LOCUS       NM_025289               1583 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus transforming growth factor beta regulated gene 1
            (Tbrg1), mRNA.
ACCESSION   NM_025289 XM_134725
VERSION     NM_025289.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1583)
  AUTHORS   Pardo,M., Yu,L., Shen,S., Tate,P., Bode,D., Letney,B.L.,
            Quelle,D.E., Skarnes,W. and Choudhary,J.S.
  TITLE     Myst2/Kat7 histone acetyltransferase interaction proteomics reveals
            tumour-suppressor Niam as a novel binding partner in embryonic stem
            cells
  JOURNAL   Sci Rep 7 (1), 8157 (2017)
   PUBMED   28811661
  REMARK    GeneRIF: The data provides a useful resource for exploring Myst2
            and Niam essential cellular functions and should contribute to
            deeper understanding of organism early development and survival as
            well as cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1583)
  AUTHORS   Steinmetz,C.C., Tatavarty,V., Sugino,K., Shima,Y., Joseph,A.,
            Lin,H., Rutlin,M., Lambo,M., Hempel,C.M., Okaty,B.W., Paradis,S.,
            Nelson,S.B. and Turrigiano,G.G.
  TITLE     Upregulation of mu3A Drives Homeostatic Plasticity by Rerouting
            AMPAR into the Recycling Endosomal Pathway
  JOURNAL   Cell Rep 16 (10), 2711-2722 (2016)
   PUBMED   27568566
REFERENCE   3  (bases 1 to 1583)
  AUTHORS   Reed,S.M., Hagen,J., Muniz,V.P., Rosean,T.R., Borcherding,N.,
            Sciegienka,S., Goeken,J.A., Naumann,P.W., Zhang,W., Tompkins,V.S.,
            Janz,S., Meyerholz,D.K. and Quelle,D.E.
  TITLE     NIAM-deficient mice are predisposed to the development of
            proliferative lesions including B-cell lymphomas
  JOURNAL   PLoS One 9 (11), e112126 (2014)
   PUBMED   25393878
  REMARK    GeneRIF: NIAM down-regulation in vivo results in a significant
            predisposition to developing benign tumors or early stage cancers.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1583)
  AUTHORS   Tompkins,V.S., Hagen,J., Frazier,A.A., Lushnikova,T.,
            Fitzgerald,M.P., di Tommaso,A., Ladeveze,V., Domann,F.E.,
            Eischen,C.M. and Quelle,D.E.
  TITLE     A novel nuclear interactor of ARF and MDM2 (NIAM) that maintains
            chromosomal stability
  JOURNAL   J Biol Chem 282 (2), 1322-1333 (2007)
   PUBMED   17110379
  REMARK    GeneRIF: novel protein with tumor suppressor-like behaviors and
            functional links to ARF-MDM2-p53 signaling
REFERENCE   5  (bases 1 to 1583)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Kitamura,H., Nakagawa,T., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of FLJ
            genes: the complete nucleotide sequences of 110 mouse
            FLJ-homologous cDnas identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 11 (2), 127-135 (2004)
   PUBMED   15449545
REFERENCE   6  (bases 1 to 1583)
  AUTHORS   Powles,N., Babbs,C., Ficker,M., Schimmang,T. and Maconochie,M.
  TITLE     Identification and analysis of genes from the mouse otic vesicle
            and their association with developmental subprocesses through in
            situ hybridization
  JOURNAL   Dev Biol 268 (1), 24-38 (2004)
   PUBMED   15031102
REFERENCE   7  (bases 1 to 1583)
  AUTHORS   Babalola,G.O. and Schultz,R.M.
  TITLE     Modulation of gene expression in the preimplantation mouse embryo
            by TGF-alpha and TGF-beta
  JOURNAL   Mol Reprod Dev 41 (2), 133-139 (1995)
   PUBMED   7654366
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC160125.2, BC065795.1 and BQ174234.1.
            
            On Mar 13, 2009 this sequence version replaced NM_025289.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021331.1, AK166547.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-87                AC160125.2         101980-102066       c
            88-1560             BC065795.1         1-1473
            1561-1583           BQ174234.1         1-23                c
FEATURES             Location/Qualifiers
     source          1..1583
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 20.79 cM"
     gene            1..1583
                     /gene="Tbrg1"
                     /gene_synonym="mFLJ00213; Niam; Tb-5"
                     /note="transforming growth factor beta regulated gene 1"
                     /db_xref="GeneID:21376"
                     /db_xref="MGI:MGI:1100877"
     exon            1..315
                     /gene="Tbrg1"
                     /gene_synonym="mFLJ00213; Niam; Tb-5"
                     /inference="alignment:Splign:2.1.0"
     exon            316..386
                     /gene="Tbrg1"
                     /gene_synonym="mFLJ00213; Niam; Tb-5"
                     /inference="alignment:Splign:2.1.0"
     exon            387..607
                     /gene="Tbrg1"
                     /gene_synonym="mFLJ00213; Niam; Tb-5"
                     /inference="alignment:Splign:2.1.0"
     exon            608..744
                     /gene="Tbrg1"
                     /gene_synonym="mFLJ00213; Niam; Tb-5"
                     /inference="alignment:Splign:2.1.0"
     exon            745..891
                     /gene="Tbrg1"
                     /gene_synonym="mFLJ00213; Niam; Tb-5"
                     /inference="alignment:Splign:2.1.0"
     exon            892..989
                     /gene="Tbrg1"
                     /gene_synonym="mFLJ00213; Niam; Tb-5"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1100
                     /gene="Tbrg1"
                     /gene_synonym="mFLJ00213; Niam; Tb-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1101..1243
                     /gene="Tbrg1"
                     /gene_synonym="mFLJ00213; Niam; Tb-5"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1565
                     /gene="Tbrg1"
                     /gene_synonym="mFLJ00213; Niam; Tb-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1543..1548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbrg1"
                     /gene_synonym="mFLJ00213; Niam; Tb-5"
                     /note="hexamer: AATAAA"
     polyA_site      1560
                     /gene="Tbrg1"
                     /gene_synonym="mFLJ00213; Niam; Tb-5"
                     /note="major polyA site"
ORIGIN      
        1 ccgaaccacc gcaacttcca aacccggaag ttacacgtgg cggtgctttt gcgcaacttc
       61 cggcgggtct tccttgggaa atcgactggg aagtgccgag gatcgccatc tgtttctgcc
      121 tgcgctccat cccctccgcg ccccggagct ccagaacccg gtctgatcat gagcgtgttg
      181 agcggcctgg cctccgagcc gcgcaccccg ctgtccagca aggccaggat gaaaaggctc
      241 ccgaggaaga gccagaacga gaagtaccgg ctgaagtacc tgcggctgcg cagagcagct
      301 aaggccacgg tgtttgaaaa tgcttccatc tgtgatgaaa ttgctcgtct tgaggaaaaa
      361 tttcttaaag caaaggaaga aagaagatac ttgctgaaga agctcctcca gatacatgct
      421 ctaactgaag gggagccaca ggccgctgct ccttcccaca gctccagttt gcccctgcct
      481 tatggtgtca ccagctctgt gggaactatg cagggagccg ggcccagcac tggggccgag
      541 gaaccatttg cgaagaaatc caagaaggag aagaaagaaa agggcaagga gaacagcaaa
      601 ctggaagttc tgaagaaaac atccaagaaa aagaaaatgg agggaggtgc tcgaaaactg
      661 gttcgaccca ttgccctgga tccttcagga cagcctgtgt tccccatcgg actagggggt
      721 ctgacagtat acagtctggg ggagatcatc accaaccgac ctggcttcca tgatgagaat
      781 gccatctatc ctgtgggcta ctgcagtacc cgagtgtatg ctagcatgaa gtgcccagac
      841 cagaagtgtc tgtatacctg tcagatcaag gacggcggtg tacagcctca gtttgaaatt
      901 gttcctgaag atgaccccca gaataccatc gtcggctcct ctgcagatgc ctgttatgaa
      961 gaactgctca gggccatcag tgccacaaca gggaaactga tgcccaaccc actttcatgc
     1021 ggtgccgact tctttgggtt ttctcatcca accatccaca acctgattca gagttgtcca
     1081 gaagctcaaa actgtgtcaa ttaccagtgg gtgaaatttg atgcgtgcaa acccaggaag
     1141 gggcagctct ctcaggaact gccagagaat gatgcaacta tgagccttga agccttccag
     1201 acacagacgt ttgatgatga ccatgatgat tccattctgc caggctccct ggacctccct
     1261 gagcttcagc atgaagcctt tgtgtcatct taccagccag agttcctgac acacgaaccc
     1321 ttggttgaca ctgacctgca gcacctgaaa tctccatccc agtgtagccc aattcagtct
     1381 tcagattgaa caggaaaggg gtggagcccc ctgccttctc ctcattatga gttttaaacg
     1441 aaaactcact ctgtggaagg aggcagcatc tgagaaacag ggaagataca cgtttcattg
     1501 tgggtgttcc cagggtaaac ctcagttgct tgtactttca gtaataaata tatcctggca
     1561 gtttcaaaaa aaaaaaaaaa aaa
//
