LOCUS       NM_013684               1842 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Mus musculus TATA box binding protein (Tbp), mRNA.
ACCESSION   NM_013684
VERSION     NM_013684.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1842)
  AUTHORS   Hisler,V., Bardot,P., Detilleux,D., Bernardini,A., Stierle,M.,
            Sanchez,E.G., Richard,C., Arab,L.H., Ehrhard,C., Morlet,B.,
            Hadzhiev,Y., Jung,M., Le Gras,S., Negroni,L., Muller,F., Tora,L.
            and Vincent,S.D.
  TITLE     RNA polymerase II transcription initiation in holo-TFIID-depleted
            mouse embryonic stem cells
  JOURNAL   Cell Rep 43 (10), 114791 (2024)
   PUBMED   39352809
  REMARK    GeneRIF: RNA polymerase II transcription initiation in
            holo-TFIID-depleted mouse embryonic stem cells.
REFERENCE   2  (bases 1 to 1842)
  AUTHORS   Kwan,J.Z.J., Nguyen,T.F., Uzozie,A.C., Budzynski,M.A., Cui,J.,
            Lee,J.M.C., Van Petegem,F., Lange,P.F. and Teves,S.S.
  TITLE     RNA Polymerase II transcription independent of TBP in murine
            embryonic stem cells
  JOURNAL   Elife 12, e83810 (2023)
   PUBMED   36995326
  REMARK    GeneRIF: RNA Polymerase II transcription independent of TBP in
            murine embryonic stem cells.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1842)
  AUTHORS   Fulton,S.L., Wenderski,W., Lepack,A.E., Eagle,A.L., Fanutza,T.,
            Bastle,R.M., Ramakrishnan,A., Hays,E.C., Neal,A., Bendl,J.,
            Farrelly,L.A., Al-Kachak,A., Lyu,Y., Cetin,B., Chan,J.C.,
            Tran,T.N., Neve,R.L., Roper,R.J., Brennand,K.J., Roussos,P.,
            Schimenti,J.C., Friedman,A.K., Shen,L., Blitzer,R.D., Robison,A.J.,
            Crabtree,G.R. and Maze,I.
  TITLE     Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn
            mouse model of Down syndrome
  JOURNAL   Nat Commun 13 (1), 6384 (2022)
   PUBMED   36289231
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1842)
  AUTHORS   El-Saafin,F., Bergamasco,M.I., Chen,Y., May,R.E., Esakky,P.,
            Hediyeh-Zadeh,S., Dixon,M., Wilcox,S., Davis,M.J., Strasser,A.,
            Smyth,G.K., Thomas,T. and Voss,A.K.
  TITLE     Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic
            neuronal cell death
  JOURNAL   Cell Death Differ 29 (5), 1013-1027 (2022)
   PUBMED   35361962
REFERENCE   5  (bases 1 to 1842)
  AUTHORS   Khang,R., Jo,A., Kang,H., Kim,H., Kwag,E., Lee,J.Y., Koo,O.,
            Park,J., Kim,H.K., Jo,D.G., Hwang,I., Ahn,J.Y., Lee,Y., Choi,J.Y.,
            Lee,Y.S. and Shin,J.H.
  TITLE     Loss of zinc-finger protein 212 leads to Purkinje cell death and
            locomotive abnormalities with phospholipase D3 downregulation
  JOURNAL   Sci Rep 11 (1), 22745 (2021)
   PUBMED   34815492
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1842)
  AUTHORS   Le Douarin,B., Zechel,C., Garnier,J.M., Lutz,Y., Tora,L.,
            Pierrat,P., Heery,D., Gronemeyer,H., Chambon,P. and Losson,R.
  TITLE     The N-terminal part of TIF1, a putative mediator of the
            ligand-dependent activation function (AF-2) of nuclear receptors,
            is fused to B-raf in the oncogenic protein T18
  JOURNAL   EMBO J 14 (9), 2020-2033 (1995)
   PUBMED   7744009
REFERENCE   7  (bases 1 to 1842)
  AUTHORS   Trachtulec,Z., Vincek,V., Hamvas,R.M., Forejt,J., Lehrach,H. and
            Klein,J.
  TITLE     Physical map of mouse chromosome 17 in the region relevant for
            positional cloning of the Hybrid sterility 1 gene
  JOURNAL   Genomics 23 (1), 132-137 (1994)
   PUBMED   7829061
REFERENCE   8  (bases 1 to 1842)
  AUTHORS   Danciger,M., Kozak,C.A., Suzuki,S., Chang,M.R., Shinohara,T. and
            Farber,D.B.
  TITLE     Transcription factor IID probes localize a single gene to the
            proximal region of mouse chromosome 17
  JOURNAL   Gene 130 (2), 283-286 (1993)
   PUBMED   8359696
REFERENCE   9  (bases 1 to 1842)
  AUTHORS   Sumita,K., Makino,Y., Katoh,K., Kishimoto,T., Muramatsu,M.,
            Mikoshiba,K. and Tamura,T.
  TITLE     Structure of a mammalian TBP (TATA-binding protein) gene: isolation
            of the mouse TBP genome
  JOURNAL   Nucleic Acids Res 21 (11), 2769 (1993)
   PUBMED   8332475
REFERENCE   10 (bases 1 to 1842)
  AUTHORS   Tamura,T., Sumita,K., Fujino,I., Aoyama,A., Horikoshi,M.,
            Hoffmann,A., Roeder,R.G., Muramatsu,M. and Mikoshiba,K.
  TITLE     Striking homology of the 'variable' N-terminal as well as the
            'conserved core' domains of the mouse and human TATA-factors
            (TFIID)
  JOURNAL   Nucleic Acids Res 19 (14), 3861-3865 (1991)
   PUBMED   1861978
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK085037.1 and AC154378.2.
            
            On Apr 4, 2008 this sequence version replaced NM_013684.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK085037.1, BC050136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-736               AK085037.1         2-737
            737-763             AC154378.2         187358-187384
            764-1349            AK085037.1         765-1350
            1350-1824           AK085037.1         1352-1826
            1825-1842           AC154378.2         197364-197381
FEATURES             Location/Qualifiers
     source          1..1842
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.95 cM"
     gene            1..1842
                     /gene="Tbp"
                     /gene_synonym="Gtf2d; GTF2D1; SCA17; TFIID"
                     /note="TATA box binding protein"
                     /db_xref="GeneID:21374"
                     /db_xref="MGI:MGI:101838"
     exon            1..137
                     /gene="Tbp"
                     /gene_synonym="Gtf2d; GTF2D1; SCA17; TFIID"
                     /inference="alignment:Splign:2.1.0"
     exon            138..301
                     /gene="Tbp"
                     /gene_synonym="Gtf2d; GTF2D1; SCA17; TFIID"
                     /inference="alignment:Splign:2.1.0"
     CDS             248..1198
                     /gene="Tbp"
                     /gene_synonym="Gtf2d; GTF2D1; SCA17; TFIID"
                     /note="TFIID core protein; TATA-binding protein; TATA-box
                     factor; TATA-binding factor; TATA sequence-binding
                     protein; transcription initiation factor TFIID TBP
                     subunit"
                     /codon_start=1
                     /product="TATA-box-binding protein"
                     /protein_id="NP_038712.3"
                     /db_xref="CCDS:CCDS37454.2"
                     /db_xref="GeneID:21374"
                     /db_xref="MGI:MGI:101838"
                     /translation="MDQNNSLPPYAQGLASPQGAMTPGIPIFSPMMPYGTGLTPQPIQ
                     NTNSLSILEEQQRQQQQQQQQQQQQQAVATAAASVQQSTSQQPTQGASGQTPQLFHSQ
                     TLTTAPLPGTTPLYPSPMTPMTPITPATPASESSGIVPQLQNIVSTVNLGCKLDLKTI
                     ALRARNAEYNPKRFAAVIMRIREPRTTALIFSSGKMVCTGAKSEEQSRLAARKYARVV
                     QKLGFPAKFLDFKIQNMVGSCDVKFPIRLEGLVLTHQQFSSYEPELFPGLIYRMIKPR
                     IVLLIFVSGKVVLTGAKVRAEIYEAFENIYPILKGFRKTT"
     exon            302..675
                     /gene="Tbp"
                     /gene_synonym="Gtf2d; GTF2D1; SCA17; TFIID"
                     /inference="alignment:Splign:2.1.0"
     exon            676..763
                     /gene="Tbp"
                     /gene_synonym="Gtf2d; GTF2D1; SCA17; TFIID"
                     /inference="alignment:Splign:2.1.0"
     exon            764..855
                     /gene="Tbp"
                     /gene_synonym="Gtf2d; GTF2D1; SCA17; TFIID"
                     /inference="alignment:Splign:2.1.0"
     exon            856..1023
                     /gene="Tbp"
                     /gene_synonym="Gtf2d; GTF2D1; SCA17; TFIID"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..1118
                     /gene="Tbp"
                     /gene_synonym="Gtf2d; GTF2D1; SCA17; TFIID"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1842
                     /gene="Tbp"
                     /gene_synonym="Gtf2d; GTF2D1; SCA17; TFIID"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1807..1812
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbp"
                     /gene_synonym="Gtf2d; GTF2D1; SCA17; TFIID"
                     /note="hexamer: AAGAAA"
     polyA_site      1828
                     /gene="Tbp"
                     /gene_synonym="Gtf2d; GTF2D1; SCA17; TFIID"
                     /note="major polyA site"
ORIGIN      
        1 aagagcgcaa ctggcggaag tgacggcatc agatgtgcgt caggcgttcg gtggatcgag
       61 tccggtagcg gtggcgggta tctgctggcg gtttggctag gtttctgcgg tcgcgtcatt
      121 ttctccgcag tgcccagcat cactatttca tggtgtgtga agataaccca gaacattgaa
      181 gacgtttcta aggagatatt cagaggatgc tctagggaag atctgagtac tgaagaaagg
      241 gagaatcatg gaccagaaca acagccttcc accttatgct cagggcttgg cctccccaca
      301 gggcgccatg actcctggaa ttcccatctt tagtccaatg atgccttacg gcacaggact
      361 tactccacag cctattcaga acaccaacag tctctctatt ttggaagagc aacaaagaca
      421 gcagcagcaa cagcaacagc agcagcaaca acagcaggca gtagcaactg cagcagcctc
      481 agtacagcaa tcaacatctc agcaacccac acagggtgcc tcaggccaga ccccacaact
      541 cttccattct caaactctga ccactgcacc gttgccaggc accaccccct tgtacccttc
      601 accaatgact cctatgaccc ctatcactcc tgccacacca gcttctgaga gctctggaat
      661 tgtaccgcag cttcaaaata ttgtatctac cgtgaatctt ggctgtaaac ttgacctaaa
      721 gaccattgca cttcgtgcaa gaaatgctga atataatccc aagcgatttg ctgcagtcat
      781 catgagaata agagagccac ggacaactgc gttgattttc agttctggaa aaatggtgtg
      841 cacaggagcc aagagtgaag aacaatccag actagcagca agaaaatatg ctagagttgt
      901 gcagaagttg ggcttcccag ctaagttctt agacttcaag atccagaaca tggtggggag
      961 ctgtgatgtg aagttcccta taaggctgga aggccttgtg ctgacccacc agcagttcag
     1021 tagctatgag ccagaattat ttcctggatt aatctacaga atgatcaaac ccagaattgt
     1081 tctccttatt tttgtttctg gaaaagttgt attaacaggt gctaaagtta gagcagagat
     1141 ttatgaagca tttgaaaaca tctaccccat cttaaaggga ttcaggaaga ccacatagtt
     1201 gtctgccatg ttctcctgcc ttccctatcc acgtgttttt taaaaccagt cagttttggt
     1261 accactgatg gtacagttgg tgaggacact cagttacagg tggcagcatg aagtgacact
     1321 gtgtgtccta ctgcaggata ctagaaaggt tccccctctg cactgaaatc accctgcagc
     1381 actactgtga gttgcttgct ctgtgctgct acttgggcgg cactgcccat ttatttatat
     1441 ttagatttta aacactgctg ttggtgattg ttggtttaag ggacagaact ttaagtgttc
     1501 aagccacctg tacaattgga cttttcattt taatctttcc cacacaagcc agtttttata
     1561 tttctaccag aaaagtaaaa atctttttta aaagtgttgt ttttctagtt tgtaactctt
     1621 aggagttatt tttgtgccag atacattccg ccttcccagt attgcaggac tgaatagttg
     1681 tattaatcaa aacaatggct gtacatactt ttctttcttc agagtactct gcacaaaaac
     1741 gcagcttgta aattgttaga tttttgttat aaatgatacc ttgtaagtca tgtgatcata
     1801 ctgtcaaaga aatttatttt agatataatg cctgagacca tt
//
