LOCUS       NM_145224               1630 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus T-box 22 (Tbx22), transcript variant 1, mRNA.
ACCESSION   NM_145224
VERSION     NM_145224.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1630)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1630)
  AUTHORS   Han,X., Feng,J., Guo,T., Loh,Y.E., Yuan,Y., Ho,T.V., Cho,C.K.,
            Li,J., Jing,J., Janeckova,E., He,J., Pei,F., Bi,J., Song,B. and
            Chai,Y.
  TITLE     Runx2-Twist1 interaction coordinates cranial neural crest guidance
            of soft palate myogenesis
  JOURNAL   Elife 10, e62387 (2021)
   PUBMED   33482080
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1630)
  AUTHORS   Welsh,I.C., Hart,J., Brown,J.M., Hansen,K., Rocha Marques,M.,
            Aho,R.J., Grishina,I., Hurtado,R., Herzlinger,D., Ferretti,E.,
            Garcia-Garcia,M.J. and Selleri,L.
  TITLE     Pbx loss in cranial neural crest, unlike in epithelium, results in
            cleft palate only and a broader midface
  JOURNAL   J Anat 233 (2), 222-242 (2018)
   PUBMED   29797482
REFERENCE   4  (bases 1 to 1630)
  AUTHORS   Van Otterloo,E., Feng,W., Jones,K.L., Hynes,N.E., Clouthier,D.E.,
            Niswander,L. and Williams,T.
  TITLE     MEMO1 drives cranial endochondral ossification and palatogenesis
  JOURNAL   Dev Biol 415 (2), 278-295 (2016)
   PUBMED   26746790
REFERENCE   5  (bases 1 to 1630)
  AUTHORS   Matsui,M. and Klingensmith,J.
  TITLE     Multiple tissue-specific requirements for the BMP antagonist Noggin
            in development of the mammalian craniofacial skeleton
  JOURNAL   Dev Biol 392 (2), 168-181 (2014)
   PUBMED   24949938
REFERENCE   6  (bases 1 to 1630)
  AUTHORS   Liu,W., Lan,Y., Pauws,E., Meester-Smoor,M.A., Stanier,P.,
            Zwarthoff,E.C. and Jiang,R.
  TITLE     The Mn1 transcription factor acts upstream of Tbx22 and
            preferentially regulates posterior palate growth in mice
  JOURNAL   Development 135 (23), 3959-3968 (2008)
   PUBMED   18948418
  REMARK    GeneRIF: Mn1 and Tbx22 function in a novel molecular pathway
            regulating mammalian palate development.
REFERENCE   7  (bases 1 to 1630)
  AUTHORS   Candille,S.I., Van Raamsdonk,C.D., Chen,C., Kuijper,S.,
            Chen-Tsai,Y., Russ,A., Meijlink,F. and Barsh,G.S.
  TITLE     Dorsoventral patterning of the mouse coat by Tbx15
  JOURNAL   PLoS Biol 2 (1), E3 (2004)
   PUBMED   14737183
REFERENCE   8  (bases 1 to 1630)
  AUTHORS   Herr,A., Meunier,D., Muller,I., Rump,A., Fundele,R., Ropers,H.H.
            and Nuber,U.A.
  TITLE     Expression of mouse Tbx22 supports its role in palatogenesis and
            glossogenesis
  JOURNAL   Dev Dyn 226 (4), 579-586 (2003)
   PUBMED   12666195
  REMARK    GeneRIF: In mouse embryos, it is expressed in distinct areas of the
            head, namely the mesenchyme of the inferior nasal septum, the
            posterior palatal shelf before fusion, the attachment of the
            tongue, and mesenchymal cells surrounding the eye anlage.
REFERENCE   9  (bases 1 to 1630)
  AUTHORS   Bush,J.O., Lan,Y., Maltby,K.M. and Jiang,R.
  TITLE     Isolation and developmental expression analysis of Tbx22, the mouse
            homolog of the human X-linked cleft palate gene
  JOURNAL   Dev Dyn 225 (3), 322-326 (2002)
   PUBMED   12412015
  REMARK    GeneRIF: primary role for Tbx22 in both palate and tongue
            development
REFERENCE   10 (bases 1 to 1630)
  AUTHORS   Braybrook,C., Lisgo,S., Doudney,K., Henderson,D., Marcano,A.C.,
            Strachan,T., Patton,M.A., Villard,L., Moore,G.E., Stanier,P. and
            Lindsay,S.
  TITLE     Craniofacial expression of human and murine TBX22 correlates with
            the cleft palate and ankyloglossia phenotype observed in CPX
            patients
  JOURNAL   Hum Mol Genet 11 (22), 2793-2804 (2002)
   PUBMED   12374769
  REMARK    GeneRIF: Craniofacial expression of human and murine TBX22
            correlates with the cleft palate and ankyloglossia (CPX) phenotype
            observed in CPX patients.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK084312.1, AL663048.12 and AF516208.1.
            
            On Mar 19, 2014 this sequence version replaced NM_145224.2.
            
            Transcript Variant: This variant (1) represents the shortest
            transcript and encodes isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AY125891.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849384, SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-577               AK084312.1         1-577
            578-585             AL663048.12        176392-176399
            586-1334            AK084312.1         587-1335
            1335-1630           AF516208.1         1439-1734
FEATURES             Location/Qualifiers
     source          1..1630
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 47.59 cM"
     gene            1..1630
                     /gene="Tbx22"
                     /gene_synonym="D230020M15Rik"
                     /note="T-box 22"
                     /db_xref="GeneID:245572"
                     /db_xref="MGI:MGI:2389465"
     exon            1..42
                     /gene="Tbx22"
                     /gene_synonym="D230020M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            43..219
                     /gene="Tbx22"
                     /gene_synonym="D230020M15Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             45..1598
                     /gene="Tbx22"
                     /gene_synonym="D230020M15Rik"
                     /note="isoform 1 is encoded by transcript variant 1; T-box
                     transcription factor TBX22; T-box protein 22"
                     /codon_start=1
                     /product="T-box transcription factor TBX22 isoform 1"
                     /protein_id="NP_660259.1"
                     /db_xref="CCDS:CCDS30350.1"
                     /db_xref="GeneID:245572"
                     /db_xref="MGI:MGI:2389465"
                     /translation="MALSSRAHAFSVEALMGRPSKRKAQDPREEMQPELQEEQFVEEG
                     EEILRSPSRDSQQPEKRLKAESSKTVFSCSDESNSQESLQEESVIQVELQGSDLWKRF
                     HDIGTEMIITKAGRRMFPSVRIKVKGMDPVKQYYVILDVVPVDSKRYRYVYHSSQWMV
                     AGNTDHSCITPRFYVHPDSPCSGENWMRQIISFDRVKLTNNEMDDKGHIILQSMHKYN
                     PRVHVVEQDSRIDLSLIESFPTEGVKTFSFKETEFTTVTAYQNQQITKLKIDRNPFAK
                     GFRDPGRNRGVLDGFLETYPWMPSFSMDFKTFVTDTQSGSSGSSPVTSSGGAPSPLNS
                     LLSPSCSPPMVYIPPSSFGMTYPDAYLHSVNIPFCYRICPTNNWRSQPFVLPTPERLP
                     SFIIPQTLPPLMMEVPVVSSRGIINPNSGLHEDCNGQCLQASHSANQMLYGLQNPGNI
                     FHPNAIAQEAISYPFHPPNGCYRYTISMPPRLENVASHLSENGTSQISFTEGSCDHSH
                     WYPAINHYL"
     exon            220..391
                     /gene="Tbx22"
                     /gene_synonym="D230020M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            392..493
                     /gene="Tbx22"
                     /gene_synonym="D230020M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            494..668
                     /gene="Tbx22"
                     /gene_synonym="D230020M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            669..833
                     /gene="Tbx22"
                     /gene_synonym="D230020M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            834..898
                     /gene="Tbx22"
                     /gene_synonym="D230020M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            899..984
                     /gene="Tbx22"
                     /gene_synonym="D230020M15Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            985..1630
                     /gene="Tbx22"
                     /gene_synonym="D230020M15Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcttctgac aggtcccagt atcaaggatt tgaggactga tgggatggct ctgagctctc
       61 gcgcgcacgc cttctccgtg gaggccttaa tggggagacc cagcaaaaga aaagctcaag
      121 acccaagaga ggagatgcag cctgagctgc aggaggagca gttcgtggag gaaggggagg
      181 agatactgag gagcccttct agggacagtc aacagcccga aaagcgactc aaggcagaat
      241 cttcaaaaac tgttttctcc tgctctgacg agagcaacag ccaggaaagt ctgcaagaag
      301 aaagtgttat ccaagtggag cttcagggat ctgacctatg gaagagattc cacgacattg
      361 gcactgagat gatcattacc aaggcgggca gacgtatgtt tccttctgtt cggatcaagg
      421 tgaaagggat ggaccctgtg aagcagtact atgtgatttt ggacgtggta ccggtggatt
      481 ccaaacgcta taggtatgtg tatcacagct cacagtggat ggtagctgga aatactgacc
      541 attcgtgcat aactcccaga ttctatgtcc acccggactc cccttgctct ggagaaaact
      601 ggatgcgtca aatcatctct tttgatcgag tgaaactcac caacaatgag atggatgaca
      661 agggccatat cattctgcag tccatgcata agtacaaccc ccgtgtgcat gtggtggaac
      721 aggacagcag gattgacctg tccctgattg agtcctttcc tacggaaggc gttaaaacat
      781 tctcctttaa agaaactgaa ttcactactg tgacagctta ccaaaaccag cagattacca
      841 aactgaaaat agacaggaat ccttttgcca aaggatttag agatcctggg agaaataggg
      901 gtgtcttaga tggattttta gagacctacc catggatgcc ttctttctct atggatttta
      961 aaacttttgt cacagacaca caaagtggaa gcagtggctc atctccagtg acctctagtg
     1021 gaggagctcc ctctcctttg aactccttac tttctccatc ttgttctcca cctatggttt
     1081 acatacctcc aagctccttt gggatgacct atccagatgc atacctgcac agtgtcaaca
     1141 tacccttctg ctacagaatt tgtccaacta ataattggcg atcacaacct tttgttttac
     1201 ctactcctga aaggctacca agtttcatca ttcctcagac cttaccccca ctcatgatgg
     1261 aagtcccagt ggtatcctcc aggggcatca tcaatccaaa cagtggctta catgaagact
     1321 gcaatgggca gtgtctacaa gcatctcatt ctgccaatca aatgttatat ggattacaga
     1381 atcctggaaa cattttccat ccaaacgcca ttgcccaaga agcaatcagt tatccttttc
     1441 atcctcctaa tggctgttat aggtacacca tctccatgcc acctagactg gaaaatgttg
     1501 ccagtcacct cagtgaaaat ggtaccagtc agatttcttt tactgaaggt agctgtgatc
     1561 attcccattg gtatccagcc attaaccatt acctttaatg ggacaacatc cacatttaag
     1621 acatttacat
//
