LOCUS       NP_038791                442 aa            linear   ROD 05-JUN-2024
DEFINITION  transducin beta-like protein 2 isoform 1 [Mus musculus].
ACCESSION   NP_038791
VERSION     NP_038791.2
DBSOURCE    REFSEQ: accession NM_013763.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 442)
  AUTHORS   DeSilva,U., Elnitski,L., Idol,J.R., Doyle,J.L., Gan,W.,
            Thomas,J.W., Schwartz,S., Dietrich,N.L., Beckstrom-Sternberg,S.M.,
            McDowell,J.C., Blakesley,R.W., Bouffard,G.G., Thomas,P.J.,
            Touchman,J.W., Miller,W. and Green,E.D.
  TITLE     Generation and comparative analysis of approximately 3.3 Mb of
            mouse genomic sequence orthologous to the region of human
            chromosome 7q11.23 implicated in Williams syndrome
  JOURNAL   Genome Res 12 (1), 3-15 (2002)
   PUBMED   11779826
REFERENCE   2  (residues 1 to 442)
  AUTHORS   Valero,M.C., de Luis,O., Cruces,J. and Perez Jurado,L.A.
  TITLE     Fine-scale comparative mapping of the human 7q11.23 region and the
            orthologous region on mouse chromosome 5G: the low-copy repeats
            that flank the Williams-Beuren syndrome deletion arose at
            breakpoint sites of an evolutionary inversion(s)
  JOURNAL   Genomics 69 (1), 1-13 (2000)
   PUBMED   11013070
REFERENCE   3  (residues 1 to 442)
  AUTHORS   de Luis,O., Valero,M.C. and Jurado,L.A.
  TITLE     WBSCR14, a putative transcription factor gene deleted in
            Williams-Beuren syndrome: complete characterisation of the human
            gene and the mouse ortholog
  JOURNAL   Eur J Hum Genet 8 (3), 215-222 (2000)
   PUBMED   10780788
REFERENCE   4  (residues 1 to 442)
  AUTHORS   Perez Jurado,L.A., Wang,Y.K., Francke,U. and Cruces,J.
  TITLE     TBL2, a novel transducin family member in the WBS deletion:
            characterization of the complete sequence, genomic structure,
            transcriptional variants and the mouse ortholog
  JOURNAL   Cytogenet Cell Genet 86 (3-4), 277-284 (1999)
   PUBMED   10575226
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK132366.1, BC048185.1, AK047090.1, AC024607.3 and BE947541.1.
            
            On Jun 9, 2003 this sequence version replaced NP_038791.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132366.1, BC048185.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..442
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 75.02 cM"
     Protein         1..442
                     /product="transducin beta-like protein 2 isoform 1"
                     /note="transducin beta-like protein 2"
                     /calculated_mol_wt=49453
     Region          36..71
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R099.2)"
     Region          <74..393
                     /region_name="WD40"
                     /note="WD40 repeat [General function prediction only];
                     COG2319"
                     /db_xref="CDD:441893"
     Region          84..123
                     /region_name="WD 1"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R099.2)"
     Region          89..132
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          130..170
                     /region_name="WD 2"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R099.2)"
     Region          182..222
                     /region_name="WD 3"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R099.2)"
     Region          187..222
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          224..263
                     /region_name="WD 4"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R099.2)"
     Region          228..267
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          273..312
                     /region_name="WD 5"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R099.2)"
     Region          278..323
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Region          323..362
                     /region_name="WD 6"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R099.2)"
     Region          366..404
                     /region_name="WD 7"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9R099.2)"
     Region          371..406
                     /region_name="WD40 repeat"
                     /note="WD40 repeat [structural motif]"
                     /db_xref="CDD:293791"
     Site            428
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9Y4P3; propagated from
                     UniProtKB/Swiss-Prot (Q9R099.2)"
     CDS             1..442
                     /gene="Tbl2"
                     /gene_synonym="WS-bTRP"
                     /coded_by="NM_013763.3:53..1381"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS19735.1"
                     /db_xref="GeneID:27368"
                     /db_xref="MGI:MGI:1351652"
ORIGIN      
        1 melpqmpelm glsllvglla lvataavarg wlraeekpsq pvcqkenepk ksgskkqkqn
       61 qrvrkekpqq hsfthpllaa alkshsgnis cmdfssngky latcaddrtv riwstkdflq
      121 rehrsmranv eldhatlvrf spdcrafivw langdtlrvf kmtkredggf tftatpedfp
      181 kkhkapiini giadtgkfim tassdttvli wnlkgqvlst intnqmnnsh avispcsrfv
      241 gscgftpdvk vwevcfgkkg efqevlrafe lkghsasvhs fafsndsrrm asvskdgtwk
      301 lwdtdveykk qqdpyllrtg rfeeastmpc rlalspdthv lalatgtnih lfntrrgeke
      361 eyfecvhgec iadltfditg rflascgdra vrlfhntpgh ravveemqsl lkrassestr
      421 qrlqqqltqa qealkslgal kk
//
