LOCUS       NM_001373938            3333 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus T-box 1 (Tbx1), transcript variant 4, mRNA.
ACCESSION   NM_001373938 XM_017316925
VERSION     NM_001373938.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3333)
  AUTHORS   Eom,T.Y., Schmitt,J.E., Li,Y., Davenport,C.M., Steinberg,J.,
            Bonnan,A., Alam,S., Ryu,Y.S., Paul,L., Hansen,B.S., Khairy,K.,
            Pelletier,S., Pruett-Miller,S.M., Roalf,D.R., Gur,R.E.,
            Emanuel,B.S., McDonald-McGinn,D.M., Smith,J.N., Li,C.,
            Christie,J.M., Northcott,P.A. and Zakharenko,S.S.
  TITLE     Tbx1 haploinsufficiency leads to local skull deformity,
            paraflocculus and flocculus dysplasia, and motor-learning deficit
            in 22q11.2 deletion syndrome
  JOURNAL   Nat Commun 15 (1), 10510 (2024)
   PUBMED   39638997
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3333)
  AUTHORS   Argiro,L., Chevalier,C., Choquet,C., Nandkishore,N., Ghata,A.,
            Baudot,A., Zaffran,S. and Lescroart,F.
  TITLE     Gastruloids are competent to specify both cardiac and skeletal
            muscle lineages
  JOURNAL   Nat Commun 15 (1), 10172 (2024)
   PUBMED   39580459
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3333)
  AUTHORS   Guijarro,C., Song,S., Aigouy,B., Clement,R., Villoutreix,P. and
            Kelly,R.G.
  TITLE     Single-cell morphometrics reveals T-box gene-dependent patterns of
            epithelial tension in the Second Heart field
  JOURNAL   Nat Commun 15 (1), 9512 (2024)
   PUBMED   39496595
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3333)
  AUTHORS   Zhu,S., Huo,S., Wang,Z., Huang,C., Li,C., Song,H., Yang,X., He,R.,
            Ding,C., Qiu,M. and Zhu,X.J.
  TITLE     Follistatin controls the number of murine teeth by limiting
            TGF-beta signaling
  JOURNAL   iScience 27 (9), 110785 (2024)
   PUBMED   39286503
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3333)
  AUTHORS   Dumas,C.E., Rousset,C., De Bono,C., Cortes,C., Jullian,E.,
            Lescroart,F., Zaffran,S., Adachi,N. and Kelly,R.G.
  TITLE     Retinoic acid signalling regulates branchiomeric neck muscle
            development at the head/trunk interface
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39082789
REFERENCE   6  (bases 1 to 3333)
  AUTHORS   Saba-el-Leil,M.K., Malo,D. and Meloche,S.
  TITLE     Chromosomal localization of the mouse genes encoding the ERK1 and
            ERK2 isoforms of MAP kinases
  JOURNAL   Mamm Genome 8 (2), 141-142 (1997)
   PUBMED   9060415
REFERENCE   7  (bases 1 to 3333)
  AUTHORS   Agulnik,S.I., Garvey,N., Hancock,S., Ruvinsky,I., Chapman,D.L.,
            Agulnik,I., Bollag,R., Papaioannou,V. and Silver,L.M.
  TITLE     Evolution of mouse T-box genes by tandem duplication and cluster
            dispersion
  JOURNAL   Genetics 144 (1), 249-254 (1996)
   PUBMED   8878690
REFERENCE   8  (bases 1 to 3333)
  AUTHORS   Chapman,D.L., Garvey,N., Hancock,S., Alexiou,M., Agulnik,S.I.,
            Gibson-Brown,J.J., Cebra-Thomas,J., Bollag,R.J., Silver,L.M. and
            Papaioannou,V.E.
  TITLE     Expression of the T-box family genes, Tbx1-Tbx5, during early mouse
            development
  JOURNAL   Dev Dyn 206 (4), 379-390 (1996)
   PUBMED   8853987
REFERENCE   9  (bases 1 to 3333)
  AUTHORS   Fitzgibbon,J., Wells,D., Pilz,A., Delhanty,J., Kai,M., Kanoh,H. and
            Hunt,D.
  TITLE     Localisation of the gene encoding diacylglycerol kinase 3 (DAGK3)
            to human chromosome 3q27-28 and mouse chromosome 16
  JOURNAL   Curr Eye Res 14 (11), 1041-1043 (1995)
   PUBMED   8585934
REFERENCE   10 (bases 1 to 3333)
  AUTHORS   Bollag,R.J., Siegfried,Z., Cebra-Thomas,J.A., Garvey,N.,
            Davison,E.M. and Silver,L.M.
  TITLE     An ancient family of embryonically expressed mouse genes sharing a
            conserved protein motif with the T locus
  JOURNAL   Nat Genet 7 (3), 383-389 (1994)
   PUBMED   7920656
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133488.30.
            
            On Sep 5, 2019 this sequence version replaced XM_017316925.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.809774.1,
                                           SRR13861859.4022464.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-913               AC133488.30        156659-157571       c
            914-1256            AC133488.30        155208-155550       c
            1257-1358           AC133488.30        153707-153808       c
            1359-1530           AC133488.30        152756-152927       c
            1531-1686           AC133488.30        152091-152246       c
            1687-1754           AC133488.30        151579-151646       c
            1755-1855           AC133488.30        151396-151496       c
            1856-3333           AC133488.30        149651-151128       c
FEATURES             Location/Qualifiers
     source          1..3333
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16"
     gene            1..3333
                     /gene="Tbx1"
                     /gene_synonym="nmf219"
                     /note="T-box 1"
                     /db_xref="GeneID:21380"
                     /db_xref="MGI:MGI:98493"
     exon            1..913
                     /gene="Tbx1"
                     /gene_synonym="nmf219"
                     /inference="alignment:Splign:2.1.0"
     CDS             730..2319
                     /gene="Tbx1"
                     /gene_synonym="nmf219"
                     /note="isoform 4 is encoded by transcript variant 4; T-box
                     transcription factor TBX1; T-box protein 1;
                     testis-specific T-box protein"
                     /codon_start=1
                     /product="T-box transcription factor TBX1 isoform 4"
                     /protein_id="NP_001360867.1"
                     /db_xref="GeneID:21380"
                     /db_xref="MGI:MGI:98493"
                     /translation="MDARSPLSARASAFSIASLVAAEASEGTAHRGPRPSDRAKLRRL
                     PGSPAGMHFSTVTRDMEAFAASSLSGLGSPSPGADPFGPREPPPPRYDPCAAVPGAPG
                     PPPPRAYPFAPAPGAAGSSAAESEGPGASRAAAVKAPVKKNPKVASVSVQLEMKALWD
                     EFNQLGTEMIVTKAGRRMFPTFQVKLFGMDPMADYMLLMDFVPVDDKRYRYAFHSSSW
                     LVAGKADPATPGRVHYHPDSPAKGAQWMKQIVSFDKLKLTNNLLDDNGHIILNSMHRY
                     QPRFHVVYVDPRKDSEKYAEENFKTFVFEETRFTAVTAYQNHRITQLKIASNPFAKGF
                     RDCDPEDWPRNHRPGALPLVSAFARSRNPVASPTQPNGSDKDAAEARREFDRDSGPAA
                     LGDATHPPQLLARVLSPALPGPGGLVPLPGGSGGRHSPPHADLRLEAPGASEPLHHHP
                     YKYPAAAYDHYLGAKSRPAPYPLPGLRGHGYHPHAHPHAHPHHHHHPAVNPAAAAAAA
                     AAANVYSSAAAPPGAYDYCPR"
     exon            914..1256
                     /gene="Tbx1"
                     /gene_synonym="nmf219"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1358
                     /gene="Tbx1"
                     /gene_synonym="nmf219"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1530
                     /gene="Tbx1"
                     /gene_synonym="nmf219"
                     /inference="alignment:Splign:2.1.0"
     exon            1531..1686
                     /gene="Tbx1"
                     /gene_synonym="nmf219"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1754
                     /gene="Tbx1"
                     /gene_synonym="nmf219"
                     /inference="alignment:Splign:2.1.0"
     exon            1755..1855
                     /gene="Tbx1"
                     /gene_synonym="nmf219"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..3333
                     /gene="Tbx1"
                     /gene_synonym="nmf219"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbx1"
                     /gene_synonym="nmf219"
                     /note="hexamer: CATAAA"
     polyA_site      2602
                     /gene="Tbx1"
                     /gene_synonym="nmf219"
                     /note="major polyA site"
     regulatory      3309..3314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbx1"
                     /gene_synonym="nmf219"
                     /note="hexamer: AATAAA"
     polyA_site      3333
                     /gene="Tbx1"
                     /gene_synonym="nmf219"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgggc ggtgcgcgcg gggtgcgcgt gacgctcggg ctccaggtct tgtgcggcct
       61 gggcggcgtc ccacggctcg cttccccacc acgaaagcaa gctgacccaa agggcctgta
      121 ggggcaattg ctggtgaggt ccagctctgc ggcacggagg gacgaaggac tccgcaagcc
      181 ctggggctat ctgcctgtgg cctgtgcgag agccggagct ctcttaccca ggtgcagggg
      241 ccgccgggga ggaggtggag gcaggtgggg ccaagcaagg gcagggctag actcaggcag
      301 catctcagtg cctcgccaat gccctgccat ctcacattgg gactgagtgt tcgagacata
      361 gaagcttctt cttggggctg tagactctgg tggtggcttc gccgaataga ggggacgccc
      421 aacctccgca aaagctgcag gatgttcaag gggcgttggt cacacagggc cccgggagga
      481 gagaccaggg acagagagct tacaaggcag gagggccctg aatttccagg gtgctccaaa
      541 tgttcggact cctgggctaa tattggctga aaatgggggg ggtctcatga cgccataatc
      601 ccttgggccc tggaccggcg gctgtgagtg gcaccacagg cccccgcccc cgggccccct
      661 gcgctgggct gggcgcggtg cggctgggcg tacgcagtcg gaggcggcgc cggtcaggcc
      721 cgggcgccta tggacgcgcg gagcccgctg tctgcccggg ccagcgcgtt cagcatcgcc
      781 tctcttgttg cagccgaggc ctcggagggc accgcccacc ggggccccag gccctcggac
      841 cgggcgaaac ttcgccggct accaggatcc ccagccggga tgcacttcag cacagtcacc
      901 agggacatgg aagccttcgc agccagcagt ctgagcggcc tgggatcccc gtcgcctggc
      961 gccgacccgt tcggccctcg cgagccgccg ccaccgcgct acgatccgtg cgctgcagtc
     1021 cccggtgccc cgggcccgcc gccgccgcgc gcctatcctt tcgcgcccgc ccccggggcg
     1081 gctggcagct cggcggcgga gtccgagggt ccgggggcta gccgcgcggc tgcggtcaag
     1141 gctccggtga agaagaaccc gaaggtggcc agcgtgagcg tgcagctgga gatgaaggcg
     1201 ctgtgggacg agttcaatca gctgggcacc gagatgatcg tcaccaaggc aggcagacga
     1261 atgttcccca cgttccaagt gaagcttttt ggaatggatc ccatggccga ctacatgctg
     1321 ctcatggact ttgtgcccgt agatgacaag cgctaccggt atgctttcca tagctcctcc
     1381 tggctggtgg ccggcaaggc agatcctgct acacctggcc gagtacacta ccacccggac
     1441 tcgccggcta agggcgcaca gtggatgaaa cagattgtgt ctttcgacaa gctgaaactg
     1501 accaataacc tgctggatga caatggccat attattctca actccatgca cagatatcag
     1561 ccccgattcc atgttgtcta tgtggaccct cgaaaagaca gtgagaaata tgcagaggag
     1621 aacttcaaaa cttttgtgtt tgaggagaca cgcttcactg cagtcactgc ctaccagaat
     1681 caccggatca cgcagcttaa gattgccagc aaccccttcg ccaaaggctt ccgggattgc
     1741 gacccggagg actggccccg gaaccaccgg cccggagcgc tgccgctcgt gagtgccttt
     1801 gctcgctctc ggaatcccgt ggcttccccc acgcagccca atggctcaga caaagacgct
     1861 gcagaagccc ggcgcgagtt cgaccgtgac tccggacccg cagcgctcgg cgacgctacg
     1921 cacccgccgc agctgctggc gcgcgtgctg agccccgcac tgcccgggcc tggcggcctc
     1981 gtcccgctac ccggcggatc cggaggccgc cacagtcccc cgcacgccga tctgcgcctg
     2041 gaggcgccgg gcgcgtccga gccgctgcac caccatccct acaagtaccc ggccgccgcc
     2101 tacgaccact acctcggggc caagagccgg ccggcgccct acccgctgcc aggcctgcgc
     2161 ggccacggct accacccgca cgcgcacccg cacgcgcacc cgcaccatca ccaccacccc
     2221 gcggtgaacc cggccgccgc cgccgctgct gccgcagcag ccaacgtgta ctcgtcggcg
     2281 gccgcgccgc ccggtgccta cgactactgc cccagatagt gcgcccgcgc gccgaccccg
     2341 agggccatcc aaggacgcgc tccccatctg gggagccatg cgggtttccc gcccgccagt
     2401 gccaaagctc ccgtccaggc ggaaggaagt ggtatttatt gttctccgcg agacctcgtc
     2461 gcctccggcc cggccggcaa ttgcagtgta gacgaccgag agagccccgc ctgcgggcgg
     2521 tgtagatacg tgtagatatg tgtagatact gtagatactg caccggcgcc gatttcataa
     2581 acggttttgc ctcttttgga aattgccggt gtggctattc ttttgcatct aattcgaatg
     2641 ggccgggcgg ctttgggaca cagagactta gtcttcccag ccctggtcac tggtgtgggt
     2701 gtggagtgag ggtctcccca gctctaatcg cccctccctc cccttggggt cgctgcctcc
     2761 ctccctcagc tccctgggtc cactacaggc tgagcattcg gttttccggg gcaggcagcg
     2821 gctttcactt cagctcacca cacctgcagc tgcgggtgca ggacttgggc ctgcacgctg
     2881 acctgtttac cggactaggc ctataagttt ttccgtgaaa gccaggaatg atgttcggga
     2941 caggacactg tccatccggc ctcggatggc atgcggaaag acagaaacaa gccgcgggct
     3001 cggctcttcc agcgttgccc tggcctggca ccagcccaga atttcgtttc ccctgtttat
     3061 tgactttatt cactgaatgt ccccacagag ttattggggg tgggggcgca caatgacagt
     3121 ggtcatgagt catcttgaaa ctcccgtgtg aagcaatttt tcccaggcca ggtggccggg
     3181 tgacctgact ccccattaac tcaacaccat caaagtggcc aaaggaaccc tttgatccct
     3241 cccttcctga gccccagcag gaagggccaa ctgaaggcca gccagagtta aggctggctt
     3301 atgcctcaaa taaatgggaa atgtcaggtt cta
//
