LOCUS       NM_023814               4679 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus T-box18 (Tbx18), mRNA.
ACCESSION   NM_023814
VERSION     NM_023814.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4679)
  AUTHORS   Tan,J., Duron,A., Sucov,H.M. and Makita,T.
  TITLE     Placode and neural crest origins of congenital deafness in mouse
            models of Waardenburg-Shah syndrome
  JOURNAL   iScience 28 (1), 111680 (2024)
   PUBMED   39868048
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4679)
  AUTHORS   Loan,A., Awaja,N., Lui,M., Syal,C., Sun,Y., Sarma,S.N., Chona,R.,
            Johnston,W.B., Cordova,A., Saraf,D., Nakhle,A., O'Connor,K.,
            Thomas,J., Leung,J., Seegobin,M., He,L., Wondisford,F.E.,
            Picketts,D.J., Tsai,E.C., Chan,H.M. and Wang,J.
  TITLE     Single-cell profiling of brain pericyte heterogeneity following
            ischemic stroke unveils distinct pericyte subtype-targeted neural
            reprogramming potential and its underlying mechanisms
  JOURNAL   Theranostics 14 (16), 6110-6137 (2024)
   PUBMED   39431007
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4679)
  AUTHORS   Oikonomakos,I., Tedesco,M., Motamedi,F.J., Peitzsch,M., Nef,S.,
            Bornstein,S.R., Schedl,A., Steenblock,C. and Neirijnck,Y.
  TITLE     In vitro differentiation of mouse pluripotent stem cells into
            corticosteroid-producing adrenocortical cells
  JOURNAL   Stem Cell Reports 19 (9), 1289-1303 (2024)
   PUBMED   39178848
REFERENCE   4  (bases 1 to 4679)
  AUTHORS   Shi,Z., Xiong,S., Hu,R., Wang,Z., Park,J., Qian,Y., Wang,J.,
            Bhalla,P., Velupally,N., Song,Q., Song,Z., Jeon,M.S., Zhang,K.K.,
            Xie,L., Layden,B.T., Ong,S.G. and Jiang,Y.
  TITLE     The Notch-PDGFRbeta axis suppresses brown adipocyte progenitor
            differentiation in early post-natal mice
  JOURNAL   Dev Cell 59 (10), 1233-1251 (2024)
   PUBMED   38569546
REFERENCE   5  (bases 1 to 4679)
  AUTHORS   Li,H., Tang,Q., Yang,T., Wang,Z., Li,D., Wang,L., Li,L., Chen,Y.,
            Huang,H., Zhang,Y. and Chen,Y.
  TITLE     Segregation of morphogenetic regulatory function of Shox2 from its
            cell fate guardian role in sinoatrial node development
  JOURNAL   Commun Biol 7 (1), 385 (2024)
   PUBMED   38553636
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4679)
  AUTHORS   White,P.H., Farkas,D.R., McFadden,E.E. and Chapman,D.L.
  TITLE     Defective somite patterning in mouse embryos with reduced levels of
            Tbx6
  JOURNAL   Development 130 (8), 1681-1690 (2003)
   PUBMED   12620991
REFERENCE   7  (bases 1 to 4679)
  AUTHORS   Rosemann,M., Kuosaite,V., Nathrath,M., Strom,T.M.,
            Quintanilla-Martinez,L., Richter,T., Imai,K. and Atkinson,M.J.
  TITLE     Allelic imbalance at intragenic markers of Tbx18 is a hallmark of
            murine osteosarcoma
  JOURNAL   Carcinogenesis 24 (3), 371-376 (2003)
   PUBMED   12663494
  REMARK    GeneRIF: identification of Tbx18 as a candidate gene for
            osteosarcoma
REFERENCE   8  (bases 1 to 4679)
  AUTHORS   Deng,J., Dekruyff,R.H., Freeman,G.J., Umetsu,D.T. and Levy,S.
  TITLE     Critical role of CD81 in cognate T-B cell interactions leading to
            Th2 responses
  JOURNAL   Int Immunol 14 (5), 513-523 (2002)
   PUBMED   11978781
REFERENCE   9  (bases 1 to 4679)
  AUTHORS   Kume,T., Jiang,H., Topczewska,J.M. and Hogan,B.L.
  TITLE     The murine winged helix transcription factors, Foxc1 and Foxc2, are
            both required for cardiovascular development and somitogenesis
  JOURNAL   Genes Dev 15 (18), 2470-2482 (2001)
   PUBMED   11562355
REFERENCE   10 (bases 1 to 4679)
  AUTHORS   Kraus,F., Haenig,B. and Kispert,A.
  TITLE     Cloning and expression analysis of the mouse T-box gene Tbx18
  JOURNAL   Mech Dev 100 (1), 83-86 (2001)
   PUBMED   11118889
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK032660.1, AF306666.1, AK012980.1 and AC131681.4.
            
            On Aug 8, 2009 this sequence version replaced NM_023814.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK032660.1, BC145691.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-685               AK032660.1         3-687
            686-703             AF306666.1         621-638
            704-3280            AK032660.1         706-3282
            3281-4050           AK012980.1         381-1150
            4051-4051           AC131681.4         79365-79365         c
            4052-4572           AK012980.1         1152-1672
            4573-4679           AC131681.4         78737-78843         c
FEATURES             Location/Qualifiers
     source          1..4679
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 47.06 cM"
     gene            1..4679
                     /gene="Tbx18"
                     /gene_synonym="2810012F10Rik; 2810404D13Rik"
                     /note="T-box18"
                     /db_xref="GeneID:76365"
                     /db_xref="MGI:MGI:1923615"
     exon            1..726
                     /gene="Tbx18"
                     /gene_synonym="2810012F10Rik; 2810404D13Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             417..2258
                     /gene="Tbx18"
                     /gene_synonym="2810012F10Rik; 2810404D13Rik"
                     /note="T-box protein 18"
                     /codon_start=1
                     /product="T-box transcription factor TBX18"
                     /protein_id="NP_076303.3"
                     /db_xref="CCDS:CCDS40718.1"
                     /db_xref="GeneID:76365"
                     /db_xref="MGI:MGI:1923615"
                     /translation="MAEKRRGSPCSMLSLKAHAFSVEALIGAEKQQQLQKKRRKLATE
                     EAAGAVEDAGCSRSGGAGEHGCSEADEEAAAPPPAAGAASGPARSCADAERSCGSRGA
                     AGSCEDGFLQGASPLASPGGSPKGSPVPGLARPGTPLPAPQAPRVDLQGAELWKRFHE
                     IGTEMIITKAGRRMFPAMRVKISGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAG
                     NADSPVPPRVYIHPDSPASGETWMRQVISFDKLKLTNNELDDQGHIILHSMHKYQPRV
                     HVIRKDCGDDLSPIKPVPSGEGVKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAKGF
                     RDSGRNRMGLEALVESYAFWRPSLRTLTFEDIPGIPKQGNTSSSALLQGTGNAVPATH
                     PHLLSGSSCSSPAFHLGPNTSQLCSLAPADYSACARSGLALNRYSTSLAETYSRLTNQ
                     SSETFAPPRTPSYVSVSSNPSVNMSMGGTDGDTFSCPQTSLSMQISGMSPQLQYIMPS
                     PSGNAFAANQTHQSSYNTFRLHSPCALYGYNFSTSPKLAASPEKIVSSQGSFLGSSPS
                     GTMTDRQMLPPVEGVHLLSSGGQQSFFDSRTLGSLTLPSSQVSAHMV"
     exon            727..931
                     /gene="Tbx18"
                     /gene_synonym="2810012F10Rik; 2810404D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            932..1033
                     /gene="Tbx18"
                     /gene_synonym="2810012F10Rik; 2810404D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1205
                     /gene="Tbx18"
                     /gene_synonym="2810012F10Rik; 2810404D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1206..1373
                     /gene="Tbx18"
                     /gene_synonym="2810012F10Rik; 2810404D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..1438
                     /gene="Tbx18"
                     /gene_synonym="2810012F10Rik; 2810404D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1533
                     /gene="Tbx18"
                     /gene_synonym="2810012F10Rik; 2810404D13Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..4679
                     /gene="Tbx18"
                     /gene_synonym="2810012F10Rik; 2810404D13Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2788..2793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbx18"
                     /gene_synonym="2810012F10Rik; 2810404D13Rik"
                     /note="hexamer: AATAAA"
     polyA_site      2814
                     /gene="Tbx18"
                     /gene_synonym="2810012F10Rik; 2810404D13Rik"
                     /note="major polyA site"
     polyA_site      3287
                     /gene="Tbx18"
                     /gene_synonym="2810012F10Rik; 2810404D13Rik"
ORIGIN      
        1 tctcctgcct tgaagtgctg acagatcaag gcaacaaatt tcaattacaa tccctaattt
       61 gtgtccgcag agtgtttttt ttttccccgt gttagtcctc tcgggctcat cagtcgaggc
      121 agatcttgga gcagcaggag gaggtggagg gtttgggagt caagaagtgc atcattgaac
      181 tcgagggaga gacagaggga aggaaacttg gcggccgcgt tcctgcttcc tcggatccca
      241 acgccagaga aagaggaaac ggcaaatttg tttttgcccg cagctaggaa ggggacagat
      301 ctcgggaggc atcgggagct gcggagcgtt tggtgggggg ccaggagggc gagcgcgtgc
      361 gtgcgcccca gccgcgagta tatgagagag gggcgagcgg gctcggggag gcggggatgg
      421 cggagaagcg gaggggctca ccgtgcagca tgctaagcct caaggcgcac gccttctctg
      481 tggaggcact gatcggcgcc gagaagcagc aacagcttca aaagaagcgg agaaagctgg
      541 ccacggaaga ggcggcgggg gcggtggaag acgcaggctg cagccgtagc ggaggcgcgg
      601 gggagcacgg ctgctcggag gccgacgaag aagcggctgc cccgccgccg gcagccgggg
      661 cggcgtccgg gccagcgcgg agctgcgcgg acgcggagcg gagctgtggc tcccgcggag
      721 cggcgggcag ctgtgaggat ggcttcctgc agggcgcctc cccgttggca tccccgggag
      781 gctccccgaa agggtctccc gtacctggct tggcacgacc ggggaccccg ctgcccgcgc
      841 cgcaggcccc gagagtagat ctgcaaggag cggagctctg gaagcgcttt cacgaaatag
      901 gcaccgagat gatcatcacc aaagccggca ggcgcatgtt tccagcaatg cgggtgaaga
      961 tctccggatt agaccctcac cagcaatatt acattgccat ggatattgtg ccggtggaca
     1021 acaagagata caggtatgtt taccatagct ctaagtggat ggtggcagga aatgctgatt
     1081 ccccggtgcc acccagagta tacattcatc cagactcacc ggcctctggg gagacttgga
     1141 tgagacaagt catcagcttc gacaagctga aacttaccaa caatgagctg gatgaccaag
     1201 gccatatcat tcttcattct atgcacaaat accaaccacg tgtgcatgtc atccgtaaag
     1261 attgcggaga tgatctgtcc cccatcaagc ctgttccatc aggagaggga gtgaaggcat
     1321 tctcctttcc agaaaccgtc ttcacaactg tcactgccta tcagaatcag cagattactc
     1381 gccttaagat agacaggaat ccatttgcca aaggtttccg agactctggg aggaacagaa
     1441 tgggtttgga agctctggtg gagtcatacg cattctggag gccatcacta cggactctca
     1501 cctttgaaga tatccctgga atcccaaagc aaggcaacac aagttcttca gctctgctcc
     1561 aaggcactgg gaatgctgtc cctgctacac atcctcacct gttgtctgga tcctcttgct
     1621 cctctcctgc cttccatctg gggccgaaca ccagccagct gtgtagtctg gctccagctg
     1681 actattcggc ctgtgcccgt tcaggccttg ccctcaatcg atacagcaca tccttggcag
     1741 agacctacag caggcttacc aaccagagca gtgagacctt tgccccacct aggactcctt
     1801 cctacgtgag tgtgagcagc aacccgtctg tgaacatgtc catgggcggc actgatgggg
     1861 acaccttcag ctgcccacag accagcctgt ccatgcagat ttcaggaatg tcccctcaac
     1921 ttcagtacat catgccatcg ccgtccggca atgcctttgc tgctaaccag acccaccaga
     1981 gttcttacaa caccttccga ttgcacagtc cctgtgcctt gtatggatat aacttctcca
     2041 catcccccaa actggctgcc agtcctgaga aaattgtttc ttcccaagga agtttcttgg
     2101 ggtcctcacc aagtgggacc atgactgatc gtcagatgtt gccccctgtg gaaggagtgc
     2161 acctgctcag cagtgggggc cagcagagtt tctttgactc caggacccta ggaagtttaa
     2221 ctctgccatc ttctcaagtg tctgcacata tggtctgatg aagcctttaa gttaaacggc
     2281 gttggaatct agtggatctt ccttattttt ttaaagcaat atagggaaaa tgtacacata
     2341 gtaggaaagg aaggcccagt gagtgttttt actttctcat ggcaagattg taattatggt
     2401 atatatgtat gctgtatata tacatagcat gtagtatact gaagccttct ctctgccttg
     2461 tctattcagt tccacagagt attggcgaca tggactatgt ttatccagaa taatcagact
     2521 ctaaaagtaa aatggtacac ttgaaagttg gtaaggatgc taccaaagac ttttctaatg
     2581 cccacgtgcc aagtgatggg ggtttattac agcagtgtca tacataccta accaaagatt
     2641 tgtaacttca tttatcagaa gaatgctctg agcagtctgt attcaagtgt tgatagcctt
     2701 gcgatctctt ttatccttgg acttgatgtg agaatgttaa gtgcagaagc tggttaaatc
     2761 ttagtatatt tctgaggtat ctatagcaat aaaggcttag ctttatgttc cttctttttt
     2821 ggttgttttt gttttttgtt ttctttttgt ttgtttgttt gaggcaggtt tctctgtgtg
     2881 acagctttga ctgtcttgga gctcactctg tataccaggt tggtctctaa tgcaggtatt
     2941 agcttgcccc tgcctcccaa gtactgggat taaaggtgtg agccagcacc gcccagccat
     3001 tcctgtttat tcttacttac tgcagacctt gggtctataa aaatccatag cttatgctga
     3061 tttattttct gaaggaaggt ggatgacagc cttgtgattt tttactttcc aataaacaga
     3121 aaatcttatt tcctgcaaaa aaaatttctg ttattttgaa attgttgccc attttattta
     3181 gtttatcaag aaggccattg aaactgttct gtaaacattt tgaaattcca attttcacta
     3241 ggggaggggt tggattgtat ggcatgagaa actgaaaaag aaagaaagaa agaaaggaag
     3301 aaagaaagaa agaaagaaag aaagaaagaa agaaagaaag aaaataagca cacctcccag
     3361 attcttttgt cccagtaagt catgtttatt tatttgtttt caattagagg aatagtgtca
     3421 agcactccct agacccttgt gtggcttggt ttcttagatt atactttttc atctttgagc
     3481 tgcttgacct ctggtctatg agttaggaaa aagtcatgta tgccccttac ttatgtctca
     3541 taactcctac aaattgaaat gtttcccctc cctcgcctta tcttcttatc tgactctttt
     3601 ctaaaaacag acaggtctcg cctttatggt gctagtgctg caagaatttc agagggttat
     3661 ctccagcaat ctgtcttgtg gccgtagtca aaggccaaag tccattacta gaaaggcctc
     3721 ctaggaggac caaggaggaa gatacttatt atgataagtg agctataaaa cttttaacct
     3781 cgacatcatt ttaactttgg aagcgaagaa atgaaaacag gattgagttc taaaagtgcc
     3841 tgaaatgaat gcatggctta ggagttcaga agaaggaact ttgatagtag atcgtgagat
     3901 aaacaggaaa gagtgaggca cgcaggatgg atgagctcct ttggctgaga agctgaaggg
     3961 atgcgtctgc ccagctgctc cgtgcatttc atgttgaaca aaggaagaga atgatttcct
     4021 tttgtttatc cacagacttg ctctaacgtg tccctaattt ggacctgaag gagtctccat
     4081 cccactttcc ttctttactg aatagggtca ttgctggtta ttggttattt agggcaatgt
     4141 tctgtttaga cagaatgcat tctggatctg cctctgttta tagattctga caaatttccc
     4201 tgcggattct gtaagaattt tcaaaatcta agattagtgt aaaggagcat gaaatatttg
     4261 cagtaggtgg atctagctaa ggttttatgc atggtgttat taacttgaca gatttagaaa
     4321 aaaggtttca agaacgaatc tagcctttgt gcacttctta atcaaggaag atggcttttc
     4381 atcctgagac agcatcccat ggcacatttc cctttttgct gttggtaatt ggagatgaca
     4441 ccttgatgcc aggagacatt tttattaatc attttggtaa aatctagcaa tactgtacaa
     4501 atgctctttc tttcagattt tgctgtaaat aataatcacc atttcgttcc aaagactagt
     4561 aaccttatat tgttttacta aatgatatac atgcattgtt gcattgttaa ttataattat
     4621 ctatctgtat tttattaaga actggttaag aaattatatt aaagtacatt atgaaaccc
//
