LOCUS       NM_001372531            3324 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus TBK1 binding protein 1 (Tbkbp1), transcript variant 6,
            mRNA.
ACCESSION   NM_001372531 XM_006534336
VERSION     NM_001372531.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3324)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3324)
  AUTHORS   Zhu,L., Li,Y., Xie,X., Zhou,X., Gu,M., Jie,Z., Ko,C.J., Gao,T.,
            Hernandez,B.E., Cheng,X. and Sun,S.C.
  TITLE     TBKBP1 and TBK1 form a growth factor signalling axis mediating
            immunosuppression and tumourigenesis
  JOURNAL   Nat Cell Biol 21 (12), 1604-1614 (2019)
   PUBMED   31792381
REFERENCE   3  (bases 1 to 3324)
  AUTHORS   Zhu,L., Xie,X., Zhang,L., Wang,H., Jie,Z., Zhou,X., Shi,J.,
            Zhao,S., Zhang,B., Cheng,X. and Sun,S.C.
  TITLE     TBK-binding protein 1 regulates IL-15-induced autophagy and NKT
            cell survival
  JOURNAL   Nat Commun 9 (1), 2812 (2018)
   PUBMED   30022064
  REMARK    GeneRIF: SINTBAD regulates IL-15-induced autophagy and NKT cell
            survival.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3324)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   5  (bases 1 to 3324)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 3324)
  AUTHORS   Fukasaka,M., Ori,D., Kawagoe,T., Uematsu,S., Maruyama,K.,
            Okazaki,T., Kozaki,T., Imamura,T., Tartey,S., Mino,T., Satoh,T.,
            Akira,S. and Takeuchi,O.
  TITLE     Critical role of AZI2 in GM-CSF-induced dendritic cell
            differentiation
  JOURNAL   J Immunol 190 (11), 5702-5711 (2013)
   PUBMED   23610142
REFERENCE   7  (bases 1 to 3324)
  AUTHORS   Soulat,D., Burckstummer,T., Westermayer,S., Goncalves,A., Bauch,A.,
            Stefanovic,A., Hantschel,O., Bennett,K.L., Decker,T. and
            Superti-Furga,G.
  TITLE     The DEAD-box helicase DDX3X is a critical component of the
            TANK-binding kinase 1-dependent innate immune response
  JOURNAL   EMBO J 27 (15), 2135-2146 (2008)
   PUBMED   18583960
REFERENCE   8  (bases 1 to 3324)
  AUTHORS   Ryzhakov,G. and Randow,F.
  TITLE     SINTBAD, a novel component of innate antiviral immunity, shares a
            TBK1-binding domain with NAP1 and TANK
  JOURNAL   EMBO J 26 (13), 3180-3190 (2007)
   PUBMED   17568778
  REMARK    GeneRIF: results suggest that efficient signal transduction upon
            viral infection requires SINTBAD, TANK and NAP1 because they link
            TBK1 and IKKi to virus-activated signalling cascades
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL627445.21.
            
            On Sep 3, 2019 this sequence version replaced XM_006534336.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7652917.1113680.1,
                                           SRR11927936.3115862.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164137
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-85                AL627445.21        39204-39288         c
            86-339              AL627445.21        38575-38828         c
            340-462             AL627445.21        38158-38280         c
            463-567             AL627445.21        37842-37946         c
            568-748             AL627445.21        36586-36766         c
            749-927             AL627445.21        35668-35846         c
            928-989             AL627445.21        35513-35574         c
            990-1108            AL627445.21        28685-28803         c
            1109-1821           AL627445.21        27835-28547         c
            1822-3324           AL627445.21        25386-26888         c
FEATURES             Location/Qualifiers
     source          1..3324
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 60.95 cM"
     gene            1..3324
                     /gene="Tbkbp1"
                     /gene_synonym="3110043L15Rik; ProSAPiP2; SINTBAD"
                     /note="TBK1 binding protein 1"
                     /db_xref="GeneID:73174"
                     /db_xref="MGI:MGI:1920424"
     exon            1..85
                     /gene="Tbkbp1"
                     /gene_synonym="3110043L15Rik; ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            86..339
                     /gene="Tbkbp1"
                     /gene_synonym="3110043L15Rik; ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     CDS             115..1950
                     /gene="Tbkbp1"
                     /gene_synonym="3110043L15Rik; ProSAPiP2; SINTBAD"
                     /note="isoform 2 is encoded by transcript variant 6;
                     TANK-binding kinase 1-binding protein 1"
                     /codon_start=1
                     /product="TANK-binding kinase 1-binding protein 1 isoform
                     2"
                     /protein_id="NP_001359460.1"
                     /db_xref="CCDS:CCDS88239.1"
                     /db_xref="GeneID:73174"
                     /db_xref="MGI:MGI:1920424"
                     /translation="MESMFEDDISILTQEALGPSEVWLDGPGDPSLGGDMCSASHFAL
                     ITAYGDIKERLGGLERENATLRRRLKVYEIKYPLITDFGEEHGFPLYELKDGSLLEVE
                     KVSLQQRLNQFQHELQKSKEQEEQLGEMIQAYEKLCVEKSDLETELGEMRALVETHLR
                     QICGLEKQLQQQQGLRDAAFSSLSPPAVPASACPDLDLHYLALRGGPALGHAGWPGPT
                     SVSVSELERRRLEEALEAAQGEARGAQLREEQLQAECERLQGELKQLQETRAQDLASN
                     QSECDMAWVKRVGDDQVNLALAYTELTEELGRLRELSSLQGRILRTLLQEQARNAGQR
                     HSPLSQRHSPAPACPSPSPPARPPPCAPCQSPAAQRRSPVPPCPSPQQRRSPASPSCP
                     SPVPQRRSPVPPSCQSPSPQRRSPVPPSCPAPQPRPPPPPGERTLAERVYAKPPSHHA
                     KAGFQGRRSYSELAEGAAYAGASPAWLQAEAATLPKPRAYGGELYGRPLSPRRAFEGI
                     RLRFEKQPSEEEEWAMPASPPSPEAGTIRCASFCAGFPIPESPAATAYAHAEHAQSWP
                     SINLLMETVGSDIRSCPLCQLGFPVGYPDDALIKHIDSHLENSKI"
     exon            340..462
                     /gene="Tbkbp1"
                     /gene_synonym="3110043L15Rik; ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            463..567
                     /gene="Tbkbp1"
                     /gene_synonym="3110043L15Rik; ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            568..748
                     /gene="Tbkbp1"
                     /gene_synonym="3110043L15Rik; ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            749..927
                     /gene="Tbkbp1"
                     /gene_synonym="3110043L15Rik; ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            928..989
                     /gene="Tbkbp1"
                     /gene_synonym="3110043L15Rik; ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1108
                     /gene="Tbkbp1"
                     /gene_synonym="3110043L15Rik; ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1109..1821
                     /gene="Tbkbp1"
                     /gene_synonym="3110043L15Rik; ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     exon            1822..3324
                     /gene="Tbkbp1"
                     /gene_synonym="3110043L15Rik; ProSAPiP2; SINTBAD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3303..3308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbkbp1"
                     /gene_synonym="3110043L15Rik; ProSAPiP2; SINTBAD"
                     /note="hexamer: AATAAA"
     polyA_site      3324
                     /gene="Tbkbp1"
                     /gene_synonym="3110043L15Rik; ProSAPiP2; SINTBAD"
                     /note="major polyA site"
ORIGIN      
        1 acagaggcca ggctgcctag cgggactagc cttccttagg agcaggcgac agaggcctgg
       61 gatgggaatc ttggcggctg tcgaggaggc ccagggtggg ctgaagccct taccatggag
      121 tccatgtttg aagatgacat cagcatcctg acccaagagg ccttggggcc cagtgaggtg
      181 tggctggatg gtcctggaga cccgtccctg ggaggggaca tgtgttctgc ctcccacttt
      241 gccctcatca cagcctacgg agacatcaag gaaaggctag gaggcctgga gagggagaat
      301 gccaccctcc gccgtcgcct caaagtctat gagatcaagt atccgctgat cactgatttt
      361 ggagaggagc atggcttccc tctgtatgaa ctcaaggatg gctccctgct ggaggtggag
      421 aaggtcagtc tgcagcaacg actcaaccaa ttccaacacg agttgcagaa gagtaaggag
      481 caggaggagc agctcgggga gatgatccag gcttacgaga aactgtgcgt ggagaaaagc
      541 gacttggaga cagagctggg ggagatgcgg gccctggtag agactcatct acggcagatc
      601 tgtggtctgg agaaacagct gcagcaacag cagggcctcc gggacgcagc tttctccagc
      661 ctgagccccc cagctgtccc cgcctcagcc tgtcctgact tggacctgca ctatctggct
      721 ctgagagggg gacctgcctt gggtcatgca ggttggcctg gccctacgag tgtaagtgtg
      781 agcgagctgg agaggaggcg cctggaagag gccctggagg ctgcgcaggg ggaggctcgg
      841 ggggctcagc tccgggagga gcaactccag gcggaatgcg agagacttca gggagagctg
      901 aagcaactgc aggagacccg ggcccaggat ctggcctcca accagtcgga atgtgacatg
      961 gcttgggtca agagagttgg ggatgatcag gtgaacttgg cgctggccta cacagaactg
     1021 acagaggagc tgggtcggct tcgggagctg agttccctgc aggggaggat cttgaggact
     1081 ttgctgcagg aacaggcccg caacgcaggc caaaggcact caccgctgtc gcaacgtcac
     1141 tccccggccc ctgcgtgccc ctcaccctcc ccgcctgccc gaccgccgcc ctgtgccccg
     1201 tgccagtccc ccgctgcaca gcgccgttcg cccgtgcccc cgtgcccttc gccccagcag
     1261 cgccgctcgc ccgcctcgcc gtcctgcccg tccccagtcc cacagcgccg ctcgcccgtg
     1321 ccgccgtcgt gccagtcgcc cagtcctcag cgccgctcgc ctgtgccacc cagctgcccg
     1381 gccccgcagc cccggccgcc gccaccaccg ggggagagga cgctggccga gcgtgtctac
     1441 gccaagccgc ccagccacca cgccaaggcc ggcttccagg gccgccgcag ctactcggag
     1501 ctggcggagg gggcggccta cgctggtgcc tcccccgcct ggctacaggc cgaggctgcc
     1561 acacttccca agccccgcgc ctatggcggc gagctctacg gcaggccgct cagcccgcgc
     1621 cgagcctttg agggcatccg cctgcgcttt gagaagcagc catctgaaga agaggagtgg
     1681 gctatgccgg ccagcccgcc cagtcccgaa gcgggcacca tccgctgcgc ttcattctgt
     1741 gcgggcttcc ccatcccaga gtcgcctgcg gccaccgcct atgcccacgc tgagcacgca
     1801 cagtcctggc catccatcaa cctactgatg gagacggtgg gctctgatat ccgcagctgc
     1861 cccctctgcc agctgggttt ccctgttggg tacccagatg atgctctcat caaacacata
     1921 gactcccacc ttgagaacag caagatctag ggcacctctc ccacaattgg ctgtttctct
     1981 gttctctctc tcatcgcccc cccaaacact cactttgaat gctgcatgaa tctcgtgggg
     2041 ggcccctgcc ccttgcggtc cccagatacc tccactagct accgagtcaa tgtgtgtgcc
     2101 gtcttccctg gtccaggcac cactcagctc tggctctttc ctggaggtcg accaaggctc
     2161 tccccatctt cctggtttcc actggggagc ggggatctgg tctgggatga ggaggatata
     2221 ccctccacct ctctctgcct ttctgttctt caacagggtt gtctccaaga ggaagtctag
     2281 tgctcagggg agggagagga ggaggtgtca agagctctgg gagccccttc ccaaatgtct
     2341 gtctttcctg ggctgtgttc ttccaggaaa gacctcttga tagggtctca gagcctgccc
     2401 tgcacactga tgccagccct tctgtctcat gaccgaccag cttggggctc gtggtactgg
     2461 ggaaggaggc atcttatttc ttgttagtca ctgcaggcca gctctgttct ccccctctgc
     2521 tcaccctggg aaaccaggtg gcagaggggt gggaggaccc tgcaggcctt ggatgatcca
     2581 gcccaaaggg gctgccttga ggctgggact cctgggccat taccctcaat ccagggaact
     2641 gtctgccagc ctcacaggcc tgggctcttc aggagcccct ggcactaagg tgcagatcac
     2701 caaggcagat gcctcccccc atcaccccca ctgcagctcc tgacaccaca ggttccccag
     2761 agcccaagtg tgactcagcc tgtgtttgct gggtaggtgt catcagcccc tgccttccag
     2821 gccagaacct gagattgggc ccagggtgct gtggagatta atttcaaaag agctaacccc
     2881 cttcccatac ctacccaccc acccctatat tccctctgtg aaatctacct cagagtcctc
     2941 ccctcagaaa gacaggggag tgggaggctg gggccccagg ctgaggtggg agcctcccga
     3001 gggagtctgc tgcccactat gaatccaccc ctcgctttga gcctccctgg ggcctcggcc
     3061 agccgatggc agtgaacgcc actgtccatc gaatgtgcca ttctgatcca aatcttccag
     3121 gccccctccc cacacccctc cttcctctgt gaagggggtg aggggtatgt cagcagggaa
     3181 ggggccaagg actccagaga catgtcattg taccctgagt gttccccagg gaggggacat
     3241 ggggaagggg gcctgtagag gggagagagg gccaagtgct ctctgaacaa gttgaaagtc
     3301 caaataaaac ttacctgttc catc
//
