LOCUS       NM_009323               3567 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus T-box 15 (Tbx15), transcript variant 1, mRNA.
ACCESSION   NM_009323 NM_011534 XM_990469
VERSION     NM_009323.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3567)
  AUTHORS   Feng,J., Han,X., Yuan,Y., Cho,C.K., Janeckova,E., Guo,T.,
            Pareek,S., Rahman,M.S., Zheng,B., Bi,J., Jing,J., Zhang,M., Xu,J.,
            Ho,T.V. and Chai,Y.
  TITLE     TGF-beta signaling and Creb5 cooperatively regulate Fgf18 to
            control pharyngeal muscle development
  JOURNAL   Elife 11, e80405 (2022)
   PUBMED   36542062
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3567)
  AUTHORS   Zhang,Y., Li,J., Ji,Y., Cheng,Y. and Fu,X.
  TITLE     Mutations in the TBX15-ADAMTS2 pathway associate with a novel soft
            palate dysplasia
  JOURNAL   Hum Mutat 43 (12), 2102-2115 (2022)
   PUBMED   36124393
REFERENCE   3  (bases 1 to 3567)
  AUTHORS   Decourtye,L., McCallum-Loudeac,J.A., Zellhuber-McMillan,S.,
            Young,E., Sircombe,K.J. and Wilson,M.J.
  TITLE     Characterization of a novel Lbx1 mouse loss of function strain
  JOURNAL   Differentiation 123, 30-41 (2022)
   PUBMED   34906895
REFERENCE   4  (bases 1 to 3567)
  AUTHORS   Xu,J., Liu,H., Lan,Y. and Jiang,R.
  TITLE     Cis-Repression of Foxq1 Expression Affects Foxf2-Mediated Gene
            Expression in Palate Development
  JOURNAL   Front Cell Dev Biol 9, 665109 (2021)
   PUBMED   33898467
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3567)
  AUTHORS   Han,X., Feng,J., Guo,T., Loh,Y.E., Yuan,Y., Ho,T.V., Cho,C.K.,
            Li,J., Jing,J., Janeckova,E., He,J., Pei,F., Bi,J., Song,B. and
            Chai,Y.
  TITLE     Runx2-Twist1 interaction coordinates cranial neural crest guidance
            of soft palate myogenesis
  JOURNAL   Elife 10, e62387 (2021)
   PUBMED   33482080
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3567)
  AUTHORS   Drake,T.A., Hannani,K., Kabo,J.M., Villa,V., Krass,K. and
            Lusis,A.J.
  TITLE     Genetic loci influencing natural variations in femoral bone
            morphometry in mice
  JOURNAL   J Orthop Res 19 (4), 511-517 (2001)
   PUBMED   11518254
REFERENCE   7  (bases 1 to 3567)
  AUTHORS   Agulnik,S.I., Papaioannou,V.E. and Silver,L.M.
  TITLE     Cloning, mapping, and expression analysis of TBX15, a new member of
            the T-Box gene family
  JOURNAL   Genomics 51 (1), 68-75 (1998)
   PUBMED   9693034
REFERENCE   8  (bases 1 to 3567)
  AUTHORS   ten Berge,D., Brouwer,A., el Bahi,S., Guenet,J.L., Robert,B. and
            Meijlink,F.
  TITLE     Mouse Alx3: an aristaless-like homeobox gene expressed during
            embryogenesis in ectomesenchyme and lateral plate mesoderm
  JOURNAL   Dev Biol 199 (1), 11-25 (1998)
   PUBMED   9676189
REFERENCE   9  (bases 1 to 3567)
  AUTHORS   Wattler,S., Russ,A., Evans,M. and Nehls,M.
  TITLE     A combined analysis of genomic and primary protein structure
            defines the phylogenetic relationship of new members if the T-box
            family
  JOURNAL   Genomics 48 (1), 24-33 (1998)
   PUBMED   9503012
REFERENCE   10 (bases 1 to 3567)
  AUTHORS   Lane,P.W. and Eicher,E.M.
  TITLE     Gene order in linkage group XVI of the house mouse
  JOURNAL   J Hered 70 (4), 239-244 (1979)
   PUBMED   489953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC080018.14, AL606747.13 and AL606745.11.
            
            On Aug 10, 2022 this sequence version replaced NM_009323.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132578.1, AY662679.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-326               AC080018.14        30053-30378         c
            327-540             AL606747.13        64160-64373
            541-642             AL606747.13        68343-68444
            643-814             AL606747.13        70074-70245
            815-982             AL606747.13        71521-71688
            983-1047            AL606747.13        81714-81778
            1048-1145           AL606747.13        95880-95977
            1146-2276           AL606747.13        107169-108299
            2277-3567           AL606745.11        2001-3291
FEATURES             Location/Qualifiers
     source          1..3567
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 43.03 cM"
     gene            1..3567
                     /gene="Tbx15"
                     /gene_synonym="de; mmTBx8; Tbx14; Tbx8"
                     /note="T-box 15"
                     /db_xref="GeneID:21384"
                     /db_xref="MGI:MGI:1277234"
     exon            1..326
                     /gene="Tbx15"
                     /gene_synonym="de; mmTBx8; Tbx14; Tbx8"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1930
                     /gene="Tbx15"
                     /gene_synonym="de; mmTBx8; Tbx14; Tbx8"
                     /note="isoform 1 is encoded by transcript variant 1; T-box
                     transcription factor TBX15; T-box protein 15; T-box
                     protein 14; T-box transcription factor TBX14; droopy ear;
                     T-box 14"
                     /codon_start=1
                     /product="T-box transcription factor TBX15 isoform 1"
                     /protein_id="NP_033349.2"
                     /db_xref="CCDS:CCDS17673.1"
                     /db_xref="GeneID:21384"
                     /db_xref="MGI:MGI:1277234"
                     /translation="MSERRRSAVALSSRAHAFSVEALIGSNKKRKLRDWEEKGLDLSM
                     EALSPAGPLGDTDDPATHGLEPHPDSEQSTGSDSEVLTERTSCSFSTHTDLASGAAGP
                     VPAAMSSMEEIQVELQCADLWKRFHDIGTEMIITKAGRRMFPAMRVKITGLDPHQQYY
                     IAMDIVPVDNKRYRYVYHSSKWMVAGNADSPVPPRVYIHPDSLASGDTWMRQVVSFDK
                     LKLTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPVGDGVKTFNFPETV
                     FTTVTAYQNQQITRLKIDRNPFAKGFRDSGRNRTGLEAIMETYAFWRPPVRTLTFEDF
                     TTMQKQQGGSTGTSPTTSSTGTPSPSASSHLLSPSCSPPTFHLAPNTFNVGCRESQLC
                     NLNLSDYPPCARSNMAALQSYPGLSDSGYNRLQSGTASATQPSETFMPQRTPSLISGI
                     PTPPSLPSNSKMEAYGGQLGSFPTSQFQYVMQAGNAASSSSSPHMFGGSHMQQSSYNA
                     FSLHNPYNLYGYNFPTSPRLAASPEKLSASQSTLLCSSPSNGAFGERQYLPTGMEHSM
                     HMISPSTNNQQATNTCDGRQYGAVPGSASQMSVHMV"
     exon            327..540
                     /gene="Tbx15"
                     /gene_synonym="de; mmTBx8; Tbx14; Tbx8"
                     /inference="alignment:Splign:2.1.0"
     exon            541..642
                     /gene="Tbx15"
                     /gene_synonym="de; mmTBx8; Tbx14; Tbx8"
                     /inference="alignment:Splign:2.1.0"
     exon            643..814
                     /gene="Tbx15"
                     /gene_synonym="de; mmTBx8; Tbx14; Tbx8"
                     /inference="alignment:Splign:2.1.0"
     exon            815..982
                     /gene="Tbx15"
                     /gene_synonym="de; mmTBx8; Tbx14; Tbx8"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1047
                     /gene="Tbx15"
                     /gene_synonym="de; mmTBx8; Tbx14; Tbx8"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1145
                     /gene="Tbx15"
                     /gene_synonym="de; mmTBx8; Tbx14; Tbx8"
                     /inference="alignment:Splign:2.1.0"
     exon            1146..3567
                     /gene="Tbx15"
                     /gene_synonym="de; mmTBx8; Tbx14; Tbx8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3547..3552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbx15"
                     /gene_synonym="de; mmTBx8; Tbx14; Tbx8"
                     /note="hexamer: AATAAA"
     polyA_site      3567
                     /gene="Tbx15"
                     /gene_synonym="de; mmTBx8; Tbx14; Tbx8"
                     /note="major polyA site"
ORIGIN      
        1 agtttcggcc gcggcgccgc cgcctctcca gggccgggtc ggcgggcgct cggagcgtgc
       61 ggccgcgggg ctgccagctc agtagcgcgg gctagaggag acccgggtgc gggcggctaa
      121 aatgagtgaa cggagaagat ctgcagtcgc cctgagctcc cgagcacatg ccttctccgt
      181 tgaagccttg atcggctcaa ataaaaagcg gaaactgcga gactgggagg agaaggggct
      241 ggacttgtcc atggaggcgc tgagtcccgc aggcccactc ggagacacag acgacccggc
      301 gacacacggc ctggagcccc acccggactc cgagcagagc actgggtcgg actccgaggt
      361 gctcaccgag cggacctcct gctccttcag cactcacact gacctggcgt ctggtgctgc
      421 aggccccgtg cctgctgcca tgtcttccat ggaagagatt caggtggagt tgcaatgtgc
      481 tgacctctgg aagaggttcc atgatatcgg aacagagatg atcatcacca aagcaggcag
      541 gaggatgttt cctgccatga gagtgaaaat cactggcctg gatccacatc agcaatacta
      601 tatagcaatg gacattgttc ctgtggacaa taaaagatac agatatgtgt atcatagctc
      661 taagtggatg gtggctggca atgctgattc ccctgtgcct ccaagggttt acatacaccc
      721 agattcccta gcttctggag acacctggat gagacaggtg gtcagttttg acaaactcaa
      781 gctgaccaac aatgaactgg atgatcaagg acatattatt ttgcactcca tgcataaata
      841 ccagcctcga gtccacgtga tccgcaaaga ctttagcagt gatctttcac ccaccaaacc
      901 tgtgcctgtg ggggacgggg tgaaaacatt caactttcct gagactgtgt ttaccacagt
      961 cacagcctat cagaaccagc agatcaccag attaaaaatt gaccgaaacc cctttgctaa
     1021 aggattcaga gattctggca gaaacagaac tggacttgaa gccatcatgg agacttatgc
     1081 attctggaga cctcctgttc gcacactgac ctttgaggac ttcactacca tgcaaaagca
     1141 gcaagggggc agtacaggta cttctccaac cacctccagc actgggacac catccccttc
     1201 ggcttcttct catctcttat ctccatcttg ttctcctcca acttttcatt tggccccgaa
     1261 tactttcaat gtgggctgtc gagaaagcca gctgtgtaat ctaaacctct ctgattatcc
     1321 accatgtgcc cgaagcaaca tggctgcctt acagagctat ccagggctga gtgacagtgg
     1381 ctacaaccgg ctccagagtg gcacagcttc agccactcag ccctctgaaa ccttcatgcc
     1441 tcagaggact ccatctctga tctcaggaat accaacacct ccctcgttgc ccagcaacag
     1501 caagatggaa gcctatggtg gccagttggg gtccttcccc acttcccagt ttcagtatgt
     1561 catgcaggca ggcaatgcag cctccagttc ctcatcgcca cacatgtttg gtggcagcca
     1621 catgcagcag agctcctata atgccttctc cctccataat ccctacaatc tgtatggata
     1681 caatttcccc acttccccca ggctagctgc aagcccagag aaactgagcg cgtctcaaag
     1741 cactttactc tgttcttctc cttctaatgg ggcctttgga gagaggcagt acctgcctac
     1801 agggatggag catagcatgc acatgatcag cccttcaact aataatcagc aggctaccaa
     1861 cacctgtgat ggccgacagt atggggcagt cccaggctct gcctctcaga tgtccgtaca
     1921 catggtttaa agagcagtgc acacactatc gaggtgatgg cggccaagac tccagaatct
     1981 ctgtgggtgg atcatcctcc ttgggaggca tgtgccttgg gaaaatagga attgtgtgtt
     2041 tgtttttgtt tttgtttttg tttttttctg gataaggaaa acagagaaca acaatagata
     2101 ccgctgaagg atccttggag tccatcatcc atatctcagt ggtcattctt ctgccttcca
     2161 aaatcttagt tttataaaag cattgtgtat gacagagtgg ccttgaagag actgaataat
     2221 cattttataa taatgttgaa ggaaatgcta gcatgtagca gccaagacaa gttttacaca
     2281 cacacacaca cacacacaca cacacacaca caccccttac atgaatatag tcatgtacac
     2341 acacgcatac aaaaagtaat acaaacacaa acatcataca cactgactct gaactgggtg
     2401 aactctgtga agggaggccc agaatgggtg ctttcaccaa aaaatttgcc cgtttacaat
     2461 cctagacgga ctgggccatc attagctaat agcctttctc ccttgccatg tttctggaat
     2521 gaaccgtgta cctagaacct ctccttgcca cagagatgga aaggcatcag tgctacacct
     2581 ggacttggct tcctgagaaa gattgttttt taacctttgg ctttcttcat tcagtgtgcc
     2641 atctttgatc ttacagcggt gcctgtggaa ggacagggtg agaaaagctc ggagagagaa
     2701 agaatcgagg gcaggagaga gtggacagca agactgagaa gatgtgaaca aatgagattt
     2761 aatccaccaa ggagaattgg ttgggtttgt ttagcctcta aagttataga aagaatgatg
     2821 gtggtagtgg agagtaagcc tctttgggac cctgcttaga gtcaagggta ccaatgagaa
     2881 gggctaggac aaggaatgct tcttgattcc atagctctga ctataatgac ccaggagaga
     2941 ggtgcccctt gtgggagttc cattctgtgg catgcaactg agcagggtta gggaaacagg
     3001 tgtcaagaat gaagagaatg gttttatctc caaggtgata ccaaaaacga gtcatggacg
     3061 acaggcctgg cctcacacgc cagatccaaa atgttgacct ggacaatctg tccctggtgc
     3121 ccatgcagga gaaaccctga gacacagaag agaattgcag ggtcttctgc cccttttcta
     3181 tctgcctgta gctctccatt ttgattaaat agttcattgc attctgaagt ttggggatgt
     3241 tttttctttc cttttctttt caaatccttt aatgatagga agacaagtga aactgggtgc
     3301 aagctaaaat ttttaaatgg tgtggagact cgaatgatac caagataata cagatattat
     3361 taagaatttt tttgtgttga ggtgatgtag ataaatgtat ttatatgcct agttggatat
     3421 tcaatattat gaatattaaa aagggggcaa taaaagggta tgtaaaatat gtatgaagaa
     3481 aaggtgtata aaaatttgcc cttatgcacg gaactgtttc tgagtgccaa gcacagaaag
     3541 ccgctaaata aaatctttgc aattgtt
//
