LOCUS       NM_198052               4783 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus T-box 3 (Tbx3), transcript variant 2, mRNA.
ACCESSION   NM_198052 XM_989690
VERSION     NM_198052.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4783)
  AUTHORS   Zheng,W., Zhang,Y., Xu,P., Wang,Z., Shao,X., Chen,C., Cai,H.,
            Wang,Y., Sun,M.A., Deng,W., Liu,F., Lu,J., Zhang,X., Cheng,D.,
            Mysorekar,I.U., Wang,H., Wang,Y.L., Hu,X. and Cao,B.
  TITLE     TFEB safeguards trophoblast syncytialization in humans and mice
  JOURNAL   Proc Natl Acad Sci U S A 121 (28), e2404062121 (2024)
   PUBMED   38968109
REFERENCE   2  (bases 1 to 4783)
  AUTHORS   Deng,S., Lu,X., Wang,X., Liang,B., Xu,H., Yang,D., Cui,G.,
            Yonemura,A., Paine,H., Zhou,Y., Zhang,Y., Simile,M.M., Urigo,F.,
            Evert,M., Calvisi,D.F., Green,B.L. and Chen,X.
  TITLE     Overexpression of TBX3 suppresses tumorigenesis in experimental and
            human cholangiocarcinoma
  JOURNAL   Cell Death Dis 15 (6), 441 (2024)
   PUBMED   38909034
  REMARK    GeneRIF: Overexpression of TBX3 suppresses tumorigenesis in
            experimental and human cholangiocarcinoma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4783)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
  REMARK    GeneRIF: TBX3 is essential for establishment of the posterior
            boundary of anterior genes and upregulation of posterior genes
            together with HAND2 during the onset of limb bud development.
REFERENCE   4  (bases 1 to 4783)
  AUTHORS   Zhang,Z., Wu,Y., Fu,J., Yu,X., Su,Y., Jia,S., Cheng,H., Shen,Y.,
            He,X., Ren,K., Zheng,X., Guan,H., Rao,F. and Zhao,L.
  TITLE     Proteostatic reactivation of the developmental transcription factor
            TBX3 drives BRAF/MAPK-mediated tumorigenesis
  JOURNAL   Nat Commun 15 (1), 4108 (2024)
   PUBMED   38750011
  REMARK    GeneRIF: Proteostatic reactivation of the developmental
            transcription factor TBX3 drives BRAF/MAPK-mediated tumorigenesis.
            Erratum:[Nat Commun. 2024 Jun 10;15(1):4936. doi:
            10.1038/s41467-024-49330-w.. PMID: 38858379]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4783)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   6  (bases 1 to 4783)
  AUTHORS   Chapman,D.L., Garvey,N., Hancock,S., Alexiou,M., Agulnik,S.I.,
            Gibson-Brown,J.J., Cebra-Thomas,J., Bollag,R.J., Silver,L.M. and
            Papaioannou,V.E.
  TITLE     Expression of the T-box family genes, Tbx1-Tbx5, during early mouse
            development
  JOURNAL   Dev Dyn 206 (4), 379-390 (1996)
   PUBMED   8853987
REFERENCE   7  (bases 1 to 4783)
  AUTHORS   Gibson-Brown,J.J., Agulnik,S.I., Chapman,D.L., Alexiou,M.,
            Garvey,N., Silver,L.M. and Papaioannou,V.E.
  TITLE     Evidence of a role for T-box genes in the evolution of limb
            morphogenesis and the specification of forelimb/hindlimb identity
  JOURNAL   Mech Dev 56 (1-2), 93-101 (1996)
   PUBMED   8798150
REFERENCE   8  (bases 1 to 4783)
  AUTHORS   Bollag,R.J., Siegfried,Z., Cebra-Thomas,J.A., Garvey,N.,
            Davison,E.M. and Silver,L.M.
  TITLE     An ancient family of embryonically expressed mouse genes sharing a
            conserved protein motif with the T locus
  JOURNAL   Nat Genet 7 (3), 383-389 (1994)
   PUBMED   7920656
REFERENCE   9  (bases 1 to 4783)
  AUTHORS   Zhang,L., Chase,M.B. and Shen,R.F.
  TITLE     Molecular cloning and expression of murine thromboxane synthase
  JOURNAL   Biochem Biophys Res Commun 194 (2), 741-748 (1993)
   PUBMED   7688225
REFERENCE   10 (bases 1 to 4783)
  AUTHORS   Namba,T., Sugimoto,Y., Hirata,M., Hayashi,Y., Honda,A., Watabe,A.,
            Negishi,M., Ichikawa,A. and Narumiya,S.
  TITLE     Mouse thromboxane A2 receptor: cDNA cloning, expression and
            northern blot analysis
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1197-1203 (1992)
   PUBMED   1375456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC096551.1, AA543734.1, BB728182.1, BB054411.2, BB694449.1 and
            CJ216213.1.
            
            On Sep 28, 2013 this sequence version replaced NM_198052.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            lacks an alternate in-frame exon in the 5' coding region, compared
            to variant 1. It encodes isoform 2, which is shorter than isoform
            1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC096551.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4050              BC096551.1         1-4050
            4051-4312           AA543734.1         230-491
            4313-4440           BB728182.1         100-227
            4441-4665           BB054411.2         354-578
            4666-4773           BB694449.1         216-323
            4774-4783           CJ216213.1         413-422
FEATURES             Location/Qualifiers
     source          1..4783
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 60.34 cM"
     gene            1..4783
                     /gene="Tbx3"
                     /gene_synonym="D5Ertd189e"
                     /note="T-box 3"
                     /db_xref="GeneID:21386"
                     /db_xref="MGI:MGI:98495"
     exon            1..196
                     /gene="Tbx3"
                     /gene_synonym="D5Ertd189e"
                     /inference="alignment:Splign:2.1.0"
     exon            197..1368
                     /gene="Tbx3"
                     /gene_synonym="D5Ertd189e"
                     /inference="alignment:Splign:2.1.0"
     CDS             980..3145
                     /gene="Tbx3"
                     /gene_synonym="D5Ertd189e"
                     /note="isoform 2 is encoded by transcript variant 2; T-box
                     transcription factor TBX3; T-box protein 3"
                     /codon_start=1
                     /product="T-box transcription factor TBX3 isoform 2"
                     /protein_id="NP_932169.1"
                     /db_xref="CCDS:CCDS19614.1"
                     /db_xref="GeneID:21386"
                     /db_xref="MGI:MGI:98495"
                     /translation="MSLSMRDPVIPGTSMAYHPFLPHRAPDFAMSAVLGHQPPFFPAL
                     TLPPNGAAALSLPGALAKPIMDQLVGAAETGIPFSSLGPQAHLRPLKTMEPEEDVEDD
                     PKVHLEAKELWDQFHKRGTEMVITKSGRRMFPPFKVRCSGLDKKAKYILLMDIIAADD
                     CRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMSKVVTFHKLKLTNNISDKHG
                     FTILNSMHKYQPRFHIVRANDILKLPYSTFRTYLFPETEFIAVTAYQNDKITQLKIDN
                     NPFAKGFRDTGNGRREKRKQLTLQSMRVFEERHKKETSDESSSEQAAFNCFAQASSPA
                     VSIVGTSNLKDLCPSEAESDAEAESKEEHGPEACDAAKISTTTAEEPGRDKGSPATRA
                     QLFPAEPSRARDTARLDKASPDSRHSPATISSSTRVPGADERRSPGREGPVATKVDEA
                     RAIPAKDAFAPLSVQTDATAHLAQGPLPGLGFAPGLAGQQFFNGHPLFLHPGQFAMGG
                     AFSSMAAGMGPLLATVSGASTGVSGLESTAMASAAAAQGLSGASAATLPFHLQQHVLA
                     SQGLAMSPFGSLFPYPYTYMAAAAAASTAAASSSVHRHPFLNLNSMRPRLRYSPYSIP
                     VPVPDSSSLLATALPSMASAAGPLDGKAAALAASPASVAVDSGSELNSRSSTLSSGSV
                     SLSPKLCSEKEAATSELQSIQRLVSGLEAKPDRSCSGSP"
     exon            1369..1636
                     /gene="Tbx3"
                     /gene_synonym="D5Ertd189e"
                     /inference="alignment:Splign:2.1.0"
     exon            1637..1783
                     /gene="Tbx3"
                     /gene_synonym="D5Ertd189e"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1860
                     /gene="Tbx3"
                     /gene_synonym="D5Ertd189e"
                     /inference="alignment:Splign:2.1.0"
     exon            1861..2012
                     /gene="Tbx3"
                     /gene_synonym="D5Ertd189e"
                     /inference="alignment:Splign:2.1.0"
     exon            2013..2683
                     /gene="Tbx3"
                     /gene_synonym="D5Ertd189e"
                     /inference="alignment:Splign:2.1.0"
     exon            2684..4777
                     /gene="Tbx3"
                     /gene_synonym="D5Ertd189e"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4012..4017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbx3"
                     /gene_synonym="D5Ertd189e"
                     /note="hexamer: AACAAG"
     polyA_site      4038
                     /gene="Tbx3"
                     /gene_synonym="D5Ertd189e"
                     /note="major polyA site"
     regulatory      4757..4762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbx3"
                     /gene_synonym="D5Ertd189e"
                     /note="hexamer: AATAAA"
     polyA_site      4777
                     /gene="Tbx3"
                     /gene_synonym="D5Ertd189e"
                     /note="major polyA site"
ORIGIN      
        1 ttctttttat aactcggctc tattccccca gcactcgacc tgtgaaaacc acgcctatgc
       61 agccacacaa ttggtccgaa agcgtcaaag agccaatcaa caagcctcgg gctcccgcag
      121 cccacagcgc tgccggaccg tccagagccg ccgagcagac gcccggggaa ttctagaggc
      181 ggaggagggt ggcgaggaaa gcgatttcgc tcacgttttt ttagcacaag gaagacagcc
      241 ggctccccga ggcagaagat cgcaggcacc attcgctcgc cacccagact ctgcgcgcag
      301 cccggagcca gagaggagga tcgcgaaccg aagccagctt cgcagttcta gttttgaaag
      361 cgccgctgga aaggggctta aatcgctttt tttttttttt tttttttaaa ggagagactt
      421 ttcctccccc ccttgatctc gctgcctgtg aaagccagag tctagctcaa ctaagacgcc
      481 tcctgcgaga aagccagaga agagctaggg ggcgggggaa ggagtcgaaa aaaaggttaa
      541 aaaaaaaagt ctccgagaac cttgcgcttt ggcaacaaag agcgtgggag ccggggagcc
      601 accccgggaa agggctgcag tgtctatttc cagctaagcc acagggcttg ggcgccagtc
      661 gagcccctgc ttgctgcttg ccctactgaa accgacttcc aggagcggct tttccaacac
      721 actccacgca ccaggacagc ccctgcagcg gctatgtctc cagatctgct gccgctttgt
      781 cctctttaaa agcggcgttc tcttcccccc aaagacactt tccccctccc tttcaaacgc
      841 tttatttgta atttgccctc ttttttattt taaacaaaac tatgcgtcgc tgttgaattt
      901 tttaattatt atttttgaaa agcaacaaca aaagcggagc caagccagca gctgcggact
      961 ggttccctgt ctggagtgga tgagcctctc catgagagat ccggttatcc ctgggacaag
     1021 catggcctat catcccttcc tacctcaccg ggcgccggac ttcgccatga gcgcggtact
     1081 gggccaccag ccgcctttct tccccgcgct aacgctgcct cccaacggcg ccgcggcgct
     1141 ctcgctcccc ggagctctgg ccaagcccat catggatcag ttagtggggg ctgctgagac
     1201 cggcatccct ttctcatccc tgggacccca ggcacatctg aggcctctga agaccatgga
     1261 acccgaagaa gacgtagaag atgaccctaa ggtgcacctg gaggccaagg aactttggga
     1321 ccagtttcac aagcggggta cagagatggt catcacgaag tcaggaaggc gaatgttccc
     1381 tccgtttaaa gtgaggtgct ctggactgga taaaaaggcc aagtatattt tattgatgga
     1441 cattatagct gctgacgact gtcgatataa atttcacaac tctcggtgga tggtggccgg
     1501 taaggcagac cccgaaatgc caaagagaat gtatatacac ccggacagcc ccgctacggg
     1561 ggagcaatgg atgtccaaag tcgtcacttt ccacaaactg aaactcacca acaacatatc
     1621 ggataaacac ggatttacta tactaaactc tatgcataag taccagccgc ggttccacat
     1681 cgtcagagcc aacgatatcc tgaaactgcc ttacagtact tttcgaacct acctgttccc
     1741 ggaaacagaa ttcatcgccg ttactgccta tcagaatgac aagataactc agttaaaaat
     1801 agacaacaat ccctttgcaa agggttttcg agacactggc aatggcagga gagaaaaaag
     1861 aaagcagctc acactgcagt ccatgagagt gtttgaggag aggcataaga aggagacttc
     1921 ggatgagtcc tccagcgagc aggcagcctt caactgcttt gcccaggcat cctctcctgc
     1981 tgtctccatc gtggggacat ccaacctcaa agatctgtgt cccagcgaag ccgagagtga
     2041 cgccgaggct gagagcaagg aggagcacgg ccctgaggcc tgcgacgcgg ccaagatttc
     2101 caccactacg gccgaggagc caggccgcga caagggcagc ccagcaacca gggcgcagct
     2161 gttccccgcg gagcccagcc gggcccgcga caccgcgcgt ctggacaagg catcgccaga
     2221 ctcgcgccat agcccggcca ccatctcgtc cagcacgcga gttccgggag ctgatgagcg
     2281 caggagtccc gggcgcgagg gtccagtcgc caccaaggtg gatgaggcgc gcgcgattcc
     2341 tgccaaggac gccttcgctc cactgtcggt gcagacagac gccaccgcgc acctagcgca
     2401 ggggcccctc ccgggcttgg gtttcgcccc aggccttgcg ggccagcagt tcttcaacgg
     2461 gcacccgctc ttcctgcacc cgggccagtt cgccatgggc ggcgccttct ctagcatggc
     2521 tgcaggcatg gggcccctgc tggccacagt atccggagca tccaccggcg tctcaggcct
     2581 agaatccaca gccatggcct cggctgccgc agcgcaggga ctgtctgggg cgtcggctgc
     2641 caccctgccc ttccacctcc aacaacacgt tctggcctcc cagggcttgg ctatgtcgcc
     2701 tttcgggagc ctgtttcctt acccctacac atacatggct gcagcagctg cagcctccac
     2761 cgcggccgcc tccagctccg tgcaccgcca cccgttcctc aatttgaaca gcatgcgccc
     2821 caggctgcgt tacagcccct attccatccc cgtcccagtg ccggatagca gcagtttgct
     2881 ggccacagct ttaccatcaa tggcttccgc cgcggggccc ctagacggca aagcggccgc
     2941 cctggcagcc agcccagcct cggtggctgt ggactcgggg tcggaactga acagccgctc
     3001 gtccacgctg tcctctggct cagtgtcctt gtcacccaaa ctctgctccg agaaggaggc
     3061 ggctaccagc gaactgcaga gtatccagcg gctggtcagt ggcttggaag ccaagccaga
     3121 caggtcttgc agcgggtccc cttaaaaaca agaaaaacaa aatcgccccc tcccccaagg
     3181 tctctccatt ccagtttggt caaatctgcc agtgcacttt gttagatgta aaataaacca
     3241 cgggccttcc acatggggtg acccccgccc tgtccctttc agttttgtct gggagggagc
     3301 actaaagcct ttccagagac tatgctagat accacaggcc ctgccaccat gggctgtgta
     3361 accaggctgc tgttgctttg aaacgcggga ctgagggggc gggaggagtg gtggcaaaca
     3421 ggcttttgtg tctagagcga cttttgtgca ggctggtatg gaagtcgggg ctgaagaaca
     3481 aggtagccag gccagccagg agcgcgggtc tttgagagac ttcaccggaa tctttccccc
     3541 ttcgtgtgtt tagtggaaac atcccccctc ctaaacaaac taacaaaacc aatatggagg
     3601 tggggggaga tgaagtcctg tggaactgtc tatgaagact gaaactcacc aattgctgag
     3661 tactttcgtt ggggcagaga gaagaggggc cttaccttgc cccatctata ttaaaggaat
     3721 cctgtctttt tttgtttgtt tgtttttaaa tattgtgatg ttttaagagc cgatgctggc
     3781 ttcttttttg catgttacag ttttctgggt ttattttgcc ccccccccct tttatggaaa
     3841 aacaacggaa gtcccattat cctcaacctt gctcaaggcg gcaaccagga ggaagtgggg
     3901 taaaaggggc agctatgggc atgaaaccaa ccgagttgat ttttatctga gcgcttgtag
     3961 agggcttcgt gtgcctgttg gaccattagt tcttttaact gtatatgcaa taacaaggtt
     4021 ttaaaagata ataataaaga ggaaacacga ctattggaca aagtatttat gtaattattt
     4081 gatatctctt gtaaataggt ggaatatgac tgctcagaaa gttaaacttt aatttattga
     4141 attgtacata gctggatgta aataggagcg tgtctgtcag gttttattct tgttttgcct
     4201 tttgggtctt atttccaggt caggagatgg ctaatccaca ctagcaagcc taggcatctt
     4261 tattcacatc tccatgcttt caagtagagc tggctgcaaa gttttttttt ttttttctga
     4321 tggagggggt gggatcggga gtactcctaa ctattttcac caaaattggg gaggtaatgg
     4381 cccttccggg ctccacttga aattccctaa actcttgaca cccccagagg ggttgagatt
     4441 gttgtgtgag tagggggggg gggggaacgg ccttgcggag gccaccatag aaccgtccta
     4501 atttttcata gactctggca tcttactaac ccatgtgagg ttttcattgt tcatctttat
     4561 ggtgttttgg attggtgtac tgagagggac ttggttcaaa cgaccatgaa aggcaaaaca
     4621 aaacaaaaaa ttaaaaaaaa aaacaaaaaa caacaacaaa aaaacaaaaa aaaaacccaa
     4681 gaaggagtat tttgtgttta gtctttgatg agttttctgt aattctcccc ctctttaaaa
     4741 acatcactga aatttcaata aatttttatt gaaatgaaaa aaa
//
