LOCUS       NM_019507               2552 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus T-box 21 (Tbx21), mRNA.
ACCESSION   NM_019507 XM_977626
VERSION     NM_019507.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2552)
  AUTHORS   Jordan,M.A., Gresle,M.M., Gemiarto,A.T., Stanley,D., Smith,L.D.,
            Laverick,L., Spelman,T., Stankovich,J., Willson,A.M., Dinh,X.T.,
            Johnson,L., Robertson,K., Reid,C.A., Field,J., Butzkueven,H. and
            Baxter,A.G.
  TITLE     Transcriptional network analysis of peripheral blood leukocyte
            subsets in multiple sclerosis identifies a pathogenic role for a
            cytotoxicity-associated gene network in myeloid cells
  JOURNAL   Immunol Cell Biol 102 (8), 702-720 (2024)
   PUBMED   38877291
REFERENCE   2  (bases 1 to 2552)
  AUTHORS   Chen,L., Yi,H., Li,Q., Duan,T., Liu,X., Li,L., Wang,H.Y., Xing,C.
            and Wang,R.F.
  TITLE     T-bet Regulates Ion Channels and Transporters and Induces Apoptosis
            in Intestinal Epithelial Cells
  JOURNAL   Adv Sci (Weinh) 11 (28), e2401654 (2024)
   PUBMED   38650111
REFERENCE   3  (bases 1 to 2552)
  AUTHORS   Wang,L., Mishra,S., Fan,K.K., Quon,S., Li,G., Yu,B., Liao,W.,
            Liu,Y., Zhang,X., Qiu,Y., Li,Y., Goldrath,A.W., Ma,C. and Zhang,N.
  TITLE     T-bet deficiency and Hic1 induction override TGF-beta-dependency in
            the formation of CD103+ intestine-resident memory CD8+ T cells
  JOURNAL   Cell Rep 43 (6), 114258 (2024)
   PUBMED   38781073
  REMARK    GeneRIF: T-bet deficiency and Hic1 induction override
            TGF-beta-dependency in the formation of CD103[+] intestine-resident
            memory CD8[+] T cells.
REFERENCE   4  (bases 1 to 2552)
  AUTHORS   Dong,H., Ren,Z., Shao,W., Duan,G., Du,A. and Du,B.
  TITLE     Effect of ADSCs on Th17/Treg and T-bet/GATA-3 in model mice with
            primary immune thrombocytopenia
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 70 (5), 150-154 (2024)
   PUBMED   38814224
  REMARK    GeneRIF: Effect of ADSCs on Th17/Treg and T-bet/GATA-3 in model
            mice with primary immune thrombocytopenia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2552)
  AUTHORS   Peng,S.L., Szabo,S.J. and Glimcher,L.H.
  TITLE     T-bet regulates IgG class switching and pathogenic autoantibody
            production
  JOURNAL   Proc Natl Acad Sci U S A 99 (8), 5545-5550 (2002)
   PUBMED   11960012
  REMARK    GeneRIF: T-bet regulates IgG class switching and pathogenic
            autoantibody production.
REFERENCE   6  (bases 1 to 2552)
  AUTHORS   Szabo,S.J., Sullivan,B.M., Stemmann,C., Satoskar,A.R.,
            Sleckman,B.P. and Glimcher,L.H.
  TITLE     Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma
            production in CD4 and CD8 T cells
  JOURNAL   Science 295 (5553), 338-342 (2002)
   PUBMED   11786644
  REMARK    GeneRIF: required for control of IFN-gamma production in CD4 and NK
            cells, but not in CD8 cells
REFERENCE   7  (bases 1 to 2552)
  AUTHORS   Finotto,S., Neurath,M.F., Glickman,J.N., Qin,S., Lehr,H.A.,
            Green,F.H., Ackerman,K., Haley,K., Galle,P.R., Szabo,S.J.,
            Drazen,J.M., De Sanctis,G.T. and Glimcher,L.H.
  TITLE     Development of spontaneous airway changes consistent with human
            asthma in mice lacking T-bet
  JOURNAL   Science 295 (5553), 336-338 (2002)
   PUBMED   11786643
  REMARK    GeneRIF: T-bet deficiency, in the absence of allergen exposure,
            induces a murine phenotype reminiscent of both acute and chronic
            human asthma.
REFERENCE   8  (bases 1 to 2552)
  AUTHORS   Zhang,W.X. and Yang,S.Y.
  TITLE     Cloning and characterization of a new member of the T-box gene
            family
  JOURNAL   Genomics 70 (1), 41-48 (2000)
   PUBMED   11087660
REFERENCE   9  (bases 1 to 2552)
  AUTHORS   Shier,P., Hofstra,C.L., Ma,X.J., Wu,Y., Ngo,K. and Fung-Leung,W.P.
  TITLE     Tbt-1, a new T-box transcription factor induced in activated Th1
            and CD8+ T cells
  JOURNAL   Immunogenetics 51 (10), 771-778 (2000)
   PUBMED   10970091
REFERENCE   10 (bases 1 to 2552)
  AUTHORS   Szabo,S.J., Kim,S.T., Costa,G.L., Zhang,X., Fathman,C.G. and
            Glimcher,L.H.
  TITLE     A novel transcription factor, T-bet, directs Th1 lineage commitment
  JOURNAL   Cell 100 (6), 655-669 (2000)
   PUBMED   10761931
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627445.21, BC137986.1 and AK054495.1.
            
            On Jul 2, 2009 this sequence version replaced NM_019507.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK054495.1, AK156271.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AL627445.21        4463-4544           c
            83-2032             BC137986.1         1-1950
            2033-2552           AK054495.1         2032-2551
FEATURES             Location/Qualifiers
     source          1..2552
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 60.95 cM"
     gene            1..2552
                     /gene="Tbx21"
                     /gene_synonym="Tbet; Tblym; TBT1"
                     /note="T-box 21"
                     /db_xref="GeneID:57765"
                     /db_xref="MGI:MGI:1888984"
     exon            1..682
                     /gene="Tbx21"
                     /gene_synonym="Tbet; Tblym; TBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            683..837
                     /gene="Tbx21"
                     /gene_synonym="Tbet; Tblym; TBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            838..959
                     /gene="Tbx21"
                     /gene_synonym="Tbet; Tblym; TBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1118
                     /gene="Tbx21"
                     /gene_synonym="Tbet; Tblym; TBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1180
                     /gene="Tbx21"
                     /gene_synonym="Tbet; Tblym; TBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..2552
                     /gene="Tbx21"
                     /gene_synonym="Tbet; Tblym; TBT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2468..2473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbx21"
                     /gene_synonym="Tbet; Tblym; TBT1"
                     /note="hexamer: AATAAA"
     polyA_site      2490
                     /gene="Tbx21"
                     /gene_synonym="Tbet; Tblym; TBT1"
                     /note="major polyA site"
ORIGIN      
        1 gctagtgaca gcgcgggctg cagagaaagc ccaggagcag ctgcgcgcct atccaacgcg
       61 cgctcaggag ccaagcgtcc cagctcccgc tccagtgaag tttcattggt cttcggacgc
      121 cgcccccgtc gccccagccc taaggaccct cgggtctctt cgacggctgc tggaaggcgc
      181 ccagcccgcc tcggatgggc atcgtggagc cgggctgcgg agacatgctg accggcaccg
      241 agccgatgcc gagtgacgag ggccgggggc ccggagcgga ccaacagcat cgtttcttct
      301 atcccgagcc gggcgcacag gacccgaccg atcgccgcgc aggtagcagc ctggggacgc
      361 cctactctgg gggcgccctg gtgcctgccg cgccgggtcg cttccttgga tccttcgcct
      421 acccgccccg ggctcaggtg gctggctttc ccgggcctgg cgagttcttc ccgccgcccg
      481 cgggtgcgga gggctacccg cccgtggatg gctaccctgc ccctgacccg cgcgcggggc
      541 tctacccagg gccgcgcgag gactacgcat tgcccgcggg gttggaggtg tctgggaagc
      601 tgagagtcgc gctcagcaac cacctgttgt ggtccaagtt caaccagcac cagacagaga
      661 tgatcatcac taagcaagga cggcgaatgt tcccattcct gtccttcacc gtggccgggc
      721 tggagcccac aagccattac aggatgtttg tggatgtggt cttggtggac cagcaccact
      781 ggcggtacca gagcggcaag tgggtgcagt gtggaaaggc agaaggcagc atgccaggga
      841 accgcttata tgtccaccca gactccccca acaccggagc ccactggatg cgccaggaag
      901 tttcatttgg gaagctaaag ctcaccaaca acaagggggc ttccaacaat gtgacccaga
      961 tgatcgtcct gcagtctctc cacaagtacc agccccggct gcacatcgtg gaggtgaatg
     1021 atggagagcc agaggctgcc tgcagtgctt ctaacacaca cgtctttact ttccaagaga
     1081 cccagttcat tgcagtgact gcctaccaga acgcagagat cactcagctg aaaatcgaca
     1141 acaacccctt tgccaaagga ttccgggaga actttgagtc catgtacgca tctgttgata
     1201 cgagtgtccc ctcgccacct ggacccaact gtcaactgct tgggggagac cccttctcac
     1261 ctcttctatc caaccagtat cctgttccca gccgtttcta ccccgacctt ccaggccagc
     1321 ccaaggatat gatctcacag ccttactggc tggggacacc tcgggaacac agttatgaag
     1381 cggagttccg agctgtgagc atgaagccca cactcctacc ctctgccccg gggcccactg
     1441 tgccctacta ccggggccaa gacgtcctgg cgcctggagc tggttggccc gtggcccctc
     1501 aatacccgcc caagatgagc ccagctggct ggttccggcc catgcgaact ctgcccatgg
     1561 acccgggcct gggatcctca gaggaacagg gctcctcccc ctcgctgtgg cctgaggtca
     1621 cctccctcca gccggagccc agcgactcag gactaggcga aggagacact aagaggagga
     1681 ggatatcccc ctatccttcc agtggcgaca gctcctctcc cgctggggcc ccttctcctt
     1741 ttgataagga aaccgaaggc cagttttata attattttcc caactgagaa aatgccgctg
     1801 aattggaagg tgcccactaa cttagaaaac agacgcgggg ctgagagccc cgagctcttc
     1861 cccatccctt ccctgtatag tgattggttg gagaggaagc ggggcaagaa ggattctggg
     1921 gtttacttct tgtttcctgg cccacaagga aatacgacag gagtgtcccc tgcccctttc
     1981 tctgcccgaa ctacagtcac gaacctggtg ctgcttctga ccccatggtt ccatggagaa
     2041 cggagaatgg actccagaga gttttggacc cagagggact tcatggcttt ctgcgaggtg
     2101 gaggggtcgg ggtggggagt ccaggagagc tgctctcttc ccctgtccag tcagtaactt
     2161 tcaactgttg gtctgacacc tgtgttaatc tctgacctga aagtgaagat acacgcattt
     2221 ttacaacagc cagccaaaca gagaagactc aggtgactgc gggcggactg ggccacctgc
     2281 gaggagacaa gagagggtgg gtgcagagga agggtttgaa gggtgcacat ttcaccaggc
     2341 gaggtcactt tgaaccggtg tgtacacaca cgggtgtctc ttttttattt cttcgggagg
     2401 ggggaggcta tttattgtag agagtggtgt ctggatgtat ttcttctgtt ttgcatcact
     2461 ttctggaaat aaacatggac ctggtaaaca cgccctcctt ctgtggctgg tcggtaggag
     2521 gtgtgtgtgt gtggatcaaa gtttgctgat ct
//
