LOCUS       NM_009324               3562 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus T-box 2 (Tbx2), mRNA.
ACCESSION   NM_009324
VERSION     NM_009324.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3562)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   2  (bases 1 to 3562)
  AUTHORS   Zhu,Z., Zou,Q., Wang,C., Li,D., Yang,Y., Xiao,Y., Jin,Y., Yan,J.,
            Luo,L., Sun,Y. and Liang,X.
  TITLE     Isl Identifies the Extraembryonic Mesodermal/Allantois Progenitors
            and is Required for Placenta Morphogenesis and Vasculature
            Formation
  JOURNAL   Adv Sci (Weinh) 11 (32), e2400238 (2024)
   PUBMED   38923264
REFERENCE   3  (bases 1 to 3562)
  AUTHORS   Bi,Z., Ren,M., Zhang,Y., He,S., Song,L., Li,X. and Liu,Z.
  TITLE     Revisiting the Potency of Tbx2 Expression in Transforming Outer
            Hair Cells into Inner Hair Cells at Multiple Ages In Vivo
  JOURNAL   J Neurosci 44 (23), e1751232024 (2024)
   PUBMED   38688721
  REMARK    GeneRIF: Revisiting the Potency of Tbx2 Expression in Transforming
            Outer Hair Cells into Inner Hair Cells at Multiple Ages In Vivo.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3562)
  AUTHORS   Soussi,G., Girdziusaite,A., Jhanwar,S., Palacio,V., Notaro,M.,
            Sheth,R., Zeller,R. and Zuniga,A.
  TITLE     TBX3 is essential for establishment of the posterior boundary of
            anterior genes and upregulation of posterior genes together with
            HAND2 during the onset of limb bud development
  JOURNAL   Development 151 (11) (2024)
   PUBMED   38828908
REFERENCE   5  (bases 1 to 3562)
  AUTHORS   Li,X., Ren,M., Gu,Y., Zhu,T., Zhang,Y., Li,J., Li,C., Wang,G.,
            Song,L., Bi,Z. and Liu,Z.
  TITLE     In situ regeneration of inner hair cells in the damaged cochlea by
            temporally regulated co-expression of Atoh1 and Tbx2
  JOURNAL   Development 150 (24) (2023)
   PUBMED   38078650
REFERENCE   6  (bases 1 to 3562)
  AUTHORS   Law,D.J., Gebuhr,T., Garvey,N., Agulnik,S.I. and Silver,L.M.
  TITLE     Identification, characterization, and localization to chromosome
            17q21-22 of the human TBX2 homolog, member of a conserved
            developmental gene family
  JOURNAL   Mamm Genome 6 (11), 793-797 (1995)
   PUBMED   8597636
REFERENCE   7  (bases 1 to 3562)
  AUTHORS   Campbell,C., Goodrich,K., Casey,G. and Beatty,B.
  TITLE     Cloning and mapping of a human gene (TBX2) sharing a highly
            conserved protein motif with the Drosophila omb gene
  JOURNAL   Genomics 28 (2), 255-260 (1995)
   PUBMED   8530034
REFERENCE   8  (bases 1 to 3562)
  AUTHORS   Agulnik,S.I., Bollag,R.J. and Silver,L.M.
  TITLE     Conservation of the T-box gene family from Mus musculus to
            Caenorhabditis elegans
  JOURNAL   Genomics 25 (1), 214-219 (1995)
   PUBMED   7774921
REFERENCE   9  (bases 1 to 3562)
  AUTHORS   Bollag,R.J., Siegfried,Z., Cebra-Thomas,J.A., Garvey,N.,
            Davison,E.M. and Silver,L.M.
  TITLE     An ancient family of embryonically expressed mouse genes sharing a
            conserved protein motif with the T locus
  JOURNAL   Nat Genet 7 (3), 383-389 (1994)
   PUBMED   7920656
REFERENCE   10 (bases 1 to 3562)
  AUTHORS   Namba,T., Sugimoto,Y., Hirata,M., Hayashi,Y., Honda,A., Watabe,A.,
            Negishi,M., Ichikawa,A. and Narumiya,S.
  TITLE     Mouse thromboxane A2 receptor: cDNA cloning, expression and
            northern blot analysis
  JOURNAL   Biochem Biophys Res Commun 184 (3), 1197-1203 (1992)
   PUBMED   1375456
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AI256645.1, CJ045432.1, AK149348.1 and CJ307790.1.
            
            On Dec 29, 2006 this sequence version replaced NM_009324.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK149348.1, U15566.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-201               AI256645.1         1-201
            202-477             CJ045432.1         6-281
            478-3248            AK149348.1         286-3056
            3249-3562           CJ307790.1         93-406
FEATURES             Location/Qualifiers
     source          1..3562
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 51.34 cM"
     gene            1..3562
                     /gene="Tbx2"
                     /note="T-box 2"
                     /db_xref="GeneID:21385"
                     /db_xref="MGI:MGI:98494"
     exon            1..887
                     /gene="Tbx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             493..2628
                     /gene="Tbx2"
                     /note="T-box protein 2"
                     /codon_start=1
                     /product="T-box transcription factor TBX2"
                     /protein_id="NP_033350.2"
                     /db_xref="CCDS:CCDS36266.1"
                     /db_xref="GeneID:21385"
                     /db_xref="MGI:MGI:98494"
                     /translation="MREPALAASAMAYHPFHAPRPADFPMSAFLAAAQPSFFPALALP
                     PGALGKPLPDPGLAGAAAAAAAAAAAAEAGLHVSALGPHPPAAHLRSLKSLEPEDEVE
                     DDPKVTLEAKELWDQFHKLGTEMVITKSGRRMFPPFKVRVSGLDKKAKYILLMDIVAA
                     DDCRYKFHNSRWMVAGKADPEMPKRMYIHPDSPATGEQWMAKPVAFHKLKLTNNISDK
                     HGFTILNSMHKYQPRFHIVRANDILKLPYSTFRTYVFPETDFIAVTAYQNDKITQLKI
                     DNNPFAKGFRDTGNGRREKRKQLTLPTLRLYEEHCKPERDGAESDASSCDPPPAREPP
                     PSPSAAPSPLRLHRARAEEKPGAADSDPEPERTGEERSAAPLGRSPSRDASPARLTEP
                     ERSRERRSPERCSKEPTEGGGDGPFSLRSLEKERPEARRKDEGRKDVGEGKEPSLAPL
                     VVQTDSASPLGAGHLPGLAFSSHLHGQQFFGPLGAGQPLFLHPGQFAMGPGAFSAMGM
                     GHLLASVAGGSGSSGGAGPGTAAGLDAGGLGPAASAASTAAPFPFHLSQHMLASQGIP
                     MPTFGGLFPYPYTYMAAAAAAASALPATSAAAAAAAAAGSLSRSPFLGSARPRLRFSP
                     YQIPVTIPPSTSLLTTGLAAEGSKGGNSREPSPLPELALRKVGGPSRGALSPSGSAKE
                     AASELQSIQRLVSGLESQRALSPGRESPK"
     exon            888..1155
                     /gene="Tbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1302
                     /gene="Tbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1379
                     /gene="Tbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1543
                     /gene="Tbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1544..2181
                     /gene="Tbx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..3562
                     /gene="Tbx2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3214..3219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbx2"
                     /note="hexamer: AATAAA"
     polyA_site      3238
                     /gene="Tbx2"
                     /note="major polyA site"
     regulatory      3537..3542
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbx2"
                     /note="hexamer: AATAAA"
     polyA_site      3562
                     /gene="Tbx2"
                     /note="major polyA site"
ORIGIN      
        1 gttgacatgt tttcttactg ctgaggcttc cgacaccttc tccctggcct cccctcccgt
       61 ccagagcttg gcctgagctg tcaaaacccc gcccccggag acccacaatt ggtccaaaaa
      121 gcgtaaaatc agcaatcaag gggggcctgg ctcgttagcg caggggatcc gaacagggca
      181 ggacatgtga gatagtcaca gttttccaga gatcaggaca agatctaacc agtcgcgcgt
      241 ggtccccggc gccggagccg gccagcccag cccagcccag cccagcccag ccccgcgcag
      301 cgccccctcc gcccccgcgt ccagagccct gcgccccttg aggtgcgcgg gacggggagc
      361 cgggagaagc cgctgccgcg cccgccgccc gggccgtccg tcctccgcgc gcgccgccgc
      421 ccgggccggg ggtccgaggc gcgcgccccc ggccccggcc ccggctccca ggagcctggg
      481 ccggatgtcc cgatgagaga gccggcgctg gcagccagcg ccatggctta ccacccgttc
      541 cacgcgccac ggcccgccga cttccccatg tccgccttcc tggcggcagc gcagccctcc
      601 ttcttcccgg cgctagcgct gccgcccggc gcgctaggca agcctctgcc ggacccgggc
      661 ctggcggggg cggcggccgc ggcagcagcg gcggcggcgg cggccgaggc ggggctgcac
      721 gtctcggcac tcggcccgca cccgcccgcc gcgcatctgc gctcgctcaa gagcctggaa
      781 cccgaggacg aggtggagga cgaccccaag gtgacgctgg aggccaagga gctgtgggac
      841 cagttccaca agctgggcac cgagatggtc atcaccaagt ccgggaggcg gatgttcccc
      901 cccttcaagg tgcgagtcag cggcctggac aagaaagcca aatacatcct gctaatggac
      961 atcgtggctg ccgatgactg ccgctataag tttcacaact cccgctggat ggtggcaggc
     1021 aaagccgacc ccgagatgcc taaacgcatg tacatccacc cggacagtcc ggccacaggg
     1081 gaacagtgga tggccaagcc tgtggccttc cacaaactga agctgaccaa caacatttct
     1141 gacaagcatg gctttaccat cctgaactcc atgcacaagt accagccgcg attccacatc
     1201 gtgcgagcca atgacatctt gaagctccca tacagcacct tccgcaccta tgtcttccca
     1261 gagaccgact tcatcgctgt cactgcctac cagaatgaca agattacaca gctgaagatc
     1321 gacaacaacc cctttgccaa gggcttccgg gacactggga acggccgtcg ggagaaaagg
     1381 aagcagctaa cgctgcccac tctccgtttg tatgaggagc actgtaagcc ggagcgtgat
     1441 ggcgctgaat ccgatgcctc gtcctgcgac cctccgcctg cgcgagaacc accgccctcc
     1501 cccagcgcag cgcccagccc tctgcgccta caccgggccc gagccgagga gaagccgggc
     1561 gcagccgaca gcgatcctga gccggagcgg acgggggagg agcgctccgc agcgcccctg
     1621 ggccgcagcc cttcgcggga cgccagcccc gctcgcttga ccgaacccga acgctcccgg
     1681 gagcggcgca gcccggagag gtgcagcaag gaaccgacgg agggcggtgg ggacggcccg
     1741 tttagcctgc ggagcctgga gaaggagcgt cccgaggccc ggaggaagga cgaggggcgc
     1801 aaggacgtgg gtgagggcaa ggagcccagc ctggcgccgc tggtggtgca gacagacagt
     1861 gcgtcccccc tgggtgcggg ccatctgcct ggcctggcct tctccagcca cctgcatggg
     1921 cagcagttct ttgggccgct gggagctggc cagcccctct tcctgcaccc aggacaattc
     1981 gccatgggcc ccggagcctt ctccgccatg ggcatgggtc atctgctagc ctcggtggca
     2041 ggcggcagtg gcagtagcgg aggcgccggt cccggaaccg cggcggggct ggacgcaggc
     2101 gggctaggtc ccgcagccag cgcagcaagc accgcggctc ccttcccgtt ccacctctcc
     2161 cagcatatgc tggcatctca gggaatccca atgcccactt tcggaggcct ctttccctac
     2221 ccgtacactt acatggcagc agcggccgcc gccgcctccg ctttacccgc caccagcgct
     2281 gcagctgccg ccgccgcagc cgctggttca ttatcacgga gcccatttct gggcagtgcc
     2341 cggccccgtc tgcgcttcag tccttaccag atccctgtca ccatcccacc tagcactagc
     2401 ctccttacca ccgggctggc ggcggagggc tccaagggcg gaaatagccg tgagcccagt
     2461 ccgctgcctg agctggctct ccgaaaagtg gggggcccat cccgcggggc cctatcgccc
     2521 agcggctcag ccaaagaggc ggccagtgaa ctgcagagca tccagagact ggtgagtggg
     2581 ctagagagcc agcgagccct ctcccccggc cgggagtcgc ccaagtgagg ggctgcttgg
     2641 ctgctgcgct gccacacgag cctcccgggc tgggctctct gcctcggctg tctaggacgt
     2701 gtacagcaca gaatgggtat ttatttaaat aaagaagcaa aagcaggctt cagcggtcag
     2761 aatagagcct cgcgtggcag gtcgggggtc tggggtctaa acgaggagtc agtctatcca
     2821 gaacacaagt cactctggaa tccctggatt tgatgcaaat ttctgttcga gagtcaacta
     2881 ccagggcacc tccttctttc aacactgtgg gggtggcctc cttccagtgg tcccattgga
     2941 agccagaagg tgcatagggt agaggtgttc cttcggaaag catcccagga tctctggcct
     3001 tgggcttgag tgtcattgag aaactggtgt ggaggatgct ggagccaggg gagcctgaag
     3061 tcagcgtaga cttgagctag gaggagtcat gtccgcttgg tcttcccacc tctaccccac
     3121 aaaagacagg cgccattcct atgtccactt ctggatcagc ggaggaagtt gcacttcttc
     3181 tttgagtccc cagggggcaa aagatattta tgaaataaat ggtaatttgt gtaaataagc
     3241 tttaaggttc ccagaggata caaattcgta ttaatttatt cgaaggtgta cattgctgtg
     3301 tacatatatt tagagattaa ctcatagcat ttaatttttt tttcatttta catgagcatc
     3361 tatattgtac agggccccag gatccttggc tgctggggaa ggggaggcac cgaaccccag
     3421 ggaaggccca ccctgcggac ccctcagcct ctgcaccccg gttttgcccg cccggcccac
     3481 gggccccacc tcaggttttc actttttgct ccagagggag aacgaagcga gaaaataata
     3541 aaaacgctat catgcgattt ga
//
