LOCUS       NM_030732               8127 bp    mRNA    linear   ROD 03-SEP-2024
DEFINITION  Mus musculus transducin (beta)-like 1X-linked receptor 1 (Tbl1xr1),
            mRNA.
ACCESSION   NM_030732 NM_175304 XM_977656 XM_977696 XM_977734
VERSION     NM_030732.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8127)
  AUTHORS   Hu,Y., Lauffer,P., Jongejan,A., Falize,K., Bruinstroop,E., van
            Trotsenburg,P., Fliers,E., Hennekam,R.C. and Boelen,A.
  TITLE     Analysis of genes differentially expressed in the cortex of mice
            with the Tbl1xr1Y446C/Y446C variant
  JOURNAL   Gene 927, 148707 (2024)
   PUBMED   38885822
  REMARK    GeneRIF: Analysis of genes differentially expressed in the cortex
            of mice with the Tbl1xr1[Y446C/Y446C] variant.
REFERENCE   2  (bases 1 to 8127)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 8127)
  AUTHORS   Hu,Y., Falize,K., van Trotsenburg,A.S.P., Hennekam,R., Fliers,E.,
            Bruinstroop,E. and Boelen,A.
  TITLE     The role of transducin beta-like 1 X-linked receptor 1 (TBL1XR1) in
            thyroid hormone metabolism and action in mice
  JOURNAL   Eur Thyroid J 12 (5), e230077 (2023)
   PUBMED   37458724
  REMARK    GeneRIF: The role of transducin beta-like 1 X-linked receptor 1
            (TBL1XR1) in thyroid hormone metabolism and action in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8127)
  AUTHORS   Hu,Y., Lauffer,P., Stewart,M., Codner,G., Mayerl,S., Heuer,H.,
            Ng,L., Forrest,D., van Trotsenburg,P., Jongejan,A., Fliers,E.,
            Hennekam,R. and Boelen,A.
  TITLE     An animal model for Pierpont syndrome: a mouse bearing the
            Tbl1xr1Y446C/Y446C mutation
  JOURNAL   Hum Mol Genet 31 (17), 2951-2963 (2022)
   PUBMED   35416977
REFERENCE   5  (bases 1 to 8127)
  AUTHORS   Mastrototaro,G., Zaghi,M., Massimino,L., Moneta,M., Mohammadi,N.,
            Banfi,F., Bellini,E., Indrigo,M., Fagnocchi,G., Bagliani,A.,
            Taverna,S., Rohm,M., Herzig,S. and Sessa,A.
  TITLE     TBL1XR1 Ensures Balanced Neural Development Through NCOR
            Complex-Mediated Regulation of the MAPK Pathway
  JOURNAL   Front Cell Dev Biol 9, 641410 (2021)
   PUBMED   33708771
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8127)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   7  (bases 1 to 8127)
  AUTHORS   Pascual,G., Fong,A.L., Ogawa,S., Gamliel,A., Li,A.C., Perissi,V.,
            Rose,D.W., Willson,T.M., Rosenfeld,M.G. and Glass,C.K.
  TITLE     A SUMOylation-dependent pathway mediates transrepression of
            inflammatory response genes by PPAR-gamma
  JOURNAL   Nature 437 (7059), 759-763 (2005)
   PUBMED   16127449
REFERENCE   8  (bases 1 to 8127)
  AUTHORS   Ishizuka,T. and Lazar,M.A.
  TITLE     The nuclear receptor corepressor deacetylase activating domain is
            essential for repression by thyroid hormone receptor
  JOURNAL   Mol Endocrinol 19 (6), 1443-1451 (2005)
   PUBMED   15695367
REFERENCE   9  (bases 1 to 8127)
  AUTHORS   Perissi,V., Aggarwal,A., Glass,C.K., Rose,D.W. and Rosenfeld,M.G.
  TITLE     A corepressor/coactivator exchange complex required for
            transcriptional activation by nuclear receptors and other regulated
            transcription factors
  JOURNAL   Cell 116 (4), 511-526 (2004)
   PUBMED   14980219
  REMARK    GeneRIF: TBLR1 and TBL1 have roles in specific nuclear
            receptor-mediated gene activation events
REFERENCE   10 (bases 1 to 8127)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC126599.10, AK033347.1 and AC121108.12.
            
            On Mar 14, 2007 this sequence version replaced NM_030732.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            CDS exon combination :: AK136255.1, AK033347.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMN00849374, SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-303               AC126599.10        139865-140167
            304-2444            AK033347.1         174-2314
            2445-8127           AC121108.12        57408-63090         c
FEATURES             Location/Qualifiers
     source          1..8127
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 7.58 cM"
     gene            1..8127
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /note="transducin (beta)-like 1X-linked receptor 1"
                     /db_xref="GeneID:81004"
                     /db_xref="MGI:MGI:2441730"
     exon            1..303
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            304..370
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            371..473
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             416..1960
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /note="nuclear receptor corepressor/HDAC3 complex subunit
                     TBLR1; F-box-like/WD repeat protein TBL1XR1; TBL1-related
                     protein 1; transducin beta-like 1X-related protein 1"
                     /codon_start=1
                     /product="F-box-like/WD repeat-containing protein TBL1XR1"
                     /protein_id="NP_109657.2"
                     /db_xref="CCDS:CCDS17266.1"
                     /db_xref="GeneID:81004"
                     /db_xref="MGI:MGI:2441730"
                     /translation="MSISSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGALV
                     PPAALISIIQKGLQYVEAEVSINEDGTLFDGRPIESLSLIDAVMPDVVQTRQQAYRDK
                     LAQQHAAAAAAAAAATNQQGSAKNGENTANGEENGAHTIANNHTDMMEVDGDVEIPSN
                     KAVVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGPTQLVLRHCIREG
                     GQDVPSNKDVTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNK
                     KGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVC
                     KLGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNK
                     EIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAF
                     SPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCWNAAGDKVGASASDGSVC
                     VLDLRK"
     exon            474..619
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            620..842
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            843..975
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1117
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1181
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1279
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1340
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1462
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1537
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1665
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1831
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1933
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..8127
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6805..6810
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /note="hexamer: AATAAA"
     polyA_site      6826
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /note="major polyA site"
     regulatory      8052..8057
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /note="hexamer: ATTAAA"
     polyA_site      8078
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
     regulatory      8100..8105
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
                     /note="hexamer: ATTAAA"
     polyA_site      8127
                     /gene="Tbl1xr1"
                     /gene_synonym="8030499H02Rik; A630076E03Rik; C21;
                     C230089I12Rik; DC42; Ira1; TBLR1"
ORIGIN      
        1 gcaggccgct cgggtttgtt ttgctgcgcg gccgtcgccg ccgcgggccc ggagctcatt
       61 tgtgcctggc tggtccccgc gctccccggt gccgagccgg agccgttggc cgctcgcgcg
      121 cttggctctc tcccttagta acagctcccc tcctgcctcg gtgctgcgcc ctgcccccgc
      181 gcccctcccc cgccggaccc gctgcccggc tgtcagcgcc cgcaccccag ggcgcctcgg
      241 ggtgccgacg gcggccagga ggggagcgcc gcgcgtcctg gaggggacag cgtcgccaag
      301 cagcttcagt aacttgtgat tggtggttgg ctatccagtt gttcatcctc acatcaatgc
      361 actgccaatg ggttatgtcc tgtgttgtga cctcatggtt taagtgggaa taaagatgag
      421 tataagcagt gatgaggtca acttcttggt atataggtac ttgcaagagt caggattttc
      481 tcattctgcg tttacctttg gtatagagag ccatataagt cagtccaaca taaatggtgc
      541 cctggttcca cccgctgcac tcatctctat catccagaaa ggcctgcagt atgtagaggc
      601 agaagttagc ataaatgagg atggcacctt atttgatggt cgacccatcg agtctctgtc
      661 cctgatagat gctgttatgc ccgatgtagt ccaaacaaga caacaagcct acagagacaa
      721 gcttgcacag cagcatgcag ccgcagccgc tgccgctgct gccgccacta accagcaagg
      781 atctgcaaaa aatggagaga atacagcaaa tggggaggag aatggagcac ataccatcgc
      841 aaataatcac actgacatga tggaagtaga tggggatgtg gaaatccctt ccaataaagc
      901 ggttgtgctt cggggccatg aatctgaagt tttcatctgt gcctggaacc ctgttagtga
      961 tctcctggca tcagggtctg gagactccac ggcaagaatc tggaacctca gtgagaacag
     1021 cacgagtggc cctacgcagc tcgtgcttag acactgcata cgggaaggag ggcaggacgt
     1081 gcccagtaac aaggatgtca cgtctctaga ttggaatagt gaaggtacac ttctagcaac
     1141 tgggtcatat gatggatttg ccagaatatg gactaaagat ggtaatcttg ccagcacctt
     1201 ggggcagcat aaaggtccta tatttgcatt aaaatggaat aagaaaggaa atttcatcct
     1261 aagtgctggc gtagataaga ccaccatcat ttgggatgcg catactggtg aagccaagca
     1321 gcagtttcct ttccattcag ccccagcatt ggatgttgac tggcagagca acaacacctt
     1381 tgcatcttgt agtacagata tgtgcattca cgtctgcaaa ttaggacaag acagacctat
     1441 caaaacattc cagggacaca cgaatgaagt aaatgctatc aaatgggacc caactggcaa
     1501 tctcctagcc tcctgttcag atgacatgac attgaagatc tggagtatga agcaagataa
     1561 ctgtgtccat gatttgcaag cacataataa agaaatttat actattaagt ggagtccaac
     1621 aggaccaggg acaaataatc caaatgccaa ccttatgcta gcaagtgcat cctttgattc
     1681 tacagttagg ttatgggacg tagacagagg gatttgcatc catactttga caaaacatca
     1741 agagcccgtg tacagtgtgg cttttagtcc tgatggcagg tatctggcaa gtggttcttt
     1801 tgacaagtgt gtgcacatct ggaacacaca gacaggtgct ctagttcaca gttacagggg
     1861 aacaggtgga atttttgaag tttgctggaa cgcagcagga gacaaagttg gagccagtgc
     1921 ttcggacggt tcagtttgtg tcttagacct tcggaaatag cgttactagt tggaagccat
     1981 ggaccgacta tgaatgtgta catagccaca agactatccc tgacccatat actgctatag
     2041 tcccacttga accatggcca gtccactaca gccaaatcta agagaaatat atacatgcag
     2101 tatatatgaa cacagctgta ccctgaagat gacagtctca tcccagcttg tgaattctgc
     2161 tcaccaagtg ctgggatcta acctgctgtg cccctaagta gcgtttagaa gtttggatat
     2221 gaaaaccaga agagaaggaa tatgcgttat aagagcaaac cacacatgtc ccagttttga
     2281 atattaatga cagccttgtt tccccctttg aatcagcaga cacatggatt atattctttt
     2341 tcccctcagt agtgcgcagt ttgtatgtac agagaacatg gacttaacaa aagcttgcgg
     2401 cagtagttgg ttcttgcttc caagtttgtt ttggtttaga ttatggatgc atgaagtaag
     2461 ggagtgaatc attatcttgc ttttttttct caccttttaa acaacaaaaa aattcttaaa
     2521 aatattttac tgcattcttt ggaagaggta gatgtttggt acatctgatg gctcccagag
     2581 catataactc aataggtgca tattatggag ggaattggaa taataggaaa ctacatgact
     2641 tccgtcatgt cactctctaa gacacatcag caaagggtgt tatgttatct ttgttttggg
     2701 tttctgggtt ttttgtttta gttctttgtg tgtgtgtgtg tgtgtgtgag agagagagag
     2761 aggggtgggg aggagagaga gcgcttaaaa tagtttcttt ttggggacat atttctgcca
     2821 attaaagact agaagggcac aacttttttt tttttttaat accataaaga agagtttggt
     2881 tttttttttt ctaaataata atcttctgat gttttgtagc cataactaaa ttatggttaa
     2941 aaatgtgcac tattgtgaga aggagcaaca tagtttgggg cttttatttt attattttta
     3001 ttttttattt taccatttgt ctgttttact ttgtttctta agagattaaa atatttctgg
     3061 ataaggatta gcttctcaaa gtgtccatca ttctgtatag aagcttaaat atgtaatgta
     3121 accagattcc agtattaaaa aatctctcat gttagttttc tttttacaaa gcaaggttac
     3181 agcagcatat aacactgcca ttacatggct aaatgtttgc taccttagtt ttgaaaacag
     3241 tttttaaagg cttgctttga gctatgtttg ggtagcagtg atggggaaat taggagaggt
     3301 gtggctggag ctatccctct gcctgcatat acggcgccaa agctgcactt aagcattgta
     3361 gatctaagct gctgttttgt ttccactata atcactacta tatcatgttt tttactcttg
     3421 tttatatcaa gtattttttt tttaaagata taggtatcca atcagattct ttttttttgg
     3481 tttttttttg agacagggtt tctctgtata gttctggcta tcctggaact cactttgtag
     3541 accaggctgt cctcgaactc agaaatccgc ctgcctctgc ctcccgaggg ctgggattaa
     3601 aggtgtgcgc caccacggcc ggcttcaatc agactcttta tgttcagcta aaagtaaaat
     3661 atacctacaa aggttcacca gaggctgtgt ttgtgaaggt ggttgacagg atagtcgata
     3721 ttaatggaag aacccaggag tgtaggttct gaagagaaag aacagttgtc aaatttatat
     3781 ctttaaattt ttaattaaga aattgcttag caaatttata acactatgtg tgtcagtagt
     3841 tattttgagg cctttggctc ctgaatccca ccctgtgttc tacgaaactg ctctaaccca
     3901 gccccgcagc tttgctgctc tgtttttgct gccttgttct ttacaaagca gcgttgattg
     3961 acgccagtct tggcttcatt aaggtagggt ggcatttgct tttggtaaag aggatggata
     4021 cacttacatt ttaccataca tcgttatatc taccccattt tgttagtggg gtctatgata
     4081 ctgtaatatt aagagttgca tccagagagg cagtcgtcta tggtttgtgc caggtgtttt
     4141 cagggttcta tcacattgag acatttagaa cccattgctc tgtggctctg taggaattct
     4201 aaaatgctga gtgtctgcca cttgagattt tgcttttact gcaagagggt cacatctgtt
     4261 ggcctctgtt gttgtttaaa aaaataataa taaaaataaa aaaactgtgc aataattttt
     4321 aaacgtgctc ccaagaatag acacaaactt tttgagtatg cctaagctgc atttccttca
     4381 gcgatgcatt tgtcaattgc actgaatctg aacctgaaag tcagaggtga ttgttgatag
     4441 tgcttttgta ttttgatatg gacattttat tcatttgcat acagtcattg acgttcttcc
     4501 cagctgattc aaagacagtc acaaattcct gaaacacagc tgccaaaatg acagctgaat
     4561 tttctgataa tgtcttgctt tctgttgggt gtgtgtttat tggtttgttt tgttttgttt
     4621 tatttttttt tttcctattt ctttggctat tttacttcag cacactagct gtgatagatt
     4681 gtctgataga agagaagtgc agagctttgc tgtcccaaag cctcgggtct ttccctcgca
     4741 gatgtggctg aagacatcta cctttaggct ggttctctgt gagcgtagga ctgtgtgctt
     4801 tgctgctgct ctcactgtcc ctgtagcctg ctgacgtgcc atgatgctgc tccacagaca
     4861 ccacaccatg tcttcatcca agcagtcaga tgatcaccag agaccacact tgagtgtgtc
     4921 aagtgctgtc atggggctct ctactttcct tcttgtcttt ttctgagaat tggctctgaa
     4981 aatccagagt ccagtagtct ttctatggtg ttcatttaga tcattgttgt atatgttact
     5041 gtaaggcaga gaataggagg cttaaatgaa tatcattgat taaagtagac tggagggagc
     5101 agctgccacc cttgaaaggc atgaaggaac ctgtgtactc caggcaggag acccttgggg
     5161 acttagattt atccctattt tccatgatca ggtaacatca ttgagttttc aaatgattta
     5221 ggcgtggtta ctggagtagg tcttagagtg taacagattg ttttcctgag ttatcctcta
     5281 ggtgagtatg ttttaggact aaacaccttt tgcagatact gaaagtgcct ccttttgtgg
     5341 tatacaaaac aaattatggt gcaaaacgta atcaatagat tgaatcacat gaagggtttt
     5401 ttgctttttg acataaaaat gtcaagagac aggccaaaga tttgtacttt tcacttataa
     5461 agcactcctt tttttcctta agattctttc tgtcgatcag atttaatgaa agagtactat
     5521 ttttaaggag ctatctgttt atgtagaatg atttcgttaa aagagtaatg taaactatga
     5581 atgaggagca gaggccggct gaggactggg ccttttgcta tttaaagaaa tcacggatga
     5641 ccaggcttct gcaagcacac ctgacaagtt ttactaaatg cataggaaaa ccatctcaga
     5701 cagtgctgtc ttgctctttt aaagaccatt tacgtttttg taagtgcttt gcacatttcc
     5761 acagaagctg gattctcagg agcttagagc ggtacttgca cagttgctgc agaaatcctg
     5821 cctccgtgga ccaacatcat ggcacagcag cagaagccag catatggggg ctagcagcca
     5881 gcctacagag acccaggggg cggttttctg tttgtttttc attccctcct tttgtctgaa
     5941 accatcaggg agggatctgt aatagctctg aagtgtcaca aatttaatat cagtctttta
     6001 atacacaatc ctagttaaat gtaggagagg aaaataaggg gggggggcgg tgctcacggt
     6061 gtttaaatgc attcgtctag aatcctgcgt ctttataaag caggtctgag gtgtccatag
     6121 tagtctttat ttctgccctt ctgtgacagt gttgaagcag gatgaataag tatgtaggct
     6181 tcttcttctt ttaaaaccta gcaaggtgtt tggtgttttc ctttggaatt tctggatgag
     6241 tttgaggaaa cattctgcat gttttatctg gtgtgctttt tcatctcatt acaaacaggc
     6301 agacatcatt gtgcatctct gccatcctta aatacagaag tgattttctt tcctgacttt
     6361 gacattgttg ctatatataa tgtttttatt tgagttttgc aaatcctttg ggtctaattc
     6421 tgtgagccta ccttagcttt gggtgatgat gtctgcagcc tttctttagt tccacagtta
     6481 accttaaagc tgttggagaa gtgtaaacca gcccatgaca gttttttgta cccgcttaag
     6541 aactttattg ttcagttttc atgatgattg tgtaaggaag actgatgcag atgttcatct
     6601 ctcctggacc atgtcaatga cacttatgat gtattttggt tctacatcac agtgatttgt
     6661 ccccaatgac cctttgaccc tttccaggca cattgtgtgt gtgtgtgtgt gtgtgtgtgt
     6721 gtgtgtgtat tgttgttgca gttttccctt tgcattgtat tgctttgaca actgtaattt
     6781 gaatcagatc tgaaagaggt ccagaataaa gtatattttg atattatgtt ggctgtgtac
     6841 atatataacc tctgatatct ctggtttgta tagactatgt agtcaagtga agcgagggac
     6901 ggtgtttgtt tacaacttcc tgtttacatt tcagttgctt ttactccccc actattcagc
     6961 atagaataaa tgattttgct ccaagagtct tccctactac aacctatctg tcctagctct
     7021 tactatctcc agtgaatata actgccatgg gaatcactgt tttcataaac attgtttccg
     7081 agatgtatac tttaaagaag cccatagatg aaattaaagt ttttgctatt ttattacttc
     7141 ttgcagggga taagattttt taaaatgaag ggattatttt ctatatttgt taaatactga
     7201 tagcatgtaa tcagctaggg ataatgatga ctcctgagtg attttgaaat actgatagtt
     7261 tatttagagg attttacaca tgaactaaga cttcagattt actgttagct tagcatccag
     7321 tagcacaagg cacaccaagt atgtggctga gggctttcac ccatgccaac caaacatgct
     7381 gcagtggttt ccacccgtaa ctgatttcgg atcttactac acacccagta acagatgaag
     7441 aacatcccaa ggcacatcca gcctcagttt cccccaactc ttgtagttgg tttccttagt
     7501 caagttcctt ctccgtgccc actgcctttc ttggttttcc ttcgtagatg caggcagctg
     7561 tagccttgtc ctgccctcac tgcaactgct aaagctaaca acctttagtt ttcaaggggt
     7621 tcatttttac tgcatggcct aggttgttaa tgacattctg ttcttacatt ttttccggaa
     7681 agcattgggc tgccaagaat tgggagtcca tatgagcctg aagctaggca gaagtttctt
     7741 gagccaccat tgcagggagg ttatttttta tttcatagtt ctaatacttt atcatgaatt
     7801 agatttctta cctattataa tatgtagctg attacagttt actggttcat ttgatttttt
     7861 tttcctatat attcacctga aaactacagt agaggaaaag ccattatgga cacctggttc
     7921 tgcggtgctt ttctctgctg taccaaggct ctgtcaacag tgaaaatgtt aactctatgc
     7981 tacctttccc cgcatgcttc tttaaatgtc atctaccaat gcttaattgt cctaacttgt
     8041 aatatttttg tattaaattt tttaggagtt ccttgtaatt tctttataat ttaaaatata
     8101 ttaaacacaa agtgtttagt aaaagta
//
