LOCUS       NM_134011               3139 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus transforming growth factor beta regulated gene 4
            (Tbrg4), transcript variant 1, mRNA.
ACCESSION   NM_134011 XM_003689255 XM_003689256 XM_003689257 XM_003689258
            XM_003689259 XM_003689260 XM_006542940
VERSION     NM_134011.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3139)
  AUTHORS   Mayere,C., Neirijnck,Y., Sararols,P., Rands,C.M., Stevant,I.,
            Kuhne,F., Chassot,A.A., Chaboissier,M.C., Dermitzakis,E.T. and
            Nef,S.
  TITLE     Single-cell transcriptomics reveal temporal dynamics of critical
            regulators of germ cell fate during mouse sex determination
  JOURNAL   FASEB J 35 (4), e21452 (2021)
   PUBMED   33749946
REFERENCE   2  (bases 1 to 3139)
  AUTHORS   Simarro,M., Gimenez-Cassina,A., Kedersha,N., Lazaro,J.B.,
            Adelmant,G.O., Marto,J.A., Rhee,K., Tisdale,S., Danial,N.,
            Benarafa,C., Orduna,A. and Anderson,P.
  TITLE     Fast kinase domain-containing protein 3 is a mitochondrial protein
            essential for cellular respiration
  JOURNAL   Biochem Biophys Res Commun 401 (3), 440-446 (2010)
   PUBMED   20869947
REFERENCE   3  (bases 1 to 3139)
  AUTHORS   Montazer-Torbati,M.B., Hue-Beauvais,C., Droineau,S., Ballester,M.,
            Coant,N., Aujean,E., Petitbarat,M., Rijnkels,M. and Devinoy,E.
  TITLE     Epigenetic modifications and chromatin loop organization explain
            the different expression profiles of the Tbrg4, WAP and Ramp3 genes
  JOURNAL   Exp Cell Res 314 (5), 975-987 (2008)
   PUBMED   18255060
  REMARK    GeneRIF: tight regulation of WAP gene expression parallels
            variations in the chromatin structure and DNA methylation profile
            throughout the Ramp3-WAP-Tbrg4 locus.
REFERENCE   4  (bases 1 to 3139)
  AUTHORS   Chu,C.C. and Paul,W.E.
  TITLE     Expressed genes in interleukin-4 treated B cells identified by cDNA
            representational difference analysis
  JOURNAL   Mol Immunol 35 (8), 487-502 (1998)
   PUBMED   9798653
REFERENCE   5  (bases 1 to 3139)
  AUTHORS   Babalola,G.O. and Schultz,R.M.
  TITLE     Modulation of gene expression in the preimplantation mouse embryo
            by TGF-alpha and TGF-beta
  JOURNAL   Mol Reprod Dev 41 (2), 133-139 (1995)
   PUBMED   7654366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY784127.1, BC031910.1, AK144813.1 and BB727683.1.
            
            On Apr 26, 2018 this sequence version replaced NM_134011.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK144813.1, BC031155.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               BY784127.1         2-312
            312-2179            BC031910.1         282-2149
            2180-2785           AK144813.1         2179-2784
            2786-3108           BB727683.1         114-436
            3109-3139           BC031910.1         2288-2318
FEATURES             Location/Qualifiers
     source          1..3139
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 4.6 cM"
     gene            1..3139
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /note="transforming growth factor beta regulated gene 4"
                     /db_xref="GeneID:21379"
                     /db_xref="MGI:MGI:1100868"
     exon            1..103
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /inference="alignment:Splign:2.1.0"
     exon            104..168
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /inference="alignment:Splign:2.1.0"
     exon            169..636
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             232..2124
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein TBRG4; transforming growth factor beta regulator
                     4; cell cycle progression 2 protein; FAST kinase
                     domain-containing protein 4"
                     /codon_start=1
                     /product="FAST kinase domain-containing protein 4 isoform
                     1"
                     /protein_id="NP_598772.1"
                     /db_xref="CCDS:CCDS24423.1"
                     /db_xref="GeneID:21379"
                     /db_xref="MGI:MGI:1100868"
                     /translation="MAVRLMKRCTCLLREATRLVPTVAPVGRLRLAGVSCKTLTSSVS
                     SPSSGSLAELLGKEQVFTPYPEHQELDFLIEKASRPEQLLELLGSDHSLHHNHAALIL
                     IRLSYLLSEKPKEKALLAEDARFQRLVKLVDSQITCVWHGTLVKLLRSLYTLVLPQIS
                     KELQSVEQEVRWRLRRLKYKHLVFLAESCASFMKEQHSQELLAELLMHLERRWTEIND
                     SRTLVTMMTMAGHLSESLMNHLEDKCLELVEQFGPDELRKVLVTLAAQSRRSVPLLRA
                     ISYHLVQKPFPMTKGMLLDLAYAYGKLSFHQTQVSQRLAADLLPFIPSMTPGEVARCA
                     KSFAFLKWLNLPLFEAFTQHLLSRVQDVSLSHVCSVLLAFARLNFHPEQEEDQFFSMV
                     HEKLDPVLGSLEPALQVDLVWALCVLQHVHETELHTVLHPGLHARFLESKSPKDQSTF
                     QKLVHINTTALLEHPEYKGPFLPASAVAPIPSPSNKKMTPLQKELQETLKALLGNTDK
                     GSLEVATQYGWVLDAEVLLDADGHFLPLRNFVAPHLAQPVGNQPLPPGAKRIAFLRWE
                     FPNFNSRSKDLLGRFVLARRHVLAAGFLVVDVPYYEWLDLKSEWQKSAYLKDKMRKAM
                     AEELAK"
     exon            637..960
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1132
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1290
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1404
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1405..1549
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1795
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1907
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2022
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2023..3139
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2291..2296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /note="hexamer: AATAAA"
     polyA_site      2314
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /note="major polyA site"
     regulatory      3116..3121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
                     /note="hexamer: AATAAA"
     polyA_site      3139
                     /gene="Tbrg4"
                     /gene_synonym="2310042P22Rik; Cpr2; Tb-12"
ORIGIN      
        1 gtcagtgagc gcgccaggcc gcgtggaggc cgtaggctga tggaggtcag tgagggtgat
       61 cgccgccgca gtctggcgtc ctggagagac cgggtttctg aacggaacaa gactggcaga
      121 cttgccgaaa gaaacgtcat gtggttatgt agcgtgttct cgaaaaagga cttcggagtc
      181 acctactagg agtcttccct ccctccctcc ctcttccctg cgcccagcat catggccgtt
      241 cgcctgatga agcggtgtac ctgcctgctt cgagaggcta cccgcctagt tcctactgtt
      301 gccccagttg gccgactgag acttgctgga gtgtcctgca agactttgac gtcctctgtc
      361 agttccccct cctcgggctc cttggcggag ctgttgggga aagagcaggt gtttactccg
      421 tacccagagc accaagagct ggacttcctc attgagaaag cctccagacc agagcagctg
      481 ctggagctgc tgggttctga ccatagcctg caccacaatc acgcggccct catcctcatc
      541 cgcctgtcct acctgctgtc tgagaagcca aaggaaaagg ccttgcttgc agaggatgct
      601 cgctttcagc gacttgtcaa gctagttgat agtcagataa cttgtgtctg gcatgggacc
      661 ctcgtgaagc tgctgcggag cctgtacaca ctagtgctcc ctcagatctc caaggagctg
      721 cagtcagtgg agcaggaagt gcgctggcgt ctgcggaggc tcaagtacaa gcacttggtc
      781 ttcctggctg agtcctgtgc ctccttcatg aaggagcaac actcgcagga actgctggcc
      841 gagctgctaa tgcacctgga gaggcgctgg acagagatca acgacagccg tacattggtg
      901 accatgatga caatggcagg gcacctctca gagtcactca tgaaccacct ggaagacaag
      961 tgcctggagc tggtggagca gtttggccct gatgagctgc ggaaggtgct agtgacgctg
     1021 gcagcacaga gccggcggtc ggtgcccttg ctgcgggcca tctcctacca cctggtacag
     1081 aagcccttcc cgatgacaaa aggcatgctc ctggacctgg cctacgccta tgggaagctc
     1141 agtttccacc aaacccaagt gtcccagcgc ctggctgctg acctcctgcc cttcattccc
     1201 agcatgacgc ctggagaggt ggcccgctgc gccaagtcct ttgccttcct caagtggctc
     1261 aacctgcctt tgtttgaagc ctttactcag cacctcctca gcagagtgca ggatgtctcc
     1321 ctgtcccatg tgtgcagcgt tcttcttgcc tttgcccgac tgaactttca tcctgaacaa
     1381 gaagaggatc agttcttcag catggtgcat gagaagctgg accccgtgct ggggagcctg
     1441 gagccggccc tgcaggtgga cctggtgtgg gcgctgtgcg tgctgcagca cgtgcacgag
     1501 acagagctgc acacggttct ccatcctgga ctccacgctc ggtttctaga gagcaagtct
     1561 ccaaaggacc agagtacctt ccagaaattg gtccacatca acaccaccgc cctgctggag
     1621 caccctgaat ataaaggccc tttcctgcca gcctcagctg tagcccccat cccctcaccc
     1681 tctaataaaa agatgacacc cctacagaag gagctgcagg agacactgaa ggcactgctg
     1741 gggaacactg acaagggcag cctggaggtg gccacacagt atggctgggt gctggatgca
     1801 gaggtgctcc tggatgccga cggccacttc ctgcccctaa gaaacttcgt tgctccccac
     1861 cttgcccagc cagtggggaa ccagccattg cccccaggag ctaaaaggat cgctttcctg
     1921 cgctgggagt tccccaactt caacagcaga agcaaggact tgttgggccg ttttgtcctg
     1981 gcccgtcgac atgtgctggc tgcaggcttc ctggtagtag atgtcccata ttatgaatgg
     2041 ctggatctga agtctgaatg gcagaaaagc gcctacctca aggacaagat gcgaaaagca
     2101 atggctgagg agctagccaa atgaccttac ccatcagttc agactgctcc caaagacctg
     2161 actgctcagg gacccagcag tgagtgttgg gcaggccaga gttgtcatcc aacatcagag
     2221 agattaactg tgtctgtagg acgtggtcag agtagggggt gctcagcatc tccaaggaac
     2281 gggtggtcct aataaatcct ttggtttggt ggaagccagc tatcttccca ggctctgtat
     2341 ctatctcctc tctctcgtat tttgcacaca catacatatc ctcttcccta gctctccagg
     2401 attctaccga gtgggctctc tttccccagc tcccccataa tgcctgtgtg ctgtggcaca
     2461 gcagagcagg gctgacttga gagacagaaa actgagactt aaatgggtag ggtcctggac
     2521 acttgagctt cctgggaaat gtacttggag tgtatagcag agttgtgatt actatcttga
     2581 gaggtgccca caccaccccc cacccccaca cccccgcacc cccgtgccac tagagaacat
     2641 ctgaagggaa caggtgctgt gaagacattt ggaaggccct agttctggga caagagtaaa
     2701 gtccacttgg ctgatgctac aagatccatg gccagactca ttctcatgac tactacagcc
     2761 aacccaggga ccgcccttca ggtggagccc tgggtcccct gcagctctga gtagcagcag
     2821 gatgtctacc ttctaccctc tgcaggagtc tcccatagat aaggctcgcc caaaggggag
     2881 acttgcaaca aagggggtta ttaccctact tggtacattc ctcaaagcac cagtcctctg
     2941 tgtgacttag cacttctatt gtcctgacag actcttggtt accacagagg tgagggagaa
     3001 gcagaaaagc ggctggaact ggcttacagg aaggagcagc tggccacaac ttgtcttaag
     3061 ttgaggtggg ttggtagtgc tgacaaccca gttggggaag tcttgtgtat gaggaaataa
     3121 aagtttgtgc tgctcacca
//
