LOCUS       NM_009322               3835 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus T-box brain transcription factor 1 (Tbr1), transcript
            variant 1, mRNA.
ACCESSION   NM_009322
VERSION     NM_009322.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3835)
  AUTHORS   Serdar,L.D., Egol,J.R., Lackford,B., Bennett,B.D., Hu,G. and
            Silver,D.L.
  TITLE     mRNA stability fine-tunes gene expression in the developing cortex
            to control neurogenesis
  JOURNAL   PLoS Biol 23 (2), e3003031 (2025)
   PUBMED   39913536
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3835)
  AUTHORS   Clemot-Dupont,S., Lourenco Fernandes,J.A., Larrigan,S., Sun,X.,
            Medisetti,S., Stanley,R., El Hankouri,Z., Joshi,S.V.,
            Picketts,D.J., Shekhar,K. and Mattar,P.
  TITLE     The chromatin remodeler ADNP regulates neurodevelopmental disorder
            risk genes and neocortical neurogenesis
  JOURNAL   Proc Natl Acad Sci U S A 122 (3), e2405981122 (2025)
   PUBMED   39808658
REFERENCE   3  (bases 1 to 3835)
  AUTHORS   Gabriel,G.C., Yagi,H., Tan,T., Bais,A., Glennon,B.J.,
            Stapleton,M.C., Huang,L., Reynolds,W.T., Shaffer,M.G.,
            Ganapathiraju,M., Simon,D., Panigrahy,A., Wu,Y.L. and Lo,C.W.
  TITLE     Mitotic block and epigenetic repression underlie neurodevelopmental
            defects and neurobehavioral deficits in congenital heart disease
  JOURNAL   Nat Commun 16 (1), 469 (2025)
   PUBMED   39774941
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3835)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3835)
  AUTHORS   Tang,I., Nisal,A., Reed,A., Ware,T.B., Johansen,A., Zaki,M.S.,
            Cravatt,B.F. and Gleeson,J.G.
  TITLE     Lipidomic profiling of mouse brain and human neuron cultures
            reveals a role for Mboat7 in mTOR-dependent neuronal migration
  JOURNAL   Sci Transl Med 17 (779), eadp5247 (2025)
   PUBMED   39742503
REFERENCE   6  (bases 1 to 3835)
  AUTHORS   Bulfone,A., Wang,F., Hevner,R., Anderson,S., Cutforth,T., Chen,S.,
            Meneses,J., Pedersen,R., Axel,R. and Rubenstein,J.L.
  TITLE     An olfactory sensory map develops in the absence of normal
            projection neurons or GABAergic interneurons
  JOURNAL   Neuron 21 (6), 1273-1282 (1998)
   PUBMED   9883721
REFERENCE   7  (bases 1 to 3835)
  AUTHORS   Wattler,S., Russ,A., Evans,M. and Nehls,M.
  TITLE     A combined analysis of genomic and primary protein structure
            defines the phylogenetic relationship of new members if the T-box
            family
  JOURNAL   Genomics 48 (1), 24-33 (1998)
   PUBMED   9503012
REFERENCE   8  (bases 1 to 3835)
  AUTHORS   Acampora,D., Avantaggiato,V., Tuorto,F. and Simeone,A.
  TITLE     Genetic control of brain morphogenesis through Otx gene dosage
            requirement
  JOURNAL   Development 124 (18), 3639-3650 (1997)
   PUBMED   9342056
REFERENCE   9  (bases 1 to 3835)
  AUTHORS   Qiu,M., Anderson,S., Chen,S., Meneses,J.J., Hevner,R., Kuwana,E.,
            Pedersen,R.A. and Rubenstein,J.L.
  TITLE     Mutation of the Emx-1 homeobox gene disrupts the corpus callosum
  JOURNAL   Dev Biol 178 (1), 174-178 (1996)
   PUBMED   8812118
REFERENCE   10 (bases 1 to 3835)
  AUTHORS   Bulfone,A., Smiga,S.M., Shimamura,K., Peterson,A., Puelles,L. and
            Rubenstein,J.L.
  TITLE     T-brain-1: a homolog of Brachyury whose expression defines
            molecularly distinct domains within the cerebral cortex
  JOURNAL   Neuron 15 (1), 63-78 (1995)
   PUBMED   7619531
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL845291.5.
            
            On Mar 18, 2023 this sequence version replaced NM_009322.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058399.1, U49251.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-805               AL845291.5         179059-179863
            806-960             AL845291.5         180438-180592
            961-1082            AL845291.5         181096-181217
            1083-1241           AL845291.5         181743-181901
            1242-1303           AL845291.5         182963-183024
            1304-3835           AL845291.5         186047-188578
FEATURES             Location/Qualifiers
     source          1..3835
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 35.56 cM"
     gene            1..3835
                     /gene="Tbr1"
                     /note="T-box brain transcription factor 1"
                     /db_xref="GeneID:21375"
                     /db_xref="MGI:MGI:107404"
     exon            1..805
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..2159
                     /gene="Tbr1"
                     /note="isoform 1 is encoded by transcript variant 1; T-box
                     brain protein 1; TBR-1; TES-56; T-brain-1; T-box brain
                     gene 1"
                     /codon_start=1
                     /product="T-box brain protein 1 isoform 1"
                     /protein_id="NP_033348.2"
                     /db_xref="CCDS:CCDS16063.1"
                     /db_xref="GeneID:21375"
                     /db_xref="MGI:MGI:107404"
                     /translation="MQLEHCLSPSIMLSKKFLNVSSSYPHSGGSELVLHDHPIISTTD
                     NLERSSPLKKITRGMTNQSDTDNFPDSKDSPGDVQRSKLSPVLDGVSELRHSFDGSAA
                     DRYLLSQSSQPQSAATAPSAMFPYPSQHGPAHPAFSIGSPSRYMAHHPVITNGAYNSL
                     LSNSSPQGYPTAGYPYPQQYGHSYQGAPFYQFSSTQPGLVPGKAQVYLCNRPLWLKFH
                     RHQTEMIITKQGRRMFPFLSFNISGLDPTAHYNIFVDVILADPNHWRFQGGKWVPCGK
                     ADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLKLTNNKGASNNNGQMVVLQSLHKYQ
                     PRLHVVEVNEDGTEDTSQPGRVQTFTFPETQFIAVTAYQNTDITQLKIDHNPFAKGFR
                     DNYDTIYTGCDMDRLTPSPNDSPRSQIVPGARYAMAGSFLQDQFVSNYAKARFHPGAG
                     AGPGPGTDRSVPHTNGLLSPQQAEDPGAPSPQRWFVTPANNRLDFAASAYDTATDFAG
                     NAATLLSYAAAGVKALPLQAAGCTGRPLGYYADPSGWGARSPPQYCGAKSGSVLPCWP
                     NSAAAAARMAGANPYLGEEAEGLAAERSPLAPAAEDAKPKDLSDSSWIETPSSIKSID
                     SSDSGIYEQAKRRRISPADTPVSESSSPLKSEVLAQRDCEKNCAKDIGGYYGFYSHS"
     exon            806..960
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1082
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1241
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1242..1303
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1304..3835
                     /gene="Tbr1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3813..3818
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbr1"
                     /note="hexamer: AATAAA"
     polyA_site      3835
                     /gene="Tbr1"
                     /note="major polyA site"
ORIGIN      
        1 atttgctggt tgaagtgctt tctgtctagt gaggggtctg tggattccta gtgtatgata
       61 aacaggactt taaaacccag ggacgggagg gccagcgttc aggttctaga gctatgcagc
      121 tggagcattg cctctctcct tctatcatgc tctccaagaa atttctcaat gtgagcagca
      181 gctacccaca ttcgggcgga tctgagcttg tcttgcatga tcatcccatt atctcgacca
      241 ctgacaacct ggagagaagt tcacctttga aaaaaattac cagggggatg acgaatcagt
      301 cagatacaga caattttcct gactccaagg actcaccagg ggacgtccag agaagtaaac
      361 tctctcctgt cttggacggg gtctctgagc ttcgtcacag tttcgatggc tctgctgcag
      421 atcgttacct actctctcag tccagccagc cacagtctgc ggccaccgct cccagtgcca
      481 tgttcccgta ccccagccag cacggaccgg cgcatcccgc cttctccatc ggcagcccca
      541 gtcgctacat ggcccaccac ccggtcatta ccaacggagc ttacaacagc ctgctgtcca
      601 actcttcgcc gcagggctac cccacggccg gctaccccta cccacagcag tacggccact
      661 cctaccaagg agcccctttc taccagttct cctccaccca gcccgggttg gtgcccggca
      721 aggcgcaagt atacctgtgc aacaggccac tttggctgaa atttcatcgg catcaaacgg
      781 agatgatcat cactaaacag ggaaggcgca tgtttccctt tttgagtttt aacatttctg
      841 gtctcgatcc caccgctcat tacaatattt ttgtggatgt gattttggcg gatcccaatc
      901 actggaggtt tcaaggaggc aaatgggttc cttgtggcaa agcggacacc aatgtgcaag
      961 gaaaccgggt ctatatgcat ccggattccc ccaacactgg ggctcactgg atgcggcaag
     1021 aaatctcttt tggaaaatta aaacttacca acaacaaggg agcatcaaac aacaatgggc
     1081 agatggtggt tttacagtcc ctgcacaagt accagccccg tctgcacgtg gtggaagtga
     1141 atgaggatgg cacagaggac accagccagc caggccgagt ccagacgttc acttttccgg
     1201 agactcagtt catcgctgtc accgcctacc agaacacgga tattacacaa ctaaaaatag
     1261 atcataaccc ctttgcaaaa ggatttcgag ataactatga cacgatctac acgggctgcg
     1321 acatggaccg cttgaccccg tcgcccaacg actctccgcg ctcgcagatc gtgcccggcg
     1381 cccgctacgc catggccggc tctttcctgc aagaccagtt cgtgagcaac tacgccaagg
     1441 cccgcttcca cccgggcgcc ggcgcgggtc ccgggccggg cacggaccgc agcgtgccgc
     1501 acaccaacgg gctgctgtcc ccgcagcagg ccgaggaccc gggcgcgccg tcgccgcagc
     1561 gctggttcgt cacgccggcc aacaaccggc tggacttcgc ggcctcggcc tacgacacgg
     1621 ccacggactt cgccggcaac gcggccacgc tgctgtcgta tgcggccgcg ggcgtgaagg
     1681 cgctgccctt gcaggccgcg ggctgcacgg gccgcccgct cggctactac gccgaccctt
     1741 cgggctgggg cgcgcgcagc cccccgcagt actgcggcgc caagtcgggc tccgtgctcc
     1801 cctgctggcc caacagcgcc gcggccgccg cgcgcatggc cggcgccaac ccctatctgg
     1861 gcgaggaggc cgagggcctg gcggccgagc gctcgccgct ggcgcccgcc gccgaggacg
     1921 ccaagcccaa ggacctgtcc gactccagct ggatcgagac gccctcctcc atcaaatcca
     1981 tcgactccag cgactcgggg atttacgagc aggccaagcg gaggcggatc tcgccggctg
     2041 acacgccggt gtctgagagc tcgtccccgc tcaagagcga ggtgctggcc cagcgggact
     2101 gcgagaagaa ctgcgccaag gacataggcg gctactatgg cttctactcg cacagctagg
     2161 ccgccagccc gctcgcccgc ccgcccgtgc ccccggcccc ccagctcggc cccacgtcct
     2221 ccttcccagg cccgttctag cgcactcgct ctttcacttg accctcgatg accgtctgcg
     2281 gggataagtg caggtctctc actatgattt taaaactctt cttttttctt tctttctttc
     2341 tctctacaca gccttctctg cagttagcgc accgaccttg aacctggctg taaaccttgt
     2401 ggttttccaa cttttcgtct gtgaggttat gatcctccct gtcttttttc cacccccttc
     2461 tccttgcccc actcatcctc tcctttctct tggaatgaaa ctcttcaact ttaggagacc
     2521 tgggcaatcc tgccaggcag cagcgattcc gacccgcctt gtcttggcct ccctatttaa
     2581 ccataggatg ttgactctag aacctgcacc cacccagcgc gtcctttctt atacccgagt
     2641 ggatggatgg atggatggat ggatggtagg gatgttaata cttttagtgg aacaaagcct
     2701 gtgaaatgat tgtatatagt gttaatttat tgtaacgaat ggctagtttt tattctcatt
     2761 gtcaaggcac aaaaccagtt cacgcttaac tttttattcc tttcctttct tctccttttc
     2821 tttttctcct ctcattcttt ctcttctccc acaccctttg ttttcttgtg agttattaaa
     2881 gatattctaa gaggctctgg aaacacgaag cacttcatag tggtggcttt ctcacttctc
     2941 agttcgttgc atgatgtaac cactgtgtgc cctggtgcac acaatgtagc taaggagaat
     3001 ccacctgaac acctgtaaaa gctagttgtc tgttcctagg cgagtcgagt aagtgacacg
     3061 atgcctgcca ggcggactta actggagttc tatgtgtttc tcccttcctt ctaaatggaa
     3121 tggccccaca tcagcaatat tattttgcct tatttgtttt tccccaaagt gccaaatcca
     3181 ttactggtct gtgcaggtgc caaatatgct gataaactgt ttctgactat cttttcagac
     3241 cccactccac ctttatatgc tgtaaatctt tgtaatgagt aatctactaa tgatatagat
     3301 gactgaattg ttggtaacta tagtgtagtc tagtgaagat gaattgtgtg agttgtatat
     3361 tttactgcat tttagtttga aaaacgattc ccccaccact tagagacagc tgaaatttga
     3421 ctttcttggg aaaacactag cattattgca agtaagactg attcccccca agtcttgtta
     3481 tatttgataa ggagcattaa tccccctgga aatagattag taggatttct aatgttgtgt
     3541 agcaaactta tacttttttt gtactttaaa atcaatgtga aatatgcatc atacacaata
     3601 ttcaatctag attccagtct atggggggat ttgtcctaat aggaattcag ggtctaaacg
     3661 tgggtatact ttggctctcc tgtaaatcaa atgttgtgat tttttatatt tgttttgttt
     3721 tgtctgtgaa ttgaataatt tatacaagta cacactccac tgagaatcgt tttgttttct
     3781 gctcgtttgt atcgtctgtg tataacaagt aaaataaatc tggtaaaatg ctaaa
//
