LOCUS       NM_019786               3031 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus TANK-binding kinase 1 (Tbk1), mRNA.
ACCESSION   NM_019786
VERSION     NM_019786.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3031)
  AUTHORS   Zhang,X., Ling,C., Xiong,Z., Gong,T., Luo,S., Liu,X., Zhang,L.,
            Liao,C., Lu,Y., Huang,X., Zhou,W., Zhou,S., Liu,Y. and Tang,J.
  TITLE     Desuccinylation of TBK1 by SIRT5 regulates inflammatory response of
            macrophages in sepsis
  JOURNAL   Cell Rep 43 (12), 115060 (2024)
   PUBMED   39673708
REFERENCE   2  (bases 1 to 3031)
  AUTHORS   Li,Y., Ji,L., Liu,C., Li,J., Wen,D., Li,Z., Yu,L., Guo,M.,
            Zhang,S., Duan,W., Yi,L., Bi,Y., Bu,H., Li,C. and Liu,Y.
  TITLE     TBK1 is involved in M-CSF-induced macrophage polarization through
            mediating the IRF5/IRF4 axis
  JOURNAL   FEBS J 291 (23), 5214-5235 (2024)
   PUBMED   39434428
REFERENCE   3  (bases 1 to 3031)
  AUTHORS   Lv,B., Dion,W.A., Yang,H., Xun,J., Kim,D.H., Zhu,B. and Tan,J.X.
  TITLE     A TBK1-independent primordial function of STING in lysosomal
            biogenesis
  JOURNAL   Mol Cell 84 (20), 3979-3996 (2024)
   PUBMED   39423796
  REMARK    GeneRIF: A TBK1-independent primordial function of STING in
            lysosomal biogenesis.
REFERENCE   4  (bases 1 to 3031)
  AUTHORS   Li,N., Kumar,S.R.P., Cao,D., Munoz-Melero,M., Arisa,S., Brian,B.A.,
            Greenwood,C.M., Yamada,K., Duan,D. and Herzog,R.W.
  TITLE     Redundancy in Innate Immune Pathways That Promote CD8+ T-Cell
            Responses in AAV1 Muscle Gene Transfer
  JOURNAL   Viruses 16 (10), 1507 (2024)
   PUBMED   39459842
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3031)
  AUTHORS   Nedomova,M., Haberecht-Muller,S., Moller,S., Venz,S.,
            Prochazkova,M., Prochazka,J., Sedlak,F., Chawengsaksophak,K.,
            Hammer,E., Kasparek,P., Adamek,M., Sedlacek,R., Konvalinka,J.,
            Kruger,E. and Grantz Saskova,K.
  TITLE     DDI2 protease controls embryonic development and inflammation via
            TCF11/NRF1
  JOURNAL   iScience 27 (10), 110893 (2024)
   PUBMED   39328932
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3031)
  AUTHORS   Hemmi,H., Takeuchi,O., Sato,S., Yamamoto,M., Kaisho,T., Sanjo,H.,
            Kawai,T., Hoshino,K., Takeda,K. and Akira,S.
  TITLE     The roles of two IkappaB kinase-related kinases in
            lipopolysaccharide and double stranded RNA signaling and viral
            infection
  JOURNAL   J Exp Med 199 (12), 1641-1650 (2004)
   PUBMED   15210742
REFERENCE   7  (bases 1 to 3031)
  AUTHORS   McWhirter,S.M., Fitzgerald,K.A., Rosains,J., Rowe,D.C.,
            Golenbock,D.T. and Maniatis,T.
  TITLE     IFN-regulatory factor 3-dependent gene expression is defective in
            Tbk1-deficient mouse embryonic fibroblasts
  JOURNAL   Proc Natl Acad Sci U S A 101 (1), 233-238 (2004)
   PUBMED   14679297
  REMARK    GeneRIF: expression of IRF3-dependent genes in embryonic
            fibroblasts derived from Tbk1(-/-) mice
REFERENCE   8  (bases 1 to 3031)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3031)
  AUTHORS   Bonnard,M., Mirtsos,C., Suzuki,S., Graham,K., Huang,J., Ng,M.,
            Itie,A., Wakeham,A., Shahinian,A., Henzel,W.J., Elia,A.J.,
            Shillinglaw,W., Mak,T.W., Cao,Z. and Yeh,W.C.
  TITLE     Deficiency of T2K leads to apoptotic liver degeneration and
            impaired NF-kappaB-dependent gene transcription
  JOURNAL   EMBO J 19 (18), 4976-4985 (2000)
   PUBMED   10990461
REFERENCE   10 (bases 1 to 3031)
  AUTHORS   Pomerantz,J.L. and Baltimore,D.
  TITLE     NF-kappaB activation by a signaling complex containing TRAF2, TANK
            and TBK1, a novel IKK-related kinase
  JOURNAL   EMBO J 18 (23), 6694-6704 (1999)
   PUBMED   10581243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124413.2, BU708441.1, BC129910.1, AK004649.2 and BU758191.1.
            
            On Jul 8, 2009 this sequence version replaced NM_019786.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004649.2, AK083214.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC124413.2         170531-170537       c
            8-88                BU708441.1         1-81
            89-2599             BC129910.1         1-2511
            2600-3026           AK004649.2         2554-2980
            3027-3031           BU758191.1         15-19               c
FEATURES             Location/Qualifiers
     source          1..3031
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 69.84 cM"
     gene            1..3031
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /note="TANK-binding kinase 1"
                     /db_xref="GeneID:56480"
                     /db_xref="MGI:MGI:1929658"
     exon            1..100
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            101..246
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2349
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /EC_number="2.7.11.1"
                     /note="T2K"
                     /codon_start=1
                     /product="serine/threonine-protein kinase TBK1"
                     /protein_id="NP_062760.3"
                     /db_xref="CCDS:CCDS24212.1"
                     /db_xref="GeneID:56480"
                     /db_xref="MGI:MGI:1929658"
                     /translation="MQSTSNHLWLLSDILGQGATANVFRGRHKKTGDLYAVKVFNNIS
                     FLRPVDVQMREFEVLKKLNHKNIVKLFAIEEETTTRHKVLIMEFCPCGSLYTVLEEPS
                     NAYGLPESEFLIVLRDVVGGMNHLRENGIVHRDIKPGNIMRVIGEDGQSVYKLTDFGA
                     ARELEDDEQFVSLYGTEEYLHPDMYERAVLRKDHQKKYGATVDLWSVGVTFYHAATGS
                     LPFRPFEGPRRNKEVMYKIITGKPSGAISGVQKAENGPIDWSGDMPLSCSLSQGLQAL
                     LTPVLANILEADQEKCWGFDQFFAETSDVLHRMVIHVFSLQHMTAHKIYIHSYNTAAV
                     FHELVYKQTKIVSSNQELIYEGRRLVLELGRLAQHFPKTTEENPIFVTSREQLNTVGL
                     RYEKISLPKIHPRYDLDGDASMAKAVTGVVCYACRTASTLLLYQELMRKGVRWLVELV
                     KDDYNETVHKKTEVVITLDFCIRNIEKTVKVYEKLMKVNLEAAELGEISDIHTKLLRL
                     SSSQGTIESSLQDISSRLSPGGLLADTWAHQEGTHPRDRNVEKLQVLLNCITEIYYQF
                     KKDKAERRLAYNEEQIHKFDKQKLYYHATKAMSHFSEECVRKYEAFKDKSEEWMRKML
                     HLRKQLLSLTNQCFDIEEEVSKYQDYTNELQETLPQKMLAASGGVKHAMAPIYPSSNT
                     LVEMTLGMKKLKEEMEGVVKELAENNHILERFGSLTMDGGLRNVDCL"
     exon            247..387
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            388..517
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            518..699
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            700..860
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            861..971
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1151
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1348
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1407
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1408..1499
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1500..1601
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1680
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1802
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1879
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1880..1919
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2021
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2118
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2225
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2297
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2298..3031
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3005..3010
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /note="hexamer: AATAAA"
     polyA_site      3031
                     /gene="Tbk1"
                     /gene_synonym="1200008B05Rik"
                     /note="major polyA site"
ORIGIN      
        1 tcggtcacgt gctccgtggc ccgggctggc gaagccggaa gtagcctggg gcgcgagaag
       61 gcccgggagc cgcgggctgt acgcggcgga cactcgcggg catacatgca aatctcttct
      121 tcccccttat cgtgaggaga agcgcctgga caagccgaga tgcagagcac ctccaaccat
      181 ctgtggctcc tgtctgatat cctaggccag ggggccactg caaatgtctt ccgaggaagg
      241 cataagaaaa ctggtgatct ctatgctgtc aaagtattta ataacataag cttccttcgc
      301 ccagtggatg ttcaaatgag agaatttgaa gtgttaaaaa aactcaatca caaaaacatt
      361 gtcaagttat ttgctattga agaggagaca acaacaagac ataaagtgct tattatggag
      421 ttttgtccct gtgggagttt atacactgtt ctagaggagc cgtccaatgc gtatggactt
      481 ccagaatcag aatttctcat tgtcttacga gatgtggtgg gcgggatgaa tcatctccga
      541 gagaacggca tagtgcaccg agatatcaag ccaggcaaca tcatgcgcgt cataggggag
      601 gacggccagt ctgtgtacaa actcacggat ttcggcgccg ctcgagagct ggaggacgat
      661 gagcagtttg tgtctctgta cggcacagaa gagtacctgc atccggacat gtatgaaagg
      721 gcagtgctaa gaaaggacca tcagaagaag tacggggcta ccgttgatct gtggagtgtt
      781 ggagtgacat tctaccatgc agccacgggg tcgctgccgt ttagaccctt cgaggggcct
      841 cggaggaaca aagaagtaat gtataaaata atcactggga agccgtctgg tgcaatatct
      901 ggagtacaga aagcagaaaa cggaccaatt gactggagtg gagacatgcc tctctcctgt
      961 agtctttctc agggtcttca ggcactgctt accccagttc ttgcaaacat acttgaagct
     1021 gatcaggaga agtgctgggg ttttgaccag ttctttgcag agaccagtga tgtgcttcac
     1081 cgaatggtga tccatgtctt ctcgctacaa cacatgacgg cgcataagat ttacattcac
     1141 agctataaca ctgctgctgt gttccatgaa ctggtctata aacaaaccaa gattgtttcc
     1201 tcaaatcaag aacttatcta cgaaggacga cgcttagtcc tagaactcgg acgactagcc
     1261 cagcattttc ctaaaaccac agaggaaaat cctatctttg tcacgagccg ggaacaactc
     1321 aataccgtag gactgagata tgaaaaaatt tccctcccta aaatacatcc acgctatgat
     1381 ctggatgggg acgccagcat ggccaaggca gtgacggggg ttgtgtgcta cgcctgcaga
     1441 actgccagta ccctgctgct ctatcaagaa ttaatgcgaa agggggtacg gtggctggtt
     1501 gaactggtta aggatgatta caacgagacc gtccacaaga agacggaggt agtgatcaca
     1561 ctggatttct gcatcaggaa cattgagaag actgtgaaag tgtatgagaa gttgatgaag
     1621 gtcaacctgg aagccgcaga gctgggtgag atttcagaca tacacaccaa gctgctgaga
     1681 ctttccagtt ctcagggaac aatagaaagc agtcttcagg acatcagcag caggctgtct
     1741 ccagggggct tgctggccga cacctgggca catcaagaag gcacgcatcc aagagacagg
     1801 aatgtagaaa aactgcaggt cctgttgaac tgcatcacag agatttacta tcagttcaaa
     1861 aaagacaaag cagaacgcag actagcttat aatgaagaac agatccacaa atttgataag
     1921 caaaaattgt attaccatgc cacaaaagca atgagccact tctcagaaga atgtgttaga
     1981 aagtatgaag cgtttaaaga taagtcggaa gagtggatga gaaagatgct tcatcttagg
     2041 aagcagctgt tatcgctaac taatcagtgt ttcgatatcg aagaggaagt gtccaagtat
     2101 caagactata ctaacgagtt acaagaaact ctgcctcaga aaatgctcgc agcctccggc
     2161 ggcgtcaagc acgccatggc cccgatctac cccagctcta acaccttagt ggagatgact
     2221 cttggtatga agaagttaaa ggaggagatg gaaggcgtgg ttaaggagct ggccgagaac
     2281 aatcatattt tagaaaggtt tgggtcttta acaatggatg gtggccttcg caatgtggac
     2341 tgtctttagc ttcctaggga gtctgggaag ttctagtttg cacaagaaga taacactggg
     2401 gcacgaaatg aacacctttg tgaatggagt tcttatttct acacttcagt atttgatgag
     2461 gtcatgtaaa tatgtacagt ttgtaaatac atatacatat atatatatat atatgaattt
     2521 tggctgctgt aacaaagaca gattgacctc agcgagctgt agaagaaagc catgaccagc
     2581 cagtgctttg gggtgctctc cctaattctt cacataaggc tggagaaatc aattgcttgg
     2641 tgcctaaaga aagtattttt tgaattggca ttcttaaaat tttgaaagga ctgatagtcg
     2701 acacagtgta actggaggag acacagggct ttgtgacggg aacagaaccg cggtttaacc
     2761 acagtcggtt ccctgacaag gataaagtgg cattatctca tttgaccggg tgcccaaatc
     2821 tcagttttcc tcggatgttt gattttaggt gaattattga gcaaaaactt taaagtgaat
     2881 tcattgttta aactattcat ttttcctttg gtcatgaatg tgtaattgtc attcagatcc
     2941 tagtatcatt tcaattgtct taagatgtat atttctgtac tttaattctg ctatttcatg
     3001 aaaaaataaa tttctcaatt ttaatgtaaa a
//
