LOCUS       NM_001001320            1795 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Mus musculus T-box 10 (Tbx10), transcript variant 1, mRNA.
ACCESSION   NM_001001320
VERSION     NM_001001320.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1795)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1795)
  AUTHORS   Suzuki,A., Abdallah,N., Gajera,M., Jun,G., Jia,P., Zhao,Z. and
            Iwata,J.
  TITLE     Genes and microRNAs associated with mouse cleft palate: A
            systematic review and bioinformatics analysis
  JOURNAL   Mech Dev 150, 21-27 (2018)
   PUBMED   29475039
REFERENCE   3  (bases 1 to 1795)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   4  (bases 1 to 1795)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1795)
  AUTHORS   Wiese,C.B., Ireland,S., Fleming,N.L., Yu,J., Valerius,M.T.,
            Georgas,K., Chiu,H.S., Brennan,J., Armstrong,J., Little,M.H.,
            McMahon,A.P. and Southard-Smith,E.M.
  TITLE     A genome-wide screen to identify transcription factors expressed in
            pelvic Ganglia of the lower urinary tract
  JOURNAL   Front Neurosci 6, 130 (2012)
   PUBMED   22988430
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1795)
  AUTHORS   Jacobson,D. and Trasler,D.G.
  TITLE     Morphometric analysis of heterozygote dancer mice predisposed to
            6-aminonicotinamide-induced cleft lip
  JOURNAL   Teratology 45 (4), 393-400 (1992)
   PUBMED   1585267
REFERENCE   7  (bases 1 to 1795)
  AUTHORS   Sweet,H.O. and Bronson,R.T.
  TITLE     Osteochondrodystrophy (ocd): a new autosomal recessive mutation in
            the mouse
  JOURNAL   J Hered 82 (2), 140-144 (1991)
   PUBMED   2013688
REFERENCE   8  (bases 1 to 1795)
  AUTHORS   Wenngren,B.I. and Anniko,M.
  TITLE     Aberrant frequency tuning and early stereociliary derangement in
            genetic inner ear disease
  JOURNAL   Acta Otolaryngol 109 (3-4), 202-212 (1990)
   PUBMED   2316343
REFERENCE   9  (bases 1 to 1795)
  AUTHORS   Wenngren,B.I. and Anniko,M.
  TITLE     Vestibular hair cell pathology in the dancer mouse mutant
  JOURNAL   Acta Otolaryngol 107 (3-4), 182-190 (1989)
   PUBMED   2784612
REFERENCE   10 (bases 1 to 1795)
  AUTHORS   Wenngren,B.I. and Anniko,M.
  TITLE     Age-related auditory brainstem response (ABR) threshold changes in
            the dancer mouse mutant
  JOURNAL   Acta Otolaryngol 106 (5-6), 386-392 (1988)
   PUBMED   3207006
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY229976.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY229976.1, BC109150.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
FEATURES             Location/Qualifiers
     source          1..1795
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 3.71 cM"
     gene            1..1795
                     /gene="Tbx10"
                     /gene_synonym="Dc; Tbx13; Tbx7"
                     /note="T-box 10"
                     /db_xref="GeneID:109575"
                     /db_xref="MGI:MGI:1261436"
     exon            1..363
                     /gene="Tbx10"
                     /gene_synonym="Dc; Tbx13; Tbx7"
                     /inference="alignment:Splign:2.1.0"
     CDS             357..1514
                     /gene="Tbx10"
                     /gene_synonym="Dc; Tbx13; Tbx7"
                     /note="isoform 1 is encoded by transcript variant 1; T-box
                     transcription factor TBX10; T-box 13; mmTBX7; T-box
                     protein 10; T-box protein 13; dancer"
                     /codon_start=1
                     /product="T-box transcription factor TBX10 isoform 1"
                     /protein_id="NP_001001320.1"
                     /db_xref="CCDS:CCDS29407.1"
                     /db_xref="GeneID:109575"
                     /db_xref="MGI:MGI:1261436"
                     /translation="MAVFLSAGLGVLAPPETCPHPETSTSWESRLGTRFPSGSCTMST
                     EAQAMAEPTGQGPKNPRVSSVMVQLEMKPLWEEFNQLGTEMIVTKAGRRMFPTFQVKI
                     LGMDTLADYALLMDFIPLDDKRYRYAFHSSAWLVAGKADPATPGRVHFHPDSPAKGAQ
                     WMRQIVSFDKLKLTNNLMDDNGHIILNSMHRYQPRFHVVFVDPRKDSARYAQENFKSF
                     VFTETQFTAVTAYQNHRITQLKIASNPFAKGFREADPDSWPVTPRPLLSIPARSRSSL
                     SPCLLKGSAEREKDTSKASASSSRTPTQPHNQLLPAPDVLLAPATYRPLPYQNLYPGS
                     PSRAGPPRARLAPYPLPNISTAGDQEDPTLAAGLGLLPTSALCLVSNQASQ"
     exon            364..631
                     /gene="Tbx10"
                     /gene_synonym="Dc; Tbx13; Tbx7"
                     /inference="alignment:Splign:2.1.0"
     exon            632..733
                     /gene="Tbx10"
                     /gene_synonym="Dc; Tbx13; Tbx7"
                     /inference="alignment:Splign:2.1.0"
     exon            734..905
                     /gene="Tbx10"
                     /gene_synonym="Dc; Tbx13; Tbx7"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1061
                     /gene="Tbx10"
                     /gene_synonym="Dc; Tbx13; Tbx7"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1129
                     /gene="Tbx10"
                     /gene_synonym="Dc; Tbx13; Tbx7"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1224
                     /gene="Tbx10"
                     /gene_synonym="Dc; Tbx13; Tbx7"
                     /inference="alignment:Splign:2.1.0"
     exon            1225..1778
                     /gene="Tbx10"
                     /gene_synonym="Dc; Tbx13; Tbx7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1757..1762
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbx10"
                     /gene_synonym="Dc; Tbx13; Tbx7"
                     /note="hexamer: ATTAAA"
     polyA_site      1778
                     /gene="Tbx10"
                     /gene_synonym="Dc; Tbx13; Tbx7"
                     /note="major polyA site"
ORIGIN      
        1 acaaccgtcc cacctgcccc cttccacatg agcctgcctc cagagccaaa cccagccagt
       61 ggcccagctc cagacactac aatcagaggc agtttggaga cacccaccag aacagcccca
      121 agctgggctt tatgaacatc caaccaagtg tcctgctcag gaggaaaagc ctcagccagg
      181 aagtcggaca gaggacaatc aaggagggaa gtactgagaa ctggggacgg gtgcatgctt
      241 gagagtgagg tctgctgctg agcacaggag ccgacccagt gtcactcact ggcgtcccct
      301 ccctgggtaa ggctgtagcc tagcctgagc tgagatccgg ctgtccagct gtccgcatgg
      361 cagtcttcct gtctgctggc cttggggtac ttgctcctcc agagacctgt ccccatcccg
      421 agaccagcac cagctgggag tcccggctgg ggacacgatt cccctcaggt tcctgcacca
      481 tgtctacaga agcccaagcc atggcagagc ccactgggca gggccccaag aacccacgtg
      541 tgtccagtgt gatggtgcag ctggagatga agccactgtg ggaagagttc aaccagctgg
      601 gcacagagat gattgtcacc aaagcgggca ggaggatgtt cccaacgttc caggtgaaga
      661 tcctgggcat ggacacgctg gctgactacg ctttgctcat ggactttatc ccgttggatg
      721 acaagagata caggtacgca ttccacagtt ctgcctggct ggtggcaggc aaggcagacc
      781 ctgccacgcc tggcagggtg cacttccacc ctgactcgcc agccaagggt gcccagtgga
      841 tgcggcagat tgtgtccttt gacaaactca agctgaccaa caacctgatg gacgacaatg
      901 gccacatcat cctcaactcc atgcatcgtt atcagccccg tttccacgtg gtcttcgtgg
      961 acccacgcaa ggacagtgcc cgctatgccc aggaaaactt caagtccttt gtcttcacgg
     1021 agacccagtt tacagctgtg acagcctatc agaaccacag gatcacgcag ctgaaaattg
     1081 ctagcaaccc ctttgccaaa ggtttcagag aggctgaccc agactcatgg cctgtgaccc
     1141 cccggccact gctcagcatc cctgcccgga gtcgtagcag cctcagtccc tgcctcctta
     1201 agggctctgc agaacgagag aaagatacca gtaaagcttc cgcttccagc tccaggaccc
     1261 ctactcagcc acacaatcag ctgctgcctg cccctgatgt cctgctagcc cctgccacct
     1321 acagacccct cccttaccag aacctgtacc ctggatcccc aagccgtgct gggcccccaa
     1381 gagctcggct ggcaccttac cctctcccca acatcagcac ggctggagat caggaggacc
     1441 caaccctcgc agctgggctg ggactcctgc ccacctctgc cttgtgcttg gtgtctaatc
     1501 aagcctcgca gtgatggctg agtgctgtgg aagcccgttt cccctgtgcc ccacctctcc
     1561 ttccctcctc tgtaagacat ctcctaaggc gagcagcaca actggaagct ctacagcagt
     1621 gggttcctgc ctcaaagtca gtctggggcc tgccagcctt ggaatcaggc ctacttccta
     1681 ctcaaaagcc ctgaatcatg ccctgctgcc tcgaggatgc ctcctctaaa tcctgcttcg
     1741 aatgtccttc ccccacatta aactgcttgg caacagcaaa aaaaaaaaaa aaaaa
//
