LOCUS       NM_020601               2302 bp    mRNA    linear   ROD 23-AUG-2023
DEFINITION  Mus musculus transducin (beta)-like 1 X-linked (Tbl1x), mRNA.
ACCESSION   NM_020601
VERSION     NM_020601.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2302)
  AUTHORS   Bedogni F and Hevner RF.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2302)
  AUTHORS   Takamizawa T, Satoh T, Miyamoto T, Nakajima Y, Ishizuka T, Tomaru
            T, Yoshino S, Katano-Toki A, Nishikido A, Sapkota S, Watanabe T,
            Okamura T, Ishida E, Horiguchi K, Matsumoto S, Ishii S, Ozawa A,
            Shibusawa N, Okada S and Yamada M.
  TITLE     Transducin beta-like 1, X-linked and nuclear receptor co-repressor
            cooperatively augment the ligand-independent stimulation of TRH and
            TSHbeta gene promoters by thyroid hormone receptors
  JOURNAL   Endocr J 65 (8), 805-813 (2018)
   PUBMED   29794369
  REMARK    GeneRIF: These results suggest that TBL1X is needed for the full
            activation of TRH and TSHbeta gene promoters by unliganded thyroid
            hormone receptors.
REFERENCE   3  (bases 1 to 2302)
  AUTHORS   Kruusvee V, Lyst MJ, Taylor C, Tarnauskaite Z, Bird AP and Cook AG.
  TITLE     Structure of the MeCP2-TBLR1 complex reveals a molecular basis for
            Rett syndrome and related disorders
  JOURNAL   Proc Natl Acad Sci U S A 114 (16), E3243-E3250 (2017)
   PUBMED   28348241
REFERENCE   4  (bases 1 to 2302)
  AUTHORS   Jeon BN, Yoon JH, Kim MK, Choi WI, Koh DI, Hur B, Kim K, Kim KS and
            Hur MW.
  TITLE     Zbtb7c is a molecular 'off' and 'on' switch of Mmp gene
            transcription
  JOURNAL   Biochim Biophys Acta 1859 (11), 1429-1439 (2016)
   PUBMED   27646874
REFERENCE   5  (bases 1 to 2302)
  AUTHORS   Stoy C, Sundaram A, Rios Garcia M, Wang X, Seibert O, Zota A,
            Wendler S, Mannle D, Hinz U, Sticht C, Muciek M, Gretz N, Rose AJ,
            Greiner V, Hofmann TG, Bauer A, Hoheisel J, Berriel Diaz M, Gaida
            MM, Werner J, Schafmeier T, Strobel O and Herzig S.
  TITLE     Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a
            checkpoint in pancreatic cancer malignancy
  JOURNAL   EMBO Mol Med 7 (8), 1048-1062 (2015)
   PUBMED   26070712
REFERENCE   6  (bases 1 to 2302)
  AUTHORS   Ishizuka T and Lazar MA.
  TITLE     The nuclear receptor corepressor deacetylase activating domain is
            essential for repression by thyroid hormone receptor
  JOURNAL   Mol Endocrinol 19 (6), 1443-1451 (2005)
   PUBMED   15695367
REFERENCE   7  (bases 1 to 2302)
  AUTHORS   Perissi V, Aggarwal A, Glass CK, Rose DW and Rosenfeld MG.
  TITLE     A corepressor/coactivator exchange complex required for
            transcriptional activation by nuclear receptors and other regulated
            transcription factors
  JOURNAL   Cell 116 (4), 511-526 (2004)
   PUBMED   14980219
  REMARK    GeneRIF: TBLR1 and TBL1 have roles in specific nuclear
            receptor-mediated gene activation events
REFERENCE   8  (bases 1 to 2302)
  AUTHORS   Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng
            EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC,
            Babbitt PC and Ferrin TE.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2302)
  AUTHORS   Bassi MT, Ramesar RS, Caciotti B, Winship IM, De Grandi A, Riboni
            M, Townes PL, Beighton P, Ballabio A and Borsani G.
  TITLE     X-linked late-onset sensorineural deafness caused by a deletion
            involving OA1 and a novel gene containing WD-40 repeats
  JOURNAL   Am J Hum Genet 64 (6), 1604-1616 (1999)
   PUBMED   10330347
REFERENCE   10 (bases 1 to 2302)
  AUTHORS   Disteche CM, Dinulos MB, Bassi MT, Elliott RW and Rugarli EI.
  TITLE     Mapping of the murine tbl1 gene reveals a new rearrangement between
            mouse and human X Chromosomes
  JOURNAL   Mamm Genome 9 (12), 1062-1064 (1998)
   PUBMED   9880679
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK038674.1.
            
            [WARNING] On Dec 4, 2023 this sequence was replaced by NM_020601.3.
            
            On Apr 6, 2007 this sequence version replaced NM_020601.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK038674.1, BC043105.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2302              AK038674.1         2-2303
FEATURES             Location/Qualifiers
     source          1..2302
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 38.31 cM"
     gene            1..2302
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /note="transducin (beta)-like 1 X-linked"
                     /db_xref="GeneID:21372"
                     /db_xref="MGI:MGI:1336172"
     exon            1..43
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            44..138
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            139..252
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     CDS             195..1778
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /note="transducin beta-like protein 1X"
                     /codon_start=1
                     /product="F-box-like/WD repeat-containing protein TBL1X"
                     /protein_id="NP_065626.1"
                     /db_xref="CCDS:CCDS41036.1"
                     /db_xref="GeneID:21372"
                     /db_xref="MGI:MGI:1336172"
                     /translation="MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLV
                     PPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREK
                     LAQQQANAAAAAAAAAATATSTAATTPAAAAQQNPPKNGEATVNGEENGAHAINNHSK
                     PMEIDGDVEIPPSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG
                     STQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLATGSYDGFARIWTEDGNLASTLG
                     QHKGPIFALKWNKKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTT
                     FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMK
                     QDACVHDLQAHSKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDVERGVCIHT
                     LTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGSLVHSYRGTGGIFEVCWNARG
                     DKVGASASDGSVCVLDLRK"
     exon            253..398
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            399..660
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            661..793
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            794..935
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            936..999
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1097
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1098..1158
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..1280
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1355
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1483
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1484..1649
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1751
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1752..2302
                     /gene="Tbl1x"
                     /gene_synonym="5330429M20; Tbl1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtacgctgag tgcgcggcca caagttgcac ggctcgcggc gagggtggtc ctggactttg
       61 tgagcacctc tcaagttctg tgatcggata ctgggtagcc cactgttcca gaggtctaca
      121 catgcactca ctgtgacgag ggtggctcac acttgatcga gacgaagacc tcatcgccga
      181 aaggtgaggc taagatgagc attaccagcg acgaggtgaa ctttctggta tatcgctacc
      241 tccaggaatc aggtttttcc cactctgcct tcacgtttgg gatcgaaagt cacattagcc
      301 agtccaacat caatggtaca ctagtgccac cggctgccct aatctccatt cttcagaaag
      361 gactgcagta tgtggaggcg gagatcagca tcaacgagga tggcacggta tttgatgggc
      421 gtcccattga gtccctatcg ttaattgatg ctgtgatgcc cgatgtggta cagacaagac
      481 agcaagcttt tcgggagaaa cttgcccagc agcaagccaa tgcagcagct gcagcagcag
      541 cagctgcagc cacagccaca agcacagcgg ctacaacacc agcagctgct gctcagcaaa
      601 acccaccaaa gaatggagaa gccaccgtga atggggaaga aaatggagcc catgcaataa
      661 ataatcactc aaagccaatg gaaatagatg gagacgttga aattccaccg agtaaagcca
      721 cagtccttcg aggccatgag tctgaggtct tcatttgtgc ctggaatcct gttagtgacc
      781 tacttgcttc tggatctgga gactccactg cgaggatatg gaaccttaat gagaacagca
      841 acgggggctc cacacagctt gtgctgaggc actgtatacg tgaaggtgga catgatgttc
      901 ccagtaataa ggatgtcact tcattggact ggaatagcga tggaacactg ttggcaacag
      961 gttcctatga tggttttgca agaatatgga cagaagatgg taacctagcc agcaccttag
     1021 gtcaacataa aggtcccatc tttgctttga agtggaacaa aaaggggaat tatattttga
     1081 gtgctggtgt agacaagaca acaataattt gggacgctca cacaggagaa gccaaacaac
     1141 agtttccttt tcattcagca cctgcccttg atgtggactg gcagaacaac actacctttg
     1201 cctcatgcag cacagacatg tgcattcatg tgtgcaggct tggctgtgat cgcccagtca
     1261 aaaccttcca aggacatact aatgaggtca atgctatcaa atgggatcct tctggaatgt
     1321 tactagcctc ctgctctgat gacatgacat taaagatctg gagtatgaag caggatgcat
     1381 gtgtccatga cctccaggct cacagcaaag agatatatac catcaagtgg agtcccacag
     1441 gaccagccac cagcaacccg aactccaaca tcatgttagc aagtgcttca tttgactcta
     1501 cggttcgact gtgggatgtg gagcgaggtg tttgcatcca cactctgacc aagcatcagg
     1561 agcctgtcta tagtgtagcg ttcagccccg acgggaagta tttggccagt ggatcttttg
     1621 acaagtgtgt ccatatctgg aatactcaga gtggaagtct cgtccacagc taccgaggaa
     1681 caggcggcat atttgaggtg tgctggaatg ctcgaggaga caaagtgggt gccagcgcat
     1741 ctgatggctc cgtctgtgtt ttagatctcc gaaagtaaac acaaaatgta gaaaacaaaa
     1801 ccattctaat ggagcagcag tgaatgtgtg ggattgcagc acccttccta tgatgggctc
     1861 caaactgtgt gaacttgact tgttcgagtc tacttggaaa tcacctgtcc ctggccacag
     1921 gattattttc cccctcccct aatctccatc cagaagttta aaacacaaac aaatacaaag
     1981 tcatacgcat ggttgtatca caggaatatg gtttccacct agaatgctca gctggggaag
     2041 gatgaagcca tcagctacat ggtgcatggt tggtttccat ccagaacagg ctctaatgac
     2101 tgaacaggga aggagaaaca caaagctgtg ccaaaaaata aagaaaaggt taaaaacaat
     2161 gaaaaagaaa aaatgctgtg ataaaccaaa agggaggaaa aacctgcccc ttatggtgtt
     2221 tccctcctat caatttggat actacagttg ctttccaaaa agaccagttt gtaccaatga
     2281 aaatgtgtga ctttgtaatc cc
//
