgahwmrql vsfqklkltn
      181 nhldpfghii lnsmhkyqpr lhivkadenn afgskntafc thvfpetsfi svtsyqnhki
      241 tqlkiennpf akgfrgsdds dlrvarlqsk eypvisksim rqrlvssqls akpdvsplhs
      301 ahqalqhyqy engahmqfaa aepqdlplnt fptqrdsslf yhclkrrdsa rhldlpckrs
      361 yletpssvgd dhyfrspppy dqqmlspsyc sevtpreacm ysssgpeiag vsavddlppp
      421 plscnmwtsv spytsysvqt metvpyqpfp ahftattvmp rlptiaaqsa qppgnahfsv
      481 ynqlsqsqvr ergpsasfpr erglpgmcer kppsphlnta neflysqsfs ltresslqyh
      541 sgmgtvenwt dg
//
