LOCUS       NM_194263               6417 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus T-box 20 (Tbx20), transcript variant 1, mRNA.
ACCESSION   NM_194263
VERSION     NM_194263.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6417)
  AUTHORS   Feng,H., Yang,S., Zhang,L., Zhu,J., Li,J. and Yang,Z.
  TITLE     A new Prdm1-Cre line is suitable for studying the second heart
            field development
  JOURNAL   Dev Biol 514, 78-86 (2024)
   PUBMED   38880275
REFERENCE   2  (bases 1 to 6417)
  AUTHORS   Sivori,M., Dempsey,B., Chettouh,Z., Boismoreau,F., Ayerdi,M.,
            Eymael,A., Baulande,S., Lameiras,S., Coulpier,F., Delattre,O.,
            Rohrer,H., Mirabeau,O. and Brunet,J.F.
  TITLE     The pelvic organs receive no parasympathetic innervation
  JOURNAL   Elife 12, 91576 (2024)
   PUBMED   38488657
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6417)
  AUTHORS   Yang,J., Zhu,L., Pan,H., Ueharu,H., Toda,M., Yang,Q., Hallett,S.A.,
            Olson,L.E. and Mishina,Y.
  TITLE     A BMP-controlled metabolic/epigenetic signaling cascade directs
            midfacial morphogenesis
  JOURNAL   J Clin Invest 134 (8), e165787 (2024)
   PUBMED   38466355
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6417)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 6417)
  AUTHORS   Longtine,C., Eliason,C.M., Mishkind,D., Lee,C., Chiappone,M.,
            Goller,F., Love,J., Kingsley,E.P., Clarke,J.A. and Tabin,C.J.
  TITLE     Homology and the evolution of vocal folds in the novel avian voice
            box
  JOURNAL   Curr Biol 34 (3), 461-472 (2024)
   PUBMED   38183987
REFERENCE   6  (bases 1 to 6417)
  AUTHORS   Iio,A., Koide,M., Hidaka,K. and Morisaki,T.
  TITLE     Expression pattern of novel chick T-box gene, Tbx20
  JOURNAL   Dev Genes Evol 211 (11), 559-562 (2001)
   PUBMED   11862462
REFERENCE   7  (bases 1 to 6417)
  AUTHORS   Bruneau,B.G., Nemer,G., Schmitt,J.P., Charron,F., Robitaille,L.,
            Caron,S., Conner,D.A., Gessler,M., Nemer,M., Seidman,C.E. and
            Seidman,J.G.
  TITLE     A murine model of Holt-Oram syndrome defines roles of the T-box
            transcription factor Tbx5 in cardiogenesis and disease
  JOURNAL   Cell 106 (6), 709-721 (2001)
   PUBMED   11572777
REFERENCE   8  (bases 1 to 6417)
  AUTHORS   Kraus,F., Haenig,B. and Kispert,A.
  TITLE     Cloning and expression analysis of the mouse T-box gene tbx20
  JOURNAL   Mech Dev 100 (1), 87-91 (2001)
   PUBMED   11118890
REFERENCE   9  (bases 1 to 6417)
  AUTHORS   Meins,M., Henderson,D.J., Bhattacharya,S.S. and Sowden,J.C.
  TITLE     Characterization of the human TBX20 gene, a new member of the T-Box
            gene family closely related to the Drosophila H15 gene
  JOURNAL   Genomics 67 (3), 317-332 (2000)
   PUBMED   10936053
REFERENCE   10 (bases 1 to 6417)
  AUTHORS   Carson,C.T., Kinzler,E.R. and Parr,B.A.
  TITLE     Tbx12, a novel T-box gene, is expressed during early stages of
            heart and retinal development
  JOURNAL   Mech Dev 96 (1), 137-140 (2000)
   PUBMED   10940636
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT025664.5.
            
            On Feb 2, 2022 this sequence version replaced NM_194263.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK052389.1, SRR9219381.200427.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-566               CT025664.5         63991-64556
            567-816             CT025664.5         67346-67595
            817-981             CT025664.5         68458-68622
            982-1090            CT025664.5         72501-72609
            1091-1249           CT025664.5         79391-79549
            1250-1326           CT025664.5         87887-87963
            1327-1436           CT025664.5         110403-110512
            1437-6417           CT025664.5         112483-117463
FEATURES             Location/Qualifiers
     source          1..6417
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 10.25 cM"
     gene            1..6417
                     /gene="Tbx20"
                     /gene_synonym="9430010M06Rik; Tbx12"
                     /note="T-box 20"
                     /db_xref="GeneID:57246"
                     /db_xref="MGI:MGI:1888496"
     exon            1..566
                     /gene="Tbx20"
                     /gene_synonym="9430010M06Rik; Tbx12"
                     /inference="alignment:Splign:2.1.0"
     CDS             440..1777
                     /gene="Tbx20"
                     /gene_synonym="9430010M06Rik; Tbx12"
                     /note="isoform a is encoded by transcript variant 1; T-box
                     transcription factor TBX20; T-box protein 20"
                     /codon_start=1
                     /product="T-box transcription factor TBX20 isoform a"
                     /protein_id="NP_919239.1"
                     /db_xref="CCDS:CCDS22933.1"
                     /db_xref="GeneID:57246"
                     /db_xref="MGI:MGI:1888496"
                     /translation="MEFTASPKPQLSSRANAFSIAALMSSGGPKEKEAAENTIKPLEQ
                     FVEKSSCAQPLGELTSLDAHAEFGGGGGSPSSSSLCTEPLIPTTPIIPSEEMAKIACS
                     LETKELWDKFHELGTEMIITKSGRRMFPTIRVSFSGVDPESKYIVLMDIVPVDNKRYR
                     YAYHRSSWLVAGKADPPLPARLYVHPDSPFTGEQLLKQMVSFEKVKLTNNELDQHGHI
                     ILNSMHKYQPRVHIIKKKDHTASLLNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKI
                     DSNPFAKGFRDSSRLTDIERESVESLIQKHSYARSPIRTYGEEDVLGEESQTTQSRGS
                     AFTTSDNLSLSSWVSSSSSFPGFQHPQPLTALGTSTASIATPIPHPIQGSLPPYSRLG
                     MPLTPSAIASSMQGSGPTFPSFHMPRYHHYFQQGPYAAIQGLRHSSAVMTPFV"
     exon            567..816
                     /gene="Tbx20"
                     /gene_synonym="9430010M06Rik; Tbx12"
                     /inference="alignment:Splign:2.1.0"
     exon            817..981
                     /gene="Tbx20"
                     /gene_synonym="9430010M06Rik; Tbx12"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1090
                     /gene="Tbx20"
                     /gene_synonym="9430010M06Rik; Tbx12"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1249
                     /gene="Tbx20"
                     /gene_synonym="9430010M06Rik; Tbx12"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1326
                     /gene="Tbx20"
                     /gene_synonym="9430010M06Rik; Tbx12"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1436
                     /gene="Tbx20"
                     /gene_synonym="9430010M06Rik; Tbx12"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..6417
                     /gene="Tbx20"
                     /gene_synonym="9430010M06Rik; Tbx12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6390..6395
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbx20"
                     /gene_synonym="9430010M06Rik; Tbx12"
                     /note="hexamer: ATTATA"
     polyA_site      6417
                     /gene="Tbx20"
                     /gene_synonym="9430010M06Rik; Tbx12"
                     /note="major polyA site"
ORIGIN      
        1 acagtttagg tcgcgccttg ctgcgctctg cagagaggag atccgactcc ctggtttccg
       61 caccctctag agtcccacgc cgatcgtcac ctcctcggac ttgggccact cagcggaccc
      121 aaggagggaa gggagggaga actcggcgtg ggtgctgggg accccgcgtt ttgcgcagtg
      181 ggcttacagt tttgagttcc cggctggtcc ccaccctgct ttcctgctgg ttcgaagtct
      241 ctgcggctcc cctgctttgc tctagtggac tggagaggcc atcaaaacct gggaacggac
      301 gcttcggggg ggtccccagt tccgctttgc ttgctctctg gaactttgag ctgcagtttc
      361 gggtctttgt ctccctttgg ggaagctgga ctgtggtttg tcagtccagg ttcctgagca
      421 ggaccgcacg ctgggaacca tggagttcac ggcgtcgccc aagccccagc tctcctctcg
      481 agccaatgcc ttctccatcg ccgcgcttat gtccagcggc ggccccaagg agaaggaggc
      541 agcagagaac accatcaaac ccctggaaca atttgtggag aaatcatcat gtgcccagcc
      601 actgggtgag ctgacgagtc tggatgctca cgcggagttt ggcggcgggg gcggcagccc
      661 atcctcatcc tctctgtgca cagagccact gatacccacc acccccatca tccccagcga
      721 agagatggct aaaatcgcct gcagcctgga aacgaaggag ctctgggaca aattccatga
      781 actgggcacg gagatgataa tcaccaagtc tggcaggagg atgttcccca ccatccgcgt
      841 gtcattttct ggagtggatc ctgagtccaa gtatatagtc ctgatggaca tcgtcccggt
      901 ggacaacaag agataccgct atgcctacca ccggtcatcc tggctggtgg ctggcaaagc
      961 tgatcccccg ctgccagcca ggctctacgt gcacccagac tcccccttta ctggcgagca
     1021 gctcctcaaa cagatggtgt cttttgaaaa ggtgaagctc accaacaatg aactggatca
     1081 acacggccat ataattttga attcaatgca taagtaccag ccacgggtgc acatcataaa
     1141 gaagaaagac cacacggcct ccttgctcaa tctgaagtca gaagaattca ggacgttcat
     1201 ctttccagag acagttttca cagcagtcac agcctaccag aaccaactga taaccaagct
     1261 gaaaatagac agcaatccgt ttgccaaagg attccgggac tcctccaggc tcactgacat
     1321 tgagagggag agtgtggaga gcctgatcca gaagcattcc tatgcccggt cacccatccg
     1381 cacctatggg gaagaggatg ttctggggga ggagagtcaa acaactcaga gtcgaggatc
     1441 agcctttaca acatctgaca atttgtctct cagttcctgg gtatcgtcat cttccagttt
     1501 tcctggattt cagcatccac agcccctgac tgctcttggt accagtacag catccatagc
     1561 gacaccgatt cctcacccta tacagggttc tctgccacca tatagccgcc tgggaatgcc
     1621 tctgacccca tctgcaatag ccagctccat gcagggaagt ggtcccacgt tcccttcatt
     1681 ccacatgcct agataccatc actacttcca gcaggggccc tacgctgcca tccaaggact
     1741 tcgccactcc tccgctgtga tgacgccatt tgtatgattc cactgagagt cggggaagct
     1801 agatacagag tgtgcaaatg gctatgaaaa tacaggaggg gtgggaagta gggtgggtgg
     1861 gaagtggggt attggagcaa ggactctcca ggaaacacag gacttattaa aggaaagagg
     1921 agagctggac tcgcaaaaca cgtactcgca agggagtgca ccacgggccg ggcttcatct
     1981 gtgattggat ccagggaaga atcagcgtga agtatattca gcatactcct acagctaatg
     2041 ggctatcagt tcacccagaa agcttaataa tcctagtgct taaaagtttt gttgatgcag
     2101 cgctgtataa aatccgtgtg tagaggtttc tttccgcttt caacaggttc agagcatcat
     2161 ccagaaggca atactatata gcgtattgac aagactaact caagcccact tctcccagta
     2221 ggaaatggaa gccagtcgtg atatgtttgt agtgctctac tttaagcatg tttagtttct
     2281 tttgtgtcag tttgcttgct gcagacgggg cagagttggt gctagtacgt cctgtggtgt
     2341 gaatgaatat gtggtaacac atttaccaag ttcctgccat atccacaggc catgataaca
     2401 taaactctgt cttccatccc ctctcttttt ttttttaaag cctaataatt ctttttcctg
     2461 caacaacttt gcagttatgc aatgaaaacc ctctacatgc cattttaaaa caagaagctc
     2521 tctcattttc aaagaggatg gcttctgggg ggctgcatta tcaacaggct gctgacagag
     2581 ccaccgagga cccgtccaga gcccgtgcat ggtgatggct gaagctctcc ctcacacatt
     2641 caaagtctgg tgtctctctt ctgagggaaa tttctctgcc ctgggaacca aagtcctctt
     2701 catttttcac tccagcgtca gcaagtctct tgtatattaa aacacactgg gccaaattct
     2761 gatttttttt taaatataca tctgctttgc tgctgtttcc atccttgtca gggatttgcc
     2821 aatggccact ctccatatgc atgcttcacc atgctctcat gtatgcttat gggcatgtac
     2881 atgccctgta gtgggtttct ccagtctgac tgtattacat ttacagactt cttttcattt
     2941 tccctggtcc ctaatatgaa gctgcatgtt aattcaatga ctcccttaca gaaatactaa
     3001 caattcttac cggaatacaa gagcttcatc cagtttttcc tatgttctta agctttcctt
     3061 ctatgtgtaa actagagttt atgttttact tctgtataac cactatgtta tttttgagca
     3121 acatgtatct tagcatttac attcaggata acacatatga tattttacaa tagtacattt
     3181 ccctaataat atagatttat taaagtcctt agactttcag ctttgaagac agtgtgttcc
     3241 acctatagga tgtgaccagt ttgctttatg taggttgcct gaatttattt tagtttcaat
     3301 ttttttttct tgtttttgtt ttttgagaca gggtttctct gtgtaaccct ggctgtcctg
     3361 gaaactcact ctatagacca ggctggcctc gaactcagaa agcaacctgc ctctgcctcc
     3421 caagagctgg gattaaaggc gtgcatgcca ccagtgcctg gcctagtttc aattttttaa
     3481 tgaagttttt attctactct gttcttattt caaaagtatt gactgtgctt aaagatacgg
     3541 gaaatctcct gacagtagaa atgtgtttag gagtaaatgc catatactta ccacatcact
     3601 ctgctgtttt atttggtagc tttaatgtta ggcttttcca tgcgggatga attccaaggc
     3661 caagtccagt ctatgaaaca aggtaccata cccagtctga gcatgggatg ctagttttag
     3721 gtttttgcac ttgatgttct ccaccaaaag tccatagttt acttacaaag aagcatgaac
     3781 tgttaaggaa atgattctaa actctcatgg cagacactgc aggtgagtgc agcttcttgt
     3841 gtgccttgta gtagtatcca caggtagttg gtttccagac aaaatacaga tgtgcatttc
     3901 tcttaaaaac ccattgtgag tggtatttaa aataaatgcc catagagcaa gggtaagggc
     3961 ttgatattta ataattggcc tcttgcaaaa gaaccttgga ataaagtgct actatttaaa
     4021 gcaggaaaga aacaaaaaac aaaaaaactg aggcacgact gtgcagggtg cccctcatct
     4081 ctcccctggt atatgctgag attctaaagt gagattctaa acacatgcct gtgttttctt
     4141 ttccatgaga atgaaaggat tgttttaata ttgtttttga attttttttg aactggtgtg
     4201 cctcacagtt ggtttttttt ttaaattgct gttaaatatg atcttttgtt ggtatttcct
     4261 gaccttataa ttttgcttga ggatgaaact cactgaaatg catgatgaca gcaaagaggg
     4321 ctcttgaaaa tgttctccct aaaagtcttt accgggtgtt tgcttcccct gttggtatta
     4381 tgtaaatcag acagaaacct cccaagagaa acagcaccat gtgagtgccc tgtcacttga
     4441 ccctgggacc accagtgcct ttctgactta ttttggcagt taaattatta ttaatccttg
     4501 gggagtttac aacttaaaat cccaaggtct ggttaacaaa aactgatggc aataattaga
     4561 tattaattga taaatccaat tgaataataa taaccaagac ttaaaaagca tttggactaa
     4621 ttcaggtctt cctcctatgg ctattacatt gtgataaagc atggcgaaag agagtgctgt
     4681 tgaagaggcc cagccaggct tgctttactg agctctaatg gacttgctca taactcagga
     4741 ggttctcact tatgctctgg ttttaaaata ttcctcaata atcccaagtt atggtgtgcc
     4801 aatcccgtat taaatgaacc ataccacctg gttcctgtcc ttagcagttc atgtggaaat
     4861 acttccagtt gtgtgtgaca catcaacagt tgtcaggtaa cattgtctag ctcagtggct
     4921 gtctgctcca ttgctggcac agtcagttaa cagcactgga ctctcgtcta gaaggttatc
     4981 agcatttatg gtgagtgctc caaagaaggc tctttatata ggttcatcgt catgcagaag
     5041 ccttgtgtat gaactgcacc aacttctggg gcattctaag atcttacctt ctcaaccact
     5101 ggataaatat ctgtcccttg acttctccac acagcatact tcttcccaga agaaaaggga
     5161 aaatgaatct gtcacaaacc caagaaataa tcttagcagt aaaatgtcat gtcttgtact
     5221 gcctatgagc atttcaggga gatgttagga tatttatcct atttctcaat ttcagattaa
     5281 ctttttaagc tacattggtt atgcaatggc caattatgtt gagaaaattc actaacaagt
     5341 aaaatgtatg ggaggacttc ccgccccatt agataggtgg gtaagcttag tggtggttta
     5401 gtcactaagg agcatgtaag acactgcatt taaattcatg ttcttattct gtattctacc
     5461 gagtatgaaa aactacttcc attatttata gggcaggaaa ctgatagtta ttgcaaacaa
     5521 aaatactcta acaaagcagc agataaaaga taaaacattt aatttgctcc tctatagagt
     5581 tactgaaggt tttatatgca ttctcatatt gttttagaat gaaagccatt gctataaaca
     5641 ccaaaggtaa gattacctac ttttaaaact ttaaggaagt ataaaagccc ctttgtttca
     5701 gcttatcatt ctatgcgagt tataaaatac caaaacacct ttcctctgca agctcaatca
     5761 tagaaaggca catttataag tatttgatgt ggtaataatc cataagtatt ttctagcttt
     5821 ctttatctat ctgtctgcct gcctgtctgt ctgtctctct ctaatataat ttcaatctct
     5881 taccccttta agaaagcatc ctgcatgaaa atgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     5941 gtgtgtgtgt gtatgtgtgt gtgtgtggta tgtgtgtgtg gaatattgaa tctggacaaa
     6001 agatacaatt tgttgtattt tactttactt ctggcacaaa gacattgtat ttagttgctt
     6061 taaaattctt ttttttagag tctgaaaagg ttcttctatt tgctaaagta agagattctg
     6121 taaccctgat cagtagtctc tgtcacagtc tccctgtttg ctgtgtcttc atttgattaa
     6181 caaattgtgt ggaaaagtca ctgtaatgca gtgtgtggga tgtgggaagg gtgtgggaaa
     6241 tgttttatgg ggaaaaatta taagcctaat actatgaagt aacatttaat gaagttctgt
     6301 ttaagtgcaa tatatttatt tctgccagaa atgtattatc aaccttatgt aatatttgat
     6361 gcataacatc ttatttgcaa acagctaaaa ttatatatta tcccaaattg tacagaa
//
