LOCUS       NM_032005               2662 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus T-box 19 (Tbx19), mRNA.
ACCESSION   NM_032005
VERSION     NM_032005.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2662)
  AUTHORS   Zhang,J., Zhou,Y., Guo,J., Li,L., Liu,H., Lu,C., Jiang,Y. and
            Cui,S.
  TITLE     MicroRNA-7a2 is Required for the Development of Pituitary Stem
            Cells
  JOURNAL   Stem Cells Dev 31 (13-14), 357-368 (2022)
   PUBMED   35652338
REFERENCE   2  (bases 1 to 2662)
  AUTHORS   Gualtieri,A., Kyprianou,N., Gregory,L.C., Vignola,M.L.,
            Nicholson,J.G., Tan,R., Inoue,S.I., Scagliotti,V., Casado,P.,
            Blackburn,J., Abollo-Jimenez,F., Marinelli,E., Besser,R.E.J.,
            Hogler,W., Karen Temple,I., Davies,J.H., Gagunashvili,A.,
            Robinson,I.C.A.F., Camper,S.A., Davis,S.W., Cutillas,P.R.,
            Gevers,E.F., Aoki,Y., Dattani,M.T. and Gaston-Massuet,C.
  TITLE     Activating mutations in BRAF disrupt the hypothalamo-pituitary axis
            leading to hypopituitarism in mice and humans
  JOURNAL   Nat Commun 12 (1), 2028 (2021)
   PUBMED   33795686
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2662)
  AUTHORS   Lodge,E.J., Xekouki,P., Silva,T.S., Kochi,C., Longui,C.A.,
            Faucz,F.R., Santambrogio,A., Mills,J.L., Pankratz,N., Lane,J.,
            Sosnowska,D., Hodgson,T., Patist,A.L., Francis-West,P.,
            Helmbacher,F., Stratakis,C. and Andoniadou,C.L.
  TITLE     Requirement of FAT and DCHS protocadherins during
            hypothalamic-pituitary development
  JOURNAL   JCI Insight 5 (23), 134310 (2020)
   PUBMED   33108146
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2662)
  AUTHORS   Khetchoumian,K., Balsalobre,A., Mayran,A., Christian,H.,
            Chenard,V., St-Pierre,J. and Drouin,J.
  TITLE     Pituitary cell translation and secretory capacities are enhanced
            cell autonomously by the transcription factor Creb3l2
  JOURNAL   Nat Commun 10 (1), 3960 (2019)
   PUBMED   31481663
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2662)
  AUTHORS   Maira,M., Couture,C., Le Martelot,G., Pulichino,A.M., Bilodeau,S.
            and Drouin,J.
  TITLE     The T-box factor Tpit recruits SRC/p160 co-activators and mediates
            hormone action
  JOURNAL   J Biol Chem 278 (47), 46523-46532 (2003)
   PUBMED   12970370
REFERENCE   6  (bases 1 to 2662)
  AUTHORS   Pulichino,A.M., Vallette-Kasic,S., Tsai,J.P., Couture,C.,
            Gauthier,Y. and Drouin,J.
  TITLE     Tpit determines alternate fates during pituitary cell
            differentiation
  JOURNAL   Genes Dev 17 (6), 738-747 (2003)
   PUBMED   12651892
  REMARK    GeneRIF: Tpit has a role as a negative regulator of gonadotroph
            differentiation in developing mouse
REFERENCE   7  (bases 1 to 2662)
  AUTHORS   Pulichino,A.M., Vallette-Kasic,S., Couture,C., Gauthier,Y.,
            Brue,T., David,M., Malpuech,G., Deal,C., Van Vliet,G., De
            Vroede,M., Riepe,F.G., Partsch,C.J., Sippell,W.G., Berberoglu,M.,
            Atasay,B. and Drouin,J.
  TITLE     Human and mouse TPIT gene mutations cause early onset pituitary
            ACTH deficiency
  JOURNAL   Genes Dev 17 (6), 711-716 (2003)
   PUBMED   12651888
  REMARK    GeneRIF: TPIT has a role in expression of the pro-opiomelanocortin
            gene and terminal differentiation of the pituitary corticotroph
            lineage, and its mutation causes early onset pituitary ACTH
            deficiency
REFERENCE   8  (bases 1 to 2662)
  AUTHORS   Asteria,C.
  TITLE     T-box and isolated ACTH deficiency
  JOURNAL   Eur J Endocrinol 146 (4), 463-465 (2002)
   PUBMED   11916612
  REMARK    GeneRIF: Review.  Association of 2 mutations with an ACTH
            deficiency is consistent with the role of tbx19 in differentiation
            of POMC cells.
            Review article
REFERENCE   9  (bases 1 to 2662)
  AUTHORS   Liu,J., Lin,C., Gleiberman,A., Ohgi,K.A., Herman,T., Huang,H.P.,
            Tsai,M.J. and Rosenfeld,M.G.
  TITLE     Tbx19, a tissue-selective regulator of POMC gene expression
  JOURNAL   Proc Natl Acad Sci U S A 98 (15), 8674-8679 (2001)
   PUBMED   11447259
REFERENCE   10 (bases 1 to 2662)
  AUTHORS   Lamolet,B., Pulichino,A.M., Lamonerie,T., Gauthier,Y., Brue,T.,
            Enjalbert,A. and Drouin,J.
  TITLE     A pituitary cell-restricted T box factor, Tpit, activates POMC
            transcription in cooperation with Pitx homeoproteins
  JOURNAL   Cell 104 (6), 849-859 (2001)
   PUBMED   11290323
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK038666.1 and AU019700.1.
            
            On May 1, 2007 this sequence version replaced NM_032005.3.
            
            Summary: This gene encodes a member of a family of transcription
            factors containing a characteristic T-box DNA-binding domain. The
            encoded protein promotes expression of the pro-opiomelanocortin
            (POMC) gene, which is important for the differentiation of cells in
            the pituitary gland. [provided by RefSeq, Mar 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK038666.1, BC137731.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849377 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2660              AK038666.1         3-2662
            2661-2662           AU019700.1         1-2                 c
FEATURES             Location/Qualifiers
     source          1..2662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 72.47 cM"
     gene            1..2662
                     /gene="Tbx19"
                     /gene_synonym="D1Ertd754e; Tpit"
                     /note="T-box 19"
                     /db_xref="GeneID:83993"
                     /db_xref="MGI:MGI:1891158"
     exon            1..408
                     /gene="Tbx19"
                     /gene_synonym="D1Ertd754e; Tpit"
                     /inference="alignment:Splign:2.1.0"
     CDS             212..1552
                     /gene="Tbx19"
                     /gene_synonym="D1Ertd754e; Tpit"
                     /note="T-box factor, pituitary; T-box protein 19"
                     /codon_start=1
                     /product="T-box transcription factor TBX19"
                     /protein_id="NP_114394.1"
                     /db_xref="CCDS:CCDS15439.1"
                     /db_xref="GeneID:83993"
                     /db_xref="MGI:MGI:1891158"
                     /translation="MSELATQKAGEGTVSRLLNVVESELQAGREKGDPTEKQLQIILE
                     DAPLWQRFKEVTNEMIVTKNGRRMFPVLKISVTGLDPNAMYSLLLDFVRTDSHRWKYV
                     NGEWVPAGKPEVSSHSCVYIHPDSPNFGAHWMKAPISFSKVKLTNKLNGGGQIMLNSL
                     HKYEPQVHIVRVGGAHRMVMNCSFPETQFIAVTAYQNEEITALKIKYNPFAKAFLDAK
                     ERNHLKDVPEAISESQHVTYSHLGGWILSNPDGVCTAANSNYQYATPLPLPAPHTHHG
                     CEHYAGLRGHRQAPYPSAYMHRNHSPSVNLIESSSNNLQVFSGPDSWTSLSSTPHASI
                     LSVPHSNGPINPGPSPYPCLWTISNGGGGPVASGSEVHASTSGTILLGNPAVTSPSSL
                     LPTQATTSAGVEVLGEPSLTSIAVSTWTAVASHPLPGWGGPGGAGRHSSSSLDS"
     exon            409..673
                     /gene="Tbx19"
                     /gene_synonym="D1Ertd754e; Tpit"
                     /inference="alignment:Splign:2.1.0"
     exon            674..808
                     /gene="Tbx19"
                     /gene_synonym="D1Ertd754e; Tpit"
                     /inference="alignment:Splign:2.1.0"
     exon            809..870
                     /gene="Tbx19"
                     /gene_synonym="D1Ertd754e; Tpit"
                     /inference="alignment:Splign:2.1.0"
     exon            871..932
                     /gene="Tbx19"
                     /gene_synonym="D1Ertd754e; Tpit"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1121
                     /gene="Tbx19"
                     /gene_synonym="D1Ertd754e; Tpit"
                     /inference="alignment:Splign:2.1.0"
     exon            1122..1257
                     /gene="Tbx19"
                     /gene_synonym="D1Ertd754e; Tpit"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..2662
                     /gene="Tbx19"
                     /gene_synonym="D1Ertd754e; Tpit"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctccccaa ctgaagctta acaggttggt ggtataattt ggagactttc aggggtgtca
       61 cactggaagc tttagcaaga gccaaggcat cttattctac tcccagacac tgaccagctg
      121 gggtcgaaaa gccagcaagt gagggaagga aggagccgga ggcagagaaa gtgggaacgg
      181 ctctcagcaa agtttgaaag ggtctacagc catgagtgaa ctggccacac agaaggctgg
      241 cgaaggcact gtgtctcgcc tgcttaacgt ggtggaaagt gagctccagg cagggaggga
      301 gaagggagac cctacagaga agcaacttca gatcatcctg gaggatgctc ccctctggca
      361 gagattcaag gaagtcacta atgaaatgat cgtgaccaag aacggcagac ggatgttccc
      421 tgtcctgaag attagtgtca cagggctgga ccccaatgct atgtactctc tcctactgga
      481 cttcgtccgg accgacagtc accgctggaa gtacgtcaat ggtgaatggg tccccgcagg
      541 caagccagag gtctctagcc acagctgtgt ctacattcac cccgactccc ccaacttcgg
      601 ggctcactgg atgaaagctc ccatctcctt cagcaaagtg aagctgacca acaagctcaa
      661 tggaggtggg cagataatgc tgaattctct gcataaatat gaacctcagg ttcatatagt
      721 ccgtgttgga ggcgcccatc gaatggtcat gaactgctca ttccctgaaa ctcagttcat
      781 cgctgtgact gcctatcaga atgaggagat aacagctctc aaaatcaagt acaacccttt
      841 cgccaaggcc ttcttggatg ccaaggagag aaaccacctc aaggatgttc cagaggccat
      901 ctctgagagc cagcatgtga cctactctca cttgggaggc tggatccttt ccaatccgga
      961 tggtgtgtgc acagcagcaa acagcaatta ccagtatgct acgcctttgc ctctgcctgc
     1021 tccccacaca caccatggct gtgagcacta cgctggcctc cgaggtcatc ggcaggctcc
     1081 ctacccttct gcctacatgc atagaaacca ttctccctca gtgaatttga tagaaagctc
     1141 aagcaacaat ctgcaagttt tctcgggacc tgacagctgg acttccttat cctccacacc
     1201 ccatgccagc atcctgtctg taccccacag caatggccca atcaacccag ggcccagccc
     1261 ctatccgtgc ctgtggacca ttagcaatgg aggtgggggc cccgtggcat caggctcaga
     1321 ggtgcacgcc agcacctcag gaacaattct ccttgggaac cctgctgtca cttcaccttc
     1381 ctctttgctc cccacccaag cgaccacttc agctggtgtg gaggtcttgg gtgaaccttc
     1441 actaaccagc attgctgtgt ccacctggac agccgtggcc tcacaccccc tcccaggctg
     1501 gggtggccca ggtggagctg ggcgccattc ttcctcttca ttggatagtt aggcaggatc
     1561 ctaggagctg ctgccagtag agaactgtct gtatttgtgt ccatagcaac ctaatctgat
     1621 gattccagag agttgagcat cagggtctct tgagccagag gcctggagcg gtgcatggtg
     1681 atgcccaaaa gcctcccaga aaaaacggtt tagtctaggt gactctgatg ttactacttg
     1741 tgtctctcac catttcctgt ggctctcctg ctttctctga gttgatttat cttggccacg
     1801 cttaggttgc aaagtcagct tggtctaagt gccctgctcc ttactctcaa gccgttctgg
     1861 gaagcctcac ttcctttttt ctggagtcgg tgcatggttt tgaggagagc tcaaattttg
     1921 cctatggagg ttgctgcttt ttagctttgt acagacttgg aaagagtgtg tggccctaag
     1981 acccgagctg gcttctgcgt tgagacctag agaagatgag aggccataaa gttaacaaca
     2041 gcaagctagt actaacgtgt tgctcacaga agtgtgctgg gaagtcagga aatgaggctg
     2101 agccctcact aggtcatcat tagtggctcc cattgcctac agaatgaagt tcgatgaccc
     2161 catattctaa agacagcctc taccatttgg cgttgctcca tgcctctggc gttgactcct
     2221 gttaaccttt cagcaccctc cgctcaaggc tcctgttaac ctttcagcac cctccgctcg
     2281 aggctcctgt taacctttca gcaccctccg ctcgaggcag acagctctcc ttactctgaa
     2341 cacttgcttc ctgtgcttga agcatcccct ctcctgtccc acctgtgtga attgtacctg
     2401 cttggccagg actggttgaa aggccactct gctgtcaatc acctgaggtg atgtttggct
     2461 tatctctgtc ccctgctttc cctctatttt tacctcaggc atagagctcg cctcattctg
     2521 ccttatattt ctgcgagtgt atctgtctcc ctcatagact gtgagcctca tgagggtgag
     2581 agctagccct cctcatcgtg cccatagccc ctggtactgt gccttgatta ccgtaggtgc
     2641 ccaataaaca tttgctgagt tg
//
